CN105616706A - 参灵扶正颗粒及其制备方法 - Google Patents
参灵扶正颗粒及其制备方法 Download PDFInfo
- Publication number
- CN105616706A CN105616706A CN201610163826.9A CN201610163826A CN105616706A CN 105616706 A CN105616706 A CN 105616706A CN 201610163826 A CN201610163826 A CN 201610163826A CN 105616706 A CN105616706 A CN 105616706A
- Authority
- CN
- China
- Prior art keywords
- parts
- strengthening
- preparation
- granules
- shenling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000005728 strengthening Methods 0.000 title claims abstract description 28
- 239000008187 granular material Substances 0.000 title claims abstract description 27
- 235000003140 Panax quinquefolius Nutrition 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 240000008397 Ganoderma lucidum Species 0.000 title abstract 4
- 235000001637 Ganoderma lucidum Nutrition 0.000 title abstract 4
- 240000005373 Panax quinquefolius Species 0.000 title abstract 4
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 241000756943 Codonopsis Species 0.000 claims abstract description 18
- 235000016425 Arthrospira platensis Nutrition 0.000 claims abstract description 15
- 240000002900 Arthrospira platensis Species 0.000 claims abstract description 15
- 230000001954 sterilising effect Effects 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000706 filtrate Substances 0.000 claims abstract description 12
- 238000010992 reflux Methods 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 3
- 238000000605 extraction Methods 0.000 claims abstract description 3
- 241000208340 Araliaceae Species 0.000 claims description 19
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 19
- 235000008434 ginseng Nutrition 0.000 claims description 19
- 241000222336 Ganoderma Species 0.000 claims description 14
- 244000241838 Lycium barbarum Species 0.000 claims description 14
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 14
- 239000009636 Huang Qi Substances 0.000 claims description 13
- 229940082787 spirulina Drugs 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- 239000003814 drug Substances 0.000 abstract description 10
- 230000000259 anti-tumor effect Effects 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 7
- 230000002588 toxic effect Effects 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 4
- 235000015468 Lycium chinense Nutrition 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 2
- 241000045403 Astragalus propinquus Species 0.000 abstract 2
- 240000000759 Lepidium meyenii Species 0.000 abstract 2
- 235000000421 Lepidium meyenii Nutrition 0.000 abstract 2
- 244000241872 Lycium chinense Species 0.000 abstract 2
- 235000006533 astragalus Nutrition 0.000 abstract 2
- 235000012902 lepidium meyenii Nutrition 0.000 abstract 2
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 description 13
- 201000011510 cancer Diseases 0.000 description 9
- 238000011282 treatment Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 4
- 206010039491 Sarcoma Diseases 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 238000001291 vacuum drying Methods 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 241001106041 Lycium Species 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000002929 anti-fatigue Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 230000000050 nutritive effect Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000005686 eating Nutrition 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000021191 food habits Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 208000037805 labour Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明属于医药技术领域，具体公开了参灵扶正颗粒及其制备方法。所述参灵扶正颗粒，由玛卡10-25份、灵芝4-9份、西洋参10-25份、党参10-30份、黄芪30-55份、螺旋藻30-45份、枸杞40-60份制成。参灵扶正颗粒的制备方法，包括以下步骤：将切片、干燥、粉碎、灭菌后的原料按重量比称量；原料玛卡、灵芝、西洋参、党参、黄芪、螺旋藻、枸杞混合得到混合原料，加入乙醇回流提取多次，过滤得到滤液，将滤液浓缩至干；将浓缩的干燥物过筛，进行灭菌，最后制得所述参灵扶正颗粒。本发明所提供的参灵扶正颗粒的有益效果为：抗肿瘤效果显著，毒副作用小，制备方法简单，价格低廉。
Description
技术领域
本发明属于医药技术领域，具体涉及一种具有抗肿瘤作用的参灵扶正颗粒及其制备方法。
背景技术
随着社会经济发展，工业化程度逐渐提高，而人类生存的环境也日益恶化，加之现代社会人们生活压力增大，以及饮食习惯和生活方式的改变等，造成肿瘤的发病率持续攀升。因此，肿瘤的预防和治疗已经成为关系人类健康生活的重要问题，抗肿瘤研究成为当今医药研究中极富挑战且意义重大的领域。
目前，治疗恶性肿瘤的主要手段为外科手术、化疗、放疗。手术虽然可以去除原发病灶，但当恶性肿瘤细胞向原发部位以外其他部位转移时，单独的手术切除已达不到治疗目的，不能从根本上杜绝癌细胞的再生与转移，此时需配合采用放疗、化疗。虽然放疗和化疗能杀死恶性肿瘤细胞，但正常组织细胞也会受到损害，毒副作用明显，这些毒副作用包括机体衰弱、食欲不振、损伤肝肾卵巢等。而常规的化学药品治疗方法难以阻止癌细胞转移并且具有很大的毒副作用，这是目前对癌症治疗中存在的主要问题。
传统中药由于其具有抗癌抑肿、毒副作用小等优势逐渐成为抗肿瘤研究的热点，并取得了较大进步，中医理论的发展也为中药治疗肿瘤打下了基础。
发明内容
本发明所解决的技术问题是提供一种可以抑制杀死肿瘤细胞、减少癌症患者痛苦的中药。其利用传统中药和现代制剂技术，克服西医治疗恶性肿瘤的缺陷，抑制杀灭肿瘤细胞，减少患者痛苦，有效延长他们的生命。
本发明所述参灵扶正颗粒，由下述原料按重量配比制成：玛卡10-25份、灵芝4-9份、西洋参10-25份、党参10-30份、黄芪30-55份、螺旋藻30-45份、枸杞40-60份。
本发明所述参灵扶正颗粒，优选玛卡15份、灵芝6份、西洋参15份、党参20份、黄芪40份、螺旋藻35份、枸杞50份制成。
所述原料是经切片、干燥、粉碎、灭菌制成。
本发明还提供了一种参灵扶正颗粒的制备方法，包括以下步骤：
(1)、将玛卡、灵芝、西洋参、党参、黄芪、螺旋藻、枸杞分别切片、干燥、粉碎、灭菌后按重量比称取；
(2)、将步骤(1)称取的原料混合，加入乙醇回流提取，过滤得到滤液，将滤液浓缩至干；
(3)、将浓缩的干燥物过筛，进行灭菌，最后制得所述参灵扶正颗粒。
其中，所述步骤(2)中加入的乙醇为原料混合物质量的5～10倍。
所述步骤(2)中，加入乙醇回流每次提取时间为2～4小时，所述回流温度为70～80℃。
所述步骤(3)中浓缩物干燥至含水率8％。
本发明采用的中药组合物中，各原料的功效如下所示：
玛卡，是无毒、无副作用、无依赖性的天然健康营养素，富含55种活力营养元素，长期食用能有效补充大量营养成分，全面调理人体生理平衡，提高免疫力，适用于抗疲劳、补充体力、提高睡眠治疗，抗更年期，增强记忆，抗氧化，延缓衰老。
灵芝，外形呈伞状，菌盖肾形、半圆形或近圆形，为多孔菌科真菌灵芝的子实体，主治虚劳、咳嗽、气喘、失眠、消化不良，恶性肿瘤等。
西洋参，别名花旗参、洋参、广东人参、西洋人参，气微香，味苦、微甘，可以增强中枢神经系统功能，保护心血管，提高免疫力、抑制癌细胞生长，有效抵抗癌症，促进血液活力。
党参，为植物党参和中药材的统称，党参为中国常用的传统补益药，古代以山西上党地区出产的党参为上品，具有补中益气，健脾益肺之功效。
黄芪，味甘性微温，归肺、脾、肝、肾经，补齐固表，托疮生肌，主治体虚自汗，久泻，脱肛，子宫脱垂，慢性肾炎，体虚浮肿，慢性溃疡，疮口久不愈合。
枸杞，是茄目茄科枸杞属(Lycium)的植物，果实称枸杞子，味甘、性平，具有延缓衰老、抗脂肪肝、抗疲劳、抗肿瘤等作用。
螺旋藻具有减轻癌症放疗、化疗的毒副反应，提高免疫功能，降低血脂，主癌症的辅助治疗，高脂血症，缺铁性贫血，营养不良，病后体虚，特别对于高血压、慢性胃肠病、胃及十二指肠溃疡症、糖尿病、白内障、肝病、便秘与痔疮、贫血症具有较好的治疗效果。上述七味药配合使用，共奏扶正祛邪、提高机体免疫之功效，抗肿瘤效果显著，毒副作用小，制备方法简单，价格低廉。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合具体实施方式对本发明进一步详细说明。应当理解，此处所描述的具体实施方式仅仅用以解释本发明，但并不用于限定本发明。
实施例1
称取玛卡10g、灵芝4g、西洋参10g、党参10g、黄芪30g、螺旋藻30g、枸杞40g，将称取的原料进行切片、干燥、粉碎、灭菌。
将原料玛卡、灵芝、西洋参、党参、黄芪、螺旋藻、枸杞混合得到混合原料，加入乙醇回流提取，过滤得到滤液，将滤液浓缩真空干燥；
将浓缩的干燥物过筛，进行灭菌，最后制得所述参灵扶正颗粒。
实施例2
称取玛卡15g、灵芝6g、西洋参15g、党参20g、黄芪40g、螺旋藻35g、枸杞50g，将称取的原料进行切片、干燥、粉碎、灭菌。
将原料玛卡、灵芝、西洋参、党参、黄芪、螺旋藻、枸杞混合得到混合原料，加入乙醇回流提取，过滤得到滤液，将滤液浓缩真空干燥；
将浓缩的干燥物过筛，进行灭菌，最后制得所述参灵扶正颗粒。
实施例3
称取玛卡25g、灵芝9g、西洋参25g、党参30g、黄芪55g、螺旋藻45g、枸杞60g，将称取的原料进行切片、干燥、粉碎、灭菌。
将原料玛卡、灵芝、西洋参、党参、黄芪、螺旋藻、枸杞混合得到混合原料，加入乙醇回流提取，过滤得到滤液，将滤液浓缩真空干燥；
将浓缩的干燥物过筛，进行灭菌，最后制得所述参灵扶正颗粒。
抗肿瘤药效评价
1、小鼠移植瘤实验
普通级ICR小鼠50只，，6-8周龄，体重18～22g，分别为空白组、阳性对照组、本发明参灵扶正颗粒药高、中、低剂量组，每组10只。其中，参灵扶正颗粒高、中、低剂量组所用药物为实施例2中制备得到的，取肿瘤细胞(S180肉瘤细胞2×106)接种于小鼠右侧腋部皮下。
2、实验药物
阳性对照药：5FU：吸取5FU注射液0.5ml(12.5mg)，加入9ml生理盐水，配成1.25mg/ml的溶液。
3、实验与结果
肿瘤接种7天后，除空白对照组外，其余组小鼠给予相应的药物。给药期间每天测定体重，连续给药2周后处死小鼠，称瘤重，计算各组平均瘤重，按照下述公式计算肿瘤抑制率。
肿瘤生长抑制率＝(空白对照组平均瘤重-治疗组平均瘤重)/空白对照组平均瘤重。
本发明抗肿瘤药参灵扶正颗粒对S180肉瘤小鼠体重影响不大，但对S180肉瘤有明显的抑制作用，结果见表1。
表1本发明抗肿瘤药物组合物对S180实体瘤生长的影响
本发明的描述并不是无遗漏的或者将本发明限于所公开的形式。其中很多修改和变化对于本领域的普通技术人员而言是显然的，在不超出权利要求所记载的技术方案的前提下还有其它的变形。
Claims (8)
1.一种参灵扶正颗粒，其特征在于，由下述原料按重量配比制成：玛卡10-25份、灵芝4-9份、西洋参10-25份、党参10-30份、黄芪30-55份、螺旋藻30-45份、枸杞40-60份。
2.根据权利要求1所述参灵扶正颗粒，其特征在于，由玛卡15份、灵芝6份、西洋参15份、党参20份、黄芪40份、螺旋藻35份、枸杞50份制成。
3.根据权利要求1所述参灵扶正颗粒，其特征在于，所述原料是经切片、干燥、粉碎、灭菌制成。
4.根据权利要求1～3任一所述参灵扶正颗粒的制备方法，其特征在于，包括以下步骤：
(1)、将玛卡、灵芝、西洋参、党参、黄芪、螺旋藻、枸杞分别切片、干燥、粉碎、灭菌后按重量比称取；
(2)、将步骤(1)称取的原料混合，加入乙醇回流提取，过滤得到滤液，将滤液浓缩至干；
(3)、将浓缩的干燥物过筛，进行灭菌，最后制得所述参灵扶正颗粒。
5.根据权利要求4所述参灵扶正颗粒的制备方法，其特征在于，所述步骤(2)中加入的乙醇为原料混合物重量的5～10倍。
6.根据权利要求4所述的参灵扶正颗粒的制备方法，其特征在于，所述步骤(2)中，加入乙醇回流每次提取时间为2～4小时。
7.根据权利要求4所述的参灵扶正颗粒的制备方法，其特征在于，所述回流温度为70～80℃。
8.根据权利要求4所述参灵扶正颗粒制备方法，其特征在于，所述步骤(3)中浓缩物干燥至含水率8％。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610163826.9A CN105616706B (zh) | 2016-03-22 | 2016-03-22 | 参灵扶正颗粒及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610163826.9A CN105616706B (zh) | 2016-03-22 | 2016-03-22 | 参灵扶正颗粒及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105616706A true CN105616706A (zh) | 2016-06-01 |
| CN105616706B CN105616706B (zh) | 2020-07-07 |
Family
ID=56032317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610163826.9A Expired - Fee Related CN105616706B (zh) | 2016-03-22 | 2016-03-22 | 参灵扶正颗粒及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105616706B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109363174A (zh) * | 2018-10-31 | 2019-02-22 | 吉林省恒实传食品科技发展有限公司 | 一种增强免疫力、缓解体力疲劳的健康养生食品及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850219A (zh) * | 2006-03-14 | 2006-10-25 | 北京国丹药物技术开发有限公司 | 一种参灵扶正中药制剂 |
| CN101199618A (zh) * | 2007-12-17 | 2008-06-18 | 李乃新 | 参灵通络胶囊 |
-
2016
- 2016-03-22 CN CN201610163826.9A patent/CN105616706B/zh not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850219A (zh) * | 2006-03-14 | 2006-10-25 | 北京国丹药物技术开发有限公司 | 一种参灵扶正中药制剂 |
| CN101199618A (zh) * | 2007-12-17 | 2008-06-18 | 李乃新 | 参灵通络胶囊 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109363174A (zh) * | 2018-10-31 | 2019-02-22 | 吉林省恒实传食品科技发展有限公司 | 一种增强免疫力、缓解体力疲劳的健康养生食品及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105616706B (zh) | 2020-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102091315A (zh) | 生姜与乌梅组合物、其制备方法及其在制备癌症放、化疗中减毒增效药物中的用途 | |
| CN102134549B (zh) | 一种舞茸酒及其制备方法 | |
| CN108853366B (zh) | 一种能促进和改善睡眠质量的药物及其生产方法 | |
| CN101342271B (zh) | 医治肿瘤化疗引起的气血两虚的中药及制备方法 | |
| CN102861284A (zh) | 一种治疗非小细胞肺癌的中药复方制剂及其制备方法 | |
| CN107789484A (zh) | 一种治疗月经不调的中药组合物及其制备方法 | |
| CN101711848B (zh) | 一种辅助治疗肿瘤的中药组合物 | |
| CN1864718A (zh) | 一种用于肿瘤辅助治疗的多糖组合物及其制剂和应用 | |
| US10953062B2 (en) | Anticancer pharmaceutical composition and application thereof | |
| CN108186794B (zh) | 一种治疗肺癌的中药组合物及其制备方法和应用 | |
| CN103933541B (zh) | 一种谷胱甘肽抗癌组合物 | |
| CN103550718B (zh) | 一种治疗肺癌的中药组合物 | |
| CN105616706A (zh) | 参灵扶正颗粒及其制备方法 | |
| CN109010495B (zh) | 一种中药组合物及其制备方法和应用 | |
| CN103877324A (zh) | 用于提高蛋鸡产蛋量的中药添加剂及其制备方法 | |
| CN114869987B (zh) | 一种用于预防肝癌的中药组合物 | |
| CN102552541B (zh) | 一种预防或治疗乳腺癌的药物组合物 | |
| CN105031389A (zh) | 一种配合放疗法抑制恶性肿瘤繁殖的中药片剂及制法 | |
| CN105832867A (zh) | 花椒蜈蚣富硒药酒泡制方法 | |
| CN106074960A (zh) | 一种治疗乳腺癌及乳腺增生的中药组合物及其制备方法 | |
| CN105056160A (zh) | 一种治疗奶牛缺乳症的药物组合物及其制备方法 | |
| CN105456951A (zh) | 一种治疗乳房纤维腺瘤的中药制剂及其制备方法 | |
| CN104840727B (zh) | 具有抗食道癌活性的中药组合物及其制备方法和应用 | |
| CN104173394B (zh) | 一种抗乳腺癌的药物组合物及其制备方法和用途 | |
| CN101822719A (zh) | 无花果防治肿瘤的脂乳透皮剂及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200707 |