CN105517993B - 芳基酰胺激酶抑制剂 - Google Patents
芳基酰胺激酶抑制剂 Download PDFInfo
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- CN105517993B CN105517993B CN201480049237.7A CN201480049237A CN105517993B CN 105517993 B CN105517993 B CN 105517993B CN 201480049237 A CN201480049237 A CN 201480049237A CN 105517993 B CN105517993 B CN 105517993B
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- phenyl
- amino
- bases
- oxazole
- alkyl
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- 0 CN1C=C(*)OC1 Chemical compound CN1C=C(*)OC1 0.000 description 12
- OQSCERIJWXIDGD-UHFFFAOYSA-N CC(C)(C)c1ccnnc1 Chemical compound CC(C)(C)c1ccnnc1 OQSCERIJWXIDGD-UHFFFAOYSA-N 0.000 description 1
- UATFFGHTXGRAOH-UHFFFAOYSA-N CC(C)CCC(C(Nc(cc1)cc(OC)c1-c1cnc[o]1)=O)N Chemical compound CC(C)CCC(C(Nc(cc1)cc(OC)c1-c1cnc[o]1)=O)N UATFFGHTXGRAOH-UHFFFAOYSA-N 0.000 description 1
- RUDQVKYEPYHFSQ-GFCCVEGCSA-N CC(C)C[C@H](C(Nc(cc1)cc(OC)c1-c1nnc[s]1)=O)N Chemical compound CC(C)C[C@H](C(Nc(cc1)cc(OC)c1-c1nnc[s]1)=O)N RUDQVKYEPYHFSQ-GFCCVEGCSA-N 0.000 description 1
- FTXAANAXUZFTRE-UHFFFAOYSA-N CCC(CC(CC1)c2cnc[o]2)CC1NC(CCC(C)C)=O Chemical compound CCC(CC(CC1)c2cnc[o]2)CC1NC(CCC(C)C)=O FTXAANAXUZFTRE-UHFFFAOYSA-N 0.000 description 1
- RLYUNPNLXMSXAX-UHFFFAOYSA-N Cc1cnc[s]1 Chemical compound Cc1cnc[s]1 RLYUNPNLXMSXAX-UHFFFAOYSA-N 0.000 description 1
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P25/16—Anti-Parkinson drugs
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
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| US61/843,588 | 2013-07-08 | ||
| PCT/US2014/045075 WO2015006100A1 (en) | 2013-07-08 | 2014-07-01 | Aryl amide kinase inhibitors |
Publications (2)
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| CN105517993A CN105517993A (zh) | 2016-04-20 |
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| WO (1) | WO2015006100A1 (OSRAM) |
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| WO2015054358A1 (en) | 2013-10-11 | 2015-04-16 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| RS58062B1 (sr) | 2014-04-02 | 2019-02-28 | Bristol Myers Squibb Co | Biaril inhibitori kinaze |
| CN108290843B (zh) | 2015-10-01 | 2021-08-24 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| CN112142655A (zh) | 2015-10-01 | 2020-12-29 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| JP7383598B2 (ja) * | 2017-07-21 | 2023-11-20 | カドモン コーポレイション,リミティド ライアビリティ カンパニー | Rho関連コイルドコイル含有プロテインキナーゼの阻害剤 |
| CA3121719A1 (en) | 2018-12-19 | 2020-06-25 | Leo Pharma A/S | Amino-acid anilides as small molecule modulators of il-17 |
| US20230250079A1 (en) * | 2020-06-12 | 2023-08-10 | Leo Pharma A/S | Small molecule modulators of il-17 |
| CN112266328B (zh) * | 2020-12-09 | 2023-11-03 | 郑州萃智医药科技有限公司 | 3-氟-4-硝基苯甲醛的合成路线及制备方法 |
| CN113321577A (zh) * | 2021-06-28 | 2021-08-31 | 上海立科化学科技有限公司 | 5-溴-2-氯苯甲酸的制备方法 |
| JP2024527618A (ja) * | 2021-07-15 | 2024-07-25 | シーザン ハイスーク ファーマシューティカル カンパニー リミテッド | Aak1阻害剤及びその用途 |
| CN119546609A (zh) * | 2022-05-18 | 2025-02-28 | 葆元生物医药科技(杭州)有限公司 | 用于制备3,6-二取代-咪唑并[1,2-b]哒嗪化合物的方法 |
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| US1309036A (en) * | 1919-07-08 | Trap-stake | ||
| US1308935A (en) * | 1919-07-08 | Hinge for metal boxes or gaits | ||
| US4317827A (en) * | 1980-05-27 | 1982-03-02 | Sterling Drug Inc. | 4-[4(or 3)-Acylaminophenyl]pyridines and their use as cardiotonics |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| AU2515992A (en) | 1991-08-20 | 1993-03-16 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5709861A (en) | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| WO2003053958A1 (en) | 2001-12-20 | 2003-07-03 | Celltech R & D Limited | Quinazolinedione derivatives |
| ES2301793T3 (es) | 2002-04-05 | 2008-07-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Cianamidas utiles como inhibidores reversibles de cisteina proteasas. |
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| EP1593667A4 (en) | 2003-02-12 | 2009-03-04 | Takeda Pharmaceutical | Amine derivative |
| WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
| US20050288338A1 (en) | 2004-06-24 | 2005-12-29 | Wenqing Yao | Amido compounds and their use as pharmaceuticals |
| CN100494167C (zh) | 2005-08-02 | 2009-06-03 | 天津大学 | 抗乙肝病毒的叔胺氧化物及制备方法和制备药物的应用 |
| JP2007064054A (ja) | 2005-08-30 | 2007-03-15 | Daihatsu Motor Co Ltd | 二サイクル式多気筒内燃機関 |
| EP1922306A2 (en) * | 2005-09-02 | 2008-05-21 | Astellas Pharma Inc. | Amide derivatives as rock inhibitors |
| US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| JP2007217408A (ja) | 2006-01-19 | 2007-08-30 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| PT2674428T (pt) | 2006-04-07 | 2016-07-14 | Vertex Pharma | Modeladores de transportadores de cassetes de ligação de atp |
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| CN101896461A (zh) * | 2007-12-13 | 2010-11-24 | 安姆根有限公司 | γ分泌酶调节剂 |
| CA2709879A1 (en) * | 2007-12-19 | 2009-06-25 | The Scripps Research Institute | Anilides and analogs as rho kinase inhibitors |
| EP2149565A1 (de) | 2008-07-24 | 2010-02-03 | Bayer Schering Pharma AG | Sulfonsubstituierte Chinazolinderivate als Immunmodulatoren zur Behandlung von enzündlichen und allergischen Erkrankungen |
| MX2011013446A (es) | 2009-07-06 | 2012-02-13 | Syngenta Participations Ag | Compuetos insecticidas. |
| US8497271B2 (en) | 2009-10-07 | 2013-07-30 | Bristol-Myers Squibb Company | Modulators of G protein-coupled receptor 88 |
| US8426414B2 (en) | 2009-10-09 | 2013-04-23 | Bristol-Myers Squibb Company | Modulators of G protein-coupled receptor 88 |
| US8304577B2 (en) | 2009-10-09 | 2012-11-06 | Bristol-Myers Squibb Company | Modulators of G protein-coupled receptor 88 |
| JP5752232B2 (ja) * | 2010-03-31 | 2015-07-22 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | プロテインキナーゼ阻害剤としての置換ピロロトリアジン化合物 |
| PL2822555T3 (pl) | 2012-03-09 | 2018-04-30 | Lexicon Pharmaceuticals Inc | Inhibicja związanej z adaptorem kinazy-1 dla leczenia bólu |
| US8703953B2 (en) | 2012-03-09 | 2014-04-22 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| US8901305B2 (en) | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| JP2016509066A (ja) | 2013-02-22 | 2016-03-24 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | アダプター関連キナーゼ1(aak1)の阻害剤としての5h−クロメノ[3,4−c]ピリジン |
| EP3035921A1 (en) | 2013-08-20 | 2016-06-29 | Bristol-Myers Squibb Company | Imidazopyridazine kinase inhibitors useful to treating a disease or disorder mediated by aak1, such as alzheimer's disease, bipolar disorder, pain, schizophrenia |
| CA2941192A1 (en) | 2013-09-11 | 2015-03-19 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| WO2015116060A1 (en) | 2014-01-29 | 2015-08-06 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| US9932320B2 (en) | 2014-01-31 | 2018-04-03 | Bristol-Myers Squibb Company | Quinoline-based kinase inhibitors |
| RS58062B1 (sr) | 2014-04-02 | 2019-02-28 | Bristol Myers Squibb Co | Biaril inhibitori kinaze |
| WO2016022312A1 (en) | 2014-08-05 | 2016-02-11 | Bristol-Myers Squibb Company | Heterocyclic kinase inhibitors |
| EP3200797A1 (en) | 2014-09-30 | 2017-08-09 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
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| US10253027B2 (en) | 2019-04-09 |
| US20160152621A1 (en) | 2016-06-02 |
| JP6573704B2 (ja) | 2019-09-11 |
| JP2016523963A (ja) | 2016-08-12 |
| JP2018199712A (ja) | 2018-12-20 |
| CN105517993A (zh) | 2016-04-20 |
| WO2015006100A1 (en) | 2015-01-15 |
| EP3019475A1 (en) | 2016-05-18 |
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