CN105498875A - Centrifugal micro-fluidic chip for preparing liquid drops - Google Patents
Centrifugal micro-fluidic chip for preparing liquid drops Download PDFInfo
- Publication number
- CN105498875A CN105498875A CN201610069321.6A CN201610069321A CN105498875A CN 105498875 A CN105498875 A CN 105498875A CN 201610069321 A CN201610069321 A CN 201610069321A CN 105498875 A CN105498875 A CN 105498875A
- Authority
- CN
- China
- Prior art keywords
- drop
- continuous phase
- storage tank
- liquid storage
- decentralized photo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
- B01L2400/028—Pin is moved through a ring which is filled with a fluid
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention discloses a centrifugal micro-fluidic chip for preparing liquid drops. The micro-fluidic chip consists of a cover plate layer, a channel layer and a bottom plate layer; the cover plate layer comprises a continuous phase inlet, a dispersed phase inlet and a gas outlet hole; the channel layer comprises a continuous phase liquid storage tank, a dispersed phase liquid storage tank, a continuous phase channel, a dispersed phase channel, a liquid drop generating structure unit, a liquid drop collecting tank and pore channels. The centrifugal micro-fluidic chip for preparing the liquid drops disclosed by the invention is the micro-fluidic chip which can generate a large amount of liquid drops in a short time, and has a foreseeable application value and a wide market prospect.
Description
Technical field
The present invention relates to microfluidic art, particularly relate to a kind of centrifugal type microfludic chip for the preparation of drop.
Background technology
Under minute yardstick, microlitre is manipulated accurately to other liquid of micro updating, have a wide range of applications in biochemical analysis, environmental monitoring, medical science and clinical detection and micro-nano material synthesis preparation etc.Be rapidly developed in recent years based on micro-fluidic drop formation technology, the generation of its drop is interface unstability when crossing in microchannel based on decentralized photo and continuous phase, decentralized photo in continuous phase, forms the microlayer model of series of discrete with the formal distribution of micro volume unit.
Liquid mainly by microchannel injection such as capillaries or spray micro liquid, and is injected micro-hole or point sample at substrate by the mode nowadays generating microlayer model, and this is a kind of easy drop formation strategy in principle.But needing the short time to generate a large amount of microlayer model in field of fast detection, traditional microlayer model generating mode cannot meet the fast development of modern needs.Therefore, if the micro-fluidic chip that a kind of short time generates a large amount of drop fast can be developed, there are foreseeable using value and market prospects widely.
Summary of the invention
For the preparation of a centrifugal type microfludic chip for drop, it is characterized in that, this micro-fluidic chip is made up of cover layer (1), channel layer (2), backplane level (3); Described cover layer comprises: continuous phase entrance (11), decentralized photo entrance (12), venthole (13); Described channel layer (2) comprising: continuous phase liquid storage tank (21), decentralized photo liquid storage tank (22), continuous phase passage (23), decentralized photo passage (24), drop formation construction unit (25), drop passage (26), drop collecting pit (27), air vent channel (28); Described continuous phase liquid storage tank (21) is connected with continuous phase entrance (11), and described continuous phase passage (23) is connected with continuous phase liquid storage tank (21); Described decentralized photo liquid storage tank (22) is connected with decentralized photo entrance (12), and described decentralized photo passage (24) is connected with decentralized photo liquid storage tank (22); Described drop formation construction unit (25) is in decentralized photo passage (24) and continuous phase passage (23) intersection; Described drop passage (26) is connected with drop formation construction unit (25); Described drop collecting pit (27) is connected with drop passage (26); Described air vent channel (28) is connected with drop collecting pit (27); Described venthole (13) is connected with air vent channel (27).
Described chip shape of cross section is fan-shaped, and fan angle is 1 ° ~ 360 °, and when fan angle is 360 °, chip shape of cross section is circle.
Described continuous phase entrance and decentralized photo entrance lean on the side in the center of circle at fan-shaped place respectively at continuous phase liquid storage tank and decentralized photo liquid storage tank.
For being full of liquid storage tank when ensureing that liquid phase is injected, described continuous phase passage should in the side of continuous phase liquid storage tank relative to continuous phase entrance; Described decentralized photo passage should in the side of decentralized photo liquid storage tank relative to decentralized photo entrance.
From the center of circle at fan-shaped place to circular arc, channel layer structure is followed successively by continuous phase liquid storage tank, decentralized photo liquid storage tank, continuous phase passage, decentralized photo passage, drop formation construction unit, drop passage, drop collecting pit.
The mode that described continuous phase and decentralized photo can be injected by aperture injects continuous phase liquid storage tank and decentralized photo liquid storage tank.
Described drop formation construction unit can be T-type structure and flow focusing type structure.
Described fan-shaped chip structure can be repeatedly repeat within the scope of 360 ° at central angle, realizes multiple repetitive.
Described continuous phase liquid storage tank and decentralized photo liquid storage tank may reside on micro-fluidic chip, also can be external in micro-fluidic chip in any form.
In described micro-fluidic chip, the driving force of liquid phase is centrifugal force.
The effect of described venthole is that the air in drop collecting pit is discharged smoothly, is convenient to drop and enters drop collecting pit.
Accompanying drawing explanation
Fig. 1. the T-type structure schematic diagram of a kind of centrifugal type microfludic chip for the preparation of drop provided by the present invention.
Fig. 2. the drop formation schematic diagram of a kind of centrifugal type microfludic chip for the preparation of drop of T-type structure provided by the present invention.
Fig. 3. a kind of centrifugal type microfludic chip flow focusing type structural representation for the preparation of drop provided by the present invention.
Fig. 4. the drop formation schematic diagram of a kind of centrifugal type microfludic chip for the preparation of drop of flow focusing type provided by the present invention.
In accompanying drawing: 1. cover layer; 11. continuous phase entrances; 12. decentralized photo entrances; 13. ventholes; 2. channel layer; 21. continuous phase liquid storage tanks; 22. decentralized photo liquid storage tanks; 23. continuous phase passages; 24. decentralized photo passages; 25. drop formation construction units; 26. drop passages; 27. drop collecting pits; 28. air vent channels; 3. backplane level.
Specific embodiments
Below in conjunction with the accompanying drawing in the embodiment of the present invention, carry out clear intactly describing to the technical scheme in the embodiment of the present invention.Obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Case study on implementation 1
See Fig. 1, the micro-fluidic chip described in the present embodiment is made up of cover layer, channel layer, backplane level; Described cover layer comprises: continuous phase entrance, decentralized photo entrance, venthole; Described channel layer comprises: continuous phase liquid storage tank, decentralized photo liquid storage tank, continuous phase passage, decentralized photo passage, drop formation construction unit, drop passage, drop collecting pit, air vent channel; Described chip shape of cross section is fan-shaped, and fan angle is 1 ° ~ 360 °; From the center of circle at fan-shaped place to circular arc, channel layer structure is followed successively by continuous phase liquid storage tank, decentralized photo liquid storage tank, continuous phase passage, decentralized photo passage, drop formation construction unit, drop passage, drop collecting pit; The mode that described continuous phase and decentralized photo can be injected by aperture injects continuous phase liquid storage tank and decentralized photo liquid storage tank; Described drop formation construction unit is T-type structure.
The schematic diagram of drop is generated as shown in Figure 2 in above-mentioned micro-fluidic chip.Be that continuous phase is injected continuous phase liquid storage tank by continuous phase entrance, decentralized photo injected decentralized photo liquid storage tank by decentralized photo entrance simultaneously.Centered by the center of circle at fan-shaped place, centrifugal action is carried out to chip.Under the influence of centrifugal force, decentralized photo and continuous phase enter T-shaped passage place, and under the shear action of continuous phase, decentralized photo forms microlayer model and is scattered in continuous phase, and microlayer model enters drop collecting pit by drop passage.
Case study on implementation 2
See Fig. 3, the micro-fluidic chip described in the present embodiment is made up of cover layer, channel layer, backplane level; Described cover layer comprises: continuous phase entrance, decentralized photo entrance, venthole; Described channel layer comprises: continuous phase liquid storage tank, decentralized photo liquid storage tank, continuous phase passage, decentralized photo passage, drop formation construction unit, drop passage, drop collecting pit, air vent channel, described chip shape of cross section are fan-shaped, and fan angle is 1 ° ~ 360 °; From the center of circle at fan-shaped place to circular arc, channel layer structure is followed successively by continuous phase liquid storage tank, decentralized photo liquid storage tank, continuous phase passage, decentralized photo passage, drop formation construction unit, drop passage, drop collecting pit.The mode that described continuous phase and decentralized photo can be injected by aperture injects continuous phase liquid storage tank and decentralized photo liquid storage tank; Described drop formation construction unit is flow focusing type structure.
The schematic diagram of drop is generated as shown in Figure 4 in above-mentioned micro-fluidic chip.Be that continuous phase is injected continuous phase liquid storage tank by continuous phase entrance, decentralized photo injected decentralized photo liquid storage tank by decentralized photo entrance simultaneously.Centered by the center of circle at fan-shaped place, centrifugal action is carried out to chip.Under the influence of centrifugal force, decentralized photo and continuous phase enter flow focusing type passage place, and in continuous phase under the extruding of decentralized photo both sides and shear action, decentralized photo forms microlayer model and is scattered in continuous phase, and microlayer model enters drop collecting pit by drop passage.
Claims (10)
1. for the preparation of a centrifugal type microfludic chip for drop, it is characterized in that, described micro-fluidic chip is made up of cover layer, channel layer, backplane level; Described cover layer comprises: continuous phase entrance, decentralized photo entrance, venthole; Described channel layer comprises: continuous phase liquid storage tank, decentralized photo liquid storage tank, continuous phase passage, decentralized photo passage, drop formation construction unit, drop passage, drop collecting pit, air vent channel; Described continuous phase liquid storage tank is connected with continuous phase entrance, and described continuous phase passage is connected with continuous phase liquid storage tank; Described decentralized photo liquid storage tank is connected with decentralized photo entrance, and described decentralized photo passage is connected with decentralized photo liquid storage tank; Described drop formation construction unit is at decentralized photo passage and continuous phase passages merge place; Described drop passage is connected with drop formation construction unit; Described drop collecting pit is connected with drop passage; Described air vent channel is connected with drop collecting pit; Described venthole is connected with air vent channel.
2. according to a kind of centrifugal type microfludic chip for the preparation of drop according to claim 1, it is characterized in that, described chip shape of cross section is fan-shaped, and fan angle is 1 ° ~ 360 °, and when fan angle is 360 °, chip shape of cross section is circle.
3. according to a kind of centrifugal type microfludic chip for the preparation of drop described in claim 1,2, it is characterized in that, described continuous phase entrance and decentralized photo entrance lean on the side in the center of circle at fan-shaped place respectively at continuous phase liquid storage tank and decentralized photo liquid storage tank.
4. according to a kind of centrifugal type microfludic chip for the preparation of drop according to claim 1, it is characterized in that, for being full of liquid storage tank when ensureing that liquid phase is injected, described continuous phase passage should in the side of continuous phase liquid storage tank relative to continuous phase entrance; Described decentralized photo passage should in the side of decentralized photo liquid storage tank relative to decentralized photo entrance.
5. according to a kind of centrifugal type microfludic chip for the preparation of drop described in claim 1,2, it is characterized in that, from the center of circle at fan-shaped place to circular arc, described channel layer structure is followed successively by continuous phase liquid storage tank, decentralized photo liquid storage tank, continuous phase passage, decentralized photo passage, drop formation construction unit, drop passage, drop collecting pit.
6. according to a kind of centrifugal type microfludic chip for the preparation of drop according to claim 1, it is characterized in that, the mode that described continuous phase and decentralized photo can inject with aperture injects continuous phase liquid storage tank and decentralized photo liquid storage tank.
7. according to a kind of centrifugal type microfludic chip for the preparation of drop according to claim 1, it is characterized in that, described drop formation construction unit can be T-type structure and flow focusing type structure.
8. according to a kind of centrifugal type microfludic chip for the preparation of drop described in claim 1,2, it is characterized in that, described chip structure can be repeatedly repeat within the scope of 360 ° at fan-shaped central angle, realizes multiple repetitive.
9. according to a kind of centrifugal type microfludic chip for the preparation of drop according to claim 1, it is characterized in that, described continuous phase liquid storage tank and decentralized photo liquid storage tank may reside on micro-fluidic chip, also can be external in micro-fluidic chip in any form.
10. according to a kind of centrifugal type microfludic chip for the preparation of drop according to claim 1, it is characterized in that, in described micro-fluidic chip, the driving force of liquid phase is centrifugal force.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610069321.6A CN105498875A (en) | 2016-01-27 | 2016-01-27 | Centrifugal micro-fluidic chip for preparing liquid drops |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610069321.6A CN105498875A (en) | 2016-01-27 | 2016-01-27 | Centrifugal micro-fluidic chip for preparing liquid drops |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105498875A true CN105498875A (en) | 2016-04-20 |
Family
ID=55707410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610069321.6A Pending CN105498875A (en) | 2016-01-27 | 2016-01-27 | Centrifugal micro-fluidic chip for preparing liquid drops |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105498875A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106589412A (en) * | 2016-11-28 | 2017-04-26 | 华南理工大学 | Preparation method for polymer microgel based on microfluidic technology |
| CN107126987A (en) * | 2017-05-19 | 2017-09-05 | 清华大学深圳研究生院 | Three-dimensional focal stream synthesis drop micro-fluidic chip and preparation method thereof |
| CN107442191A (en) * | 2017-09-20 | 2017-12-08 | 厦门大学 | A kind of centrifugal type microfludic chip for Water-In-Oil drop formation |
| CN107583693A (en) * | 2017-08-30 | 2018-01-16 | 武汉科技大学 | A kind of T-shaped microchannel integrates droplet generation chip |
| CN107661782A (en) * | 2017-08-30 | 2018-02-06 | 武汉科技大学 | A kind of cross type microchannel integrates droplet generation chip |
| CN108148743A (en) * | 2016-12-06 | 2018-06-12 | 中山百慧生物科技有限公司 | A kind of drop number pcr chip and corresponding method of detection and detecting system |
| CN108514895A (en) * | 2018-03-01 | 2018-09-11 | 北京天健惠康生物科技有限公司 | A kind of microlayer model generates and monitoring device |
| WO2020177088A1 (en) * | 2019-03-01 | 2020-09-10 | 深圳市博瑞生物科技有限公司 | Microfluidic chip |
| CN112969779A (en) * | 2018-09-29 | 2021-06-15 | 青岛华大智造普惠科技有限公司 | Micro-fluidic chip system and preparation method of liquid drop |
| CN113318796A (en) * | 2021-04-22 | 2021-08-31 | 深圳市第二人民医院(深圳市转化医学研究院) | Centrifugal droplet generation chip |
| WO2022048374A1 (en) * | 2020-09-07 | 2022-03-10 | 深圳市亚辉龙生物科技股份有限公司 | Droplet microfluidic chip and microdroplet preparation method |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007502979A (en) * | 2003-08-19 | 2007-02-15 | バイエル・ヘルスケア・エルエルシー | Mixing in microfluidic devices |
| US20090197977A1 (en) * | 2005-10-07 | 2009-08-06 | Stefan Haeberle | Device and Method for Producing a Mixture of Two Phases that are Insoluble in Each Other |
| CN103386333A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Micro-fluidic liquid drop production chip |
| CN104155463A (en) * | 2014-08-27 | 2014-11-19 | 南京大学 | Device and method for producing and measuring droplet on micro-fluidic chip |
| CN104826674A (en) * | 2015-04-27 | 2015-08-12 | 北京工业大学 | Reverse-Y shaped channel microfluid chip for generating droplets |
| CN104888873A (en) * | 2015-05-08 | 2015-09-09 | 沈阳航空航天大学 | Centrifugal type micro fluidic chip having backward pumping function |
| CN204816577U (en) * | 2015-07-30 | 2015-12-02 | 天津大学 | Novel microbubble / liquid drop generates regulation and control device |
| CN105233893A (en) * | 2015-11-02 | 2016-01-13 | 华东理工大学 | Method for preparing micro-droplets based on micro-fluidic chip modification technology |
-
2016
- 2016-01-27 CN CN201610069321.6A patent/CN105498875A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007502979A (en) * | 2003-08-19 | 2007-02-15 | バイエル・ヘルスケア・エルエルシー | Mixing in microfluidic devices |
| US20090197977A1 (en) * | 2005-10-07 | 2009-08-06 | Stefan Haeberle | Device and Method for Producing a Mixture of Two Phases that are Insoluble in Each Other |
| CN103386333A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Micro-fluidic liquid drop production chip |
| CN104155463A (en) * | 2014-08-27 | 2014-11-19 | 南京大学 | Device and method for producing and measuring droplet on micro-fluidic chip |
| CN104826674A (en) * | 2015-04-27 | 2015-08-12 | 北京工业大学 | Reverse-Y shaped channel microfluid chip for generating droplets |
| CN104888873A (en) * | 2015-05-08 | 2015-09-09 | 沈阳航空航天大学 | Centrifugal type micro fluidic chip having backward pumping function |
| CN204816577U (en) * | 2015-07-30 | 2015-12-02 | 天津大学 | Novel microbubble / liquid drop generates regulation and control device |
| CN105233893A (en) * | 2015-11-02 | 2016-01-13 | 华东理工大学 | Method for preparing micro-droplets based on micro-fluidic chip modification technology |
Non-Patent Citations (2)
| Title |
|---|
| 张玲等: "基于离心力驱动微流控芯片的研究进展", 《广州化工》 * |
| 胡雪等: "T型微通道装置制备尺寸均一壳聚糖微球", 《过程工程学报》 * |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106589412A (en) * | 2016-11-28 | 2017-04-26 | 华南理工大学 | Preparation method for polymer microgel based on microfluidic technology |
| CN106589412B (en) * | 2016-11-28 | 2018-09-14 | 华南理工大学 | A kind of preparation method of the polymer microgel based on microflow control technique |
| CN108148743A (en) * | 2016-12-06 | 2018-06-12 | 中山百慧生物科技有限公司 | A kind of drop number pcr chip and corresponding method of detection and detecting system |
| CN107126987A (en) * | 2017-05-19 | 2017-09-05 | 清华大学深圳研究生院 | Three-dimensional focal stream synthesis drop micro-fluidic chip and preparation method thereof |
| CN107661782B (en) * | 2017-08-30 | 2020-09-15 | 武汉科技大学 | Cross-shaped micro-channel integrated droplet generation chip |
| CN107661782A (en) * | 2017-08-30 | 2018-02-06 | 武汉科技大学 | A kind of cross type microchannel integrates droplet generation chip |
| CN107583693A (en) * | 2017-08-30 | 2018-01-16 | 武汉科技大学 | A kind of T-shaped microchannel integrates droplet generation chip |
| CN107442191A (en) * | 2017-09-20 | 2017-12-08 | 厦门大学 | A kind of centrifugal type microfludic chip for Water-In-Oil drop formation |
| CN108514895A (en) * | 2018-03-01 | 2018-09-11 | 北京天健惠康生物科技有限公司 | A kind of microlayer model generates and monitoring device |
| CN112969779A (en) * | 2018-09-29 | 2021-06-15 | 青岛华大智造普惠科技有限公司 | Micro-fluidic chip system and preparation method of liquid drop |
| WO2020177088A1 (en) * | 2019-03-01 | 2020-09-10 | 深圳市博瑞生物科技有限公司 | Microfluidic chip |
| US12030048B2 (en) | 2019-03-01 | 2024-07-09 | Shenzhen Biorain Technology Co., Ltd. | Microfluidic chip |
| WO2022048374A1 (en) * | 2020-09-07 | 2022-03-10 | 深圳市亚辉龙生物科技股份有限公司 | Droplet microfluidic chip and microdroplet preparation method |
| CN113318796A (en) * | 2021-04-22 | 2021-08-31 | 深圳市第二人民医院(深圳市转化医学研究院) | Centrifugal droplet generation chip |
| WO2022222925A1 (en) * | 2021-04-22 | 2022-10-27 | 深圳市第二人民医院(深圳市转化医学研究院) | Centrifugal droplet generation chip |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105498875A (en) | Centrifugal micro-fluidic chip for preparing liquid drops | |
| CN107674820B (en) | Microfluidic device for sorting cells and application method thereof | |
| CN112547145B (en) | Rare cell rapid screening micro-fluidic device | |
| CN105618167A (en) | Centrifugal microfluidic chip for preparing droplets in high-throughput manner | |
| CN205235997U (en) | One -component multicomponent liquid drop preparation facilities based on integrated microchannel | |
| CN209287355U (en) | Micro-fluidic chip and device containing the micro-fluidic chip | |
| CN103386333A (en) | Micro-fluidic liquid drop production chip | |
| CN106215988B (en) | A kind of double branch roads realize the microchannel of microlayer model splitting function twice | |
| CN104084247A (en) | Elastic wall surface micro-fluidic chip based on T-shaped micro-channel | |
| Kunstmann-Olsen et al. | Uniform droplet splitting and detection using Lab-on-Chip flow cytometry on a microfluidic PDMS device | |
| CN109289951B (en) | Droplet splitting microfluidic chip and application | |
| CN107970847B (en) | Plane bending passive micro mixer with double T-shaped inlet structure | |
| TW200909338A (en) | Autonomous microfluidic apparatus | |
| CN103386336A (en) | Microfluidic chip for producing droplets with concentration gradients | |
| CN209646393U (en) | A kind of non-concentric O shape channel microfluid mixer | |
| US20070128082A1 (en) | Microflow coverage ratio control device | |
| CN104826674A (en) | Reverse-Y shaped channel microfluid chip for generating droplets | |
| CN106943938A (en) | A kind of imitative vein channel design passive type micro-mixer | |
| CN111957360A (en) | Droplet microfluidic chip and preparation method of micro-droplets | |
| CN105413779A (en) | Micro-fluidic chip clamp for preparing multi-element emulsion and preparing system for multi-element emulsion | |
| CN106076446B (en) | A kind of double branches realize the microchannel of interval microlayer model fusion function | |
| CN101275926B (en) | Special micro-flow control chip and single sampling continuous separation electrophoresis method | |
| CN206381935U (en) | A kind of asymmetric separation-and-combination structure passive type micro-mixers of 3D | |
| CN109833921A (en) | A kind of preparation method of the controllable aqueous two-phase drop of high throughput based on microflow control technique | |
| CN105214546A (en) | A kind of concussion jetting type micro-mixer based on Pulsating Flow |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160420 |
|
| RJ01 | Rejection of invention patent application after publication |