CN106076446B - A kind of double branches realize the microchannel of interval microlayer model fusion function - Google Patents
A kind of double branches realize the microchannel of interval microlayer model fusion function Download PDFInfo
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- CN106076446B CN106076446B CN201610696301.1A CN201610696301A CN106076446B CN 106076446 B CN106076446 B CN 106076446B CN 201610696301 A CN201610696301 A CN 201610696301A CN 106076446 B CN106076446 B CN 106076446B
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- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
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Abstract
A kind of double branches realize the microchannel of interval microlayer model fusion function, which includes two functional units, first is that microlayer model generation unit, which is the T-type channel to generate microlayer model；Another is to realize that microlayer model integrated unit, the microlayer model integrated unit are made of two bypass passages that upstream bifurcated downstream is converged again.Microlayer model generation unit is connected with water phase entrance with oily phase entrance.Double branch structures that the upstream bifurcated downstream that microlayer model integrated unit is made of the first branch and second branch is converged again form, the first branch and the connection composition buccal glyph shaped structure of second branch two, the first branch is the horizontal structure of bottom, the end of the first branch is equipped with spherical port, and second branch is inverted U-shaped.The configuration of the present invention is simple and the controllable fusion function that can flexibly realize drop, this will occur complicated controllable biochemical reaction for microlayer model and provides safeguard.
Description
Technical field
Picoliters to nanoliter volumes range microlayer model because having the advantages such as no cross contamination, it is in blood testing, protein
It is latent that the biochemistries such as crystallization, cell analysis, polymerase chain reaction (PCR), medical diagnosis on disease, particle synthesis show huge application
Power.
Background technique
Microfluidic chip technology (Microfluidics) is otherwise known as chip lab (Lab-on-a-chip), can be one
The basic function in traditional biological and chemical laboratory, including sample separation, system are integrated on a several square centimeters of micro chip
The operations such as standby, chemical reaction, detection.Drop microflow control technique is an important branch of microfluidic chip technology.Microlayer model because
With flux height, the advantages such as no cross contamination, in inkjet printing, microring array, DNA analysis, materials synthesis, crystallization of protein etc.
Field shows huge application potential.Some biochemical reactions based on microlayer model, if micro-nano particle synthesize, need in the process by
Two different droplet coalescences together, to obtain preferable hybrid reaction effect.The controllable fusion of drop has become as a result,
One important drop microflow control technique, for realizing that multistep reaction is particularly significant in drop.
Summary of the invention
A kind of double branches realize the microchannel of interval microlayer model fusion function, and the present invention is converged again based on upstream bifurcated downstream
The double branch microchannel flow resistance difference principles closed devise the microchannel for realizing that interval microlayer model blends.
A kind of double branches realize the microchannel of interval microlayer model fusion function, which includes two functional units, one
It is microlayer model generation unit 9, which is the T-type channel to generate microlayer model；Another is to realize microlayer model
Integrated unit 10, the microlayer model integrated unit 10 are made of two bypass passages that upstream bifurcated downstream is converged again.Microlayer model generates
Unit 9 is connected with water phase entrance 8 with oily phase entrance 7.Microlayer model integrated unit 10 is by the first branch 11 and second branch 12
Double branch structures composition that the upstream bifurcated downstream of composition is converged again, the 12 liang of connections of the first branch 11 and second branch form mouth word
Shape structure, the first branch 11 are the horizontal structure of bottom, and the end of the first branch 11 is equipped with spherical port, and second branch 12 is to fall
U-shaped structure.
When work, discrete phase (water phase) is connected by syringe pump with water phase entrance 8, continuous phase (oily phase) pass through syringe pump and
Oily phase entrance 7 is connected, and outlet 13 is connected to liquid pool by PE pipe.Continuous phase be applied to discrete phase shearing force and pressure it is common
Under effect, uniform microlayer model is generated at drop formation unit 9, this does " early-stage preparations " for the subsequent fusion of drop.This
Afterwards, the fusion behavior different from the drop generation in second branch 12 of the first branch 11.
First drop 1 moves in the first branch 11, the flow resistance R of the first branch 1111Less than the flow resistance of second branch 12
R12；The drop of movement increases the flow resistance R of the branch11, and increased to over the flow resistance R of second branch 1212；Second drop 2 is then
Second branch 12 is selected to move." necking down " structure due to the first drop 1 along the spherical port of the first branch 11 makes first path
11 flow resistance R11Become larger, so that third drop 3 and the 4th drop 4 continue to move to second branch 12.At this time in second branch 12
Second drop 2, third drop 3, the 4th drop 4 considerably increase R12, so that the 5th drop 5 moves to the first branch 11 and second
When the upstream junction of branch 12, the first drop 1 is handed over by continuous phase " extruding " to the downstream of the first branch 11 and second branch 12
It is merged at remittance with the second drop 2.In order to make drop be faster than the first branch 11 in the movement velocity of second branch 12, and by
The width of two branches 12 reduces, to achieve the purpose that first branch drop 1 and second branch drop 2 are merged in downstream intersection.
Occur after merging for the first time, the first drop 1 leaves first branch branch 11 completely, by subsequent 5th drop 5 " supplement " to the
One branch 11.5th drop 5 and third drop 3 carry out second and merge, and the 6th drop 6 and the 4th drop 4 carry out third time and melt
It closes.Hereafter, so repeat, with the drop of the first branch 11 fusion three times to occur for second branch 12 be for the first time to be adjacent liquid
Drop fusion, second is one droplet coalescence in interval with third time.Therefore, the microchannel of the invention can not only realize adjacent drops
The function of interval droplet coalescence is merged but also may be implemented, this will occur complicated biochemical reaction for microlayer model and provides very just
The condition of benefit.
Microchannel is process by soft light carving technology, and used material is dimethyl silicone polymer (PDMS).
The present invention crosses structure not only using simple two branch on the basis of not increasing additional driving or control device
Adjacent drops fusion can be achieved but also the function of interval droplet coalescence may be implemented, with existing realization droplet coalescence function
Microchannel is compared, and the inventive structure is simple and can flexibly realize the controllable fusion function of drop, this will occur complicated for microlayer model
Controllable biochemical reaction provide safeguard.
Detailed description of the invention
Fig. 1 realizes double branch microchannel structure schematic diagrames of microlayer model fusion
The bis- branch partial structurtes enlarged diagrams of Fig. 2
Fig. 3 realizes double branch microchannel real work schematic diagrames of microlayer model fusion
Specific embodiment
It is further elaborated and verifies in conjunction with 3 pairs of attached drawing the microchannel courses of work and effect of the invention.
Microchannel real work mainly includes water phase entrance, oily phase entrance, drop formation unit, integrated unit and outlet.
Syringe pump passes through PE pipe respectively and is connected with water phase entrance with oily phase entrance when work.Outlet is connected to waste liquid pool by PE pipe.
In order to prove that the function of interval droplet coalescence may be implemented in the invention, Fig. 3 gives experiment effect figure, and figure (a) and figure (b) are respectively
To test actual effect figure before and after two droplet coalescences.From the figure 3, it may be seen that the invention can achieve expected syncretizing effect.
Claims (2)
1. the microchannel that a kind of double branches realize interval microlayer model fusion function, it is characterised in that: the microchannel includes two function
Energy unit, first is that microlayer model generation unit (9), which is the T-type channel to generate microlayer model；Separately
First is that realizing microlayer model integrated unit (10), which is led to by two branches that upstream bifurcated downstream is converged again
Road is constituted；Microlayer model generation unit (9) is connected with water phase entrance (8) with oily phase entrance (7)；Microlayer model integrated unit (10) is
It is made of double branch structures that the upstream bifurcated downstream that the first branch (11) and second branch (12) are constituted is converged again, the first branch
(11) and the connection of second branch (12) two forms buccal glyph shaped structure, and second branch (12) is inverted U-shaped, and the first branch (11) is
The horizontal structure of bottom, the end of the first branch (11) are equipped with spherical port；
When work, discrete phase is connected by syringe pump with water phase entrance (8), and continuous phase passes through syringe pump and oily phase entrance (7) phase
Even, (13) are exported and liquid pool is connected to by PE pipe；In the case where continuous phase is applied to the shearing force and pressure collective effect of discrete phase,
Uniform microlayer model is generated at drop formation unit (9), this does " early-stage preparations " for the subsequent fusion of drop；Hereafter, first
Branch (11) fusion behavior different from the drop generation in second branch (12)；
First drop (1) movement, flow resistance R of the first branch (11) in the first branch (11)11Less than the stream of second branch (12)
Hinder R12；The drop of movement increases the flow resistance R of the branch11, and increased to over the flow resistance R of second branch (12)12；Second liquid
Drop (2) then selects second branch (12) to move；Since the first drop (1) is along " necking down " structure of the spherical port of the first branch (11)
So that the flow resistance R of first path (11)11Become larger, so that third drop (3) and the 4th drop (4) continue to move to second branch
(12)；The second drop (2), third drop (3), the 4th drop (4) considerably increase R in second branch (12) at this time12, so that the
When five drops (5) move to the upstream junction of the first branch (11) and second branch (12), the first drop (1) is by continuous phase
" extruding " is merged to the downstream intersection of the first branch (11) and second branch (12) with the second drop (2)；In order to make liquid
The movement velocity dripped in second branch (12) is faster than the first branch (11), and the width of second branch (12) is reduced, to reach
The purpose that first branch drop (1) and second branch drop (2) are merged in downstream intersection；Occur after merging for the first time, first
Drop (1) leaves first branch branch (11) completely, by subsequent 5th drop (5) " supplement " to the first branch (11)；5th
Drop (5) and third drop (3) carry out second and merge, and the 6th drop (6) and the 4th drop (4) carry out third time fusion；This
Afterwards, so repeat, fusion three times occurs for the drop of second branch (12) the same to first branch (11) be for the first time to be adjacent liquid
Drop fusion, second is one droplet coalescence in interval with third time；Therefore, the microchannel of the invention can not only realize adjacent drops
The function of interval droplet coalescence is merged but also may be implemented, this will occur complicated biochemical reaction for microlayer model and provides very just
The condition of benefit.
2. the microchannel that a kind of double branches according to claim 1 realize interval microlayer model fusion function, it is characterised in that:
Microchannel is process by soft light carving technology, and used material is dimethyl silicone polymer.
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108273454A (en) * | 2016-12-27 | 2018-07-13 | 中国科学院微生物研究所 | A kind of method that nanoliter level microlayer model merges in small-sized reaction tube |
| CN109647547A (en) * | 2017-10-12 | 2019-04-19 | 中国科学院大连化学物理研究所 | A kind of preparation method of the controllable aqueous two-phase drop based on microflow control technique |
| CN210146032U (en) * | 2018-06-07 | 2020-03-17 | 洛阳华清天木生物科技有限公司 | Device and chip for quantitatively dividing and fusing micro-droplets |
| CN111068799B (en) * | 2018-10-18 | 2021-03-23 | 浙江达普生物科技有限公司 | Microfluidic channel for generating droplets and use thereof |
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