CN108993337A - A kind of integrating device of drop fluid micro-reactor - Google Patents
A kind of integrating device of drop fluid micro-reactor Download PDFInfo
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- CN108993337A CN108993337A CN201810683587.9A CN201810683587A CN108993337A CN 108993337 A CN108993337 A CN 108993337A CN 201810683587 A CN201810683587 A CN 201810683587A CN 108993337 A CN108993337 A CN 108993337A
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- 239000012530 fluid Substances 0.000 title claims abstract description 44
- 239000007788 liquid Substances 0.000 claims abstract description 152
- 238000006243 chemical reaction Methods 0.000 claims abstract description 11
- 239000011521 glass Substances 0.000 claims abstract description 9
- 239000000758 substrate Substances 0.000 claims abstract description 9
- 239000002245 particle Substances 0.000 claims description 19
- 238000000926 separation method Methods 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 7
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 7
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 7
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- 230000004927 fusion Effects 0.000 claims description 3
- 238000004581 coalescence Methods 0.000 abstract description 6
- 230000015572 biosynthetic process Effects 0.000 abstract description 5
- -1 chip Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108091006146 Channels Proteins 0.000 description 25
- 102000003691 T-Type Calcium Channels Human genes 0.000 description 3
- 108090000030 T-Type Calcium Channels Proteins 0.000 description 3
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 229920005573 silicon-containing polymer Polymers 0.000 description 3
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The present invention relates to a kind of integrating devices of drop fluid micro-reactor, belong to micro-fluidic field.The present invention includes glass substrate, chip, liquid inlet I, liquid inlet II, liquid outlet I, liquid outlet II, fluid passage；On a glass substrate, liquid outlet, liquid-inlet are arranged on chip for chip setting, and in the chip, and chip is broadly divided into three parts to fluid passage: intake section, folder stream part and expansion.The present invention collects drop formation, droplet coalescence reaction and drop and is collected in one, different size of microlayer model can be made to enter different channels by adjusting liquid outlet flow, and the microlayer model of specified size can be made to enter specified channel, realize the control of particular size drop outflow position.It by the independent operation to drop, efficiently can controllably realize that liquid drop movement, internal mix and reaction and drop are collected, high reliablity and be easily achieved.
Description
Technical field
The present invention relates to a kind of integrating devices of drop fluid micro-reactor, belong to micro-fluidic field.
Background technique
It is tens of channel interiors to hundreds of microns that reaction compartment is limited in size range by microreactor.It is anti-under the scale
It answers system that there is high specific surface area and high mass-transfer performance, not only can significantly be shortened by accurate process control anti-
Between seasonable and reduce sample consumption, it is often more important that the increase that quantity is directly carried out using microreactor as basic unit can be realized
Module integrates, and then realizes high-throughput product controllable preparation, causes so as to avoid the direct geometry amplification of traditional reactor
Be difficult to expected non-ideal behavior.Different from traditional reactor, the unfixed container of drop fluid micro-reactor, a system
The drop of moving volume-tunable section is arranged, each independent microlayer model can be regarded as the small intermittent reaction of a flowing
Kettle.Another big outstanding advantage of drop fluid micro-reactor is that the microresponse list of a large amount of specificity can be generated in a short time
Member, this makes it possible efficiently quickly Parallel testing and test, can obtain a large amount of data in a short time.
Folder flow separation method is that a kind of structure is very simple, and separation method applied widely.In cost, flow separation is pressed from both sides
Method chip need to only produce channel according to corresponding parameter, and not have to increase any other structure in channel, be by
Originally it has been down to minimum, and comparatively, the actives partition method such as magnetic separation method, photoacoustic waves separation is required by external means, from
And increase the cost of separation, and micro-column structure, the partition methods such as shape structure comparatively also than folder flow separation method it is at high cost (need
Make labyrinth).In the scope of application, as long as microlayer model is in different size, so that it may with folder stream method separation, it may be said that
It is applied widely.The design of structure of the invention carries out analogue simulation by using COMSOL multiple physical field coupling software, uses
PDMS material makes microchannel structure, can be restored to original state under certain deformation condition and structure there is no forever
Long property is destroyed.The present invention collects drop formation, droplet coalescence reaction and drop and is collected in one, there is important application value.
Summary of the invention
The present invention provides a kind of integrating device of drop fluid micro-reactor, for solving existing drop fluid micro-reactor liquid
Drop generates the problem of slow, device is cumbersome, reaction speed is slow, low efficiency.
The technical scheme is that: a kind of integrating device of drop fluid micro-reactor, including glass substrate 1, chip 2 and liquid
Body channel 11, the chip 2 are arranged in glass substrate 1, and fluid passage 11 is arranged on chip 2, the starting of fluid passage 11
End is equipped with liquid inlet I 3, sets that there are three liquid inlets II 4 arranged in parallel, liquid in the vertical direction of the side of fluid passage 11
Body entrance III 5 and liquid inlet IV 6, the end of fluid passage 11 are equipped with expansion 12, and the expansion 12 includes being located at
The monosymmetric arc section in 11 end of fluid passage, the opening between the arc section of two sides are divided into four contiguous branch, the end of branch
End is equipped with liquid outlet I 7, liquid outlet II 8, liquid outlet III 9 and liquid outlet IV 10.
The chip 2 and fluid passage 11 are all made of PDMS(dimethyl silicone polymer) material is made.
The both sides that midpoint behind the end of the arc section to two sections of arc sections connections is formed are open with four contiguous branch
Four sides at place form an equilateral hexagon.
2 length of chip is 25mm, width 10mm, with a thickness of 5mm；11 height of fluid passage is 0.1mm, wide
Degree is 0.1mm；The liquid inlet I 3, liquid inlet II 4, liquid inlet III 5, liquid inlet IV 6, liquid outlet I 7, liquid
The diameter for exporting II 8, liquid outlet III 9 and liquid outlet IV 10 is 0.1mm；The liquid inlet II 4, liquid inlet III 5
Adjacent distance between the two is 3mm, the water between liquid inlet II 6 and its equidirectional liquid outlet I 7 with liquid inlet IV 6
Flat distance is 9mm；The arc section radius of the expansion 12 is 0.15mm.
It is using the method that above-mentioned apparatus carries out the micro- reaction of drop stream: gives injection in liquid-inlet I 3 oily phase, liquid inlet
II 4, it is injected separately into water phase in liquid inlet III 5 and liquid inlet IV 6, the water phase of three entrances contains different chemicals respectively
Matter and three can react to each other, by the flow of control liquid inlet II 4, liquid inlet III 5 and liquid inlet IV 6, right
Generate different size of microlayer model at the channel answered, microlayer model is of different sizes to be had different in flow rate, and then droplet can be caught up with greatly
Drop merges, and when the drop of fusion reaches expansion 12, due to the expansionary effect in channel, biggish particle be will receive
One lift effect, so that particle deviates the track of original streamline, realizes the separation of sized particles, and in liquid outlet
I 7, the collection of drop is realized at liquid outlet II 8, liquid outlet III 9 and liquid outlet IV 10.
Wherein the collection of drop is that enter different size of microlayer model different by adjusting the flow of liquid outlet I 7
Channel, and the microlayer model of specified size can be made to enter specified channel, to realize particular size drop outflow position
Control；The determination that drop flows out position is as follows:
WhereinWO is the folder stream sector width i.e. width of fluid passage 11, and η is the outflow ratio of liquid outlet I 7,DFor liquid-drop diameter,
NBFor total flow pass, that is, liquid outlet number,NFor liquid outlet I 7, liquid outlet II 8, liquid outlet III 9 and liquid
IV 10 number is exported, four number is sequentially increased, and works as liquid-drop diameterDWhen meeting equation, drop can flow intoNA channel.
Such as the drop of generation is smaller at liquid-inlet II 4 and then has larger flow velocity, can catch up at liquid-inlet II 5
The drop of generation, two microlayer models are all water phase, and then are merged, and the chemical substance of drop internal carries out hybrid reaction,
When reaching expansion, by the flow control to liquid outlet I 7, so that the biggish drop of fused volume is under
Wall surface is collected by liquid outlet II 8, and the drop that small part does not merge is collected by liquid outlet IV 10.
The beneficial effects of the present invention are:
1, the present invention can generate drop with high-efficiency and continuous, and can be by controlling liquid inlet flow control droplet size.By
Droplet distribution in microchannel can accurately the size to single drop, pattern and be controlled at being grouped as, and drop has
Size uniformity and be easy to regulate and control etc. significant advantages.
2, present invention collection drop formation, droplet coalescence reaction and drop are collected in one, by adjusting liquid outlet stream
Amount can make different size of microlayer model enter different channels, and the microlayer model of specified size can be made to enter specified lead to
The control of particular size drop outflow position is realized in road.
3, the present invention collects drop using folder flow separation method.In cost, folder flow separation method chip only need to be according to corresponding
Parameter produces channel, and does not have to increase any other structure in channel again, be cost has been down to it is minimum.It is imitated in separation
In terms of rate, folder flow separation method can be adjusted channel width according to the parameter of target cell, to realize efficiently separating for cell.
4, the present invention makes chip using PDMS material, and material translucency is good, biocompatibility is good and good chemistry
Inertia, the toughness of material is relatively high, and elasticity is good.The device uses simply, at low cost, is that one kind is widely used in micro-fluidic equal neck
The polymer material in domain.
Detailed description of the invention
Fig. 1 is overall structure of the present invention；
Fig. 2 is A-A cross-sectional view in channel of the present invention；
Fig. 3 is B-B cross-sectional view in channel of the present invention；
Each label in Fig. 1-3: 1- glass substrate, 2- chip, the liquid inlet 3- I, the liquid inlet 4- II, the liquid inlet 5- III, 6-
Liquid inlet IV, 7- liquid outlet I, 8- liquid outlet II, 9- liquid outlet III, 10- liquid outlet IV, 11- fluid passage,
12- expansion.
Specific embodiment
In the following with reference to the drawings and specific embodiments, the invention will be further described.
Embodiment 1: as shown in Figure 1-3, a kind of integrating device of drop fluid micro-reactor, including glass substrate 1, chip 2
With fluid passage 11, the chip 2 is arranged in glass substrate 1, and fluid passage 11 is arranged on chip 2, fluid passage 11
Starting point is equipped with liquid inlet I 3, sets that there are three liquid inlets II arranged in parallel in the vertical direction of the side of fluid passage 11
4, the end of liquid inlet III 5 and liquid inlet IV 6, fluid passage 11 is equipped with expansion 12, and the expansion 12 includes
Positioned at the monosymmetric arc section in 11 end of fluid passage, the opening between the arc section of two sides is divided into four contiguous branch, branch
End be equipped with liquid outlet I 7, liquid outlet II 8, liquid outlet III 9 and liquid outlet IV 10；Wherein the end of arc section is arrived
Four sides on both sides and four contiguous branch openings that the midpoint after two sections of arc section connections is formed form an equilateral hexagon.
Wherein chip 2 and fluid passage 11 are all made of PDMS(dimethyl silicone polymer) material is made.Due to entire chip
It is to be made of PDMS (dimethyl silicone polymer) material, material translucency is good, convenient for observing the flow behavior of fluid when experiment,
Biocompatibility is good and good chemical inertness, and the toughness of material is relatively high, and elasticity is good, and durability and resistance to pressure are relatively high.
The device uses simply, at low cost, is a kind of polymer material for being widely used in micro-fluidic equal fields.
Embodiment 2: it is using the method that above-mentioned apparatus carries out the micro- reaction of drop stream: gives injection in liquid-inlet I 3 oily phase,
Water phase is injected separately into liquid inlet II 4, liquid inlet III 5 and liquid inlet IV 6, the water phase of three entrances contains difference respectively
Chemical substance and three can react to each other, pass through control liquid inlet II 4, liquid inlet III 5 and liquid inlet IV 6 stream
Amount, generates different size of microlayer model at corresponding channel, and microlayer model is of different sizes to have different in flow rate, and then droplet meeting
Big drop is caught up with to merge, when the drop of fusion reaches expansion 12, due to the expansionary effect in channel, biggish particle
It will receive a lift effect, so that particle deviates the track of original streamline, realize the separation of sized particles, and in liquid
The collection of drop is realized at body outlet I 7, liquid outlet II 8, liquid outlet III 9 and liquid outlet IV 10.
Wherein drop formation part is by control liquid inlet II 4, liquid inlet III 5 and IV 6(of liquid inlet dispersion
Phase) with I 3(continuous phase of liquid inlet) flow-rate ratio, can be in IV 6 pairs of liquid inlet II 4, liquid inlet III 5 and liquid inlet
Different size of drop is efficiently produced at the T-type channel that should be formed.And it can be by controlling liquid inlet flow control droplet size.
There is size uniformity by drop caused by T-type channel and be easy to the significant advantages such as regulation.
3 T-type channels wherein can be made by the control to flow at liquid inlet I 3 when droplet coalescence reactive moieties
Place's biggish drop of flow velocity catch up with the lesser drop of flow velocity and realizes that droplet coalescence reacts.
Wherein drop collection part is based on folder flow separation method --- according to the method for the continuous separating particles of particle size.This
Kind of Method And Principle be after microlayer model enters expansion, due to the expansionary effect in channel, biggish particle will receive one and rise
Power effect, so that particle deviates the track of original streamline.The hints on operation of this method is the stream for controlling different outlets
Ratio is measured, so that small particles are than big particle closer to wall surface.Fluid in channel can amplify in solution sized particles horizontally
Distance, to realize the separation of sized particles.The present invention can make different size of micro- liquid by adjusting I 7 flow of liquid outlet
Drop enters different channels, and the microlayer model of specified size can be made to enter specified channel, to realize particular size drop
Flow out the control of position；The determination that drop flows out position is as follows:
WhereinWoIt is folder stream sector width, η is the outflow ratio of liquid outlet I 7, and D is liquid-drop diameter, NBFor total flow pass
Number, when particle diameter meets above-mentioned equation, particle can flow into n-th channel.
2 length of chip is 25mm, width 10mm, with a thickness of 5mm in the present embodiment；11 height of fluid passage is
0.1mm, width 0.1mm；The liquid inlet I 3, liquid inlet II 4, liquid inlet III 5, liquid inlet IV 6, liquid outlet
I 7, the diameter of liquid outlet II 8, liquid outlet III 9 and liquid outlet IV 10 is 0.1mm；The liquid inlet II 4, liquid
The adjacent distance between the two of entrance III 5 and liquid inlet IV 6 is 3mm, and liquid outlet IV 10 and liquid outlet I 7 are located at liquid
The vertical upper and lower of 11 end of body channel, the horizontal distance between liquid inlet II 6 and its equidirectional liquid outlet I 7 are
9mm；The arc section radius of the expansion 12 is 0.15mm.
Liquid outlet I 7, liquid outlet II 8, liquid outlet III 9 and liquid outlet IV 10 it is corresponding number be respectively 1,2,
3、4。
If drop effective diameter be 50 μm, outflow than η be 0.1 when, according to above-mentioned formula N=1, i.e. drop will be by liquid
It collects body outlet I 7；Change outflow than η, can obtain that the results are shown in Table 1.
The different outflows of table 1 are more corresponding than formula drop to be exported
By COMSOL Multiphysics analogue simulation: the present invention can effectively realize drop formation, droplet coalescence
And drop is collected, and different size of microlayer model can be made to enter different channels by adjusting I 7 flow of liquid outlet, and can be with
So that the microlayer model of specified size is entered specified channel, realizes the control of particular size drop outflow position.
Specific embodiments of the present invention are explained in detail above in conjunction with attached drawing, but the present invention is not limited to above-mentioned realities
Example is applied, it within the knowledge of a person skilled in the art, can also be without departing from the purpose of the present invention
Various changes can be made.
Claims (6)
1. a kind of integrating device of drop fluid micro-reactor, including glass substrate (1), chip (2) and fluid passage (11), special
Sign is: the chip (2) is arranged on glass substrate (1), and fluid passage (11) is arranged on chip (2), fluid passage
(11) starting point is equipped with liquid inlet I (3), sets that there are three arranged in parallel in the vertical direction of the side of fluid passage (11)
The end of liquid inlet II (4), liquid inlet III (5) and liquid inlet IV (6), fluid passage (11) is equipped with expansion
(12), the expansion (12) includes being located at the monosymmetric arc section in fluid passage (11) end, between the arc section of two sides
Opening be divided into four contiguous branch, the end of branch is equipped with liquid outlet I (7), liquid outlet II (8), liquid outlet III (9)
With liquid outlet IV (10).
2. the integrating device of drop fluid micro-reactor according to claim 1, it is characterised in that: the chip (2) and liquid
Body channel (11) is all made of PDMS polydimethyl siloxane material and is made.
3. the integrating device of drop fluid micro-reactor according to claim 1, it is characterised in that: the end of the arc section
The four of both sides and four contiguous branch openings that midpoint after connecting to two sections of arc sections is formed are when forming one equilateral six
Shape.
4. the integrating device of drop fluid micro-reactor according to claim 1, it is characterised in that: chip (2) length
For 25mm, width 10mm, with a thickness of 5mm；The fluid passage (11) is highly 0.1mm, width 0.1mm；The liquid
Entrance I (3), liquid inlet II (4), liquid inlet III (5), liquid inlet IV (6), liquid outlet I (7), liquid outlet II
(8), the diameter of liquid outlet III (9) and liquid outlet IV (10) is 0.1mm；The liquid inlet II (4), liquid inlet III
(5) and the adjacent distance between the two in liquid inlet IV (6) is 3mm, liquid inlet II (6) and its equidirectional liquid outlet I (7)
Between horizontal distance be 9mm；The arc section radius of the expansion (12) is 0.15mm.
5. a kind of method that the integrating device using the drop fluid micro-reactor as described in claim 1-4 carries out drop reaction,
It is characterized by: to oily phase, liquid inlet II (4), liquid inlet III (5) and liquid inlet IV is injected in liquid-inlet I (3)
(6) water phase is injected separately into, the water phase of three entrances contains different chemical substances respectively and three can react to each other, and passes through
The flow for controlling liquid inlet II (4), liquid inlet III (5) and liquid inlet IV (6) generates different big at corresponding channel
Small microlayer model, microlayer model is of different sizes to be had different in flow rate, and then droplet can catch up with big drop and merge, when fusion
When drop reaches expansion (12), due to the expansionary effect in channel, biggish particle will receive a lift effect, to make
Particle deviates the track of original streamline, realize the separation of sized particles, and liquid outlet I (7), liquid outlet II (8),
The collection of drop is realized at liquid outlet III (9) and liquid outlet IV (10).
6. the method according to claim 5 for carrying out drop reaction, it is characterised in that: the collection of the drop is to pass through tune
The flow of section liquid outlet I (7) makes different size of microlayer model enter different channels, and can make micro- liquid of specified size
Drop enters specified channel, to realize the control of particular size drop outflow position；The determination that drop flows out position is as follows:
WhereinWO is the folder stream sector width i.e. width of fluid passage 11, and η is the outflow ratio of liquid outlet I (7),DIt is straight for drop
Diameter, NBFor total flow pass, that is, liquid outlet number,NFor liquid outlet I (7), liquid outlet II (8), liquid outlet III
(9) it is sequentially increased with the number of liquid outlet IV (10), four number, works as liquid-drop diameterDWhen meeting equation, drop can be flowed into
TheNA channel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810683587.9A CN108993337A (en) | 2018-06-28 | 2018-06-28 | A kind of integrating device of drop fluid micro-reactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810683587.9A CN108993337A (en) | 2018-06-28 | 2018-06-28 | A kind of integrating device of drop fluid micro-reactor |
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| Publication Number | Publication Date |
|---|---|
| CN108993337A true CN108993337A (en) | 2018-12-14 |
Family
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| CN201810683587.9A Pending CN108993337A (en) | 2018-06-28 | 2018-06-28 | A kind of integrating device of drop fluid micro-reactor |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109622080A (en) * | 2019-01-08 | 2019-04-16 | 新羿制造科技（北京）有限公司 | Microlayer model for multi-target analysis generates chip |
| CN110560188A (en) * | 2019-09-19 | 2019-12-13 | 济南大学 | Synthetic Ag/Ag2Preparation method of S/CdS heterojunction multi-stage sample injection microfluidic chip |
| CN111215160A (en) * | 2019-11-05 | 2020-06-02 | 昆明理工大学 | Method for measuring droplet speed in micro-reactor channel based on light absorption turbidimetry |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109622080A (en) * | 2019-01-08 | 2019-04-16 | 新羿制造科技（北京）有限公司 | Microlayer model for multi-target analysis generates chip |
| CN110560188A (en) * | 2019-09-19 | 2019-12-13 | 济南大学 | Synthetic Ag/Ag2Preparation method of S/CdS heterojunction multi-stage sample injection microfluidic chip |
| CN110560188B (en) * | 2019-09-19 | 2021-09-28 | 济南大学 | Preparation method of multi-stage sample injection micro-fluidic chip for synthesizing Ag/Ag2S/CdS heterojunction |
| CN111215160A (en) * | 2019-11-05 | 2020-06-02 | 昆明理工大学 | Method for measuring droplet speed in micro-reactor channel based on light absorption turbidimetry |
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Application publication date: 20181214 |