CN105214546B - A kind of concussion jetting type micro-mixer based on Pulsating Flow - Google Patents
A kind of concussion jetting type micro-mixer based on Pulsating Flow Download PDFInfo
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- CN105214546B CN105214546B CN201510604398.4A CN201510604398A CN105214546B CN 105214546 B CN105214546 B CN 105214546B CN 201510604398 A CN201510604398 A CN 201510604398A CN 105214546 B CN105214546 B CN 105214546B
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Abstract
A kind of concussion jetting type micro-mixer based on Pulsating Flow, the micro-mixer include glass cover-plate, underlying substrate；Glass cover-plate is bonded connection with underlying substrate using high temperature, constitutes micro-mixer.Present invention incorporates the advantages of passive type micro-mixer and active micro-mixer, can effectively improve the efficiency of micro-mixer, solve the defects of existing micro-mixer mixed mechanism is single, difficulty of processing is big.The present invention mainly by applying the Pulsating Flow with saw-tooth wave type flowing velocity to a kind of fluid respectively in symmetrical two inlet of micro-mixer, promotes fluid-mixing to generate concussion；And increase strength of turbulence by two level mixing chamber, branch structure, zigzag structure etc., realize that fluid is sufficiently mixed under minute yardstick.The micro-mixer has structure easy processing, of low cost, the advantages such as mixing efficiency height.
Description
Technical field
The present invention provides a kind of novel micro-mixer can be used for improving differential responses object mixing efficiency.The internal mixer
The rapid fusion of multiple fluid under minute yardstick may be implemented in feature with chaotic advection.It is related to the technologies such as life science, chemical industry
Field more particularly to a kind of micro-mixer.
Background technology
The target of micro-full analytical system is the sampling of entire chemical laboratory, mixing, dilution, sample-adding, reaction, separation
It is concentrated on a chip with functions such as detections, to save reaction reagent to the full extent, reduces the danger of analytic process
(such as high poison or inflammable and explosive reagent) improves analysis efficiency, while also having and being easy to the advantages such as minimize and automate.Due to
The above advantage, the technology application prospect are extremely wide.
Under macro-size, most fluids are in turbulence state, can quickly be realized by turbulent flow between different fluid
Be thoroughly mixed, and the surface area of micro-fluidic chip internal flow and the ratio of volume increased dramatically under minute yardstick, surface force with
The influence of viscous force is occupied an leading position, and the effect of inertia force is reduced rapidly, makes the flowing of inside microchannels fluid based on laminar flow,
It is difficult rapidly and efficiently to mix in micro fluidic device.Therefore, it is that cannot meet modern biotechnology, chemistry point to be spread by molecule merely
Needs reaction speed fast, few using drug dose, quick analysis in analysis and detected in real time.It is anti-under the conditions of minute yardstick in order to realize
Efficient, the uniform mixing of object, micro-mixer is answered to come into being.
According to whether there is or not outside energy driving micro-mixers can be divided into two classes：One kind is active micro-mixer, another kind of to be
Passive type micro-mixer.The former mechanism is to generate the relative motion between liquid by the effect in outfield to achieve the effect that mixing.
The mechanism of passive type micro-mixer increases mixed area, reaches increasing as far as possible mainly by the internal structure and shape that change pipeline
The effect mixed by force.The flow phenomenons such as studies have shown that chaotic flow, Secondary Flow, eddy structure in relation to passive mixing device can be with
The contact area being effectively increased between fluid promotes the mixing of liquid.Wherein there are many realizations of chaotic advection and eddy structure
Mode such as improves channel design, periodically variable flowing etc..
Invention content
Present invention incorporates the advantages of passive type micro-mixer and active micro-mixer, can effectively improve micro-mixer
Efficiency solves the defects of existing micro-mixer mixed mechanism is single, difficulty of processing is big.The present invention in micro-mixer mainly by entering
The Pulsating Flow with saw-tooth wave type flowing velocity is applied to a kind of fluid respectively at mouthful, fluid-mixing is promoted to generate concussion；And it borrows
It helps two level mixing chamber, branch structure, zigzag structure etc. to increase strength of turbulence, realizes that fluid is sufficiently mixed under minute yardstick.It should
Micro-mixer has structure easy processing, of low cost, the advantages such as mixing efficiency height.
The technical solution adopted by the present invention is as follows, a kind of concussion jetting type micro-mixer based on Pulsating Flow, the microring array
Device includes glass cover-plate (11), underlying substrate (12), and wherein underlying substrate is carved with micro-mixer channel；Glass cover-plate (11) is under
The surface of laminar substrate (12) constitutes micro-mixer (13) using high temperature bonding connection.
The glass cover-plate (11) is high grade of transparency material, to facilitate the flowing inside observation micro-mixer, and is played close
The effect of envelope.
Micro-mixer channel in the underlying substrate (12) is a kind of droplet-shaped structure of variation, the droplet-shaped of the variation
The bottom and top and the two connection of structure are circle arc curve, wherein bottom curvature is more than apical curvature.The lower layer
Substrate (12) is multiple access road forms, to realize the mixing of multiple fluid；The quantity of access road is more than or equal to three；
Access road preferred amount is three, i.e. access road a (1), access road b (2), access road c (3).Wherein access road a
(1), access road b (2), access road c (3) are uniformly and symmetrically distributed.Above-mentioned each access road end passes through class nozzle arrangements (4)
Mixing cavity configuration is connect and formed with the both ends of exit passageway (10), which is divided into upper, middle, and lower part, mixing
The top of cavity configuration is the first mixing chamber (5), and middle part is equipped with bar shaped branch structure (6), and lower part is equipped with the second mixing chamber (7) and the
Cylindrical type baffle structure (8) is equipped in two mixing chambers (7), the second mixing chamber (7) is connect with exit passageway (10), and exit passageway
(10) zigzag structure (9) is equipped in.
The access road a (1), access road b (2), access road c (3) are schematic construction, and are mixed with two kinds of fluids
Premised on；If the mixing number of type of fluid need to be increased, branch structure is added at access road a (1).
The access road b (2), access road c (3) width and fluid inlet angle degree depend on wanting for fluid mixing
It asks.
The height distance jet inlet height of first mixing chamber (5) is 5~10 times of inlet passageway width.
Number of branches in the middle part of mixing chamber can increase as needed, and the minimum widith of branch is not less than 20 μm, in order to
Processing.
The diameter of cylindrical type baffle structure (8) is more than the width of exit passageway (10), and is placed in the center line of access road
On, to ensure baffle effect.
Zigzag structure (9) number in exit passageway (10) suitably increases as needed, and theoretically number gets over polyhybird
Effect is better, but corresponding flow resistance also increases therewith.
The course of work of the present invention is as follows, wherein flowing into a kind of fluid by access road a (1), another fluid is logical
Cross access road b (2), access road c (3) is flowed into different wave mode speed.Three fluid streams accelerate through nozzle arrangements respectively, are formed
Regular jet stream flows into the first mixing chamber of micro-mixer；In the first mixing chamber, three strands of jet streams cross, and form jet stream shake
It swings, and is pre-mixed.It shakes jet stream after premixing to enter in the middle part of mixing chamber, and respectively enters strip branch structure and carry out by force
Change mixing.To strengthen mixed fluid through each branch, converges in the second mixing chamber, intracavitary is provided with cylindrical baffle structure, with
Increase the incorporation time and mixing intensity of tributary in the cavity.Fluid enters exit passageway through the second mixing chamber, in the channel
Portion's zigzag structure helps and forms eddy structure and chaotic advection in a fluid, further strengthens mixing.
Compared with prior art, the present invention has the advantages that.
1, TRANSFER BY PULSATING FLOW is introduced at the access road of such mixer, which helps inducing the chaos in channel
Convection current promotes mixing.
2, in micro-mixer, mixing chamber is designed as water-drop-shaped structure, which can form jet stream under the premise of TRANSFER BY PULSATING FLOW
Mixing is strengthened in concussion.
3, in mixer, bar shaped branch structure, baffle harden structure and zigzag structure can be effectively increased fluid point
Uneven collision between son, improves reactant mixing efficiency.
Description of the drawings
Fig. 1 is the glass cover-plate schematic three dimensional views of the present invention.
Fig. 2 is the micro-mixer inner flow passage schematic three dimensional views of the present invention.
Fig. 3 is the micro-mixer vertical view of the present invention.
Fig. 4 is the micro-mixer assembling schematic three dimensional views of the present invention.
Fig. 5 is the access road b of the present invention, access road c flowing velocity mode charts.
In figure：1, access road a, 2, access road b, 3, access road c, 4, class nozzle arrangements, the 5, first mixing chamber, 6,
Bar shaped branch structure, the 7, second mixing chamber, 8, cylindrical type baffle structure, 9, zigzag structure, 10, micro-mixer exit passageway,
11, glass cover-plate, 12, underlying substrate, 13, micro-mixer.
Specific implementation mode
1, processing request
A) material of such micro-mixer uses chemical etching using the transparent materials such as glass material, PDMS, processing method
Method, teflon plastics sebific duct can be used in feeder connection, exit external catheter.Pay attention between glass plate and underlying substrate
Bonding quality ensures system lock.
B) such micro-mixer may be implemented the mixing of multiple fluid, access road can be arranged it is a plurality of, in order to just in text
In explaining, three access roades are only set.It therefore, can in actual design if necessary to the mixing number of increase type of fluid
Branch structure is added at access road a (1), to meet requirement of actual working condition.
C) access road b (2), access road c (3) width and inflow angle can require be changed according to mixing.
D) the first mixing chamber need to keep height appropriate, generally apart from 5 that jet inlet height is inlet passageway width~
10 times.
E) the branch structure number in the middle part of mixing chamber can increase as needed, and general minimum widith is (convenient not less than 20 μm
Processing).
F) diameter of cylindrical type baffle structure should be greater than the width of exit passageway, and need to be placed in the center line of access road
On, to ensure to swing stream effect.
G) number of exit passageway (10) interior zigzag structure (9) can suitably increase as needed, and theoretically number is more
Mixed effect is better, but corresponding flow resistance also increases therewith.
2, flow input requirements (by taking two kinds of fluids uniformly mixing as an example)
Following principle need to be followed by access road a (1), access road b (2), access road b (3) flow (speed)：
A) flow (speed) in access road a (1) is kept constant.
B) access road b (2), access road c (3) are respectively TRANSFER BY PULSATING FLOW, access road b (2), access road c (3)
Entrance velocity can refer to Fig. 5.If needing to change, following principle please be follow：Access road b (2), access road c (3) flowing velocity
Phase difference need to ensure 180 °, and ripple frequency is theoretically the smaller the better.
Claims (7)
1. a kind of concussion jetting type micro-mixer based on Pulsating Flow, it is characterised in that：The micro-mixer includes glass cover-plate
(11), underlying substrate (12)；Glass cover-plate (11) is bonded connection with the surface of underlying substrate (12) using high temperature, constitutes microring array
Device (13)；
The glass cover-plate (11) is high grade of transparency material, to facilitate the flowing inside observation micro-mixer, and plays sealing
Effect；
Micro-mixer channel in the underlying substrate (12) is a kind of droplet-shaped structure of variation, the droplet-shaped structure of the variation
Bottom and top and the two connection be circle arc curve, wherein bottom curvature be more than apical curvature；The underlying substrate
(12) it is multiple access road forms, to realize the mixing of multiple fluid；The quantity of access road is more than or equal to three；Entrance
Number of channels is three, i.e. access road a (1), access road b (2), access road c (3)；Wherein access road a (1), entrance
Channel b (2), access road c (3) are uniformly and symmetrically distributed；Above-mentioned each access road end is logical with outlet by class nozzle arrangements (4)
The both ends in road (10) connect and form mixing cavity configuration, which is divided into upper, middle, and lower part, mixes cavity configuration
Top is the first mixing chamber (5), and middle part is equipped with bar shaped branch structure (6), and lower part is equipped with the second mixing chamber (7) and the second mixing chamber
(7) cylindrical type baffle structure (8) is equipped in, the second mixing chamber (7) is connect with exit passageway (10), and is set in exit passageway (10)
There is zigzag structure (9).
2. a kind of concussion jetting type micro-mixer based on Pulsating Flow according to claim 1, it is characterised in that：It is described enter
Mouth channel a (1), access road b (2), access road c (3) are premised on two kinds of fluids mix；If the mixed of type of fluid need to be increased
Number is closed, branch structure is added at access road a (1).
3. a kind of concussion jetting type micro-mixer based on Pulsating Flow according to claim 1, it is characterised in that：It is described enter
Mouth channel b (2), access road c (3) width and fluid inlet angle degree depend on the requirement of fluid mixing.
4. a kind of concussion jetting type micro-mixer based on Pulsating Flow according to claim 1, it is characterised in that：First is mixed
The height distance jet inlet height for closing room (5) is 5~10 times of inlet passageway width.
5. a kind of concussion jetting type micro-mixer based on Pulsating Flow according to claim 1, it is characterised in that：Mixing chamber
The number of branches at middle part can increase as needed, and the minimum widith of branch is not less than 20 μm.
6. a kind of concussion jetting type micro-mixer based on Pulsating Flow according to claim 1, it is characterised in that：Cylindrical type
The diameter of baffle structure (8) is more than the width of exit passageway (10), and is placed on the center line of access road.
7. a kind of concussion jetting type micro-mixer based on Pulsating Flow according to claim 1, it is characterised in that：Outlet is logical
Zigzag structure (9) number in road (10) suitably increases as needed, and theoretically number more polyhybird effect is better, but corresponding
Flow resistance also increase therewith.
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| CN105771763B (en) * | 2016-03-07 | 2018-09-21 | 东南大学 | Jet stream destroys high concentration gradient microfluidic mixer chip |
| CN110465338A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Promote the chip of fluid mixing and promotes the method for fluid mixing |
| CN110470610A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Water quality many reference amounts detection device and detection method |
| CN109682574B (en) * | 2019-01-14 | 2020-10-27 | 北京工业大学 | Device and method for measuring flow resistance of micro-droplets/bubbles in motion in channel in real time |
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| DE10317451A1 (en) * | 2003-04-16 | 2004-11-18 | Degussa Ag | Reactor for heterogeneously catalyzed reactions |
| KR101324405B1 (en) * | 2010-06-28 | 2013-11-01 | 디아이씨 가부시끼가이샤 | Micro mixer |
| CN102000518A (en) * | 2010-09-27 | 2011-04-06 | 华北电力大学 | Micro mixing system of pulsating flow driven by micro bubble pump loop |
| CN103638852B (en) * | 2013-11-11 | 2015-08-05 | 江苏大学 | A kind of synthesizing jet-flow Valveless piezoelectric micro-mixer |
| CN104084247B (en) * | 2014-06-30 | 2017-02-08 | 北京工业大学 | Elastic wall surface micro-fluidic chip based on T-shaped micro-channel |
| CN104525286B (en) * | 2014-12-21 | 2016-06-08 | 北京工业大学 | The micro-fluidic chip of drop synchronous fusion is realized based on T-shaped passage |
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