CN207446126U

CN207446126U - A kind of passive type micro-mixer

Info

Publication number: CN207446126U
Application number: CN201721158542.7U
Authority: CN
Inventors: 吉祥; 葛鉴; 王瀚林; 史留勇; 周腾; 张先满
Original assignee: Hainan University
Current assignee: Hainan University
Priority date: 2017-09-11
Filing date: 2017-09-11
Publication date: 2018-06-05
Anticipated expiration: 2027-09-11

Abstract

The utility model belongs to micro-fluidic field, specifically discloses a kind of passive type micro-mixer, includes inlet tube, outlet, mixing chamber, square wave interface channel.Mixing chamber is made of mixing chamber inlet, mixing chamber outlet, hybrid channel, contraction structure etc..By designing a kind of microring array passage of special construction, microfluid generates impact when flowing through the passage, breaks original laminar condition, strengthen the convection effect of microfluid to be mixed.The main advantage of the utility model is：Compared with tapering contracting bend pipe structure micro-mixer, hence it is evident that the Microfluidic Mixing time can be shortened, afterbody contraction structure so that Microfluidic Mixing is more abundant, improves mixing efficiency.Meanwhile it is simple in structure, at low cost, meet the requirement of large quantities of mass productions.

Description

A kind of passive type micro-mixer

Technical field

The utility model is related to a kind of new micro-mixers.The hybrid mode of the mixer is passive type.

Background technology

Micro-fluidic chip is a kind of to be manipulated the science and technology for main feature to fluid in micro-meter scale space, tool Have the ability on the basic function micro in the laboratories such as biology, chemistry to a several square centimeter chips, therefore be otherwise known as Chip lab；Microfluid mixer is one of important component of micro-fluidic chip, is had quick, efficient, easily controllable The characteristics of with being easily integrated, and cost is relatively low, simple in structure, good mixing.

Microring array is the basic physical phenomenon in micro-mixer, and micro-mixer has become microfluidic system Integrated design Important component；Some require biological process such as DNA hybridization, cell-stimulating, enzyme reaction, the protein folding of fast reaction Folded grade is inevitably related to the mixing of reactant；Quick homogeneous mixing is for chemical synthesis, biochemical analysis, drug conveying, core The microfluidic system calculated in the fields such as sequencing or synthesis is of great significance.

In the micron-scale, flow rate of liquid is usually relatively low for channel characteristics scale in microfluidic system, and Reynolds number is much smaller than 2000, Therefore fluid mixing is based primarily upon Laminar flow mixing mechanism, and the influence of molecule diffusion is very notable, so in certain requirement of experiment Under, the mixing of fluid becomes more difficult；Low cost micro-mixer by simple structure improve can lifting fluid it Between the efficiency that mixes, reach expected mixed effect.

The micro-mixer design of document report is divided into active micro-mixer and passive type micro-mixer at present, actively declines Mixer relies primarily on exterior power（Such as ultrasound, magnetic force, mechanical agitation）It realizes to the disturbance of fluid in microchannel to reach Mixed effect, design is complex, and processing cost is higher；Passive type micro-mixer mainly follow stretching and fold fluid passageway with Contact area between increase fluid, promotes diffusion；Passive type micro-mixer realizes liquid by optimizing the structure design of microchannel Shunting or the chaotic advection for increasing liquid in passage promote mixing efficiency；Passive type micro-mixer adds without any exterior power Work difficulty is small, is easily integrated, and fast response time, easy to use, is used widely.

Existing passive type micro-mixer realizes that the major way of mixing is：Baffle or stop block, disturbance are set in runner Fluid generates mixing, and flow losses are big；According to the micro-mixer of SAR conceptual designs, by generating chaotic flow come fluid-mixing, Good mixing effect, but there is the shortcomings of mixing runner is long, and incorporation time is long, and flow losses are big；The utility model only relies on In addition designed flow passage structure need not set block so that incorporation time is short, fast response time, and fluid mixing is abundant, mixes Efficiency is closed to greatly improve.

The content of the invention

The purpose of this utility model is to provide a kind of passive type micro-mixer simple in structure, easy to use, for into One step shortens hybrid channel length, improves response speed, promotes mixing efficiency.

The technical solution of the utility model is：A kind of passive type micro-mixer, including inlet tube, outlet, mixing chamber, side Ripple interface channel；Mixing chamber is made of mixing chamber inlet, mixing chamber outlet, hybrid channel, contraction structure etc..Fluid to be mixed by Inlet tube flows into mixed cell, flows through hybrid channel cross section afterwards and is gradually reduced, and is drastically received at mixing chamber contraction structure Contracting flows into square wave interface channel by mixing chamber outlet, increases the flow disturbance of microfluid again.

The passive type micro-mixer is characterized in that：The hybrid channel is left by Inner arc structure and external arc structure Right two cuttings rectangle cutting forms, and Inner arc structure and the external arc structure center of circle are misaligned, radius ratio 1:2；Left cut cutting torch Shape is 1 in X-direction penetraction depth ratio with right cut cutting torch shape:1, penetraction depth ratio in the Y direction is 3:2；Left cut cutting torch shape is in X side It is 3 to penetraction depth and the external arc structure radius ratio:10, penetraction depth and the external arc structure radius ratio in the Y direction For 3:4；The distance of center circle of Inner arc structure and external arc structure is in X-direction component and Inner arc structure（3）The ratio between radius is 1:5, Component is zero in the Y direction.

The income of the utility model is：Microfluid to be mixed from inlet tube enter, by mixing chamber passage mixing after by Outlet flows out, and mixing chamber channel cross-section is gradually reduced, and constantly breaks the laminar condition of streaming flow, at mixing chamber outlet The contraction structure drastically shunk is formed, largely increases the flow disturbance to fluid；Two neighboring microfluidic elements are used Square wave interface channel connects, and secondary mixing is formed in square wave interface channel, combines square wave passage fluid flow well Perturbation action.

The utility model uses commercialization finite element software COMSOL Multiphysics, and as simulation softwares, this is soft Part is based on FInite Element, by solving partial differential equation（Single game）Or partial differential equations（More）To realize true object The emulation of phenomenon is managed, mathematically solves the physical phenomenon of real world.

Structure designed by the utility model is single layer structure, and mold and traditional can be manufactured by a photoetching Multilayered structure compared to have the characteristics that it is simple in structure, assembled convenient for large-scale production configuration, lower-cost, and the utility model Advantage be that there is the single layer structure that more optimizes compared to other microfluid mixers, can make to complete between fluid it is very fast, More efficient mixing, the reynolds number range being applicable in is wide, can meet the needs of largely testing.

The above is some contents of the utility model, is not restricted to the utility model, as long as not departing from this practicality Several changes such as made modification, replacement and deformation under new thought, these belong to the scope of protection of the utility model Within.

Description of the drawings

Fig. 1 is the utility model structure diagram.

In figure：A, b is the flow channel of two kinds of fluids to be mixed respectively, and c is the flow pass of fluid after mixing, dotted line Frame choosing part is a Microfluidic Mixing unit.

Fig. 2 is the main mixed cell structure diagram of the utility model.

In figure：1：Inlet tube；2：Mixing chamber inlet；3：Inner arc structure；4：Contraction structure；5：Mixing chamber outlet；6：Go out Mouth pipe；7：Square wave interface channel；8：Left cut cutting torch shape；9：External arc structure；10：Mixing chamber；11：Microfluidic Mixing unit；12： Hybrid channel；13：Right cut cutting torch shape.

Fig. 3 is the main mixed cell structural front view of the utility model.

In figure：O₁：The external arc center of circle；0₂：The Inner arc center of circle；R：Outer arc radius；r：Inner arc radius；a：Inside and outside circular arc Distance of center circle；b：Inlet tube cross-sectional width；c：Left cut cutting torch shape Y-direction depth of cut；d：The cutting of right cut cutting torch shape Y-direction is deep Degree；e：Left cut cutting torch shape X-direction depth of cut；f：Right cut cutting torch shape X-direction depth of cut.

Specific embodiment

A kind of microfluid mixer, uses PDMS as material, and SU8 molds are made by processing steps such as photoetching, developments；So The PDMS material mixed with curing agent is applied on mold afterwards, is demoulded after being heating and curing and PDMS formers is made；It again will be with The PDMS material that curing agent mixed is applied to PC on pieces, reheats curing and demolding and PDMS tablets are made；PDMS formers and tablet Bonding gained micro-structure is the microfluid mixer structure.

A kind of passive microfluid mixer, including inlet tube 1, outlet 6, mixing chamber 10, square wave interface channel 7.

By two, concentric, the circular arc of different radii by the cutting rectangle cutting of left and right two are not formed, exported mixing chamber Place forms contraction structure 4, and contraction structure 4 is to intercept out using right cut cutting torch shape 13 by external arc structure, and interception face is flat Face, interception face are connected with outlet 6 and in 90 ° of angles.

The connection mixing chamber outlet 5 that mixing chamber afterbody contraction structure 4 is connected is connected with outlet 6.

Exit width ratio of the exit cross-section width and square wave interface channel 7 of mixing chamber outlet 5 on unicom face is 1： 1。

The center of circle of Inner arc structure 3 and external arc structure 9 is but misaligned on same straight line, place straight line perpendicular to Main mixed cell pipeline and square wave connecting pipe unicom face.

The microfluid mixer is easily integrated, and according to the requirement of specific experiment mixed-precision height, can connect multiple institutes Microfluidic Mixing unit 11 is stated, passes through square wave interface channel between two neighboring mixed cell（7）Connection, until reaching requirement Until mixed-precision.

Fluid in mixer is driven by entrance, but streamline becomes intensive when by contraction structure, this is because shrinking Structure forces fluid to be flowed through by narrow and small passage, and similar to contraction-expansion pipe, fluid flow rate increases in narrow and small passage, Simultaneously because the pipeline wall surface of line style, the flowable space of fluid is reduced, main hybrid channel is strengthened under the two collective effect Interior fluid convection, forces fluid quickly to mix.

Claims

1. a kind of passive type micro-mixer, including inlet tube（1）, outlet（6）, mixing chamber（10）, square wave interface channel（7）； The mixing chamber（10）By mixing chamber inlet（2）, mixing chamber outlet（5）, contraction structure（4）, hybrid channel（12）, Inner arc knot Structure（3）, external arc structure（9）Composition；The passive type micro-mixer is characterized in that：The hybrid channel（12）By Inner arc structure （3）, external arc structure（9）By left cut cutting torch shape（8）, right cut cutting torch shape（13）It cuts, it is continually changing to form cross section Microfluidic channels form contraction structure at mixing chamber outlet（4）；The inlet tube（1）, outlet（6）, mixing chamber（10）Shape Into a Microfluidic Mixing unit（11）, pass through square wave interface channel between two mixed cells（7）Connection, can be mixed according to experiment The requirement of conjunction degree increases the linking number of mixed cell.

2. micro-mixer according to claim 1, it is characterised in that the mixing chamber（10）, mixing chamber inlet（2） Cross-sectional area and mixing chamber outlet（5）Cross-sectional area ratio is 2:1.

3. micro-mixer according to claim 1, it is characterised in that the left cut cutting torch shape（8）With right cut cutting torch shape （13）It is 1 in X-direction penetraction depth ratio:1, penetraction depth ratio in the Y direction is 3:2.

4. micro-mixer according to claim 1, it is characterised in that the left cut cutting torch shape（8）It is cut in X-direction deep Degree and the external arc structure（9）The ratio between radius is 3:10, penetraction depth and the external arc structure in the Y direction（9）Radius it Than for 3:4.

5. micro-mixer according to claim 1, it is characterised in that the Inner arc structure（3）With external arc structure （9）The ratio between radius is 1:2.

6. micro-mixer according to claim 1, it is characterised in that the Inner arc structure（3）With external arc structure （9）Distance of center circle in X-direction component and Inner arc structure（3）The ratio between radius is 1:5, component is zero in the Y direction.

7. micro-mixer according to claim 1, it is characterised in that according to the requirement of mixed-precision height, can connect multiple The Microfluidic Mixing unit（11）, pass through square wave interface channel between two neighboring mixed cell（7）Connection, to reach requirement Mixed-precision, improve mixing efficiency.