CN114452874A - Flexible micro mixer and preparation method thereof - Google Patents
Flexible micro mixer and preparation method thereof Download PDFInfo
- Publication number
- CN114452874A CN114452874A CN202210099064.6A CN202210099064A CN114452874A CN 114452874 A CN114452874 A CN 114452874A CN 202210099064 A CN202210099064 A CN 202210099064A CN 114452874 A CN114452874 A CN 114452874A
- Authority
- CN
- China
- Prior art keywords
- mixing
- pipe
- heating
- flexible
- tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention discloses a flexible micro mixer and a preparation method thereof, wherein the flexible micro mixer comprises: feed liquor pipe, pipeline connector, hybrid tube, drain pipe and fixed die plate, the feed liquor pipe the pipeline connector the hybrid tube reaches the drain pipe is connected in order, the hybrid tube is fixed in the fixed die plate, the hybrid tube is equipped with multistage circulation pantographic structure. The flexible micro mixer can be prepared by simple pipeline processing and assembly, the preparation process of the micro mixer is greatly simplified, the production period is shortened, the cost is reduced, meanwhile, the mixing tube of the flexible micro mixer is a micro channel with a circulating and zooming type inner diameter, the flow velocity change of the micro fluid can be effectively regulated and controlled by the mixing tube with the multistage circulating and zooming type structure, Chaotic convection (Chaotic convection) is formed at the pipe diameter zooming part, the diffusion and mass transfer among different reagents are accelerated, the mixing efficiency is improved, and the flexible micro mixer can be widely applied to the technical field of micro total analysis systems.
Description
Technical Field
The invention relates to the technical field of micro total analysis systems, in particular to a flexible micro mixer and a preparation method thereof.
Background
The micromixer is an important component of chip Laboratory (LOC) equipment and a micro total analysis system ((-TAS), the high-efficiency mixing efficiency of the micromixer can obviously improve the detection sensitivity and reduce the analysis time, and the micromixer is indispensable to be applied in the fields of synthesis of nano materials, bioengineering, biochemical systems and the like.
The passive micro mixer mainly mixes the molecular diffusion and chaotic convection among microfluids, and external energy such as a magnetic field, an electric field, ultrasonic vibration and the like is not needed except for pumping the fluid, so that energy can be effectively saved.
However, in the prior art, a micro-mixer is mostly prepared by adopting a micro-fluidic chip technology, and multi-step processes such as micro-channel mold processing, micro-channel pattern transfer printing, chip bonding and the like are required, wherein the mold processing usually uses technologies such as photoetching, plasma etching, laser engraving and the like; the micro-channel pattern transfer molding generally uses techniques such as polymer casting, injection molding, compression molding and the like; chip bonding generally uses techniques such as thermal bonding, plasma bonding, ultrasonic bonding, and the like. The technology needs expensive equipment and consumables, and has the advantages of high production cost, long preparation period, complex manual operation and low repeatable utilization rate. In addition, in the prior art, a micro mixer is prepared by using a rotating spring type glass pipeline, but the glass pipeline has high material cost, fragile rigidity and poor surface hydrophobicity, so that the flow resistance in a micro channel is large, and the mixing efficiency is influenced.
Disclosure of Invention
In view of this, embodiments of the present invention provide a flexible micro-mixer and a method for manufacturing the same, which can effectively improve mixing efficiency through a multi-stage circular scaling structure of a mixing tube, and can manufacture the micro-mixer through simple pipeline processing and assembly, thereby greatly simplifying a micro-mixer manufacturing process, shortening a production period, and reducing cost.
A first aspect of an embodiment of the present invention provides a flexible micro mixer, including:
feed liquor pipe, pipeline connector, hybrid tube, drain pipe and fixed die plate, the feed liquor pipe the pipeline connector the hybrid tube reaches the drain pipe is connected in order, the hybrid tube is fixed in the fixed die plate, the hybrid tube is equipped with multistage circulation pantographic structure.
Optionally, the flexible micromixer further comprises a reagent tank connected to the front end of the liquid inlet pipe.
Optionally, the flexible micromixer further comprises a negative pressure pump feeder connected to the rear end of the liquid outlet pipe.
Optionally, the liquid inlet pipe, liquid outlet pipe and mixing pipe are polymer pipes.
Optionally, the number of the liquid inlet pipes is greater than or equal to 2.
Optionally, the mixing tube is fixed to the fixed template in a three-dimensional configuration, the three-dimensional configuration including a serpentine shape, a sinusoidal shape, and a helical shape, the fixed template including a flat plate structure, a cylindrical structure, a conical structure, and a columnar array structure.
The second aspect of the embodiments of the present invention provides a method for preparing a flexible micro mixer, including:
selecting a liquid inlet pipe, a pipeline connector, a mixing pipe and a liquid outlet pipe;
heating the mixing pipe by a plurality of heating devices, wherein a multi-stage circulating zooming structure is arranged on the mixing pipe;
connecting the liquid inlet pipe, the pipeline connector, the mixing pipe of the multistage circulating zooming structure and the liquid outlet pipe in sequence;
and fixing the mixing pipe of the multistage circulating zooming structure on a fixed template.
Optionally, the heating treatment of the mixing tube by the multi-page heating device is performed by a multi-stage cyclic convergent-divergent structure provided on the mixing tube, and the method comprises the following steps:
mounting a plurality of heating molds on a heating table to form a plurality of heating devices;
placing the mixing tube in the multi-page heating apparatus;
starting the heating table to perform preheating treatment until the target temperature is reached;
and (3) rotating the mixing pipe along the axial direction to perform heating treatment, and arranging a multi-stage circulating zooming structure on the mixing pipe.
Optionally, the axially rotating the mixing tube for heat treatment includes:
rotating the mixing tube along the axial direction to carry out drawing method heating treatment;
or, the mixing tube is rotated along the axial direction to carry out heat shrinkage and heat treatment.
Optionally, the fixing the circular scaling mixing tube to a fixed template includes:
and fixing the circular scaling type mixing tube on a fixed template in a three-dimensional configuration, wherein the three-dimensional configuration comprises a snake shape, a sine shape and a spiral shape, and the fixed template comprises a flat plate structure, a cylindrical structure, a conical structure and a columnar array structure.
The embodiment of the invention provides a flexible micro-mixer and a preparation method thereof, the flexible micro-mixer can be prepared by simple pipeline processing and assembly, the preparation process of the micro-mixer is greatly simplified, the production period is shortened, the cost is reduced, meanwhile, a mixing pipe of the flexible micro-mixer is a micro-channel with a circular scaling type inner diameter, the flow velocity change of micro-fluid can be effectively regulated and controlled by the mixing pipe with a multistage circular scaling type structure, chaotic convection is formed at the pipe diameter scaling position, the diffusion and mass transfer among different reagents are accelerated, and the mixing efficiency is improved.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a flexible micro mixer according to an embodiment of the present invention;
fig. 2 is a schematic flow chart of a method for preparing a flexible micro mixer according to an embodiment of the present invention;
FIG. 3 is a schematic view of a multi-page heating apparatus according to an embodiment of the present invention;
FIG. 4 is a top view of another multi-page heating apparatus according to an embodiment of the present invention;
FIG. 5 is a schematic structural diagram of an A-A direction of another multi-page heating apparatus according to FIG. 3 according to an embodiment of the present invention;
FIG. 6 is an optical microscopic view of the reagent mixing effect of a flexible mixer according to an embodiment of the present invention;
FIG. 7 is an optical microscopic view of the reagent mixing effect of another flexible mixer provided in the embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.
In order to make the content and technical solution of the present application more clear, the related terms and meanings are explained as follows:
lab-on-a-chip/micro total analysis system: lab-on-a-chip (Lab-on-a-chip), or Micro Total Analysis System (or microTAS), refers to a technology for integrating or substantially integrating basic operation units related to biological and chemical fields, such as sample preparation, biological and chemical reactions, separation and detection, on a chip with several square centimeters to complete different biological or chemical reaction processes and analyze the products.
Chaotic convection (Chaotic convection): chaotic convection is generally achieved by changing the geometry of the microchannel, reducing the diffusion length by manipulating or recombining the fluid flows, maximizing the interfacial area between the fluids;
dean Vortex (Dean Vortex): in flow through curved channel geometries, the curvature amplifies the lateral instability, driving a secondary cross-sectional flow field (dean flow), characterized by the presence of two counter-rotating vortices located above and below the horizontal plane of symmetry of the channel.
Mixing index (Mixing index): an indication of the homogeneity of the liquid.
The structure and function of the device of the present invention are described in detail below:
the embodiment of the invention provides a flexible micro mixer which comprises a liquid inlet pipe, a pipeline connector, a mixing pipe, a liquid outlet pipe and a fixed template, wherein the liquid inlet pipe, the pipeline connector, the mixing pipe and the liquid outlet pipe are sequentially connected, the mixing pipe is fixed on the fixed template, and the mixing pipe is provided with a multi-stage circulating zooming structure.
It should be noted that the liquid inlet pipe is used for conveying a reagent to be mixed, the pipeline connector is used for connecting the liquid inlet pipe and the mixing pipe to form a communication structure, wherein the pipeline connector includes but is not limited to a three-way pipe connector, and can be used for mixing two-phase fluids and multi-phase fluids, the mixing pipe is a flexible micro-flow channel with a circular scaling type inner diameter, the mixing pipe is prepared by a polymer processing and forming method, including a drawing method, a pressing method, a thermal shrinkage method and the like, and the mixing pipe can be used for regulating and controlling the flow rate change of the micro-flow and forming Chaotic convection (Chaotic convection) at the pipe diameter scaling position, thereby accelerating the diffusion and mass transfer between different reagents and improving the mixing efficiency.
In some embodiments, the flexible micromixer further comprises a reagent tank connected to the front end of the liquid inlet tube.
It should be noted that, the reagent groove is used for splendid attire the reagent that waits to mix, and the feed liquor pipe inserts in the reagent groove.
In some embodiments, the flexible micromixer further comprises a negative pressure pump feeder connected to the back end of the drain tube.
It should be noted that the negative pressure pump transmitter is used for providing negative pressure for the micro mixer, so that different reagents flow into the mixing pipe from the reagent tank through the liquid inlet pipe, and finally, before being sucked into the container of the negative pressure pump transmitter, passive rapid mixing is realized without intervention of external force.
In some embodiments, the inlet tube, outlet tube, and mixing tube are polymer tubes.
It should be noted that the liquid inlet pipe, the liquid outlet pipe and the mixing pipe are all made of polymer pipelines with strong hydrophobicity, so as to reduce the flow resistance of the fluid and realize the rapid mixing of different reagents, and in addition, the pipeline connector is also made of polymer pipelines with strong hydrophobicity. The polymer pipeline comprises polytetrafluoroethylene, polyvinyl chloride, fluorinated ethylene propylene, silica gel, fluorinated ethylene propylene copolymer, polyether ether ketone and the like.
In some embodiments, the number of liquid inlet pipes is greater than or equal to 2.
It should be noted that the flexible micro-mixer can be used for mixing at least two-phase fluids, the number of the liquid inlet pipes is consistent with the phasor of the fluid to be mixed, and correspondingly, the number of the reagent tanks is consistent with the number of the liquid inlet pipes and is connected in a one-to-one correspondence manner.
In some embodiments, the mixing tubes are fixed to the fixed template in a three-dimensional configuration, including serpentine, sinusoidal, and helical, including flat plate, cylindrical, conical, and columnar array configurations.
It should be noted that the mixing tube is a flexible micro-channel, and can be configured in a serpentine, sinusoidal, spiral or other complex three-dimensional configurations, and is used to form Dean vortex (Dean vortex) induced by inertial force, so as to accelerate diffusion and mass transfer between different reagents, and further improve mixing efficiency. Correspondingly, in order to facilitate the mixing tube to be arranged in the three-dimensional configuration, the fixed template can be a flat plate structure, a cylindrical structure, a conical structure and a columnar array structure.
Specifically, referring to fig. 1, in some embodiments, a flexible micromixer includes a first reagent tank 1, a second reagent tank 2, a first liquid inlet pipe 3, a second liquid inlet pipe 4, a pipe connector 5, a reagent mixing pipe 6, a negative pressure pump feeder 7, and a fixed template 8; two different reagents are filled in the first reagent tank 1 and the second reagent tank 2, one end of the first liquid inlet pipe 3 is inserted into the reagent contained in the first reagent tank 1, and the other end is connected with the pipeline connector 5; one end of a second liquid inlet pipe 4 is inserted into the reagent contained in the second reagent tank 2, and the other end is connected with a pipeline connector 5; one end of the reagent mixing pipe 6 is connected with the pipeline connector 5, and the other end is connected with the negative pressure pump transmitter 7; the reagent mixing tube 6 is disposed on the fixed platen.
The liquid outlet end of the reagent mixing tube can be directly connected with the negative pressure pump transmitter, and can also be connected with the negative pressure pump transmitter by connecting with a liquid outlet tube, the reagent mixing tube is a flexible micro-channel with a multistage circulating zoom type inner diameter, can be used for regulating and controlling the flow velocity change of micro-fluid, and forms Chaotic convection (Chaotic convection) at the tube diameter zoom position, so that the diffusion and mass transfer among different reagents are accelerated, and the mixing efficiency is improved;
the reagent mixing tube is a flexible micro-channel and can be set into a snake shape, a sine shape, a spiral shape and other complex three-dimensional configurations, so that Dean vortex (Dean vortex) induced by inertia force is formed, diffusion and mass transfer among different reagents are accelerated, and the mixing efficiency is further improved;
the fixed template is used for arranging a reagent mixing tube, and tools such as an auxiliary clamp, an adhesive, a bypassing support and the like can be arranged on the substrate, so that the reagent mixing tube forms and keeps a specific flow passage structure;
the reagent mixing tube is prepared by a polymer processing and forming method, including a drawing method, a pressing method, a heat shrinking method and the like;
the first liquid inlet pipe, the second liquid inlet pipe, the pipeline connector and the reagent mixing pipe are all made of polymer pipelines with strong hydrophobicity, and are used for reducing the flow resistance of fluid and realizing the rapid mixing of different reagents;
the polymer pipeline comprises polytetrafluoroethylene, polyvinyl chloride, fluorinated ethylene propylene, silica gel, fluorinated ethylene propylene copolymer, polyether ether ketone and the like;
the negative pressure pump transmitter is used for providing negative pressure for the micro mixer, so that different reagents flow into the reagent mixing pipe from the reagent tank through the liquid inlet pipe, and finally, before being sucked into a container of the negative pressure pump transmitter, passive rapid mixing is realized without intervention of external force.
Referring to fig. 2, an embodiment of the present invention provides a method for preparing a flexible micro mixer, including:
selecting a liquid inlet pipe, a pipeline connector, a mixing pipe and a liquid outlet pipe;
heating the mixing pipe by a plurality of heating devices, and arranging a multistage circulating zooming structure on the mixing pipe;
connecting a liquid inlet pipe, a pipeline connector, a mixing pipe with a multistage circulating zooming structure and a liquid outlet pipe in sequence;
and fixing the mixing pipe of the multistage circulating zooming structure on the fixed template.
In some embodiments, a mixing tube is heat treated by a multi-page heating apparatus, providing a multi-stage cyclic convergent-divergent structure in the mixing tube, comprising:
mounting a plurality of heating molds on a heating table to form a plurality of heating devices;
placing the mixing tube in a multipage heating apparatus;
starting a heating table to perform preheating treatment until the target temperature is reached;
and (3) rotating the mixing pipe along the axial direction to perform heating treatment, and arranging a multi-stage circulating zooming structure on the mixing pipe.
The mixing tube is axially rotated for heat treatment, comprising:
rotating the mixing tube along the axial direction to carry out drawing method heating treatment;
or, the mixing tube is rotated along the axial direction to carry out heat shrinkage and heat treatment.
It should be noted that, the drawing method of the circular scaling type mixed pipe processing process flow specifically includes:
installing a heating mould on the surface of a heating table, straightening a polymer pipeline (a mixing pipe 6) to be processed along an axis, and then placing the polymer pipeline on the heating mould (a multi-page heating module 9), wherein the wall of the pipeline is in contact with the surface of a blade of the heating mould, as shown in figure 3;
setting the molding temperature of the heating table, and starting the heating table for preheating;
after the temperature is stable, the polymer pipeline to be processed is axially rotated, so that the polymer pipeline is prevented from being adhered to the heating module, and the polymer pipeline is uniformly heated;
and stretching the polymer pipeline to be processed at a constant speed towards the directions of the two ends, and then separating from the surface of the heating mould to carry out natural cooling and shaping, thus preparing the circular convergent-divergent mixing tube.
The processing process flow of the circular scaling type mixing tube comprises the following specific steps of:
installing a heating mould on the surface of a heating table, straightening a polymer heat-shrinkable pipeline (a mixing pipe 6) to be processed along an axis, and then placing the pipeline on the heating mould (a plurality of heating modules 9), wherein the wall of the pipeline is in contact with the surface of a blade of the heating mould, as shown in figures 4 and 5;
setting the molding temperature of the heating table, and starting the heating table for preheating;
after the temperature is stable, the polymer heat-shrinkable pipeline to be processed is axially rotated, so that the polymer heat-shrinkable pipeline is prevented from being adhered to the heating module, and the polymer pipeline is uniformly heated;
in the heating process, the heated area of the heat-shrinkable pipeline automatically generates necking effect, and the inner diameter is reduced;
and (4) moving the formed heat-shrinkable pipeline away from the heating mould for natural cooling, thus obtaining the circular convergent-divergent mixing tube.
In some embodiments, securing the circular scaled mixing tube to a stationary platen comprises:
the circular scale mixing tube is fixed to the fixed die plate in a three-dimensional configuration, including serpentine, sinusoidal, and helical.
The invention will be further described in detail with reference to the accompanying drawings by taking some specific flexible micromixers as examples. It should be understood that the specific embodiments described herein are illustrative only and are not limiting of the invention:
example 1: drawing method for preparing micro mixer and using method thereof
1. Preparing 3 polytetrafluoroethylene pipelines with the same specification and 1T-shaped three-way silica gel pipeline joint, wherein the outer diameter of each polytetrafluoroethylene pipeline is 0.6mm, the inner diameter of each polytetrafluoroethylene pipeline is 0.3mm, and the length of each polytetrafluoroethylene pipeline is 55 mm;
2. one polytetrafluoroethylene pipeline (a mixing pipe 6) is placed on a special heating module (a multi-page heating module 9) for local heating, as shown in figure 3, the heating temperature is 330 ℃, the width of a heating area is 1mm, the interval of heating areas is 3mm, and the total heating area is 15;
3. after the temperature of the heated area of the polytetrafluoroethylene pipeline is uniform, the polytetrafluoroethylene pipeline is rapidly stretched from the two ends of the pipeline and is far away from a heating table, and the stretched viscosity of the heated part of the pipeline is greatly reduced, so that the inner diameter of the pipeline can be fully stretched to be reduced to 0.1mm, the viscosity of the unheated part is relatively higher, and the inner diameter of the pipeline is basically unchanged when the pipeline is pulled, thereby forming a flexible micro-channel with 15-step zoom type inner diameter;
4. connecting and sealing three polytetrafluoroethylene pipelines in the processed reagent mixing tube with T-shaped three-way silicone tube joints respectively to form a micro mixer;
5. installing a design mixing pipe of a micro mixer on a fixed template and setting the design mixing pipe into a sine structure;
6. preparing two reagent vessel containers, adding deionized water into one container and adding a fluorescein solution into the other container; inserting two unprocessed polytetrafluoroethylene pipelines into vessels containing deionized water and a fluorescein solution respectively, and connecting an outlet of the other reagent mixing tube with a negative pressure pump;
7. starting a negative pressure pump to adjust the pressure to-30 KPa, continuously sucking the ionized water and the fluorescein solution into a negative pressure pump container through a reagent mixing tube after several seconds, and shooting the tail end of the reagent mixing tube by using an optical microscope;
8. fig. 6 is an optical microscopic view showing the mixing effect of the micromixer of mixing effect example 1, and the mixing index of the two-phase fluid can be calculated to be 0.98 by analyzing the optical microscopic image with image analysis software.
Example 2: micro mixer prepared by thermal shrinkage method and use method thereof
1. Preparing 2 polytetrafluoroethylene pipelines and 1 Teflon heat-shrinkable pipeline with the same specification, wherein the outer diameter of each polytetrafluoroethylene pipeline is 0.6mm, the inner diameter of each polytetrafluoroethylene pipeline is 0.3mm, and the length of each polytetrafluoroethylene pipeline is 55 mm; the outer diameter of the Teflon thermal shrinkage pipeline is 0.8mm, the inner diameter of the Teflon thermal shrinkage pipeline is 0.7mm, and the length of the Teflon thermal shrinkage pipeline is 55 mm;
2. a Teflon heat-shrinkable pipeline (a mixing pipe 6) passes through a special heating module (a multi-page heating module 9) to be locally heated, as shown in figure 4, the heating temperature is 300 ℃, the width of a heating area is 1mm, the interval of heating areas is 3mm, and the total heating area is 15;
3. axially rotating the Teflon heat-shrinkable pipeline to ensure that the Teflon heat-shrinkable pipeline is uniformly heated and continuously shrunk in the local heating process, reducing the inner diameter of the pipeline in a heated area, and basically keeping the inner diameter of an unheated part unchanged, thereby forming a flexible micro-channel with 15-step zoom-type inner diameter, as shown in figure 5;
4. connecting and sealing three polytetrafluoroethylene pipelines in the processed reagent mixing tube with T-shaped three-way silicone tube joints respectively to form a micro mixer;
5. mounting a designed mixing tube of the micro mixer on a fixed template, and winding the designed mixing tube on a winding support to form a spiral structure;
6. preparing two reagent vessel containers, adding deionized water into one container and adding a fluorescein solution into the other container; inserting two unprocessed polytetrafluoroethylene pipelines into vessels containing deionized water and a fluorescein solution respectively, and connecting an outlet of the other reagent mixing tube with a negative pressure pump;
7. starting a negative pressure pump to adjust the pressure to-30 KPa, continuously sucking the ionized water and the fluorescein solution into a negative pressure pump container through a reagent mixing tube after several seconds, and shooting the tail end of the reagent mixing tube by using an optical microscope;
8. fig. 7 is an optical microscopic view showing the mixing effect of the micromixer of mixing effect example 2, and the mixing index of the two-phase fluid can be calculated to be 0.96 by analyzing the optical microscopic image with image analysis software.
The content of the embodiment of the device of the invention is applicable to the embodiment of the method, the function realized by the embodiment of the method is the same as the function of the embodiment of the device, and the beneficial effect achieved by the embodiment of the method is also the same as the beneficial effect achieved by the embodiment of the device.
In summary, aiming at the problems of expensive equipment and consumables, high production cost, long preparation period, complex manual operation, low repeatable utilization rate and the like of the microcontroller in the prior art, the flexible micro mixer and the preparation method thereof are provided, wherein a commercial polymer capillary is used as a raw material, and is processed into a flexible micro channel with a circular scaling type inner diameter by a stretching or pressing method, and the flexible micro channel is assembled into a three-way or multi-way pipeline for fast and efficient mixing of two-phase fluid or multi-phase fluid. The high-efficiency low-cost flexible micro mixer provided by the invention can be prepared only by simple pipeline processing and assembly without complex preparation procedures such as molding, transfer printing, packaging and the like, the preparation procedures of the micro mixer can be greatly simplified, the production period is shortened, and the cost is reduced; all the pipelines are made of hydrophobic polymers, have low friction coefficient and are resistant to acid and alkali, so that the flow resistance of the fluid can be effectively reduced, the pipelines are easy to clean, and the repeated utilization rate is improved; expensive equipment is not needed in the pipeline processing, the process conditions are simple and controllable, automatic production can be realized, and errors caused by manpower are reduced; the structural design of the mixer comprises various mixing mechanisms (molecular diffusion, chaotic convection and dean vortex), improves the mixing efficiency and can realize the rapid and efficient mixing of two-phase and multi-phase fluids.
In alternative embodiments, the functions/acts noted in the block diagrams may occur out of the order noted in the operational illustrations. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality/acts involved. Furthermore, the embodiments presented and described in the flow charts of the present invention are provided by way of example in order to provide a more thorough understanding of the technology. The disclosed methods are not limited to the operations and logic flows presented herein. Alternative embodiments are contemplated in which the order of various operations is changed and in which sub-operations described as part of larger operations are performed independently.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A flexible micromixer, comprising: feed liquor pipe, pipeline connector, hybrid tube, drain pipe and fixed die plate, the feed liquor pipe the pipeline connector the hybrid tube reaches the drain pipe is connected in order, the hybrid tube is fixed in the fixed die plate, the hybrid tube is equipped with multistage circulation pantographic structure.
2. A flexible micromixer according to claim 1 further comprising a reagent tank connected to the front end of said inlet pipe.
3. A flexible micromixer according to claim 1, further comprising a negative pressure pump feeder connected to the back end of said outlet pipe.
4. A flexible micromixer according to claim 1, characterized in that said inlet pipes, outlet pipes and said mixing pipes are polymer pipes.
5. A flexible micromixer according to claim 4, characterized in that the number of said inlet pipes is greater than or equal to 2.
6. A flexible micromixer according to claim 1 wherein said mixing tubes are fixed to said fixed template in a three dimensional configuration comprising serpentine, sinusoidal and helical, said fixed template comprising a flat plate configuration, a cylindrical configuration, a conical configuration and a columnar array configuration.
7. A method for preparing a flexible micromixer, comprising:
selecting a liquid inlet pipe, a pipeline connector, a mixing pipe and a liquid outlet pipe;
heating the mixing pipe by a plurality of heating devices, wherein a multi-stage circulating zooming structure is arranged on the mixing pipe;
connecting the liquid inlet pipe, the pipeline connector, the mixing pipe of the multistage circulating zooming structure and the liquid outlet pipe in sequence;
and fixing the mixing pipe of the multistage circulating zooming structure on a fixed template.
8. The method of claim 7, wherein the heating of the mixing tube by the multi-page heating device is performed by a multi-stage cyclic scaling structure disposed on the mixing tube, comprising:
mounting a plurality of heating molds on a heating table to form a plurality of heating devices;
placing the mixing tube in the multi-page heating apparatus;
starting the heating table to perform preheating treatment until the target temperature is reached;
and (3) rotating the mixing pipe along the axial direction to perform heating treatment, and arranging a multi-stage circulating zooming structure on the mixing pipe.
9. A method of preparing a flexible micromixer according to claim 8 wherein said axially rotating said mixing tube for heat treatment comprises:
rotating the mixing tube along the axial direction to carry out drawing method heating treatment;
or, the mixing pipe is rotated along the axial direction to carry out heat shrinkage method heating treatment.
10. The method of claim 7, wherein said affixing said circular scale mixing tube to a stationary platen comprises:
and fixing the circular scaling type mixing tube on a fixed template in a three-dimensional configuration, wherein the three-dimensional configuration comprises a snake shape, a sine shape and a spiral shape, and the fixed template comprises a flat plate structure, a cylindrical structure, a conical structure and a columnar array structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210099064.6A CN114452874B (en) | 2022-01-27 | 2022-01-27 | Preparation method of flexible micro mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210099064.6A CN114452874B (en) | 2022-01-27 | 2022-01-27 | Preparation method of flexible micro mixer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114452874A true CN114452874A (en) | 2022-05-10 |
| CN114452874B CN114452874B (en) | 2023-03-28 |
Family
ID=81411191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210099064.6A Active CN114452874B (en) | 2022-01-27 | 2022-01-27 | Preparation method of flexible micro mixer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114452874B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115283034A (en) * | 2022-08-21 | 2022-11-04 | 东北电力大学 | Micro-fluidic chip based on light-temperature coupling response hydrogel |
Citations (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060051448A1 (en) * | 2004-09-03 | 2006-03-09 | Charles Schryver | Extruded tubing for mixing reagents |
| US20070077169A1 (en) * | 2005-09-27 | 2007-04-05 | Fuji Photo Film Co., Ltd. | Microchip and liquid mixing method and blood testing method using this microchip |
| CN102120153A (en) * | 2010-12-22 | 2011-07-13 | 东南大学 | Multi-mode micro mixer chip and high-flux mixing and flexible mixing method |
| CN102213718A (en) * | 2011-03-24 | 2011-10-12 | 中国人民解放军第四军医大学 | Heat-shrinkable combined micro-channel chip, and preparation and application method |
| CN103121660A (en) * | 2013-03-06 | 2013-05-29 | 江苏科技大学 | Microfluid-system-oriented glass-based bionic microchannel processing device and method |
| CN103145086A (en) * | 2013-03-06 | 2013-06-12 | 江苏科技大学 | Glass-based biomimetic micro-nano channel and manufacturing method thereof |
| WO2014167506A1 (en) * | 2013-04-10 | 2014-10-16 | Council Of Scientific & Industrial Research | Flow reactor with pinched pipe sections for mixing and heat transfer |
| US20160250615A1 (en) * | 2013-10-14 | 2016-09-01 | Universidade Do Porto | Apparatus for mixing based on oscillatory flow reactors provided with smooth periodic constrictions |
| CN106390883A (en) * | 2016-10-31 | 2017-02-15 | 山东豪迈化工技术有限公司 | Microfluidic reactor |
| CN106756777A (en) * | 2016-11-28 | 2017-05-31 | 山东大学 | A kind of method and application by straining regulation and control wrinkled surface hydrophilic and hydrophobic reversible transition |
| CN107488582A (en) * | 2017-08-08 | 2017-12-19 | 上海交通大学 | Micro fluidic device |
| CN107649059A (en) * | 2017-11-16 | 2018-02-02 | 海南大学 | A kind of asymmetric wall structure micro-mixer of the passive type of optimization |
| CN107803125A (en) * | 2017-12-15 | 2018-03-16 | 上海梵坤环保科技发展有限公司 | String data Venturi tube combines gas-liquid fusing device |
| CN207446126U (en) * | 2017-09-11 | 2018-06-05 | 海南大学 | A kind of passive type micro-mixer |
| CN109071942A (en) * | 2016-03-03 | 2018-12-21 | 新加坡国立大学 | Multi-functional, flexible and biocompatible elastomer micro-pipe |
| CN109529692A (en) * | 2018-12-26 | 2019-03-29 | 大连理工大学 | A kind of passive type for low diffusion coefficient fluid restrains-dissipate micro-mixer |
| WO2021091704A1 (en) * | 2019-11-04 | 2021-05-14 | Parker-Hannifin Corporation | Inline mixer device, methods of mixing, and methods of making an inline mixer device |
| US20210330864A1 (en) * | 2020-04-23 | 2021-10-28 | The Trustees Of Indiana University | Methods for creating three-dimensional biosynthetic tissue |
-
2022
- 2022-01-27 CN CN202210099064.6A patent/CN114452874B/en active Active
Patent Citations (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060051448A1 (en) * | 2004-09-03 | 2006-03-09 | Charles Schryver | Extruded tubing for mixing reagents |
| US20070077169A1 (en) * | 2005-09-27 | 2007-04-05 | Fuji Photo Film Co., Ltd. | Microchip and liquid mixing method and blood testing method using this microchip |
| CN102120153A (en) * | 2010-12-22 | 2011-07-13 | 东南大学 | Multi-mode micro mixer chip and high-flux mixing and flexible mixing method |
| CN102213718A (en) * | 2011-03-24 | 2011-10-12 | 中国人民解放军第四军医大学 | Heat-shrinkable combined micro-channel chip, and preparation and application method |
| CN103121660A (en) * | 2013-03-06 | 2013-05-29 | 江苏科技大学 | Microfluid-system-oriented glass-based bionic microchannel processing device and method |
| CN103145086A (en) * | 2013-03-06 | 2013-06-12 | 江苏科技大学 | Glass-based biomimetic micro-nano channel and manufacturing method thereof |
| WO2014167506A1 (en) * | 2013-04-10 | 2014-10-16 | Council Of Scientific & Industrial Research | Flow reactor with pinched pipe sections for mixing and heat transfer |
| US20160250615A1 (en) * | 2013-10-14 | 2016-09-01 | Universidade Do Porto | Apparatus for mixing based on oscillatory flow reactors provided with smooth periodic constrictions |
| CN109071942A (en) * | 2016-03-03 | 2018-12-21 | 新加坡国立大学 | Multi-functional, flexible and biocompatible elastomer micro-pipe |
| CN106390883A (en) * | 2016-10-31 | 2017-02-15 | 山东豪迈化工技术有限公司 | Microfluidic reactor |
| CN106756777A (en) * | 2016-11-28 | 2017-05-31 | 山东大学 | A kind of method and application by straining regulation and control wrinkled surface hydrophilic and hydrophobic reversible transition |
| CN107488582A (en) * | 2017-08-08 | 2017-12-19 | 上海交通大学 | Micro fluidic device |
| CN207446126U (en) * | 2017-09-11 | 2018-06-05 | 海南大学 | A kind of passive type micro-mixer |
| CN107649059A (en) * | 2017-11-16 | 2018-02-02 | 海南大学 | A kind of asymmetric wall structure micro-mixer of the passive type of optimization |
| CN107803125A (en) * | 2017-12-15 | 2018-03-16 | 上海梵坤环保科技发展有限公司 | String data Venturi tube combines gas-liquid fusing device |
| CN109529692A (en) * | 2018-12-26 | 2019-03-29 | 大连理工大学 | A kind of passive type for low diffusion coefficient fluid restrains-dissipate micro-mixer |
| WO2021091704A1 (en) * | 2019-11-04 | 2021-05-14 | Parker-Hannifin Corporation | Inline mixer device, methods of mixing, and methods of making an inline mixer device |
| US20210330864A1 (en) * | 2020-04-23 | 2021-10-28 | The Trustees Of Indiana University | Methods for creating three-dimensional biosynthetic tissue |
Non-Patent Citations (3)
| Title |
|---|
| 张晓乐;侯丽雅;章维一;: "玻璃三通微流体管道热流变拉制仪设计及实验" * |
| 张高朋等: "微流体系统中微通道制作工艺的研究进展", 《微纳电子技术》 * |
| 杜鹏等: "微型微通道管的连续挤压成形工艺", 《锻压技术》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115283034A (en) * | 2022-08-21 | 2022-11-04 | 东北电力大学 | Micro-fluidic chip based on light-temperature coupling response hydrogel |
| CN115283034B (en) * | 2022-08-21 | 2023-05-16 | 东北电力大学 | Micro-fluidic chip based on light-temperature coupling response hydrogel |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114452874B (en) | 2023-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114452874B (en) | Preparation method of flexible micro mixer | |
| CN109603935B (en) | Micro-fluidic chip processing method based on plug-in capillary | |
| CN110075934B (en) | 3D printing microfluidic device and method for preparing monodisperse emulsion in large flux | |
| CN103145086B (en) | Glass-based biomimetic micro-nano channel and manufacturing method thereof | |
| CN109173949B (en) | Closed injection pump mixing-promoting microfluidic reaction device and method | |
| CN113058669A (en) | Coaxial focusing micro-channel integrated device and method capable of being customized according to requirements | |
| CN208642693U (en) | Chip and water quality many reference amounts detection device | |
| CN114653414A (en) | Capillary microfluidic device with interference fit for auxiliary positioning and preparation method thereof | |
| EP2377607B1 (en) | Fluid connectors for microreactor modules | |
| CN103723676A (en) | Manufacturing method of micro-fluid channel | |
| CN213824722U (en) | Continuous flow micro-reactor | |
| CN213193496U (en) | Passive micro mixer | |
| KR102324465B1 (en) | Microfluidic mixer and method of mixing fluid using the same | |
| Agnihotri et al. | Controlling interfacial mixing zone for microfluidic flow of liquid streams | |
| CN114931988B (en) | Micro-fluidic chip for generating nano-scale molecular concentration gradient liquid drops and application method thereof | |
| KR101515403B1 (en) | Microfluidic Channel Using Hook-Shaped Structures, Manufacturing Method Thereof, and Analysis System Having the Same | |
| CN100427194C (en) | Microfluid dynamic mixer, mixing pond mould in chip and driving method thereof | |
| CN111632534B (en) | Photo-thermal micro-flow mixer based on single-hole optical fiber | |
| CN113578404A (en) | Multi-concentration micro-droplet chip for drug microspheres and manufacturing method thereof | |
| CN110841728B (en) | Manufacturing method of 3D micro-channel | |
| CN101308135B (en) | Convex concave mould for manufacturing chip microfluid dynamic mixer mixing pool | |
| US8303909B2 (en) | Microfluidic assembly | |
| CN115350734A (en) | Laminated multi-channel liquid drop micro-fluidic chip and preparation method thereof | |
| CN115069134B (en) | Micro-fluid high-efficiency mixer based on Dien vortex | |
| CN112723865B (en) | Method for preparing aluminum oxide hollow film by microfluidics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |