CN205886751U - Flow mixer passively declines - Google Patents

Flow mixer passively declines Download PDF

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Publication number
CN205886751U
CN205886751U CN201620250211.5U CN201620250211U CN205886751U CN 205886751 U CN205886751 U CN 205886751U CN 201620250211 U CN201620250211 U CN 201620250211U CN 205886751 U CN205886751 U CN 205886751U
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CN
China
Prior art keywords
rectangular configuration
diffluence room
main pipeline
outlet
mixing
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Expired - Fee Related
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CN201620250211.5U
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Chinese (zh)
Inventor
周腾
汝绍锋
王瀚林
徐凡
徐一凡
刘震宇
史留勇
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Hainan University
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Hainan University
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Priority to CN201620250211.5U priority Critical patent/CN205886751U/en
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Publication of CN205886751U publication Critical patent/CN205886751U/en
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Abstract

The utility model belongs to the micro -fluidic chip field specifically discloses a flow mixer passively declines, imported pipe, outlet pipe and reposition of redundant personnel room have been included. The reposition of redundant personnel room comprises semi -circular structure, rectangle structure and contracting structure, and the adjacent rectangle structure that flows the pipe includes semicircular hollow structure, and there is contracting structure in the passageway afterbody of reposition of redundant personnel room. The mixed method is the reposition of redundant personnel room that sets up special construction after the microfluid crosses, and the fluid gets into from import pipe, makes an appointment with half the flow to get into the reposition of redundant personnel room, carries out the partial mixing, then through behind the reposition of redundant personnel passageway again in the inward -remittance outlet pipe, produces the fluid impact to the main entrance, accomplishes the high -efficient of microfluid and mixes. The utility model discloses a main advantage lies in: its work overall process does not all have drive arrangement and participates in, and equipment adopts totally enclosedly, have simple structure, with low costs, use characteristics such as extensive, reduced fluidic mixing time evidently, improved the mixing efficiency for the fluid mixing is abundant.

Description

Passive microfluid mixer
Technical field
This utility model is related to a kind of new no driving passive microfluid mixer.The hybrid mode of this blender is Passive type.
Background technology
Microfluid all can be used before carrying out test reaction in the fields such as chemical experiment, environmental monitoring and analysis, dna detection to mix Clutch, to realize being sufficiently mixed of the different lower plurality of reagents of requirement.Microfluid mixer lighter weight, cost is relatively low, structure letter Single, good mixing, and current passive microfluid mixer mixing efficiency is low, mixing homogeneity is not high, and detection can be produced Bad impact.
Fluid mixing is exactly to mix together two or more fluid, and is finally obtained by certain hybrid mode Obtain a kind of homogeneous mixture.Physical mixed is convection action and the coefficient process of diffusion mode, and convection current is made With making different fluid molecules rely on cold-thermal effect that relative displacement occurs, make fluid phase enantiotropy, segmentation;Diffusion makes height Concentration molecule shifts at low concentration, and in fluid, each component distribution is relatively uniform.
In the experiment high to required precision, various biochemical test reactions need mixing quickly and efficiently, to ensure in experiment Each sample react simultaneously, but, under the yardstick of micron dimension, the effect that the convection action of fluid is brought is not strong Strong, in this case, the mixing of microfluid relies primarily on intermolecular diffusion, thus certain requirement of experiment it Under, the mixing of fluid becomes more difficult.The microfluid mixer of low cost is improved by simple structure being capable of lifting fluid Between mixing efficiency, reach expected mixed effect.
In the experimentation of fluid, it usually needs the fluid of two or more is sufficiently mixed.This at present mixed Conjunction mode is flowed into from respective pipeline using two kinds of fluids, is just expelled directly out so that mixing efficiency is low after crossing.
According to whether additional driving means are defining, the blender of microfluid is divided into active and passive type, active Microfluid mixer mainly orders about fluid mixing in test by additional different field although the mixing of this blender Effect is preferable, but due to complex structure, relatively costly, the universality realizing this technology in every field is not high.Quilt The microfluid mixer of dynamic formula mainly pass through design adjustment microfluid mixer in the profile geometric properties of hybrid channel or Material character, to change the process of Microfluidic Mixing, reaches the Convention diffusion effect strengthening fluid, realizes efficient microfluid Mixed effect.
Main method to the mixing of different microfluids is to increase a number of baffle plate in microfluid mixer now, Increased baffle plate can produce to the fluid in passage and obstruct effect, increased the Convention diffusion effect of fluid mixing, also make simultaneously The flow losses obtaining fluid are larger.The structure that this utility model feature is improved and innovated in runner is so that incorporation time is short, mixed Interflow road is short, fluid mixing is abundant, mixing efficiency greatly improves.
Passive microfluid mixer has many good qualities compared to the hybrid instrument under traditional macro.Microfluid mixer Small volume, greatly reduces the loss to experimental resources, obtains higher degree with less experiment reagent to be mixed simultaneously Reagent mixed effect, and fast response time, mixing efficiency is high, therefore suffers from being widely applied prospect in all trades and professions.
Content of the invention
The purpose of this utility model is to provide a kind of structure passive microfluid mixer simple, easy to use, uses In shortening hybrid channel length further, reduce incorporation time, the efficiency of lifting mixing.
The technical solution of the utility model is: a kind of passive microfluid mixer, including inlet tube, outlet and shunting Room, described diffluence room is formed by shunting chamber inlet, diffluence room's outlet, semicircular structure and rectangular configuration;Described rectangular configuration It is connected with main pipeline, and includes semicircular hollow-core construction, the afterbody outlet of diffluence room has contraction structure and outlet It is connected, this passive microfluid mixer is characterised by: entered after main pipeline by inlet tube after two kinds of Microfluidic Mixing A kind of semicircle diffluence room combining with rectangular configuration of setting, this diffluence room is with main pipeline even;Wherein, the structure of diffluence room is: After semicircular structure and rectangular configuration splicing, semicircle hollow knot at the contact surface position hollow out one with main pipeline for the rectangular configuration Structure, and obtain contraction structure using the intercepting of rectangle cutting structure;The center of circle of the semicircular structure of described diffluence room and rectangle knot The center of circle of the semicircle hollow-core construction that structure includes is on same vertical line, and the line in two centers of circle is perpendicular to main pipeline;Described Diffluence room in contraction structure be that the combining unit of semicircular structure and rectangular configuration is gone a part using rectangle cutting, cut Face be plane and perpendicular to main pipeline so that diffluence room outlet be gradually reduced formation necking;Described microfluid mixer, its It is characterised by, described rectangular configuration is connected with main pipeline, the maximal side phase of the diameter of semicircular structure and rectangular configuration Deng;In rectangular configuration, the radius of semicircle hollow-core construction and the ratio of the minimum length of side of rectangular configuration are 1:2;Described contraction structure With the connected surface of main pipeline, its cross-sectional width and pipe diameter ratio are 1:1;The width in described contraction structure afterbody exit Value adds that the minimum edge long value of rectangle cutting structure is equal to the width value of diffluence room porch;And the height according to mixed-precision Require, this microfluid mixer multiple of can connecting at inlet tube or outlet, such as accompanying drawing 1, to reach higher mixing efficiency.
Fluid-mixing is after import enters into main channel, before running into diffluence room's passage, weaker due at this moment creating Dean effect, a part of fluid of main channel is brought into diffluence room, and the fluid of about half can enter eventually into diffluence room.Weaker Dean effect can effectively increase mixing efficiency.
A part of fluid enters in diffluence room, special the brought geometry of semicircular structure being had by diffluence room The expansion of structure and contraction, so that the fluid possessing the inertia effect originally defines vortex in vivo in it, change stream further The distribution situation of line.
When exporting entrance main channel through diffluence room, the motion of fluid-mixing is retracted structure and accelerates fluid-mixing, The microfluid in exit creates the impact to main channel fluid, and Dean vortex is just formed in the position that crosses of two fluids, finally Enhance the convective motion of fluid so that fluid is more fully mixed, the uniformity of mixing is higher.This dependence geometry Design had not only been saved cost but also increased the efficiency of mixing.
Income of the present utility model is: fluid shunt conduit outlet formed vortex while, due in diffluence room The presence of shrinkage expansion structure and arcuate structure, so that fluid defines Secondary Flow in motor process, equally enhances fluid Convective motion so that fluid mixing more abundant.
The cross-sectional width on contraction structure and the connected surface of main pipeline in order to lift mixing efficiency further, in diffluence room With the diameter proportion of pipeline close to one to one, ratio is excessive or the too small abundant degree that all can affect to mix is so that mixing effect Rate reduces.
Structure designed by this utility model is single layer structure, just can manufacture mould by a photoetching, and traditional Multiple structure compare with structure simple, be easy to large-scale production configuration assembling, lower-cost feature, and this utility model Advantage be that there is the single layer structure of more optimization compared to other microfluid mixers, can make to complete between fluid very fast, Mixing in hgher efficiency, the reynolds number range being suitable for is wide, can meet the demand of most of experiment.
Above-described is some contents of the present utility model, is not restricted to this utility model, as long as without departing from this reality With some changes such as done modification under the thought of new and innovative, replacement and modification, these broadly fall into guarantor of the present utility model Within the scope of shield.
Brief description
Fig. 1 is structural representation of the present utility model;
In figure: from left side two arm a, b entrance separately flows into entrance structure main pipeline to microfluid to be mixed.
Fig. 2 is part-structure cell schematics of the present utility model
In figure: 1. inlet tube;2. fluid main pipe;3. shunt chamber inlet;4. rectangular configuration;5. semicircular hollow knot Structure;6. diffluence room;7. semicircular structure;8. rectangle cutting structure;9. contraction structure;10. the afterbody outlet of diffluence room;11. go out Mouth pipe.
Fig. 3 is construction unit front view;
In figure: r and r is the radius of two semicircular structures;o1And o2It is respectively the center of circle of two semicircular structures;lo1It is The center of circle is with respect to the length on rectangular configuration border;lbIt is the length with respect to rectangular configuration border for the cutting plane of contraction structure;lcIt is The intercepting width of rectangle cutting structure.
Fig. 4 is the flow measurement streamline analogous diagram of mixing microfluid process;
In figure: different colors represents the friction speed size of microfluid;
Specific embodiment
A kind of microfluid mixer, is material using pdms, su8 mould is obtained through processing steps such as photoetching, developments;So Afterwards the pdms material being mixed with firming agent is applied on mould, the demoulding after being heating and curing is obtained pdms former;Again will be with The pdms material that firming agent mixed is applied on pc piece, then the demoulding is obtained pdms flat board after being heating and curing;Pdms former and flat board Bonding gained micro structure is described microfluid mixer structure.
A kind of passive microfluid mixer, including inlet tube 1, outlet 11 and diffluence room 6.
Diffluence room 6 is connected on main pipeline 2 and communicates therewith, and interface channel is respectively and shunts chamber inlet 3 and diffluence room's outlet 10.
Rectangular configuration 4 includes semicircular hollow-core construction 5, the diameter of semicircular hollow-core construction 5 and the pipe face of main pipeline 2 Overlap.
Contraction structure 9 be stitched together by rectangular configuration 4 and semicircular structure 7 after, intercepted using rectangle cutting structure 8 Out, intercepting face is plane, and intercepting face is connected with main pipeline 2 and is in 90 degree of angles.
There is contraction structure 9 and be connected with outlet 11 in the afterbody outlet 10 of diffluence room.
The diameter proportion of exit width and pipeline on the connected surface of the afterbody outlet 10 of diffluence room and main pipeline 2 is close to one Ratio one.
Fluid is entered by inlet tube 1, continues to flow in main channel 2 by shunting a part of fluid during chamber inlet 3, another It is partially into diffluence room 6, flowed out by diffluence room's afterbody outlet 10 after then having passed through contraction structure 9, and the fluid in main channel 2 Converge, flow out finally by outlet 11.
As shown in Fig. 2 lo1Equal with the radius r of semicircular structure;lbLength add lcLength be equal to twice r length Degree.
As shown in Fig. 2 the center of circle o of two semicircular structures1And o2On the same line, and this straight line is perpendicular to master Pipeline.
The flow measurement streamline analogous diagram of fluid-mixing process is as shown in Figure 3.In figure illustrates the streamline of different colours, fluid from From left to right is moved, and significantly can find out from figure, the flow line speed having converged at outlet is greater than at inlet tube Speed, and the streamline distribution at outlet will more crypto set compared to the streamline distribution of porch.

Claims (5)

1. a kind of passive microfluid mixer, including inlet tube (1), outlet (11) and diffluence room (6), described diffluence room (6) it is made up of shunting chamber inlet (3), diffluence room's outlet (10), semicircular structure (7) and rectangular configuration (4), described rectangle is tied Structure (4) is connected with main pipeline (2), and includes semicircular hollow-core construction (5), and afterbody outlet (10) of diffluence room has receipts Shrinking structure (9) is connected with outlet (11), and this passive microfluid mixer is characterised by: after two kinds of Microfluidic Mixing Main pipeline (2) is entered by inlet tube (1) diffluence room (6) that a kind of semicircle and rectangular configuration combines is set afterwards, this diffluence room with Main pipeline (2) is connected;Wherein, the structure of diffluence room is: after semicircular structure (7) and rectangular configuration (4) splicing, in rectangular configuration (4) with the contact surface position hollow out one of main pipeline (2) at semicircle hollow-core construction (5), and intercepted using rectangle cutting structure (8) Obtain contraction structure (9);The semicircle that the center of circle of semicircular structure (7) of described diffluence room (6) and rectangular configuration (4) include The center of circle of hollow-core construction (5) is on same vertical line, and the line in two centers of circle is perpendicular to main pipeline;Described diffluence room (6) In contraction structure (9) be that the combining unit of semicircular structure (7) and rectangular configuration (4) is gone a part using rectangle cutting, Section be plane and perpendicular to main pipeline so that diffluence room outlet (10) be gradually reduced formation necking.
2. microfluid mixer according to claim 1 is it is characterised in that described rectangular configuration (4) and main pipeline (2) It is connected, the diameter of semicircular structure (7) is equal with the maximal side of rectangular configuration (4);Semicircle hollow knot in rectangular configuration The radius of structure (5) is 1:2 with the ratio of the minimum length of side of rectangular configuration (4).
3. microfluid mixer according to claim 1 is it is characterised in that described contraction structure (9) and main pipeline (2) Connected surface, its cross-sectional width and pipe diameter ratio are 1:1.
4. microfluid mixer according to claim 1 is it is characterised in that described contraction structure afterbody exports (10) place Width value add rectangle cutting structure (8) minimum edge long value be equal to shunting chamber inlet (3) place width value.
5. microfluid mixer according to claim 1 is it is characterised in that require according to the height of mixed-precision, can be Inlet tube (1) or outlet (11) place series connection this microfluid mixer multiple, to reach higher mixing efficiency.
CN201620250211.5U 2016-03-29 2016-03-29 Flow mixer passively declines Expired - Fee Related CN205886751U (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107051304A (en) * 2017-03-29 2017-08-18 海南大学 A kind of active electric osmose micro-mixer of unsymmetric structure and electrode
CN107649059A (en) * 2017-11-16 2018-02-02 海南大学 A kind of asymmetric wall structure micro-mixer of the passive type of optimization
WO2021227544A1 (en) * 2020-05-15 2021-11-18 Stemirna Therapeutics Co., Ltd Mixer for generating particles
CN113663573A (en) * 2020-05-15 2021-11-19 斯微(上海)生物科技有限公司 Mixer for particle generation
CN113976013A (en) * 2021-11-01 2022-01-28 西安交通大学 Microstructure enhanced micro mixer and three-dimensional forming preparation and application thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107051304A (en) * 2017-03-29 2017-08-18 海南大学 A kind of active electric osmose micro-mixer of unsymmetric structure and electrode
CN107649059A (en) * 2017-11-16 2018-02-02 海南大学 A kind of asymmetric wall structure micro-mixer of the passive type of optimization
WO2021227544A1 (en) * 2020-05-15 2021-11-18 Stemirna Therapeutics Co., Ltd Mixer for generating particles
CN113663573A (en) * 2020-05-15 2021-11-19 斯微(上海)生物科技有限公司 Mixer for particle generation
CN113976013A (en) * 2021-11-01 2022-01-28 西安交通大学 Microstructure enhanced micro mixer and three-dimensional forming preparation and application thereof
CN113976013B (en) * 2021-11-01 2022-08-05 西安交通大学 Microstructure enhanced micro mixer and three-dimensional forming preparation and application thereof

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C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20170118

Termination date: 20180329