CN113976013B - Microstructure enhanced micro mixer and three-dimensional forming preparation and application thereof - Google Patents
Microstructure enhanced micro mixer and three-dimensional forming preparation and application thereof Download PDFInfo
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- CN113976013B CN113976013B CN202111285214.4A CN202111285214A CN113976013B CN 113976013 B CN113976013 B CN 113976013B CN 202111285214 A CN202111285214 A CN 202111285214A CN 113976013 B CN113976013 B CN 113976013B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
- B29C64/124—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/30—Auxiliary operations or equipment
- B29C64/386—Data acquisition or data processing for additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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Abstract
A micro-structure enhanced micro-mixer and three-dimensional forming preparation and application thereof are disclosed, wherein the micro-mixer comprises a main flow channel and a built-in micro-structure, the main flow channel adopts a three-dimensional Tesla type flow channel form, and the built-in micro-structure is a built-in triangular structure on the side surface of the main flow channel; the preparation method comprises the steps of firstly introducing the magnetic particle composite photosensitive resin solution into a resin groove, then constructing a three-dimensional structure model, carrying out slicing processing to obtain a bitmap file, and inputting the bitmap file into a digital dynamic mask plate; then, reforming ultraviolet light emitted by a light source into light consistent with the bitmap file, solidifying the magnetic particle composite photosensitive resin solution positioned above the forming platform, controlling the forming platform to descend, and continuously repeating the shaping-exposure-solidification process, wherein the microstructure enhanced micro mixer is formed layer by layer; the built-in microstructure realizes dynamism by combining the action of an external energy field; the invention realizes the change of the built-in micro-structure of the micro mixer from static state to dynamic state, has simple preparation method, and can be applied to different flow rates or carry out multi-step adjustable reaction.
Description
Technical Field
The invention relates to the technical field of micro-mixer manufacturing, in particular to a micro-structure enhanced micro-mixer and three-dimensional forming preparation and application thereof.
Background
The micro mixer is used as an important functional unit in a micro-fluidic system, is the basis for carrying out chemical reaction, biological reaction and biochemical analysis and detection by a micro-fluidic technology, can realize biochemical reaction processes such as crystallization, extraction, polymerization and organic synthesis and biological analysis processes such as cell lysis, virus detection and DNA analysis, and is widely applied to clinical medicine and biological research such as biochemical product generation, identification, drug discovery and disease diagnosis.
At present, many researches promote the structurization of the micro mixer mainly through two aspects of a flow channel form and a built-in microstructure form. The structure of the plane type micro mixer is simpler, and the flow channel forms comprise a direct flow channel, a bent flow channel, a separation and recombination flow channel and the like; the built-in micro-structure forms are circular, teardrop-shaped, wedge-shaped and the like, and can be positioned at the bottom and the side surface of the flow passage. The manufacturing method of the micro mixer mainly comprises soft lithography, molding and the like, the micro mixer is usually manufactured in a layering mode along the thickness direction and is finally packaged and bonded, and the manufacturing process is complex and long in time consumption.
In the three-dimensional micro mixer, the three-dimensional flow channel forms comprise an H-C type, a twisted flow channel type, a cross flow channel type and the like, the flow channel structure is complex, forming methods such as laser processing and the like can be adopted, the technical requirement is high, and the cost is high; the three-dimensional built-in structure has a staggered array type, a spiral array type and the like, and usually adopts a fused deposition processing method, a high-precision micro processing method and other forming methods, so that the quality of a workpiece is low, and the forming efficiency is low.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a microstructure enhanced micro mixer, and three-dimensional forming preparation and application thereof, which can realize the change of a built-in microstructure of the micro mixer from static state to dynamic state, and have simple preparation method and lower cost.
In order to achieve the purpose, the invention adopts the technical scheme that:
a micro-structure enhanced micro-mixer comprises a main flow channel 11 and a built-in micro-structure 12 thereon; the main flow channel 11 is integrally formed based on a micro-stereolithography technology, and a three-dimensional Tesla type flow channel form is adopted, wherein the separation flow channel part is a part of the main flow channel 11 which is separated into two flow channel branches with different widths in a direction parallel to the flow channel, and the flow channel part is of a single-layer structure which is alternately changed in the height direction of the flow channel; the recombination flow channel part is a part of the main flow channel 11 which is intersected in the direction parallel to the flow channel after passing through the separation flow channel, is of a double-layer structure in the height direction of the flow channel and is connected with the two separation flow channel parts;
the built-in microstructure 12 is a built-in triangular structure on the side surface of the main runner 11, the ratio of the height of the built-in microstructure to the width of the main runner 11 in the direction parallel to the runner is 0.6-0.8, and the built-in microstructure is positioned on a recombination runner part of the three-dimensional Tesla type runner; the number of built-in microstructures 12 is determined according to the mixing efficiency required for a specific application.
A three-dimensional forming preparation method of a microstructure enhanced micro mixer comprises the following steps:
the first step is as follows: introducing the magnetic particle composite photosensitive resin solution 1 into a resin tank 2;
the second step is that: a three-dimensional structure model 3 of the microstructure enhanced micro mixer is constructed by using modeling software;
the third step: slicing the three-dimensional structure model 3, wherein the layer thickness is 10-40 μm, so as to obtain a series of bitmap files 4, and inputting the bitmap files into a digital dynamic mask 6;
the fourth step: combining with a digital dynamic mask plate 6, reforming ultraviolet light emitted by a light source 5 into light consistent with a bitmap file 4, and curing the magnetic particle composite photosensitive resin solution 1 which is exposed under the ultraviolet light and positioned above a forming platform 7;
the fifth step: controlling the forming platform 7 to descend according to the layer thickness during slicing treatment, continuously repeating the shaping, exposing and curing processes in the fourth step according to the bitmap file 4, and forming the microstructure enhanced micro mixer layer by layer to obtain a formed part 8 of the microstructure enhanced micro mixer;
and a sixth step: and washing the uncured magnetic particle composite photosensitive resin solution 1 in the forming piece 8 to obtain the microstructure enhanced micro mixer.
The application of a microstructure enhanced micro mixer combines the action of an external energy field 22, and a built-in microstructure 12 of the micro mixer realizes dynamism; the external energy field 22 is an alternating magnetic field applied to two side surfaces of the main channel 11, the built-in microstructures 12 are controlled not to be connected with the upper side wall and the lower side wall in the height direction of the channel, the built-in microstructures 12 are dynamic under the action of the external energy field 22, the tips of the built-in microstructures are displaced in the length direction of the channel, and surrounding fluid is influenced by the dynamic built-in microstructures (12) to generate disturbance.
The built-in microstructure 12 has multiple static and dynamic modes, the dynamic built-in microstructure 12 enables fluid to generate local disturbance at a low flow rate with Re <40, and the static built-in microstructure 12 enables secondary vortex action in a flow channel to be enhanced at a high flow rate with Re greater than or equal to 40; by freely adjusting the external energy field 22, the microstructure enhanced micromixer is capable of conducting controllable reactions at different flow rates or in multiple steps.
Compared with the prior art, the invention has the following advantages:
1) the built-in micro-structure type micro-mixer prepared based on the three-dimensional forming technology has the advantages that the form of a main runner is not limited, and a three-dimensional complex runner form can be adopted, so that the mixing effect is enhanced; the built-in microstructure of the device enables streamline stretching and folding or secondary vortex action to be generated in multiple directions in the main flow channel, and the mixing capability is strong;
2) the method for preparing the built-in microstructure type micro mixer based on the three-dimensional forming technology adopts the composite resin material doped with the magnetic particles, realizes the integrated forming of the material structure function of the micro mixer, shortens the manufacturing time and simplifies the manufacturing steps;
3) the micro-mixer built-in micro-structure can generate displacement in the length and width directions of the flow channel, so that the fluid generates local disturbance, and the mixing effect is improved.
4) The micro mixer has various passive and active forms, and can be applied to different flow rates or perform multi-step adjustable reaction by freely adjusting an external energy field.
Drawings
Fig. 1 is a schematic structural diagram of a microstructure enhanced micro-mixer according to the present invention.
FIG. 2 is a flow chart of the method of the present invention.
Fig. 3 is a dynamic schematic diagram of a built-in microstructure of a microstructure enhanced micro mixer according to the present invention under the action of external energy.
Detailed description of the invention
The present invention will be described in further detail below with reference to examples and the accompanying drawings.
Referring to fig. 1, a microstructure enhanced micro mixer includes a main channel 11 and a built-in microstructure 12 thereon; the main flow channel 11 is integrally formed based on a micro-stereolithography technology, and a three-dimensional Tesla type flow channel form is adopted, wherein the separation flow channel part is a part of the main flow channel 11 which is separated into two flow channel branches with different widths in a direction parallel to the flow channel, and the flow channel part is of a single-layer structure which is alternately changed in the height direction of the flow channel; the recombination flow channel part is a part of the main flow channel 11 which is intersected in the direction parallel to the flow channel after passing through the separation flow channel, is of a double-layer structure in the height direction of the flow channel and is connected with the two separation flow channel parts;
the built-in microstructure 12 is a built-in triangular structure on the side surface of the main runner 11, the ratio of the height of the built-in microstructure parallel to the runner direction to the width of the main runner 11 is 0.6-0.8, and the built-in microstructure is positioned on a recombination runner part of the three-dimensional Tesla type runner; wherein, the first built-in microstructure 12 is connected with the left side wall of the recombination flow channel part, the second built-in microstructure 12 is connected with the right side wall of the recombination flow channel part, and the number of the built-in microstructures 12 is determined according to the mixing efficiency required by specific application; the number of built-in microstructures 12 in one recombination flow path section is 3 in this embodiment.
The microstructure enhanced micro-mixer can generate streamline stretching and folding or secondary vortex and separation recombination action in multiple directions, and the mixing capability is enhanced.
Referring to fig. 2, a three-dimensional forming preparation method of a microstructure enhanced micro mixer includes the following steps:
the first step is as follows: mixing Fe 3 O 4 Mixing the nanoparticles with the flexible photosensitive resin solution to obtain magnetic particle composite photosensitive resin solution 1, and introducing the solution into treeA fat tank 2;
the second step is that: a three-dimensional structure model 3 of the microstructure enhanced micro mixer is constructed by using modeling software;
the third step: slicing the three-dimensional structure model 3, wherein the layer thickness is 10-40 μm, so as to obtain a series of bitmap files 4, and inputting one bitmap file into a digital dynamic mask 6;
the fourth step: combining the digital dynamic mask 6, reforming the ultraviolet light emitted by the light source 5 into light consistent with the bitmap file 4, and curing the magnetic particle composite photosensitive resin solution 1 which is exposed under the ultraviolet light and positioned above the forming platform 7;
the fifth step: controlling the forming platform 7 to continuously repeat the shaping, exposing and curing processes in the fourth step according to the layer thickness reduction during slicing treatment and according to the bitmap file 4, and forming the microstructure enhanced micro mixer layer by layer to obtain a formed part 8 of the microstructure enhanced micro mixer;
and a sixth step: and washing the uncured magnetic particle composite photosensitive resin solution 1 in the formed part 8 to obtain the microstructure enhanced micro mixer.
Referring to fig. 3, a microstructure enhanced micro mixer, which is made of a material magnetic particle composite photosensitive resin solution 1 with functionality, is dynamically built with a built-in microstructure 12 under the action of an external energy field 22.
The external energy field 22 is an alternating magnetic field applied to two side surfaces of the main flow channel 11, and can realize the dynamization of the built-in microstructure 12 by combining the built-in microstructure 12 made of magnetic particle composite photosensitive resin to perform an active micro-mixing action; when a model is established, the built-in microstructures 12 are controlled not to be connected with the upper side wall and the lower side wall in the height direction of the flow channel, and the built-in microstructures 12 made of magnetic particle composite photosensitive resin are dynamic under the action of an external energy field 22, so that the tips of the built-in microstructures are displaced in the length direction and the height direction of the flow channel; at low flow rate (Re <40), the movement of the tip of the built-in microstructure 12 causes the surrounding fluid to be disturbed, the layer mode among the fluids is destroyed, and the mixing efficiency is improved;
at high flow rate (Re is more than or equal to 40), when the external energy field 22 does not act, the built-in microstructures 12 distributed in the length direction and the width direction of the flow channel in a staggered manner can enhance the secondary vortex action in the flow channel, weaken the layer mode among fluids and improve the mixing efficiency, and at the moment, the microstructure enhanced micro mixer performs passive micro mixing action.
The built-in micro-structure 12 of the micro-structure enhanced micro-mixer has multiple static and dynamic modes, and the micro-structure enhanced micro-mixer can perform multi-step adjustable reaction at different flow rates by freely adjusting the external energy field 22.
Claims (3)
1. A microstructure enhanced micromixer characterized by: comprises a main flow channel (11) and a built-in microstructure (12) on the main flow channel; the main flow channel (11) is integrally formed based on a micro-stereolithography technology, a three-dimensional Tesla type flow channel form is adopted, wherein the separation flow channel part is a part of the main flow channel (11) which is separated into two flow channel branches with different widths in a direction parallel to the flow channel, and the flow channel branch is of a single-layer structure which is changed alternately in the height direction of the flow channel; the recombination flow channel part is a part where a main flow channel (11) passes through the separation flow channel and then meets in a direction parallel to the flow channel, is of a double-layer structure in the height direction of the flow channel and is connected with the two separation flow channel parts;
the built-in microstructure (12) is a built-in triangular structure on the side surface of the main flow channel (11), the ratio of the height of the built-in microstructure parallel to the flow channel to the width of the main flow channel (11) is 0.6-0.8, and the built-in microstructure is positioned on a recombination flow channel part of the three-dimensional Tesla type flow channel; determining the number of built-in microstructures (12) according to the mixing efficiency required by a specific application;
the three-dimensional forming preparation method of the microstructure enhanced micro mixer comprises the following steps:
the first step is as follows: introducing the magnetic particle composite photosensitive resin solution (1) into a resin tank (2);
the second step is that: building a three-dimensional structure model (3) of the microstructure enhanced micro mixer by using modeling software;
the third step: slicing the three-dimensional structure model (3) to obtain a series of bitmap files (4) with the thickness of 10-40 μm, and inputting the bitmap files into a digital dynamic mask (6);
the fourth step: the ultraviolet light emitted by the light source (5) is reformed into light consistent with the bitmap file (4) by combining a digital dynamic mask plate (6), and the magnetic particle composite photosensitive resin solution (1) which is exposed under the ultraviolet light and positioned above the forming platform (7) is cured;
the fifth step: controlling the forming platform (7) to descend according to the layer thickness during slicing treatment, and continuously repeating the shaping, exposure and curing processes in the fourth step according to the bitmap file (4), and forming the microstructure enhanced micro mixer layer by layer to obtain a formed part (8) of the microstructure enhanced micro mixer;
and a sixth step: and washing the uncured magnetic particle composite photosensitive resin solution (1) in the formed part (8) to obtain the microstructure enhanced micro mixer.
2. Use of a microstructure enhanced micromixer according to claim 1, characterized in that: the built-in microstructure (12) is dynamically realized by combining the action of an external energy field (22); the external energy field (22) is an alternating magnetic field applied to two side faces of the main runner (11), the built-in microstructures (12) are controlled not to be connected with the upper side wall and the lower side wall in the height direction of the runner, the built-in microstructures (12) are dynamic under the action of the external energy field (22), the tips of the built-in microstructures are displaced in the length direction and the height direction of the runner, and surrounding fluid is influenced by the dynamic built-in microstructures (12) to generate disturbance.
3. Use of a microstructure enhanced micromixer according to claim 2, characterized in that: the built-in microstructure (12) has multiple static and dynamic modes, the dynamic built-in microstructure (12) enables fluid to generate local disturbance at a low flow rate with Re <40, and the static built-in microstructure (12) enables the secondary vortex effect in a flow channel to be enhanced at a high flow rate with Re greater than or equal to 40; by freely adjusting the external energy field (22), the microstructure enhanced micromixer can perform controllable reactions at different flow rates or in multiple steps.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105771765A (en) * | 2016-03-30 | 2016-07-20 | 江苏大学 | Passive micromixer with built-in periodical stop blocks and baffle plates |
| CN205886751U (en) * | 2016-03-29 | 2017-01-18 | 海南大学 | Flow mixer passively declines |
| CN109001269A (en) * | 2018-09-19 | 2018-12-14 | 重庆大学 | Integrate the bacterium chip and its detection method of DEP separation, magnetic microsphere selective enrichment and EIS in situ detection |
| CN112041069A (en) * | 2018-04-06 | 2020-12-04 | 紫荆实验室公司 | Magnetic-based actuation mechanism and method for actuating magnetically reactive microcolumns in a reaction chamber |
| CN112755867A (en) * | 2020-12-17 | 2021-05-07 | 广东省医疗器械研究所 | Micro-mixing chip and micro-mixing device |
| CN213193496U (en) * | 2020-08-25 | 2021-05-14 | 三诺生物传感股份有限公司 | Passive micro mixer |
| CN113203302A (en) * | 2020-12-03 | 2021-08-03 | 山东大学 | Micro-channel heat exchange device for enhancing mixing of two micro-fluids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9610580B2 (en) * | 2013-06-03 | 2017-04-04 | Massachusetts Institute Of Technology | Magnetically tunable microstructured surfaces |
-
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- 2021-11-01 CN CN202111285214.4A patent/CN113976013B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205886751U (en) * | 2016-03-29 | 2017-01-18 | 海南大学 | Flow mixer passively declines |
| CN105771765A (en) * | 2016-03-30 | 2016-07-20 | 江苏大学 | Passive micromixer with built-in periodical stop blocks and baffle plates |
| CN112041069A (en) * | 2018-04-06 | 2020-12-04 | 紫荆实验室公司 | Magnetic-based actuation mechanism and method for actuating magnetically reactive microcolumns in a reaction chamber |
| CN109001269A (en) * | 2018-09-19 | 2018-12-14 | 重庆大学 | Integrate the bacterium chip and its detection method of DEP separation, magnetic microsphere selective enrichment and EIS in situ detection |
| CN213193496U (en) * | 2020-08-25 | 2021-05-14 | 三诺生物传感股份有限公司 | Passive micro mixer |
| CN113203302A (en) * | 2020-12-03 | 2021-08-03 | 山东大学 | Micro-channel heat exchange device for enhancing mixing of two micro-fluids |
| CN112755867A (en) * | 2020-12-17 | 2021-05-07 | 广东省医疗器械研究所 | Micro-mixing chip and micro-mixing device |
Non-Patent Citations (2)
| Title |
|---|
| "A high-performance micromixer using three-dimensional Tesla structures for bio-applications";An-Shik Yang et al.;《Chemical Engineering Journal》;20141112;第263卷;第2节，图1 * |
| "Tesla微混合器结构参数对混合强度的影响";夏国栋等;《工程热物理学报》;20110331;第32卷(第3期);第1.1节，图1 * |
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