CN103331121B - Minisize fluid hybrid system - Google Patents
Minisize fluid hybrid system Download PDFInfo
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- CN103331121B CN103331121B CN201310233639.XA CN201310233639A CN103331121B CN 103331121 B CN103331121 B CN 103331121B CN 201310233639 A CN201310233639 A CN 201310233639A CN 103331121 B CN103331121 B CN 103331121B
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Abstract
The invention discloses a kind of minisize fluid hybrid system, relate to a kind of active hybrid technology of micro-channel, comprise housing, in housing, be provided with blender, blender is provided with the first feed pathway and the second feed pathway, the first feed pathway and the second feed pathway have the first inlet and the second inlet, the first inlet and the second inlet are connected with respectively through the first conduit of housing and the second conduit, the first feed pathway is all communicated with one end of hybrid channel with the second feed pathway, and the other end of hybrid channel has liquid outlet; Housing is embedded with to the point-like light spot laser device of launch spot in housing, and the light-emitting window of point-like light spot laser device is positioned at the top, hybrid channel of blender. The present invention can strengthening fluid mixed effect, improved greatly mixing efficiency, avoided being unfavorable for the factor of biomolecule growth and survival simultaneously, the present invention also has advantages of that simple in structure being convenient to make.
Description
Technical field
The present invention relates to a kind of active hybrid technology of micro-channel, particularly relate to a kind of minisize fluid mixed stockerSystem.
Background technology
Microfluid based Lab on a chip is important science and technology in this century, be modern science and technology civilization can not orScarce part, has produced active influence to the development process of wholly human's civilization. Modern science and technology civilizationOne of theme of development is microminiaturized and integrated, and mobile phone is more and more less, and integrated functionality is more and more; ElectricityBrain CPU live width is more and more narrow, and information processing capability is more and more stronger. These are with miniature or be integrated into basic spyThe scientific and technological achievement of levying has made people's a thousand li of being separated by just can accessiblely converse, home-confinedly just can handle official business,Can see a film in wilderness, field. Started to have made more imagination with these people afterwards, and micro-fluidic chipLaboratory is exactly one of numerous imaginations, and it possesses a biology or chemical laboratory micro to piece are only hadAbility on the thin slice of several square centimeters. Compared with traditional analysis, micro-fluidic chip has response speedHurry up, sample and reagent consumption is few, the outside connection of system less, pollute few advantage, it can also be real simultaneouslyTime, original position, continuous detecting, can under microenvironment, work.
Sample mix is a requisite link in contemporary chemical industry production and analytical chemistry, owing to receivingThe Requirement and development of rice biotechnology, micro-fluidic technologies obtains the aspect such as biological micro electronmechanical, biochip in the pastTo application widely. Therefore, realize a kind of micro-mixer efficiently and just become macro process engineering and micro-coreA vital task in sheet laboratory. Micro-mixer is normally as the pre-treatment of biochip, for example, by fermentAfter element fully mixes with DNA etc., give fluid channel be transported to PCR processing region do amplify machine-processed orPerson does the analysis of counting. Traditional large scale flows, and can utilize flows can utilize stirring or other modesCause turbulent flow to promote to mix, and in micro-system, because flow velocity is very slow, size is little, cause Reynolds number veryLittle, fluid can flow in the mode of laminar flow, is not easy to mix with the form of turbulent flow. There is hydraulically smooth surfaceIn straight channel, the mass exchange between two of laminar condition adjacent fluids is only entered by molecular diffusionOK, in the microchannel of 100 microns of left and right width, protein solution is if reach sufficient mixing needsThe axial distance of several meters, this does not gear to actual circumstances certainly, and the diffusion of therefore accelerating sample will strengthen sampleBetween reciprocal motion. How designing a kind of high efficiency and stable micro-mixer, is current miniflowThe considerable problem in body research aspect.
At present existing dissimilar microfluid mixer, according to having or not external power source, micro-mixer conventionallyBe divided into two large classes: active mixer and passive mixer, their major function is all to realize fast low ReynoldsThe Quick uniform of number fluid mixes.
Passive mixing mode refers to simple utilizes geometry or fluid behaviour produces mixed effect,Rely on molecular diffusion or chaotic advection between fluid to mix, the main mode of carrying out relates to differenceFluid channel, comprise the thing etc. of placing obstacles in the change, runner of geometry. Although passive mixing deviceRelate to and can both improve to a certain extent mixing efficiency, but these mixing not very even, have besidesA little passive mixers just just have higher mixing efficiency under higher Reynolds number, when external condition becomesWhen change, not necessarily can obtain satisfied effect. And the geometry of passive mixing device all comparesComplexity, is not easy to manufacture.
Because passive mixing mode exists above-mentioned variety of problems, also there are some scholars to study under study for actionActive blender. Active blender strengthens mixed effect by the lateral flow of fluid conventionally, concreteThe method adopting has piezoelectric approach, aerodynamic processes, acoustic method, EOF, dielectrophoresis, magnetic currentThe electric humidity method in body dynamics, wild country, periodic shock, the bubble of effluent to the main flow sound causing that breaksLearn active force etc. But these hybrid modes often follow high shear rate, high voltage etc. to be unfavorable for biomoleculeThe factor of growth and survival.
Summary of the invention
Because the above-mentioned defect of prior art, technical problem to be solved by this invention is to provide one moreThe minisize fluid hybrid system safe and reliable and efficiency is higher.
For achieving the above object, the invention provides a kind of minisize fluid hybrid system, comprise housing, described inIn housing, be provided with blender, described blender is provided with the first feed pathway and the second feed pathway, described inThe first feed pathway and the second feed pathway have the first inlet and the second inlet, and described first entersLiquid mouth and the second inlet are connected with respectively through the first conduit of housing and the second conduit, described the first feed liquorPassage is all communicated with one end of hybrid channel with described the second feed pathway, and the other end of described hybrid channel is openedThere is liquid outlet; Described housing is embedded with to the point-like light spot laser device of launch spot in housing, described some shaped laser spotThe light-emitting window of laser instrument is positioned at the top, hybrid channel of described blender.
When use, two kinds of fluids that needs are mixed flow into the first feed liquor from the first conduit and the second conduit respectivelyPipeline and the second input duct, be placed on blender on base, then base put into housing, by baseWith regulating block butt, to control accurately the position of blender, then open point-like light spot laser device, makeThe Laser Focusing that point-like light spot laser device sends is on hybrid channel, so that the mixing of two kinds of fluids of strengthening.
Owing to being less than 500 microns in the size of minute yardstick lower channel, even in the situation that flow velocity is very large, itsReynolds number also can be very little, makes to flow to remain on laminar condition always, in the time that Laser Focusing is on fluid, swashsThe interior fluid temperature (F.T.) that can cause focus place that the luminous energy of light can be converted into fluid by absorption of fluids raises, and focusFluid temperature (F.T.) around can not marked change, and the temperature rise meeting of fluid makes the Brownian movement aggravation of fluid,The diffusion of strengthening fluid molecule, strengthening mixes. The temperature of fluid raises, and the viscosity of fluid will decline, andFluid suffered flow resistance in the time that this point flows also can decline thereupon. So the fluid at focus place is along fortuneThe flow velocity of moving direction can increase, and the rate of flow of fluid of its downstream part will be less than the fluid at focus place, causes JiaoA part in the fluid at some place is opened to both sides diffuse flow, and this diffuse flow will be strengthened the mixed of two kinds of fluidsClose effect.
Further, described housing has blender and picks and places mouth and position adjustments mouth, and described position adjustments mouth is insertedHave regulating block, be also provided with base in described housing, described blender is arranged on described base; The described endSeat and described regulating block butt. Adopt above technical scheme, the regulating block at position adjustments mouth place can be according to needBe drawn into or extract out, base and regulating block butt are so that the position of adjusting mixer.
Preferably, described the first feed pathway, the second feed pathway are mixed with described hybrid channel composition Y typeDevice, forms acute angle between described the first feed pathway and the second feed pathway.
Further, on described base, be carved with cartesian coordinate system, so that blender can be according to fixing positionPut and be arranged on base, further ensured the accuracy of blender position.
For the ease of observing, adjust the position of blender, described housing is that transparent material is made, preferably,Described housing is lucite.
The invention has the beneficial effects as follows: the mixed effect that the present invention can strengthening fluid, has improved mixed greatlyClose efficiency, avoided being unfavorable for the factor of biomolecule growth and survival simultaneously, the present invention also has structure letterSingly be convenient to the advantage of making.
Brief description of the drawings
Fig. 1 is the top view of the embodiment of the invention.
Fig. 2 is the side view of the embodiment of the invention.
Fig. 3 is that blender of the present invention picks and places mouthful structural representation at place.
Fig. 4 is the structural representation of blender in the embodiment of the invention.
Detailed description of the invention
Below in conjunction with drawings and Examples, the invention will be further described:
As shown in Figures 1 to 4, a kind of minisize fluid hybrid system, comprises housing 1, in described housing 1, establishesBe equipped with base 14, on described base 14, be provided with blender 2, it is logical that described blender 2 is provided with the first feed liquorRoad 3 and the second feed pathway 4,
Described the first feed pathway 3 and the second feed pathway 4 have the first inlet 5 and the second feed liquorMouth 6, described the first inlet 5 and the second inlet 6 are connected with respectively the first conduit 7 Hes through housing 1The second conduit 8, described the first feed pathway 3 and described the second feed pathway 4 all with one end of hybrid channel 9Be communicated with, the other end of described hybrid channel 9 has liquid outlet 10; Described the first feed pathway 3, second is enteredLiquid passage 4 forms Y type blender, described the first feed pathway 3 and the second feed liquor with described hybrid channel 9Between passage 4, form acute angle. Described housing 1 is embedded with the point-like light spot laser device to housing 1 interior launch spot11, the light-emitting window of described point-like light spot laser device 11 is positioned at 9 tops, hybrid channel of described blender 2. InstituteState housing 1 side and have blender and pick and place mouthfuls 12 and three position adjustments mouths, described position adjustments mouth dividesBe not inserted with three regulating blocks 13, described base 14 and three regulating blocks 13 butt respectively, adopt three adjustingsPiece can play the effect of spacing and stable blender more accurately. On described base 14, be carved with cartesian coordinateSystem. Described housing 1 is lucite.
More than describe preferred embodiment of the present invention in detail. Should be appreciated that the ordinary skill of this areaPersonnel just can design according to the present invention make many modifications and variations without creative work. Therefore, allIn the art technical staff under this invention's idea on the basis of existing technology by logic analysis, push awayReason or the limited available technical scheme of experiment, all should be by the determined protection model of claimsIn enclosing.
Claims (5)
1. a minisize fluid hybrid system, it is characterized in that: comprise housing (1), in described housing (1), be provided with blender (2), described blender (2) is provided with the first feed pathway (3) and the second feed pathway (4), described the first feed pathway (3) has the first inlet (5) and the second inlet (6) with the second feed pathway (4), described the first inlet (5) and the second inlet (6) are connected with respectively through first conduit (7) of housing (1) and the second conduit (8), described the first feed pathway (3) is all communicated with the one end of hybrid channel (9) with described the second feed pathway (4), the other end of described hybrid channel (9) has liquid outlet (10), described housing (1) is embedded with the point-like light spot laser device (11) that the part in the fluid at focus place is opened to the interior launch spot of housing (1) to both sides diffuse flow, the light-emitting window of described point-like light spot laser device (11) is positioned at the top, hybrid channel (9) of described blender (2), described housing (1) has blender and picks and places mouthful (12) and three position adjustments mouths, described position adjustments mouth is inserted with respectively three regulating blocks (13), in described housing (1), be also provided with base (14), described blender (2) is arranged on described base (14), described base (14) and three regulating blocks (13) butt respectively.
2. minisize fluid hybrid system as claimed in claim 1, it is characterized in that: described the first feed pathway (3), the second feed pathway (4) and described hybrid channel (9) composition Y type blender, form acute angle between described the first feed pathway (3) and the second feed pathway (4).
3. minisize fluid hybrid system as claimed in claim 1, is characterized in that: described base is carved with cartesian coordinate system on (14).
4. minisize fluid hybrid system as claimed in claim 1, is characterized in that: described housing (1) is made for transparent material.
5. minisize fluid hybrid system as claimed in claim 4, is characterized in that: described housing (1) is lucite.
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| CN201310233639.XA CN103331121B (en) | 2013-06-13 | 2013-06-13 | Minisize fluid hybrid system |
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| CN201310233639.XA CN103331121B (en) | 2013-06-13 | 2013-06-13 | Minisize fluid hybrid system |
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| CN103331121B true CN103331121B (en) | 2016-05-18 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103566807B (en) * | 2013-11-14 | 2015-07-22 | 哈尔滨工程大学 | Microminiature mixing device for strengthening fluid mixing by micronization boiling of steam bubbles |
| CN104941469B (en) * | 2015-05-25 | 2017-05-17 | 重庆大学 | Method for generating emulsion in micro-channel |
| CN107608069B (en) * | 2017-08-31 | 2020-04-21 | 华南师范大学 | Filling liquid filling device, preparation method thereof and filling method of electrowetting filling liquid |
| CN112138554B (en) * | 2019-06-28 | 2022-05-31 | 沈阳化工研究院有限公司 | Dispersed collision flow mixing device |
| CN110330393B (en) * | 2019-07-17 | 2021-11-30 | 南京理工大学 | Nano explosive preparation system and method based on passive micro mixer |
| CN111804355A (en) * | 2020-07-15 | 2020-10-23 | 上海理工大学 | Micro-channel structure and device for electroosmotic flow transmission |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030082079A1 (en) * | 2001-10-26 | 2003-05-01 | Fuji Photo Film Co., Ltd. | Laser heating micro reactor |
| GB2393668A (en) * | 2002-08-14 | 2004-04-07 | Hewlett Packard Development Co | Mixing by use of circulators responsive to electric current |
| CN101907631A (en) * | 2010-07-19 | 2010-12-08 | 中国科学院长春光学精密机械与物理研究所 | Double-liquid capillary micro-flow control valve in micro-flow control chip, and manufacturing method thereof |
| CN203342716U (en) * | 2013-06-13 | 2013-12-18 | 重庆大学 | Micro-fluid mixing system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3373113B2 (en) * | 1996-05-28 | 2003-02-04 | シャープ株式会社 | Sample fine movement mechanism and sample holder |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030082079A1 (en) * | 2001-10-26 | 2003-05-01 | Fuji Photo Film Co., Ltd. | Laser heating micro reactor |
| GB2393668A (en) * | 2002-08-14 | 2004-04-07 | Hewlett Packard Development Co | Mixing by use of circulators responsive to electric current |
| CN101907631A (en) * | 2010-07-19 | 2010-12-08 | 中国科学院长春光学精密机械与物理研究所 | Double-liquid capillary micro-flow control valve in micro-flow control chip, and manufacturing method thereof |
| CN203342716U (en) * | 2013-06-13 | 2013-12-18 | 重庆大学 | Micro-fluid mixing system |
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