TWI450852B - Micromixer - Google Patents

Micromixer Download PDF

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TWI450852B
TWI450852B TW096125646A TW96125646A TWI450852B TW I450852 B TWI450852 B TW I450852B TW 096125646 A TW096125646 A TW 096125646A TW 96125646 A TW96125646 A TW 96125646A TW I450852 B TWI450852 B TW I450852B
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baffle
rhombic
connecting portion
flow
micromixer
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TW096125646A
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TW200902427A (en
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C K Chung
T R Shih
T C Chen
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Univ Nat Cheng Kung
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微型混合器Micro mixer

本發明係關於一種微型混合器之結構,詳言之,係關於一種內含複數個菱形流道及至少一檔板之微型混合器之結構。The present invention relates to the construction of a micromixer, and more particularly to a structure of a micromixer containing a plurality of diamond shaped flow passages and at least one baffle.

微流體晶片中,檢體和試劑混合是最關鍵的程序。巨觀世界中,利用紊流(Turbulent flow)混合流體是常見的方式。但在微尺度系統中,流體要達到紊流混合是困難且不實際的,所以許多不同的流體混合方法正廣泛的被研究開發。而微型混合器發展至今,依其混合機制大致可分為兩類:主動式混合與被動式混合。主動式混合器除了驅動流體所需能量,尚須提供額外的能量、機械元件等外力使流體形成混合;被動式混合器主要利用流道設計達到流體間的對流與擴散作用達到混合效果。In microfluidic wafers, sample and reagent mixing is the most critical procedure. In the giant world, it is a common way to mix fluids with Turbulent flow. However, in microscale systems, it is difficult and impractical for fluids to achieve turbulent mixing, so many different fluid mixing methods are being researched and developed extensively. Since the development of micro-mixers, they can be roughly divided into two categories according to their mixing mechanism: active mixing and passive mixing. In addition to the energy required to drive the fluid, the active mixer must provide additional energy, mechanical components and other external forces to mix the fluid; the passive mixer mainly uses the flow channel design to achieve the convection and diffusion between the fluids to achieve the mixing effect.

一般將被動式混合器分成兩類,一為利用流體之間的擴散達到完全混合,另一為利用三維之流道設計促使流體產生渾沌流達到混合。J.Branebjerg等人製作立體結構之微型混合器,其概念是以上下左右相互之交叉流道,使得欲混合之流體有更多的接觸面積來增加混合效果,如[J.Branebjerg,P.Gravesen,J.P.Krog,and C.R.Nielsen,"Fast mixing by nomination," IEEE,pp.441-446,1996.]所揭示。S.C.Jacobson等人利用多分支之管道結構,使流體不斷經由十字交錯的管道來增進接觸面積,達到可混合多種不同比例與成分之混合流體,如[S.C.Jacobson,T.E.McKnight,and J.M.Ramsey,"Microfluidic devices for electrokinetically driven parallel and serial mixing," Analytical Chemistry,Vol.71,pp.4455-4459,1999.]所揭示。此方式需要長時間長混合長度達到流體混合。Passive mixers are generally divided into two categories, one to achieve complete mixing by diffusion between fluids, and the other to utilize three-dimensional flow path design to promote fluid flow to achieve mixing. J. Branebjerg et al. make a micro-mixer with a three-dimensional structure, the concept of which is the cross-flow path between the upper and lower sides, so that the fluid to be mixed has more contact area to increase the mixing effect, such as [J.Branebjerg, P.Gravesen , JPKrog, and CRNielsen, "Fast mixing by nomination," IEEE, pp. 441-446, 1996.]. SCJacobson et al. utilize a multi-branched tube structure to allow fluids to continuously increase the contact area via cross-staggered tubes to a mixture of fluids of various ratios and compositions, such as [SCJacobson, TEMcKnight, and JMRamsey, "Microfluidic Devices for electrokinetically driven parallel and serial mixing, "Analytical Chemistry, Vol. 71, pp. 4545-4459, 1999." This method requires a long mixing length to achieve fluid mixing.

此外,尚有一些學者利用渾沌流現象增進混合。A.D.Stroock等人在流道中製作出規則排列之魚脊凹槽,如[A.D.Stroock,S.K.W.Dertinger,A.Ajdari,I.Mezic,H.A.Stone and G.M.Whitesides,"Chaotic mixer for microchannels," Science,Vol.295,pp.647-651,2002.]所揭示。當液體通過此凹槽結構,會產生三維旋轉渦流(Spiral recirculation),使流體產生三維螺旋運動達到混合。此缺點為凹槽內之流體流動性不佳,容易產生靜滯區(Dead Zone)。In addition, some scholars have used the phenomenon of chaotic flow to enhance mixing. ADStroock et al. created regularly arranged fish ridge grooves in the flow channel, such as [ADStroock, SKWDertinger, A. Ajdari, I. Mezic, HAStone and GM Whitesides, "Chaotic mixer for microchannels," Science, Vol. 295, pp. 647-651, 2002.]. When the liquid passes through the groove structure, a three-dimensional spiral vortex is generated, which causes the fluid to generate a three-dimensional spiral motion to achieve mixing. This disadvantage is that the fluid in the groove is not fluid, and it is easy to generate a dead zone.

產生渾沌流之三維度流道設計普遍存在製程繁瑣,整合度低等缺點。快速混合之研究中,M.Engler等人是以T型流道作為混合器,並且利用數值模擬分析在不同流速下,微流體在T型流道處的流場改變,根據其流場狀態而定義三種不同的機制,以利後者對於T型流道混合器之研究,如[M.Engler,N.Kockmann,T.Kiefer,and P.Woias,"Numerical and experimental investigations on liquid mixing in static micromixers," Chemical Engineering Journal,vol.101,pp.315-322,2004.]所揭示。S.H.Wong等人探討深寬比與雷諾數對於T型流道混合器之影響,並以矽晶圓為基材與玻璃做接合增加其微型混合器之強度,如[S.H.Wong,M.C.L.Ward,and C.W.Wharton,"Micro T-mixer as a rapid mixing micromixer," Sensor and Actuator B:Chemical,vol.100,pp.359-379,2004.]所揭示。上述設計中,流體在雷諾數500以上會有不錯的混合效果,雷諾數500以下之應用將受限。另一缺點為需提供極高之驅動能量。The three-dimensional flow channel design that produces the chaotic flow has the disadvantages of cumbersome process and low integration. In the rapid mixing study, M. Engler et al. used a T-flow channel as a mixer and used numerical simulation to analyze the flow field of the microfluid at the T-flow channel at different flow rates, depending on the flow field state. Three different mechanisms are defined to facilitate the latter's research on T-flow channel mixers, such as [M. Engler, N. Kockmann, T. Kiefer, and P. Woias, "Numerical and experimental investigations on liquid mixing in static micromixers, "Chemical Engineering Journal, vol. 101, pp. 315-322, 2004.]. SHWong et al. explored the effect of aspect ratio and Reynolds number on the T-type flow channel mixer, and joined the glass with a silicon wafer as the substrate to increase the strength of the micro-mixer, such as [SHWong, MCLWard, and CWWharton, "Micro T-mixer as a rapid mixing micromixer," Sensor and Actuator B: Chemical, vol. 100, pp. 359-379, 2004. In the above design, the fluid will have a good mixing effect above the Reynolds number of 500, and the application of the Reynolds number below 500 will be limited. Another disadvantage is the need to provide extremely high drive energy.

因此,有必要提供一種創新、簡單且具進步性的微型混合器,以解決上述問題。Therefore, it is necessary to provide an innovative, simple and progressive micro-mixer to solve the above problems.

本發明之主要目的係提供一種微型混合器,其係利用簡單平面式流道即可達到非常好的混合效果,而不用製作複雜的幾何形狀流道,可減少額外的設計與製程步驟且降低成本。SUMMARY OF THE INVENTION The primary object of the present invention is to provide a micromixer that achieves very good mixing results with a simple planar flow path without the need to create complex geometry runners, reducing additional design and processing steps and reducing costs. .

本發明之另一目的係提供一種微型混合器,其係利用簡單的菱形流道與擋板之設計,使流體經過時會產生複數個渦流,而可達到非常好的混合效果,其在較低的雷諾數下就有較佳的混合效果。Another object of the present invention is to provide a micro-mixer which utilizes a simple rhombic flow path and a baffle design to generate a plurality of eddy currents as the fluid passes, thereby achieving a very good mixing effect, which is lower The Reynolds number has a better mixing effect.

為達上述目的,本發明提出一種微型混合器,包含複數個菱形流道、一主入口、至少一側入口、至少一檔板及一出口。每個菱形流道具有四個角落部,相鄰菱形流道係利用彼此之角落部互相連接而形成一連接部。該主入口及該側入口係連接至最上游之菱形流道,用以分別注入複數所欲混合之流體。該檔板之一端係連接至該連接部之內側壁。該出口係連接至最下游之菱形流道。To achieve the above object, the present invention provides a micromixer comprising a plurality of diamond shaped flow channels, a main inlet, at least one side inlet, at least one baffle and an outlet. Each of the rhombic flow passages has four corner portions, and the adjacent rhombic flow passages are connected to each other by a corner portion to form a joint portion. The main inlet and the side inlet are connected to the most upstream diamond-shaped flow passage for injecting a plurality of fluids to be mixed, respectively. One end of the baffle is connected to the inner side wall of the connecting portion. The outlet is connected to the most downstream diamond shaped flow path.

參考圖1,顯示根據本發明微型混合器之第一實施例之示意圖。本實施例之微型混合器1包含一第一菱形流道2、一第二菱形流道3、一主入口11、二個側入口12、一檔板13及一出口14。在本實施例中,該第一菱形流道2係為最上游之菱形流道,該第二菱形流道3係為最下游之菱形流道。該第一菱形流道2具有四個子流道21及四個角落部(包括一上角落部22、一右角落部23、一左角落部24及一下角落部25),該等子流道21之寬度皆相同,且二個相鄰子流道21之夾角較佳為30度至90度。Referring to Figure 1, there is shown a schematic view of a first embodiment of a micromixer in accordance with the present invention. The micromixer 1 of the present embodiment comprises a first rhombic channel 2, a second rhombic channel 3, a main inlet 11, two side inlets 12, a baffle 13 and an outlet 14. In this embodiment, the first rhombic flow channel 2 is the most upstream diamond-shaped flow channel, and the second rhombic flow channel 3 is the most downstream diamond-shaped flow channel. The first rhombic flow channel 2 has four sub-flow channels 21 and four corner portions (including an upper corner portion 22, a right corner portion 23, a left corner portion 24 and a lower corner portion 25), and the sub-flow paths 21 The widths are all the same, and the angle between the two adjacent sub-flow paths 21 is preferably from 30 degrees to 90 degrees.

該第二菱形流道3具有四個子流道31及四個角落部(包括一上角落部32、一右角落部33、一左角落部34及一下角落部35),該等子流道31之寬度皆相同,且二個相鄰子流道31之夾角較佳為30度至90度。The second rhombic flow channel 3 has four sub-flow channels 31 and four corner portions (including an upper corner portion 32, a right corner portion 33, a left corner portion 34 and a lower corner portion 35), and the sub-flow paths 31 The widths are all the same, and the angle between the two adjacent sub-flow paths 31 is preferably 30 to 90 degrees.

該第一菱形流道2係利用其下角落部25與該第二菱形流道3之上角落部32互相連接而形成一連接部15。該檔板13之一端係連接至該連接部15之內側壁,且該檔板13之長度係大於該連接部15之寬度之一半。在本實施例中,該檔板13係為一平板狀結構,且與該連接部15之內側壁相垂直。然而,該檔板13也可以與該連接部15之內側壁間傾斜一角度。The first rhombic flow passage 2 is connected to the upper corner portion 32 of the second rhombic flow passage 3 by a lower corner portion 25 thereof to form a joint portion 15. One end of the baffle 13 is connected to the inner side wall of the connecting portion 15, and the length of the baffle 13 is greater than one half of the width of the connecting portion 15. In the present embodiment, the baffle 13 is a flat plate structure and is perpendicular to the inner side wall of the connecting portion 15. However, the baffle 13 can also be inclined at an angle to the inner side wall of the connecting portion 15.

該主入口11及該等側入口12係連接至該第一菱形流道2,用以分別注入複數所欲混合之流體。本發明所欲混合之流體係選自由水、酒精、生物血清、可相溶之化學流體、可相溶之生物流體、可互溶之化學流體及可互溶之生物流 體所組成之群。在本實施例中,該主入口11係連接至該第一菱形流道2之上角落部22,該等側入口12係連接至該第一菱形流道2之右角落部23及左角落部24。該出口14係連接至該第二菱形流道3。在本實施例中,該出口14係連接至該第二菱形流道3之下角落部35,用以流出混合後之流體。The main inlet 11 and the side inlets 12 are connected to the first rhombic flow channel 2 for injecting a plurality of fluids to be mixed, respectively. The flow system to be mixed by the present invention is selected from the group consisting of water, alcohol, biological serum, compatible chemical fluids, compatible biological fluids, miscible chemical fluids, and miscible biological fluids. a group of bodies. In this embodiment, the main inlet 11 is connected to the upper corner portion 22 of the first rhombic flow passage 2, and the side inlets 12 are connected to the right corner portion 23 and the left corner portion of the first rhombic flow passage 2. twenty four. The outlet 14 is connected to the second rhombic flow channel 3. In the present embodiment, the outlet 14 is connected to the lower corner portion 35 of the second rhombic flow passage 3 for flowing out the mixed fluid.

參考圖2,顯示根據本發明微型混合器之第二實施例之示意圖。本實施例之微型混合器4包含一第一菱形流道5、一第二菱形流道6、一第三菱形流道7、一主入口41、二個側入口42、一第一檔板43、一第二檔板44及一出口45。在本實施例中,該第一菱形流道5係為最上游之菱形流道,該第三菱形流道7係為最下游之菱形流道。Referring to Figure 2, there is shown a schematic view of a second embodiment of a micromixer in accordance with the present invention. The micro-mixer 4 of the embodiment comprises a first diamond flow channel 5, a second diamond flow channel 6, a third diamond flow channel 7, a main inlet 41, two side inlets 42, and a first baffle. 43. A second baffle 44 and an outlet 45. In this embodiment, the first rhombic flow passage 5 is the most upstream rhombic flow passage, and the third rhombic flow passage 7 is the most downstream rhombic flow passage.

該第一菱形流道5具有四個子流道51及四個角落部(包括一上角落部52、一右角落部53、一左角落部54及一下角落部55),該等子流道51之寬度皆相同,且二個相鄰子流道51之夾角較佳為30度至90度。The first rhombic flow channel 5 has four sub-flow channels 51 and four corner portions (including an upper corner portion 52, a right corner portion 53, a left corner portion 54, and a lower corner portion 55), and the sub-flow paths 51 The widths are all the same, and the angle between the two adjacent sub-flow paths 51 is preferably 30 to 90 degrees.

該第二菱形流道6具有四個子流道61及四個角落部(包括一上角落部62、一右角落部63、一左角落部64及一下角落部65),該等子流道61之寬度皆相同,且二個相鄰子流道61之夾角較佳為30度至90度。The second rhombic flow path 6 has four sub-flow paths 61 and four corner portions (including an upper corner portion 62, a right corner portion 63, a left corner portion 64 and a lower corner portion 65), and the sub-flow paths 61 The widths are all the same, and the angle between the two adjacent sub-flow paths 61 is preferably 30 to 90 degrees.

該第三菱形流道7具有四個子流道71及四個角落部(包括一上角落部72、一右角落部73、一左角落部74及一下角落部75),該等子流道71之寬度皆相同,且二個相鄰子流道71之夾角較佳為30度至90度。The third rhombic flow passage 7 has four sub-flow passages 71 and four corner portions (including an upper corner portion 72, a right corner portion 73, a left corner portion 74 and a lower corner portion 75), and the sub-flow passages The widths of 71 are all the same, and the angle between the two adjacent sub-flow paths 71 is preferably 30 to 90 degrees.

該第一菱形流道5係利用其下角落部55與該第二菱形流道6之上角落部62互相連接而形成一第一連接部46。該第一檔板43之一端係連接至該第一連接部46之內側壁,且該第一檔板43之長度係大於該第一連接部46之寬度之一半。在本實施例中,該第一檔板43係為一平板狀結構,且與該第一連接部46之內側壁相垂直。然而,該第一檔板43也可以與該第一連接部46之內側壁間傾斜一角度。The first rhombic flow passage 5 is connected to the upper corner portion 62 of the second rhombic flow passage 6 by a lower corner portion 55 thereof to form a first connecting portion 46. One end of the first baffle 43 is connected to the inner side wall of the first connecting portion 46, and the length of the first baffle 43 is greater than one half of the width of the first connecting portion 46. In this embodiment, the first baffle 43 is a flat plate structure and is perpendicular to the inner side wall of the first connecting portion 46. However, the first baffle 43 may also be inclined at an angle to the inner side wall of the first connecting portion 46.

該第二菱形流道6係利用其下角落部65與該第三菱形流道7之上角落部72互相連接而形成一第二連接部47。該第二檔板44之一端係連接至該第二連接部47之內側壁,且該第二檔板44之長度係大於該第二連接部47之寬度之一半。在本實施例中,該第二檔板44係為一平板狀結構,且與該第二連接部47之內側壁相垂直。然而,該第二檔板44也可以與該第二連接部47之內側壁間傾斜一角度。The second rhombic flow path 6 is connected to the upper corner portion 72 of the third rhombic flow path 7 by a lower corner portion 65 thereof to form a second connecting portion 47. One end of the second baffle 44 is connected to the inner side wall of the second connecting portion 47, and the length of the second baffle 44 is greater than one half of the width of the second connecting portion 47. In this embodiment, the second baffle 44 is a flat plate structure and is perpendicular to the inner side wall of the second connecting portion 47. However, the second baffle 44 may also be inclined at an angle to the inner side wall of the second connecting portion 47.

在本實施例中,該第一檔板43及該第二檔板44係連接至相對應之側壁,亦即該第一檔板43之右端係連接至該第一連接部46之右邊內側壁,其左端與該第一連接部46之左邊內側壁間具有一間距。該第二檔板44之左端係連接至該第二連接部47之左邊內側壁,其右端與該第二連接部47之右邊內側壁間具有一間距。In this embodiment, the first baffle 43 and the second baffle 44 are connected to the corresponding side walls, that is, the right end of the first baffle 43 is connected to the right inner side wall of the first connecting portion 46. There is a distance between the left end and the left inner side wall of the first connecting portion 46. The left end of the second baffle 44 is connected to the left inner side wall of the second connecting portion 47, and the right end thereof has a distance from the right inner side wall of the second connecting portion 47.

該主入口41及該等側入口42係連接至最上游之菱形流道(即該第一菱形流道5),用以分別注入複數所欲混合之流體。在本實施例中,該主入口41係連接至該第一菱形流道5之上角落部52,該等側入口42係連接至該第一菱形流道5之右角落部53及左角落部54。該出口45係連接至最下游之菱形流道(即該第三菱形流道7)。在本實施例中,該出口45係連接至該第三菱形流道7之下角落部75,用以流出混合後之流體。The main inlet 41 and the side inlets 42 are connected to the most upstream diamond-shaped flow path (i.e., the first diamond-shaped flow path 5) for injecting a plurality of fluids to be mixed, respectively. In this embodiment, the main inlet 41 is connected to the upper corner portion 52 of the first rhombic flow passage 5, and the side inlets 42 are connected to the right corner portion 53 and the left corner portion of the first rhombic flow passage 5. 54. The outlet 45 is connected to the most downstream diamond-shaped flow passage (i.e., the third diamond-shaped flow passage 7). In the present embodiment, the outlet 45 is connected to the lower corner portion 75 of the third rhombic flow passage 7 for flowing out the mixed fluid.

在本發明中,該第一及第二實施例分別具有二個及三個菱形流道,然而可以理解的是,本發明之菱形流道之數目也可以是四個以上。In the present invention, the first and second embodiments respectively have two and three rhombic flow paths, but it is understood that the number of rhombic flow paths of the present invention may be four or more.

參考圖3,顯示本發明微型混合器之第二實施例中因檔板之作用而產生之渦流分佈圖。本發明主要是利用該等檔板(該第一檔板43及該第二檔板44)搭配菱形流道之設計,當流體流經過該第一檔板43及該第二檔板44時,會形成渦流。此外,流體流經過該第二菱形流道6之右角落部63及左角落部64,以及該第三菱形流道7之右角落部73及左角落部74時,亦會形成渦流,如此使得該主入口41及該等側入口42所注入之流體有較佳的混合效率。Referring to Fig. 3, there is shown a vortex distribution map produced by the action of the baffle in the second embodiment of the micromixer of the present invention. The present invention mainly utilizes the design of the baffles (the first baffle 43 and the second baffle 44) with the rhombic flow passages, when the fluid flows through the first baffle 43 and the second baffle 44. A vortex will form. In addition, when the fluid flows through the right corner portion 63 and the left corner portion 64 of the second rhombic flow passage 6, and the right corner portion 73 and the left corner portion 74 of the third rhombic flow passage 7, eddy currents are also formed. The fluid injected by the main inlet 41 and the side inlets 42 has a better mixing efficiency.

本實施例之製法如下,首先採用SU-8厚膜光阻以微影製程在矽晶圓上製作該微型混合器4之母模;再以聚二甲基矽氧烷(Polydimethysiloxane,PDMS)為材料翻模製作該微型混合器4。可以理解的是,製作該微型混合器4之材質也可以是高分子材料、玻璃、矽或陶瓷等。該微型混合器4之尺寸如下,(1)該主入口41之寬度a1 為500 μm,長度L1 為5000 μm;(2)該等側入口42之寬度a2 為100 μm,長度L2 為5000 μm;(3)該第一菱形流道5之子流道51寬度c為250 μm,相鄰二子流道51之夾角α為90度,該第二菱形流道6及該第三菱形流道7之尺寸與該第一菱形流道5相同,且二相鄰菱形流道之距離S為1500 μm;(4)該第一連接部46之長度x為210 μm,寬度H為700 μm,該第二連接部47之尺寸與該第一連接部46相同;(5)該第一檔板43之長度h為613 μm,厚度w為70 μm,該第二檔板44之尺寸與該第一檔板43相同;(6)該出口45之寬度a3 為500 μm,長度L3 為8000 μm。The method of the present embodiment is as follows. First, the mother mold of the micro-mixer 4 is fabricated on a germanium wafer by a lithography process using a SU-8 thick film photoresist; and polydimethysiloxane (PDMS) is used as a mask. The material is overmolded to make the micromixer 4. It can be understood that the material of the micro-mixer 4 can also be a polymer material, glass, enamel or ceramic. The dimensions of the micro-mixer 4 are as follows: (1) the width a 1 of the main inlet 41 is 500 μm, and the length L 1 is 5000 μm; (2) the width a 2 of the side inlets 42 is 100 μm, and the length L 2 5,000 μm; (3) the width of the sub-channel 51 of the first rhombic channel 5 is 250 μm, the angle α between the adjacent two sub-channels 51 is 90 degrees, the second rhombic channel 6 and the third diamond The size of the flow path 7 is the same as that of the first rhombic flow path 5, and the distance S of two adjacent rhombic flow paths is 1500 μm; (4) the length l of the first connecting portion 46 is 210 μm, and the width H is 700 μm. The second connecting portion 47 has the same size as the first connecting portion 46; (5) the first baffle 43 has a length h of 613 μm and a thickness w of 70 μm, and the size of the second baffle 44 is The first baffle 43 is the same; (6) the outlet 45 has a width a 3 of 500 μm and a length L 3 of 8000 μm.

參考圖4,顯示利用本發明第二實施例之微型混合器混合時之俯視照片圖,其中雷諾數為10。參考圖5,顯示利用本發明第二實施例之微型混合器混合時之俯視照片圖,其中雷諾數為20。在圖4及圖5中,該主入口41係注入一黑色液體,該黑色液體為墨汁和水的混合,其比例約為1:20。該等側入口42係注入一透明液體,該透明的液體則為水。該出口45係流出混合後之流體。由圖4可看出,當雷諾數為10時混合效果已大大提升。由圖5可看出,當雷諾數升至20時流體確實達到良好的混合效果。Referring to Fig. 4, there is shown a top view photograph of a micromixer in accordance with a second embodiment of the present invention, in which the Reynolds number is 10. Referring to Fig. 5, there is shown a top view photograph of a micromixer in accordance with a second embodiment of the present invention, in which the Reynolds number is 20. In Figures 4 and 5, the main inlet 41 is filled with a black liquid which is a mixture of ink and water at a ratio of about 1:20. The side inlets 42 are infused with a transparent liquid which is water. The outlet 45 is the fluid that flows out of the mixing. It can be seen from Fig. 4 that the mixing effect is greatly improved when the Reynolds number is 10. As can be seen from Figure 5, the fluid does achieve a good mixing effect when the Reynolds number is raised to 20.

本發明之混合器之優點為,流道設計簡單且為平面式流道設計,具有容易製作及低設計成本之優點。再者,本發明可採用翻模方式製作,而可以應用於大量生產。此外,如同前述,本發明之混合器在低速流場具有良好的流體混合能力。The mixer of the present invention has the advantages of simple flow passage design and planar flow passage design, and has the advantages of easy manufacture and low design cost. Furthermore, the present invention can be produced by overturning, and can be applied to mass production. Further, as described above, the mixer of the present invention has good fluid mixing ability in a low speed flow field.

惟上述實施例僅為說明本發明之原理及其功效,而非用以限制本發明。因此,習於此技術之人士可在不違背本發明之精神對上述實施例進行修改及變化。本發明之權利範圍應如後述之申請專利範圍所列。However, the above embodiments are merely illustrative of the principles and effects of the invention and are not intended to limit the invention. Therefore, those skilled in the art can make modifications and changes to the above embodiments without departing from the spirit of the invention. The scope of the invention should be as set forth in the appended claims.

a1 ...主入口之寬度a 1 . . . Width of main entrance

L1 ...主入口之長度L 1 . . . Length of main entrance

a2 ...側入口之寬度a 2 . . . Side entrance width

L2 ...側入口之長度L 2 . . . Side entrance length

c...第一菱形流道之子流道之寬度c. . . The width of the sub-flow path of the first rhombic flow channel

α...相鄰子流道之夾角α. . . Angle between adjacent sub-flow paths

S...相鄰菱形流道之距離S. . . Distance of adjacent diamond flow channels

x...第一連接部之長度x. . . Length of the first connecting portion

H...第一連接部之寬度H. . . Width of the first connecting portion

h...第一檔板之長度h. . . Length of the first baffle

w...第一檔板之厚度w. . . First plate thickness

a3 ...出口之寬度a 3 . . . Width of the exit

L3 ...出口之長度L 3 . . . Length of exit

1...本發明第一實施例之微型混合器1. . . Micro-mixer of the first embodiment of the present invention

2...第一菱形流道2. . . First diamond flow channel

3...第二菱形流道3. . . Second diamond flow channel

4...本發明第二實施例之微型混合器4. . . Micro-mixer of the second embodiment of the present invention

5...第一菱形流道5. . . First diamond flow channel

6...第二菱形流道6. . . Second diamond flow channel

7...第三菱形流道7. . . Third diamond flow channel

11...主入口11. . . main entrance

12...側入口12. . . Side entrance

13...檔板13. . . Baffle

14...出口14. . . Export

15...連接部15. . . Connection

21...子流道twenty one. . . Sub-flow channel

22...上角落部twenty two. . . Upper corner

23...右角落部twenty three. . . Right corner

24...左角落部twenty four. . . Left corner

25...下角落部25. . . Lower corner

31...子流道31. . . Sub-flow channel

32...上角落部32. . . Upper corner

33...右角落部33. . . Right corner

34...左角落部34. . . Left corner

35...下角落部35. . . Lower corner

41...主入口41. . . main entrance

42...側入口42. . . Side entrance

43...第一檔板43. . . First gear

44...第二檔板44. . . Second gear

45...出口45. . . Export

46...第一連接部46. . . First connection

47...第二連接部47. . . Second connection

51...子流道51. . . Sub-flow channel

52...上角落部52. . . Upper corner

53...右角落部53. . . Right corner

54...左角落部54. . . Left corner

55...下角落部55. . . Lower corner

61...子流道61. . . Sub-flow channel

62...上角落部62. . . Upper corner

63...右角落部63. . . Right corner

64...左角落部64. . . Left corner

65...下角落部65. . . Lower corner

71...子流道71. . . Sub-flow channel

72...上角落部72. . . Upper corner

73...右角落部73. . . Right corner

74...左角落部74. . . Left corner

75...下角落部75. . . Lower corner

圖1顯示根據本發明微型混合器之第一實施例之示意圖;圖2顯示根據本發明微型混合器之第二實施例之示意圖;圖3顯示本發明微型混合器之第二實施例中因檔板之作用而產生之渦流分佈圖;圖4顯示利用本發明第二實施例之微型混合器混合時之俯視照片圖,其中雷諾數為10;及圖5顯示利用本發明第二實施例之微型混合器混合時之俯視照片圖,其中雷諾數為20。1 shows a schematic view of a first embodiment of a micromixer according to the present invention; FIG. 2 shows a schematic view of a second embodiment of a micromixer according to the present invention; and FIG. 3 shows a second embodiment of the micromixer of the present invention. FIG. 4 is a top plan view showing the mixing of the micro-mixer of the second embodiment of the present invention, wherein the Reynolds number is 10; and FIG. 5 shows the miniature using the second embodiment of the present invention. A top-down photo of the mixer when it is mixed, with a Reynolds number of 20.

a1 ...主入口之寬度a 1 . . . Width of main entrance

L1 ...主入口之長度L 1 . . . Length of main entrance

a2 ...側入口之寬度a 2 . . . Side entrance width

L2 ...側入口之長度L 2 . . . Side entrance length

c...第一菱形流道之子流道之寬度c. . . The width of the sub-flow path of the first rhombic flow channel

α...相鄰子流道之夾角α. . . Angle between adjacent sub-flow paths

S...相鄰菱形流道之距離S. . . Distance of adjacent diamond flow channels

x...第一連接部之長度x. . . Length of the first connecting portion

H...第一連接部之寬度H. . . Width of the first connecting portion

h...第一檔板之長度h. . . Length of the first baffle

w...第一檔板之厚度w. . . First plate thickness

a3 ...出口之寬度a 3 . . . Width of the exit

L3 ...出口之長度L 3 . . . Length of exit

4...本發明第二實施例之微型混合器4. . . Micro-mixer of the second embodiment of the present invention

5...第一菱形流道5. . . First diamond flow channel

6...第二菱形流道6. . . Second diamond flow channel

7...第三菱形流道7. . . Third diamond flow channel

41...主入口41. . . main entrance

42...側入口42. . . Side entrance

43...第一檔板43. . . First gear

44...第二檔板44. . . Second gear

45...出口45. . . Export

46...第一連接部46. . . First connection

47...第二連接部47. . . Second connection

51...子流道51. . . Sub-flow channel

52...上角落部52. . . Upper corner

53...右角落部53. . . Right corner

54...左角落部54. . . Left corner

55...下角落部55. . . Lower corner

61...子流道61. . . Sub-flow channel

62...上角落部62. . . Upper corner

63...右角落部63. . . Right corner

64...左角落部64. . . Left corner

65...下角落部65. . . Lower corner

71...子流道71. . . Sub-flow channel

72...上角落部72. . . Upper corner

73...右角落部73. . . Right corner

74...左角落部74. . . Left corner

75...下角落部75. . . Lower corner

Claims (11)

一種微型混合器,包含:複數個菱形流道,每個菱形流道具有四個角落部,相鄰菱形流道係利用彼此之角落部互相連接而形成一連接部;一主入口;至少一側入口,該主入口及該側入口係連接至最上游之菱形流道,用以分別注入複數所欲混合之流體;至少一檔板,其一端係連接至該連接部之內側壁;及一出口,係連接至最下游之菱形流道;其中,每一相鄰菱形流道的連接部均設置至少一個檔板;其中該等菱形流道包括一第一菱形流道、一第二菱形流道及一第三菱形流道,該等檔板包括一第一檔板及一第二檔板,該主入口及該側入口係連接至該第一菱形流道,該第一菱形流道及該第二菱形流道之間具有一第一連接部,該第一檔板係位於該第一連接部,該第二菱形流道及該第三菱形流道之間具有一第二連接部,該第二檔板係位於該第二連接部,該出口係連接至該第三菱形流道。 A micro-mixer comprising: a plurality of diamond-shaped flow passages, each of the rhombic flow passages having four corner portions, the adjacent rhombic flow passages being connected to each other by a corner portion thereof to form a joint portion; a main inlet; at least one side An inlet, the main inlet and the side inlet are connected to the most upstream diamond-shaped flow passage for respectively injecting a plurality of fluids to be mixed; at least one baffle having one end connected to the inner side wall of the connecting portion; and an outlet Connected to the most downstream diamond-shaped flow passage; wherein each connecting portion of the adjacent rhombic flow passages is provided with at least one baffle; wherein the rhombic flow passages include a first rhombic flow passage and a second rhombic flow passage And a third diamond-shaped flow channel, the baffle plate includes a first baffle and a second baffle, the main inlet and the side inlet are connected to the first rhombic flow channel, the first rhombic flow channel and A first connecting portion is disposed between the second rhombic flow passages, the first baffle is located at the first connecting portion, and a second connecting portion is disposed between the second rhombic flow passage and the third rhombic flow passage The second plate is located at the second connecting portion, the outlet Connected to the third flow passage diamond. 如請求項1之微型混合器,其中該第一檔板及該第二檔板係連接至相對應之側壁。 The micro-mixer of claim 1, wherein the first baffle and the second baffle are connected to corresponding side walls. 如請求項1之微型混合器,其中該主入口及該側入口係分別連接至最上游之菱形流道之不同角落部。 The micromixer of claim 1, wherein the main inlet and the side inlet are respectively connected to different corner portions of the most upstream rhombic flow passage. 如請求項1之微型混合器,其中每個菱形流道具有四個子流道,二個相鄰子流道之夾角係介於30度與90度之間。 The micro-mixer of claim 1, wherein each of the rhombic channels has four sub-flow paths, and the angle between the two adjacent sub-flow channels is between 30 and 90 degrees. 如請求項1之微型混合器,其中該檔板之長度係大於該連接部之寬度之一半。 A micromixer according to claim 1, wherein the length of the baffle is greater than one half of the width of the connecting portion. 如請求項1之微型混合器,其中該等側入口之數目係為複數個。 The micromixer of claim 1, wherein the number of the side inlets is plural. 如請求項1之微型混合器,其中該等流體係選自由水、酒精、生物血清、可相溶之化學流體、可相溶之生物流體、可互溶之化學流體及可互溶之生物流體所組成之群。 The micromixer of claim 1, wherein the flow system is selected from the group consisting of water, alcohol, biological serum, a compatible chemical fluid, a miscible biological fluid, a miscible chemical fluid, and a miscible biological fluid. Group. 如請求項1之微型混合器,其中該微型混合器之材質係選自由高分子材料、玻璃、矽及陶瓷所組成之群。 The micromixer of claim 1, wherein the material of the micromixer is selected from the group consisting of a polymer material, glass, tantalum, and ceramic. 如請求項1之微型混合器,其中該檔板係為一平板狀結構。 The micromixer of claim 1, wherein the baffle is a flat structure. 如請求項9之微型混合器,其中該檔板係與該連接部之內側壁相垂直。 The micromixer of claim 9, wherein the baffle is perpendicular to an inner sidewall of the connecting portion. 如請求項9之微型混合器,其中該檔板與該連接部之內側壁間傾斜一角度。 A micromixer according to claim 9, wherein the baffle is inclined at an angle to an inner side wall of the connecting portion.
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JPH10192671A (en) * 1996-12-27 1998-07-28 Jiinasu:Kk Multipoint collision type atomizing apparatus
TWM266555U (en) * 2004-10-11 2005-06-01 Antig Tech Co Ltd Mixing tank for feed-in material
TW200621617A (en) * 2004-12-21 2006-07-01 Univ Nat Cheng Kung Micromixer

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JPH10192671A (en) * 1996-12-27 1998-07-28 Jiinasu:Kk Multipoint collision type atomizing apparatus
TWM266555U (en) * 2004-10-11 2005-06-01 Antig Tech Co Ltd Mixing tank for feed-in material
TW200621617A (en) * 2004-12-21 2006-07-01 Univ Nat Cheng Kung Micromixer

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