CN108144659A - Based on chip lab microflow control technique micro-structure assisted extraction device and method - Google Patents
Based on chip lab microflow control technique micro-structure assisted extraction device and method Download PDFInfo
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- CN108144659A CN108144659A CN201711174732.2A CN201711174732A CN108144659A CN 108144659 A CN108144659 A CN 108144659A CN 201711174732 A CN201711174732 A CN 201711174732A CN 108144659 A CN108144659 A CN 108144659A
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- supplementary structure
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- 238000000605 extraction Methods 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 39
- 239000012530 fluid Substances 0.000 claims abstract description 25
- 239000011521 glass Substances 0.000 claims abstract description 11
- 239000000758 substrate Substances 0.000 claims abstract description 10
- WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims abstract description 9
- -1 chip Substances 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 11
- 239000012071 phase Substances 0.000 claims description 9
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 7
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 7
- 238000000622 liquid--liquid extraction Methods 0.000 claims description 7
- 239000012074 organic phase Substances 0.000 claims description 7
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 7
- 238000000638 solvent extraction Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 4
- 238000004088 simulation Methods 0.000 description 3
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 229920005573 silicon-containing polymer Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
Abstract
The present invention relates to based on chip lab microflow control technique micro-structure assisted extraction device and method, belong to precision equipment technical field.The present invention includes glass substrate, chip, liquid outlet I, liquid outlet II, fluid passage, liquid-inlet I, liquid-inlet II；The chip setting is on a glass substrate, liquid outlet I, liquid outlet II, liquid-inlet I, liquid-inlet II are arranged on chip, and fluid passage is provided with several to right angled triangle supplementary structure I, right angled triangle supplementary structure II in the chip and in fluid passage.The present invention effectively raises the extraction efficiency of microchip, and reliability is high and is easily achieved.
Description
Technical field
The present invention relates to based on chip lab microflow control technique micro-structure assisted extraction device and method, belong to precision and set
Standby technical field.
Background technology
Microfluidic device is widely used in the fields such as integrated electronic, precision instrument, Medical Devices and bio-pharmaceuticals, Microfluidizer
Part is suitble to the exploitation of various flow control systems, and control technology includes light, electricity, gas, magnetic, heat, gas phase variation etc..For testing
Chip structure on the glass substrate of room fluid processing, the design of the structure are carried out by using COMSOL Multiphysics
Analogue simulation makes microchannel structure using PDMS material, can be restored to original state under certain deformation condition and
Permanent damage does not occur for structure.Existing micro-fluidic chip inner passage is the length by extending channel either logical
Cross supplementary structure is added in road to improve extraction efficiency and shorten extraction time, but the present invention passes through COMSOL
Multiphysics analogue simulations it is found that the present invention by adding in supplementary structure in fluid passage, with passing through extending channel
Length either adds in cross supplementary structure in channel and compares, and can greatly improve liquid-liquid extraction efficiency and shorten extraction
Time.
Invention content
The technical problem to be solved by the present invention is to：The technical scheme is that：It is micro- based on chip lab microflow control technique
Structure assisted extraction device and method, for solving, existing micro-fluidic chip liquid-liquid extraction efficiency is low, extraction time length is asked
Topic.
The technical scheme is that：Based on chip lab microflow control technique micro-structure assisted extraction device, including glass
Substrate 1, chip 2, liquid outlet I 3, liquid outlet II 4, fluid passage 5, liquid-inlet I 6, liquid-inlet II 7；The chip 2
It being arranged in glass substrate 1, liquid outlet I 3, liquid outlet II 4, liquid-inlet I 6, liquid-inlet II 7 are arranged on chip 2,
Fluid passage 5 is provided with several to I 5-1 of right angled triangle supplementary structure, right angled triangle in chip 2 and in fluid passage 5
II 5-2 of supplementary structure.
The chip 2, I 5-1 of right angled triangle supplementary structure, II 5-2 of right angled triangle supplementary structure are gathered using PDMS
Dimethyl siloxane material is made.
It is described it is several to I 5-1 of right angled triangle supplementary structure, II 5-2 of right angled triangle supplementary structure in fluid passage 5
Heart line both sides are alternately distributed, pair and pair between period for 3mm, one of I 5-1 of right angled triangle supplementary structure in a cycle
It is 1mm with another II 5-2 level interval of right angled triangle supplementary structure, one of right angled triangle auxiliary in a cycle
I 5-1 of structure and II 5-2 width direction spacing 200um of another right angled triangle supplementary structure.
The 2 long 100mm of chip, wide 50mm, thick 10mm, liquid outlet I 3, liquid outlet II 4, liquid-inlet I 6, liquid
II 7 diameter of import is 8mm；
The 5 long 30mm of fluid passage, high 150um, wide 600um, I 5-1 of right angled triangle supplementary structure, right angled triangle auxiliary
II 5-2 width of structure is 100um, and length is 0.5mm, is highly 80um.
Using described device carry out micro-structure auxiliary extraction method, the method the specific steps are：To liquid-inlet I
Organic phase is injected in 6, injects the water phase containing target molecule in liquid-inlet II 7, two kinds of liquid enter fluid passage 5, flow through
It is several to I 5-1 of right angled triangle supplementary structure, right angled triangle II 5-2 of supplementary structure when generate disturbance, and then be sufficiently mixed simultaneously
Realize liquid-liquid extraction, wherein the organic phase containing target molecule is flowed out by liquid outlet I 3, water phase is flowed out by liquid outlet II 4.
The beneficial effects of the invention are as follows：
1st, by adding in supplementary structure in the microchannel to micro-fluidic chip, increase liquid in channel using triangle supplementary structure
Disturbance, improves the efficiency of laminar flow liquid-liquid extraction, shortens extraction time.
2nd, using PDMS (dimethyl silicone polymer) material make chip, material translucency is good, biocompatibility is good and
Good chemical inertness, the toughness of material is higher, and elasticity is good.
3rd, the device uses simple, at low cost, is a kind of polymer material for being widely used in the fields such as micro-fluidic.
Description of the drawings
Fig. 1 is overall structure diagram of the present invention；
Fig. 2 is the channel micro-structure front view of the present invention；
Fig. 3 is the channel micro-structure side view of the present invention.
Each label in Fig. 1-3：1- glass substrates, 2- chips, 3- liquid outlets I, 4- liquid outlets II, 5- fluid passages,
6- liquid-inlets I, 7- liquid-inlets II, 5-1- triangles supplementary structure I, 5-2- triangles supplementary structure II.
Specific embodiment
In the following with reference to the drawings and specific embodiments, the invention will be further described.
Embodiment 1：As shown in Figs. 1-3, based on chip lab microflow control technique micro-structure assisted extraction device, including glass
Glass substrate 1, chip 2, liquid outlet I 3, liquid outlet II 4, fluid passage 5, liquid-inlet I 6, liquid-inlet II 7；The core
Piece 2 is arranged in glass substrate 1, and liquid outlet I 3, liquid outlet II 4, liquid-inlet I 6, liquid-inlet II 7 are arranged on chip 2
On, fluid passage 5 is provided with several to I 5-1 of right angled triangle supplementary structure, right angle trigonometry in chip 2 and in fluid passage 5
II 5-2 of shape supplementary structure.
Further, the chip 2, I 5-1 of right angled triangle supplementary structure, II 5-2 of right angled triangle supplementary structure are adopted
It is made of PDMS polydimethyl siloxane materials.
Further, it is described it is several to I 5-1 of right angled triangle supplementary structure, II 5-2 of right angled triangle supplementary structure in liquid
5 center line both sides of body channel are alternately distributed, pair and pair between period for 3mm, one of right angled triangle is auxiliary in a cycle
I 5-1 of structure and another II 5-2 level interval of right angled triangle supplementary structure are helped as 1mm, one of right angle in a cycle
I 5-1 of triangle supplementary structure and II 5-2 width direction spacing 200um of another right angled triangle supplementary structure, such as Fig. 2-3 institutes
The size marking shown.
Further, the 2 long 100mm of chip, wide 50mm, thick 10mm, liquid outlet I 3, liquid outlet II 4, liquid into
Mouth I 6, II 7 diameter of liquid-inlet are 8mm；
The 5 long 30mm of fluid passage, high 150um, wide 600um, I 5-1 of right angled triangle supplementary structure, right angled triangle auxiliary
II 5-2 width of structure is 100um, and length is 0.5mm, is highly 80um.
Using described device carry out micro-structure auxiliary extraction method, the method the specific steps are：To liquid-inlet I
Organic phase is injected in 6, injects the water phase containing target molecule in liquid-inlet II 7, two kinds of liquid enter fluid passage 5, flow through
It is several to I 5-1 of right angled triangle supplementary structure, right angled triangle II 5-2 of supplementary structure when generate disturbance, and then be sufficiently mixed simultaneously
Realize liquid-liquid extraction, wherein the organic phase containing target molecule is flowed out by liquid outlet I 3, water phase is flowed out by liquid outlet II 4.
Since entire chip is made of PDMS (dimethyl silicone polymer) material, material translucency is good, convenient for experiment
When observe the flow behavior of fluid, biocompatibility is good and good chemical inertness, and the toughness of material is higher, and elasticity is good,
Durability and resistance to pressure are higher.The device uses simply, at low cost, is a kind of polymerization for being widely used in the fields such as micro-fluidic
Object material.
Produce vortex and disturbance in a small distance after triangle supplementary structure so that stable laminar flow have occurred compared with
Big disturbance, disturbance is so that diffusion process of the target molecule from high concentration to low concentration is accelerated in water phase and organic phase.Therefore, three
Angular supplementary structure not only promotes molecular motion of the target molecule in the vertical direction in each liquid phase, but also enhances phase
The transmittance process of the target molecule of interface, so as to considerably improve the extraction efficiency of liquid-liquid extraction and shorten extraction time.
Pass through COMSOL Multiphysics analogue simulations：There is the streamline of the fluid in the microchannel of supplementary structure
It is distributed with vector, finds the mechanism of supplementary structure enhancement layer stream extraction, micro-structure is by promoting the mixing inside each liquid phase and two
Solute at intersection interface exchanges to promote laminar flow extraction efficiency.It, can by increasing supplementary structure in extracting microchip in laminar flow
To greatly improve liquid liquid layer stream extraction efficiency and shorten extraction time.
Specific embodiments of the present invention are explained in detail above in conjunction with attached drawing, but the present invention is not limited to above-mentioned realities
Example is applied, it within the knowledge of a person skilled in the art, can also be under the premise of present inventive concept not be departed from
Various changes can be made.
Claims (5)
1. based on chip lab microflow control technique micro-structure assisted extraction device, it is characterised in that：Including glass substrate（1）、
Chip（2）, liquid outlet I（3）, liquid outlet II（4）, fluid passage（5）, liquid-inlet I（6）, liquid-inlet II（7）；Institute
State chip（2）It is arranged on glass substrate（1）On, liquid outlet I（3）, liquid outlet II（4）, liquid-inlet I（6）, liquid-inlet
Ⅱ（7）It is arranged on chip（2）On, fluid passage（5）In chip（2）Interior and fluid passage（5）It is inside provided with several to right angle three
Angular supplementary structure I（5-1）, right angled triangle supplementary structure II（5-2）.
2. according to claim 1 based on chip lab microflow control technique micro-structure assisted extraction device, feature exists
In：The chip（2）, right angled triangle supplementary structure I（5-1）, right angled triangle supplementary structure II（5-2）Gathered using PDMS
Dimethyl siloxane material is made.
3. according to claim 1 based on chip lab microflow control technique micro-structure assisted extraction device, feature exists
In：It is described several to right angled triangle supplementary structure I（5-1）, right angled triangle supplementary structure II（5-2）In fluid passage（5）
Center line both sides are alternately distributed, pair and pair between period for 3mm, one of right angled triangle supplementary structure I in a cycle
（5-1）With another right angled triangle supplementary structure II（5-2）Level interval is 1mm, one of right angle three in a cycle
Angular supplementary structure I（5-1）With another right angled triangle supplementary structure II（5-2）Width direction spacing 200um.
4. according to claim 1 based on chip lab microflow control technique micro-structure assisted extraction device, feature exists
In：The chip（2）Long 100mm, wide 50mm, thick 10mm, liquid outlet I（3）, liquid outlet II（4）, liquid-inlet I（6）、
Liquid-inlet II（7）Diameter is 8mm；
The fluid passage（5）Long 30mm, high 150um, wide 600um, right angled triangle supplementary structure I（5-1）, right angled triangle
Supplementary structure II（5-2）Width is 100um, and length is 0.5mm, is highly 80um.
5. the method for micro-structure auxiliary extraction is carried out using claim 1-4 described devices, it is characterised in that：The tool of the method
Body step is：To liquid-inlet I（6）Middle injection organic phase, liquid-inlet II（7）Middle water phase of the injection containing target molecule, two
Kind liquid enters fluid passage（5）, flow through several to right angled triangle supplementary structure I（5-1）, right angled triangle supplementary structure II
（5-2）When generate disturbance, and then be sufficiently mixed and realize liquid-liquid extraction, wherein the organic phase containing target molecule is by liquid outlet
Ⅰ（3）Outflow, water phase is by liquid outlet II（4）Outflow.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711174732.2A CN108144659A (en) | 2017-11-22 | 2017-11-22 | Based on chip lab microflow control technique micro-structure assisted extraction device and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711174732.2A CN108144659A (en) | 2017-11-22 | 2017-11-22 | Based on chip lab microflow control technique micro-structure assisted extraction device and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108144659A true CN108144659A (en) | 2018-06-12 |
Family
ID=62468085
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711174732.2A Pending CN108144659A (en) | 2017-11-22 | 2017-11-22 | Based on chip lab microflow control technique micro-structure assisted extraction device and method |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108993337A (en) * | 2018-06-28 | 2018-12-14 | 昆明理工大学 | A kind of integrating device of drop fluid micro-reactor |
| CN109304050A (en) * | 2018-11-14 | 2019-02-05 | 昆明理工大学 | A kind of efficient auxiliary extraction integrating device and method |
| CN109331501A (en) * | 2018-10-16 | 2019-02-15 | 昆明理工大学 | A kind of pneumatic type assisted extraction device and method |
| CN109954525A (en) * | 2019-04-08 | 2019-07-02 | 广东药科大学 | It is a kind of for detecting the three-phase layer micro-fluidic chip and detection method of free drug concentration and blood medicine total concentration in blood simultaneously |
| CN111185029A (en) * | 2020-01-09 | 2020-05-22 | 昆明理工大学 | Multi-metal ion extraction device and method based on micro-fluidic chip and extraction rate calculation method |
| CN112557261A (en) * | 2020-12-07 | 2021-03-26 | 昆明理工大学 | Erythrocyte separation detection device and separation detection method based on C-shaped microcolumn |
| CN114425260A (en) * | 2020-10-29 | 2022-05-03 | 中国石油化工股份有限公司 | Liquid-liquid mixing device and mixing method |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100008183A1 (en) * | 2002-12-02 | 2010-01-14 | Cfd Research Corporation | Self-Cleaning and Mixing Microfluidic Elements |
| CN203002392U (en) * | 2012-12-25 | 2013-06-19 | 广东药学院 | Solid-phase extraction microfluidic analysis chip |
| CN103604797A (en) * | 2013-11-29 | 2014-02-26 | 重庆绿色智能技术研究院 | Micro-fluidic chip with surface-enhanced Raman activity and preparation method thereof |
| US20140099570A1 (en) * | 2012-10-08 | 2014-04-10 | National Tsing Hua University | Fuel Directing Reaction Device for Passive Fuel Cell |
| WO2014065861A1 (en) * | 2012-10-26 | 2014-05-01 | The Trustees Of The University Of Pennsylvania | Compositions, methods and microfluidics device for telomerase based in vitro diagnostic assays for detecting circulating tumor cells (ctc) |
| CN104820003A (en) * | 2015-05-13 | 2015-08-05 | 江苏大学 | Paper-based micro-fluidic system and method for detection of pesticide residues |
| CN105771763A (en) * | 2016-03-07 | 2016-07-20 | 东南大学 | High concentration gradient microfluidic mixing chip with jet flow damaging function |
| CN106215985A (en) * | 2016-07-26 | 2016-12-14 | 西安交通大学 | A kind of micro-fluidic chip quickly mixing for fluid and detecting |
| CN106215989A (en) * | 2016-08-22 | 2016-12-14 | 东南大学 | Device prepared by a kind of microemulsion rapid, high volume |
| CN106268472A (en) * | 2016-08-26 | 2017-01-04 | 苏州含光微纳科技有限公司 | A kind of inverted V-shaped for passive micro-mixer multistage mixing array structure |
-
2017
- 2017-11-22 CN CN201711174732.2A patent/CN108144659A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100008183A1 (en) * | 2002-12-02 | 2010-01-14 | Cfd Research Corporation | Self-Cleaning and Mixing Microfluidic Elements |
| US20140099570A1 (en) * | 2012-10-08 | 2014-04-10 | National Tsing Hua University | Fuel Directing Reaction Device for Passive Fuel Cell |
| WO2014065861A1 (en) * | 2012-10-26 | 2014-05-01 | The Trustees Of The University Of Pennsylvania | Compositions, methods and microfluidics device for telomerase based in vitro diagnostic assays for detecting circulating tumor cells (ctc) |
| CN203002392U (en) * | 2012-12-25 | 2013-06-19 | 广东药学院 | Solid-phase extraction microfluidic analysis chip |
| CN103604797A (en) * | 2013-11-29 | 2014-02-26 | 重庆绿色智能技术研究院 | Micro-fluidic chip with surface-enhanced Raman activity and preparation method thereof |
| CN104820003A (en) * | 2015-05-13 | 2015-08-05 | 江苏大学 | Paper-based micro-fluidic system and method for detection of pesticide residues |
| CN105771763A (en) * | 2016-03-07 | 2016-07-20 | 东南大学 | High concentration gradient microfluidic mixing chip with jet flow damaging function |
| CN106215985A (en) * | 2016-07-26 | 2016-12-14 | 西安交通大学 | A kind of micro-fluidic chip quickly mixing for fluid and detecting |
| CN106215989A (en) * | 2016-08-22 | 2016-12-14 | 东南大学 | Device prepared by a kind of microemulsion rapid, high volume |
| CN106268472A (en) * | 2016-08-26 | 2017-01-04 | 苏州含光微纳科技有限公司 | A kind of inverted V-shaped for passive micro-mixer multistage mixing array structure |
Non-Patent Citations (1)
| Title |
|---|
| 熊鹏辉: "液液萃取微流控芯片的制备工艺及应用研究", 《中国博士学位论文全文数据库 信息科技辑》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108993337A (en) * | 2018-06-28 | 2018-12-14 | 昆明理工大学 | A kind of integrating device of drop fluid micro-reactor |
| CN109331501A (en) * | 2018-10-16 | 2019-02-15 | 昆明理工大学 | A kind of pneumatic type assisted extraction device and method |
| CN109331501B (en) * | 2018-10-16 | 2021-09-17 | 昆明理工大学 | Pneumatic auxiliary extraction device and method |
| CN109304050A (en) * | 2018-11-14 | 2019-02-05 | 昆明理工大学 | A kind of efficient auxiliary extraction integrating device and method |
| CN109954525A (en) * | 2019-04-08 | 2019-07-02 | 广东药科大学 | It is a kind of for detecting the three-phase layer micro-fluidic chip and detection method of free drug concentration and blood medicine total concentration in blood simultaneously |
| CN109954525B (en) * | 2019-04-08 | 2021-07-20 | 广东药科大学 | Three-phase layer micro-fluidic chip for simultaneously detecting concentration of free drug and total concentration of blood drug in blood and detection method |
| CN111185029A (en) * | 2020-01-09 | 2020-05-22 | 昆明理工大学 | Multi-metal ion extraction device and method based on micro-fluidic chip and extraction rate calculation method |
| CN114425260A (en) * | 2020-10-29 | 2022-05-03 | 中国石油化工股份有限公司 | Liquid-liquid mixing device and mixing method |
| CN112557261A (en) * | 2020-12-07 | 2021-03-26 | 昆明理工大学 | Erythrocyte separation detection device and separation detection method based on C-shaped microcolumn |
| CN112557261B (en) * | 2020-12-07 | 2022-12-09 | 昆明理工大学 | Erythrocyte separation detection device and separation detection method based on C-shaped microcolumn |
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