CN109331501A - A kind of pneumatic type assisted extraction device and method - Google Patents
A kind of pneumatic type assisted extraction device and method Download PDFInfo
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- CN109331501A CN109331501A CN201811201203.1A CN201811201203A CN109331501A CN 109331501 A CN109331501 A CN 109331501A CN 201811201203 A CN201811201203 A CN 201811201203A CN 109331501 A CN109331501 A CN 109331501A
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- 238000000605 extraction Methods 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title claims abstract description 7
- 239000012530 fluid Substances 0.000 claims abstract description 103
- 239000007788 liquid Substances 0.000 claims abstract description 80
- 239000011521 glass Substances 0.000 claims abstract description 12
- 239000000758 substrate Substances 0.000 claims abstract description 11
- 230000000694 effects Effects 0.000 claims abstract description 5
- 239000012071 phase Substances 0.000 claims description 23
- 239000000463 material Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 6
- 239000007791 liquid phase Substances 0.000 claims description 5
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 5
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 5
- 206010016766 flatulence Diseases 0.000 claims description 3
- 230000000630 rising effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 1
- 238000013461 design Methods 0.000 abstract description 4
- 238000000622 liquid--liquid extraction Methods 0.000 abstract description 4
- 238000000638 solvent extraction Methods 0.000 abstract description 4
- 239000012074 organic phase Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000005611 electricity Effects 0.000 description 3
- 230000005501 phase interface Effects 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0446—Juxtaposition of mixers-settlers
- B01D11/0469—Juxtaposition of mixers-settlers with gas agitation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0484—Controlling means
Abstract
The invention discloses a kind of pneumatic type assisted extraction device and methods, belong to microfluidic art, the present invention includes fluid passage, liquid inlet I, two channel solenoid valves, two gas control pipeline micro-valves I, air-operated solenoid valve I, chip, liquid outlet, two gas control pipeline micro-valves II, gas control microring array room, air-operated solenoid valve II, control line of electromagnetic valve, liquid inlet II, glass substrate, the present invention is different from traditional reactor, its outstanding advantage is by designing the control micro-valve of supplementary structure and two sides inside fluid pipeline, gas control microring array room, in structure, fluid passage and air-control device design up and down, it can achieve better mixed effect, liquid-liquid extraction efficiency can greatly be improved and shorten extraction time.
Description
Technical field
The present invention relates to a kind of pneumatic type assisted extraction device and methods, belong to microfluidic art.
Background technique
Microfluidic device is widely used in the fields such as integrated electronic, precision instrument, Medical Devices and bio-pharmaceuticals, Microfluidizer
Part is suitble to the exploitation of various flow control systems, and control technology includes light, electricity, gas, magnetic, heat, gas phase variation etc..For testing
The design of chip structure on the glass substrate of room fluid processing, the structure is carried out by using COMSOL Multiphysics
Analogue simulation makes microchannel structure using PDMS material, can be restored to original state under certain deformation condition and
There is no permanent damages for structure.Minute fluid control valve (abbreviation miniature valve) be microfluidic control system critical component it
One, it is the Important Components of indispensable important component and microfluid on-off and traffic organising in micrometeor system.
Its performance directly affects the working condition of entire microfluidic control system.With miniature valve answering in every field extensively
With higher and higher to its attainable required precision of institute.
Summary of the invention
One of the objects of the present invention is to provide a kind of pneumatic type assisted extraction device, the present invention solves existing multiphase
The slow problem of liquid extraction low efficiency, reaction speed, the present invention are different from traditional reactor, and outstanding advantage is to pass through design
The control micro-valve of supplementary structure and two sides inside fluid pipeline, gas control microring array room, in structure, fluid passage and gas control
Device designs up and down, can achieve better mixed effect, can greatly improve liquid-liquid extraction efficiency and shorten extraction time.
The technical scheme is that a kind of pneumatic type assisted extraction device, including fluid passage, liquid inlet I, two
Channel solenoid valve, two gas control pipeline micro-valves I, air-operated solenoid valve I, chip, liquid outlet, two gas control pipeline micro-valves II, gas
Control microring array room, air-operated solenoid valve II, control line of electromagnetic valve, liquid inlet II, glass substrate；
The chip is placed on a glass substrate, and the chip is equipped with liquid inlet I, liquid inlet II, liquid outlet, described
Fluid passage is equipped in chip, one end of the fluid passage is equipped with two branched bottoms, the liquid inlet I, liquid inlet
II is connected to by branched bottom with one end of fluid passage respectively, and the upper and lower two sides of fluid passage one end are respectively equipped with channel
The other end of solenoid valve, fluid passage is connected to liquid outlet, and the lower section of the fluid passage is equipped with gas control microring array room, described
The upper/lower terminal of the fluid passage of gas control microring array room two sides is respectively equipped with gas control pipeline micro-valve I, gas control pipeline micro-valve II, institute
It states and is equipped with air-operated solenoid valve I, air-operated solenoid valve II in chip, and air-operated solenoid valve I, air-operated solenoid valve II are located at liquid and lead to
Above and below road, and the liquid that air-operated solenoid valve I controls gas control microring array room two sides by control line of electromagnetic valve respectively is logical
The gas control pipeline micro-valve I of road upper end, air-operated solenoid valve II control gas control microring array room two sides by control line of electromagnetic valve respectively
The gas control pipeline micro-valve II of fluid passage lower end.
Supplementary structure is equipped in the fluid passage, the supplementary structure includes more than one semi-cylindrical hill, respectively
It is arranged on the upper and lower inner wall of fluid passage, and the protrusion for being located at the supplementary structure of upper inner wall is downward, positioned at the auxiliary of lower inner wall
Upwards, the structure of the I gas control pipeline micro-valve II of gas control pipeline micro-valve is identical for the protrusion of structure, include controller I, one with
On gas pipeline, more than one diaphragm, the controller I is located on the outside of fluid passage, one above flue
Road, more than one diaphragm are respectively positioned in fluid passage, and one above diaphragm is located at more than one gas
The top of pipeline, the gas control pipeline micro-valve I and gas control pipeline micro-valve II are positioned opposite, i.e. the flue of gas control pipeline micro-valve I
The gas pipeline opposed in road and gas control pipeline micro-valve II, the gas control pipeline micro-valve I, one of gas control pipeline micro-valve II with
On gas pipeline, more than one diaphragm be located at fluid passage upper and lower inner wall supplementary structure it is more than one
Between semi-cylindrical hill.
Gas control microring array room includes micro- II, two controller II of gas chamber of two micro- gas chambers I, two, described two micro-
It is connected, is connected between described two micro- gas chambers II by pipeline, and set on one of them micro- gas chamber I by pipeline between gas chamber I
There is chamber inlet I, the inlet of chamber inlet I is equipped with controller II, one of them micro- gas chamber II is equipped with chamber inlet II, gas
The inlet of chamber inlet II is equipped with controller II, and the controller II of the inlet of the chamber inlet I passes through control line of electromagnetic valve
Connected with the controller II of air-operated solenoid valve I, II inlet of chamber inlet by control line of electromagnetic valve and air-operated solenoid valve II
It connects, the thickness h of described two micro- I, two micro- gas chamber II of gas chamber2It is 0.35mm, described two I, two micro- gas chamber of micro- gas chamber
II is spherical in shape when rising full of tympanites, and volume is 1mm3。
The chip, two micro- gas chambers, I, two micro- gas chamber II are all made of PDMS polydimethyl siloxane material and are made, material
Expect that translucency is good, convenient for observing the flow behavior of fluid when experiment, biocompatibility is good and good chemical inertness, the material
Toughness is relatively high, and elasticity is good, and durability and resistance to pressure are relatively high.The device uses simply, at low cost, is that one kind is widely used in
The polymer material in micro-fluidic equal fields.
The long 45mm of chip, wide 15mm, thick 5mm.
The liquid inlet I, liquid inlet II, liquid outlet diameter be 0.5mm, the wide d of fluid passage2For
0.5mm, high h3For 0.35mm, a length of 4mm of gas control microring array room, width d3For 3mm, high h3For 0.35mm, glass substrate thickness
For 0.1mm.
The length of described two I, two gas control pipeline micro-valve II of gas control pipeline micro-valve is 7mm, and wide is 0.3mm, Gao Jun
For 0.3mm.
The gas control pipeline micro-valve I, gas control pipeline micro-valve II controller I at a distance from fluid passage be 1 ~ 2mm.
The second object of the present invention is to provide a kind of method for carrying out auxiliary extraction using the device, and specific steps are such as
Under: water phase is injected to liquid inlet I first, after water phase is full of device, then injects organic phase into liquid inlet II, two enter
It can react to each other containing different chemical substance and the two respectively in oral fluid phase, by controlling liquid inlet I, liquid inlet II
Flow and speed can improve the two reaction efficiency in fluid passage, and the two sides of fluid passage is logical after the mixing of two-phase liquid
The size of flow in road solenoid valve control fluid passage, after the channel solenoid valves of the two sides of fluid passage, two channel electricity
The electromagnet of magnet valve attracts each other, to squeeze lower wall surface on fluid passage, realizes the size of flow in control fluid passage, gas
The controller that solenoid valve I controls the inlet of two gas control pipeline micro-valves I and chamber inlet I simultaneously is controlled, air-operated solenoid valve II is same
When control two gas control pipeline micro-valves II and chamber inlet II inlet controller, alternately to air-operated solenoid valve I, gas control electricity
Magnet valve II is powered, i.e., when two gas control pipeline micro-valves I and chamber inlet I work, two gas control pipeline micro-valves II and gas chamber enter
The controller of the inlet of mouth II does not work, at this point, the more than one gas pipeline of two gas control pipeline micro-valves I is full of gas
Body, more than one diaphragm are heaved downwards, two micro- I gassies of gas chamber, and when two gas control pipeline micro-valves II and gas chamber enter
When the controller work of the inlet of mouth II, two gas control pipeline micro-valves I and chamber inlet I do not work, at this point, two pneumatic tubes
The more than one gas pipeline gassy of road micro-valve II, more than one diaphragm are heaved upwards, and two micro- gas chambers II are full of
Gas, more than one diaphragm is alternately heaved and constitutes fluid passage two sides vortex and disturbance with supplementary structure, in addition, two micro-
The fluid passage above it is deformed after gas chamber I, two micro- II gassy of gas chamber, the extraction efficiency between accelerating liquid,
Reach better two-phase liquid extraction effect.
The present invention, which first gives in liquid inlet I 2, injects water phase, infuses after water phase is full of device, then into liquid inlet II 12
Enter organic phase, can react to each other containing different chemical substance and the two respectively in two entrances liquid phase, by controlling liquid
The flow and speed of entrance I 2 and liquid inlet II 12 can improve the two reaction efficiency in fluid passage 1, mixed in two-phase liquid
The two sides of fluid passage are equipped with channel solenoid valve 3 after conjunction, and wherein the electromagnet in channel solenoid valve 3 connects direct current, work as energization
The electromagnet of 1 two sides of fluid pipeline attracts each other afterwards, so that the chip thin films in liquid duct wall face are squeezed, to realize control liquid
The size of the flow of pipeline 1 carries out current limliting to the fluid in the channel, reduces the flow of pipeline, can achieve preferable micro-valve
Throttling action.
Two sides are equipped with pipeline supplementary structure 14 in fluid passage 1, and fluid present invention channel 1 is from input duct to liquid outlet
We improve the extraction efficiency of the device using increase pipeline supplementary structure 14 to internal mixing duct, after each supplementary structure
A small distance in produce vortex and disturbance so that stable laminar flow has occurred biggish disturbance, disturbance so that water phase and
Diffusion process of the target molecule from high concentration to low concentration is accelerated in organic phase.Therefore, semicircle supplementary structure not only promotes
Molecular motion of the target molecule in the vertical direction in each liquid phase, and enhance the transmitting of the target molecule at phase interface
Journey, to improve the extraction efficiency of liquid-liquid extraction significantly.
The gas in two micro- gas chambers, I 17, two micro- gas chambers II 18 of gas control microring array room 9 is controlled, to promote gas control
The vortex and disturbance of circulating liquid, the transmitting of the target molecule of reinforced phase interface in the fluid passage 1 of 9 top of microring array room
Journey.
Compared with prior art, the beneficial effects of the present invention are:
(1) present invention can efficiently promote two-phase liquid extraction efficiency, by fluid pipeline be arranged channel solenoid valve to
The size that can be very good the flow of control two-phase liquid carries out current limliting to the fluid in the channel, reduces the flow of pipeline, can
To reach preferable micro-valve throttling action.
(2) in fluid present invention pipeline two sides be equipped with supplementary structure, and the every two semi-cylindrical hill of supplementary structure it
Between an all corresponding gas pipeline can control in gas pipeline by the control to air-operated solenoid valve I, air-operated solenoid valve II
Gas, and air-operated solenoid valve I, II alternate energisation of air-operated solenoid valve, and make in fluid pipeline gas in the gas pipeline of two sides
Intersect filling, so that the diaphragm of two sides be made alternately to heave, plays the role of very strong flow-disturbing, substantially increase between two-phase liquid
Reaction efficiency.
(3) present invention below fluid pipeline by being provided with gas control microring array room, by the gas of gas control microring array room,
To improve the efficiency of liquid-liquid extraction in upper liquid channel, extraction time is shortened.
(4) present invention uses PDMS(dimethyl silicone polymer) material makes chip, and material translucency is good, biocompatibility
Good and good chemical inertness, the toughness of material is relatively high, and elasticity is good.
(5) device uses simple, at low cost, is a kind of polymer material for being widely used in micro-fluidic equal fields.
Detailed description of the invention
Fig. 1 is overall structure diagram of the invention；
Signal when Fig. 2 is supplementary structure and gas control pipeline micro-valve I, the gas supply of gas control pipeline micro-valve II in fluid present invention channel
Figure；
Schematic diagram when Fig. 3 is I stuffiness of gas control pipeline micro-valve of the present invention, gas control pipeline II stuffiness of micro-valve；
Fig. 4 is the structural schematic diagram of gas control microring array room；
Each label in figure: 1- fluid passage, the liquid inlet 2- I, the channel 3- solenoid valve, 4- gas control pipeline micro-valve I, 5- gas control electromagnetism
Valve I, 6- chip, 7- liquid outlet, 8- gas control pipeline micro-valve II, 9- gas control microring array room, 10- air-operated solenoid valve II, 11- electromagnetism
Valve control line, the liquid inlet 12- II, 13- glass substrate, 14- supplementary structure, 15- diaphragm, 16- gas pipeline, the micro- gas chamber of 17-
I, the micro- gas chamber II of 18-, 19- chamber inlet I, 20- chamber inlet II, 21- controller I, 22- controller II.
Specific embodiment
In the following with reference to the drawings and specific embodiments, the invention will be further described.
Embodiment 1: as shown in Figure 1, this pneumatic type assisted extraction device, including fluid passage 1, liquid inlet I 2, two
7, two 3, two gas control pipeline micro-valves I 4 of channel solenoid valve, air-operated solenoid valve I 5, chip 6, liquid outlet gas control pipeline micro-valves
II 8, gas control microring array room 9, air-operated solenoid valve II 10, control line of electromagnetic valve 11, liquid inlet II 12, glass substrate 13；
The chip 6 is placed in glass substrate 13, and the chip 6 is equipped with liquid inlet I 2, liquid inlet II 12, liquid discharge
Mouth 7, the chip 6 is interior to be equipped with fluid passage 1, and one end of the fluid passage 1 is equipped with two branched bottoms, the liquid inlet
I 2, liquid inlet II 12 is connected to by branched bottom with one end of fluid passage 1 respectively, and upper and lower the two of 1 one end of fluid passage
Side is respectively equipped with channel solenoid valve 3, and the other end of fluid passage 1 is connected to liquid outlet 7, and the lower section of the fluid passage 1 is set
There is gas control microring array room 9, it is micro- that the upper/lower terminal of the fluid passage 1 of 9 two sides of gas control microring array room is respectively equipped with gas control pipeline
Valve I 4, gas control pipeline micro-valve II 8, the chip 6 is interior to be equipped with air-operated solenoid valve I 5, air-operated solenoid valve II 10, and air-operated solenoid valve I
5, air-operated solenoid valve II 10 is located above and below fluid passage 1, and air-operated solenoid valve I 5 passes through control line of electromagnetic valve
11 control the gas control pipeline micro-valve I 4 of 1 upper end of fluid passage of 9 two sides of gas control microring array room respectively, and air-operated solenoid valve II 10 passes through
Control line of electromagnetic valve 11 controls the gas control pipeline micro-valve II 8 of 1 lower end of fluid passage of 9 two sides of gas control microring array room respectively.
It is equipped with supplementary structure 14 in the fluid passage 1, as shown in Fig. 2, the supplementary structure 14 includes multiple semicircles
Protrusion is arranged on the upper and lower inner wall of fluid passage 1, and two sides cross-distribution is uniform, and is located at the supplementary structure of upper inner wall
Downwards, the protrusion positioned at the supplementary structure 14 of lower inner wall is upward, the I 4 gas control pipeline micro-valve of gas control pipeline micro-valve for 14 protrusion
II 8 structure is identical, as shown in figure 3, including the gas pipeline 16,12 of controller I 21,12 diaphragm 15, the controller I
21 are located at 1 outside of fluid passage, and 12 gas pipelines, 16,12 diaphragms 15 are respectively positioned in fluid passage 1, and described 12
Diaphragm 15 is located at the top of 12 gas pipelines 16, and the gas control pipeline micro-valve I 4 is with gas control pipeline micro-valve II 8 with respect to cloth
It sets, i.e. 16 opposed of gas pipeline of the gas pipeline 16 of gas control pipeline micro-valve I 4 and gas control pipeline micro-valve II 8, the gas control
Pipeline micro-valve I 4, the gas pipeline 16 of gas control pipeline micro-valve II 8, diaphragm 15 are located at the auxiliary of the upper and lower inner wall of fluid passage 1
It helps between the adjacent two halves circular protrusions of structure 14.
As shown in figure 4, gas control microring array room 9 includes micro- gas chamber II 18, two control of two micro- gas chambers I 17, two
Device II 22 is connected by pipeline between described two micro- gas chambers I 17, by pipeline connection between described two micro- gas chambers II 18,
And one of them micro- gas chamber I 17 is equipped with chamber inlet I 19, the inlet of chamber inlet I 19 is equipped with controller II 22, wherein one
A micro- gas chamber II 18 is equipped with chamber inlet II 20, and the inlet of chamber inlet II 20 is equipped with controller II 22, and the gas chamber enters
The controller II 22 of the inlet of mouth I 19 is entered by control line of electromagnetic valve 11 and air-operated solenoid valve I 5, the chamber inlet II 20
Controller II 22 at mouthful is connect by control line of electromagnetic valve 11 with air-operated solenoid valve II 10, described two micro- gas chambers I 17, two
The thickness h of micro- gas chamber II 182It is 0.35mm, is in ball when described two I 17, two micro- gas chambers II 18 of micro- gas chamber rise full of tympanites
Shape, volume are 1mm3。
I 17, the two micro- gas chambers II 18 of micro- gas chamber of the chip 6, two are all made of PDMS polydimethyl siloxane material system
At.
The chip 6 is 45mm long, wide 15mm, thick 5mm.
The liquid inlet I 2, liquid inlet II 12, liquid outlet 7 diameter be 0.5mm, the fluid passage 1 is wide
d2For 0.5mm, high h3For 0.35mm, a length of 4mm of gas control microring array room 9, width d3For 3mm, high h3For 0.35mm, glass base
Piece 13 is with a thickness of 0.1mm.
The length of described two I 4, two gas control pipeline micro-valves II 8 of gas control pipeline micro-valve is 7mm, and wide is 0.3mm, high
It is 0.3mm.
The gas control pipeline micro-valve I 4, gas control pipeline micro-valve II 8 controller I 21 at a distance from fluid passage 1 for 1 ~
2mm。
The step of the present embodiment device auxiliary extraction, is as follows: injecting water phase to liquid inlet I 2 first, fills to water phase
After full device, then organic phase is injected into liquid inlet II 12, in two entrances liquid phase respectively containing different chemical substances and
The two can react to each other, and by control liquid inlet I 2, II 12 flow of liquid inlet and speed, can mention in fluid passage 1
Both high reaction efficiency, the channel solenoid valve 3 of the two sides of fluid passage 1, which controls in fluid passage 1, after the mixing of two-phase liquid flows
The size of amount, after the channel solenoid valve 3 of the two sides of fluid passage 1 is powered, the electromagnet of two channel solenoid valves 3 attracts each other,
To squeeze lower wall surface on fluid passage 1, the size of flow in control fluid passage 1 is realized, and in addition to micro- gas on fluid passage 1
Outside room 9, supplementary structure is designed with from import to outlet to increase disturbance two-phase liquid mixing.Air-operated solenoid valve I 5 controls two simultaneously
The controller 22 of the inlet of a gas control pipeline micro-valve I 4 and chamber inlet I 19, air-operated solenoid valve II 10 control two gas simultaneously
The controller 22 of the inlet of keyholed back plate road micro-valve II 8 and chamber inlet II 20, alternately to air-operated solenoid valve I 5, air-operated solenoid valve II
10 are powered, i.e., when two gas control pipeline micro-valves I 4 and chamber inlet I 19 work, two gas control pipeline micro-valves II 8 and gas chamber enter
The controller 22 of the inlet of mouth II 20 does not work, at this point, 16 gassy of each gas pipeline of two gas control pipeline micro-valves I 4,
Each diaphragm 15 is heaved downwards, two micro- I 17 gassies of gas chamber, and when two gas control pipeline micro-valves II 8 and chamber inlet II 20
Inlet controller II 22 work when, two gas control pipeline micro-valves I 4 and chamber inlet I 19 do not work, at this point, two gas
16 gassy of each gas pipeline of keyholed back plate road micro-valve II 8, each diaphragm 15 are heaved upwards, two micro- II 18 gassies of gas chamber,
Each diaphragm 15 is alternately heaved and constitutes 1 two sides of fluid passage vortex and disturbance with supplementary structure 14, in addition, two micro- gas chambers I 17,
Upward thrust is generated to the fluid passage 1 above it after two micro- II 18 gassies of gas chamber, becomes 1 flow velocity of fluid passage
It is small, reach better two-phase liquid extraction effect.
It is analyzed in the microchannel of supplementary structure by COMSOL Multiphysics Finite Element Simulation software
The streamline and vector of fluid are distributed, and supplementary structure is by promoting the mixing inside each liquid phase and the solute exchange at two intersection interfaces
To promote laminar flow extraction efficiency.Increase supplementary structure and air-control device in microchip by extracting in laminar flow, it can be greatly
Improve the extraction efficiency of liquid liquid layer stream extraction.
Specific embodiments of the present invention are explained in detail above in conjunction with attached drawing, but the present invention is not limited to above-mentioned realities
Example is applied, it within the knowledge of a person skilled in the art, can also be without departing from the purpose of the present invention
Various changes can be made.
Claims (9)
1. a kind of pneumatic type assisted extraction device, which is characterized in that including fluid passage (1), liquid inlet I (2), two channels
Solenoid valve (3), two gas control pipeline micro-valves I (4), air-operated solenoid valve I (5), chip (6), liquid outlet (7), two pneumatic tubes
Road micro-valve II (8), gas control microring array room (9), air-operated solenoid valve II (10), control line of electromagnetic valve (11), liquid inlet II (12),
Glass substrate (13)；
The chip (6) is placed on glass substrate (13), and the chip (6) is equipped with liquid inlet I (2), liquid inlet II
(12), liquid outlet (7), the chip (6) is interior to be equipped with fluid passage (1), and one end of the fluid passage (1) is equipped with two points
Subchannel, the liquid inlet I (2), liquid inlet II (12) are connected by one end of branched bottom and fluid passage (1) respectively
It is logical, and the upper and lower two sides of fluid passage (1) one end are respectively equipped with channel solenoid valve (3), the other end and liquid of fluid passage (1)
Body exports (7) connection, and the lower section of the fluid passage (1) is equipped with gas control microring array room (9), gas control microring array room (9) two
The upper/lower terminal of the fluid passage (1) of side is respectively equipped with gas control pipeline micro-valve I (4), gas control pipeline micro-valve II (8), the chip
(6) air-operated solenoid valve I (5), air-operated solenoid valve II (10), and air-operated solenoid valve I (5), air-operated solenoid valve II (10) point are equipped in
Wei Yu not be above and below fluid passage (1), and air-operated solenoid valve I (5) controls gas by control line of electromagnetic valve (11) respectively
The gas control pipeline micro-valve I (4) of fluid passage (1) upper end of microring array room (9) two sides is controlled, air-operated solenoid valve II (10) passes through electromagnetism
Valve control line (11) controls the gas control pipeline micro-valve II (8) of fluid passage (1) lower end of gas control microring array room (9) two sides respectively.
2. efficient air dynamic formula assisted extraction device according to claim 1, it is characterised in that: in the fluid passage (1)
Equipped with supplementary structure (14), the supplementary structure (14) includes more than one semi-cylindrical hill, is arranged in fluid passage
(1) on upper and lower inner wall, and the protrusion for being located at the supplementary structure (14) of upper inner wall is downward, positioned at the supplementary structure of lower inner wall
(14) upwards, the structure of I (4) gas control pipeline micro-valve II (8) of gas control pipeline micro-valve is identical for protrusion, includes controller I
(21), more than one gas pipeline (16), more than one diaphragm (15), the controller I (21) are located at fluid passage (1)
Outside, one above gas pipeline (16), more than one diaphragm (15) are respectively positioned in fluid passage (1), and described
More than one diaphragm (15) is located at the top of more than one gas pipeline (16), the gas control pipeline micro-valve I (4) with
II (8) of gas control pipeline micro-valve are positioned opposite, i.e. the gas pipeline (16) of gas control pipeline micro-valve I (4) and gas control pipeline micro-valve II (8)
Gas pipeline (16) opposed, the gas control pipeline micro-valve I (4), gas control pipeline micro-valve II (8) gas pipeline (16),
Diaphragm (15) is located between the adjacent two halves circular protrusions of the supplementary structure (14) of the upper and lower inner wall of fluid passage (1).
3. efficient air dynamic formula assisted extraction device according to claim 1, it is characterised in that: gas control microring array room
It (9) include two micro- gas chambers I (17), two micro- gas chambers II (18), two controllers II (22), described two micro- gas chambers I (17)
Between connected by pipeline, by pipeline connection between described two micro- gas chambers II (18), and on one of them micro- gas chamber I (17)
Equipped with chamber inlet I (19), the inlet of chamber inlet I (19) is equipped with controller II (22), one of them micro- gas chamber II (18)
It is equipped with chamber inlet II (20), the inlet of chamber inlet II (20) is equipped with controller II (22), the chamber inlet I (19)
The controller II (22) of inlet pass through control line of electromagnetic valve (11) and air-operated solenoid valve I (5), the chamber inlet II (20)
The controller II (22) of inlet is connect by control line of electromagnetic valve (11) with air-operated solenoid valve II (10), described two micro- gas chambers
I (17), two micro- gas chambers II (18) thickness h2It is 0.35mm, described two micro- gas chambers I (17), two micro- gas chambers II (18)
Spherical in shape when rising full of tympanites, volume is 1mm3。
4. efficient air dynamic formula assisted extraction device according to claim 3, it is characterised in that: the chip (6), two it is micro-
Gas chamber I (17), two micro- gas chambers II (18) are all made of PDMS polydimethyl siloxane material and are made.
5. efficient air dynamic formula assisted extraction device according to claim 1, it is characterised in that: the long 45mm of the chip (6),
Wide 15mm, thick 5mm.
6. efficient air dynamic formula assisted extraction device according to claim 1, it is characterised in that: the liquid inlet I (2),
Liquid inlet II (12), liquid outlet (7) diameter be 0.5mm, fluid passage (1) the width d2For 0.5mm, high h3For
0.35mm, a length of 4mm of gas control microring array room (9), width d3For 3mm, high h3For 0.35mm, glass substrate (13) thickness h1For
0.1mm。
7. efficient air dynamic formula assisted extraction device according to claim 1, it is characterised in that: described two gas control pipelines are micro-
Valve I (4), two gas control pipeline micro-valves II (8) length be 7mm, wide is 0.3mm, and height is 0.3mm.
8. efficient air dynamic formula assisted extraction device according to claim 2, it is characterised in that: the gas control pipeline micro-valve I
(4), the controller I (21) of gas control pipeline micro-valve II (8) is 1 ~ 2mm at a distance from fluid passage (1).
9. the method for efficient air dynamic formula assisted extraction device auxiliary extraction described in claim 1 ~ 8, which is characterized in that specific step
It is rapid as follows: to inject water phase to liquid inlet I (2) first, be injected with after water phase is full of device, then into liquid inlet II (12)
Machine phase can react to each other respectively containing different chemical substance and the two in two entrances liquid phase, pass through control liquid inlet I
(2), liquid inlet II (12) flow and speed can improve the two reaction efficiency in fluid passage (1), mix in two-phase liquid
The size of channel solenoid valve (3) control fluid passage (1) interior flow of the two sides of fluid passage (1) afterwards, the two of fluid passage (1)
After the channel solenoid valve (3) of side is powered, the electromagnet of two channel solenoid valves (3) attracts each other, to squeeze fluid passage (1)
Upper lower wall surface realizes the size of control fluid passage (1) interior flow, and it is micro- that air-operated solenoid valve I (5) controls two gas control pipelines simultaneously
The controller II (22) of the inlet of valve I (4) and chamber inlet I (19), air-operated solenoid valve II (10) control two gas controls simultaneously
The controller II (22) of the inlet of pipeline micro-valve II (8) and chamber inlet II (20), alternately to air-operated solenoid valve I (5), gas control
Solenoid valve II (10) is powered, i.e., when two gas control pipeline micro-valves I (4) and chamber inlet I (19) work, two gas control pipelines are micro-
The controller (22) of the inlet of valve II (8) and chamber inlet II (20) does not work, at this point, two gas control pipeline micro-valves I (4)
More than one gas pipeline (16) gassy, more than one diaphragm (15) are heaved downwards, and two micro- gas chambers I (17) are full of
Gas, and when the work of the controller (22) of two gas control pipeline micro-valves II (8) and the inlet of chamber inlet II (20), two
Gas control pipeline micro-valve I (4) and chamber inlet I (19) do not work, at this point, two gas control pipeline micro-valves II (8) is more than one
Gas pipeline (16) gassy, more than one diaphragm (15) are heaved upwards, two micro- gas chamber II (18) gassies, and one
Above diaphragm (15) is alternately heaved and same supplementary structure (14) constitutes fluid passage (1) two sides vortex and disturbance, in addition, two
Upward thrust is generated after micro- gas chamber I (17), two micro- gas chamber II (18) gassies to the fluid passage (1) above it, is made
Fluid passage (1) flow velocity becomes smaller, and reaches better two-phase liquid extraction effect.
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| CN102459565A (en) * | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | Fluidic devices with diaphragm valves |
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| CN102459565A (en) * | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | Fluidic devices with diaphragm valves |
| CN103861668A (en) * | 2012-12-17 | 2014-06-18 | 中国科学院沈阳自动化研究所 | Microfluidic chip based on pneumatic micro pumps and micro mixer |
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