CN109331501B - Pneumatic auxiliary extraction device and method - Google Patents
Pneumatic auxiliary extraction device and method Download PDFInfo
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- CN109331501B CN109331501B CN201811201203.1A CN201811201203A CN109331501B CN 109331501 B CN109331501 B CN 109331501B CN 201811201203 A CN201811201203 A CN 201811201203A CN 109331501 B CN109331501 B CN 109331501B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0446—Juxtaposition of mixers-settlers
- B01D11/0469—Juxtaposition of mixers-settlers with gas agitation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0484—Controlling means
Abstract
The invention discloses a pneumatic auxiliary extraction device and a method, belonging to the technical field of microfluidics, and comprising a liquid channel, a liquid inlet I, two channel electromagnetic valves, two pneumatic control pipeline micro valves I, a pneumatic control electromagnetic valve I, a chip, a liquid outlet, two pneumatic control pipeline micro valves II, a pneumatic control micro mixing chamber, a pneumatic control electromagnetic valve II, an electromagnetic valve control line, a liquid inlet II and a glass substrate.
Description
Technical Field
The invention relates to a pneumatic auxiliary extraction device and method, and belongs to the technical field of microfluidics.
Background
The microfluidic device is widely applied to the fields of integrated electronics, precision instruments, medical equipment, biopharmaceuticals and the like, and is suitable for the development of various flow control systems, and the control technologies of the microfluidic device comprise optical, electrical, gas, magnetic, thermal, gas phase change and the like. A chip structure on a glass substrate for laboratory fluid treatment, which is designed by using COMSOL Multiphysics to perform simulation, and adopting PDMS material to manufacture a micro-channel structure, can be restored to an original state under a certain deformation condition without permanent damage to the structure. The micro fluid control valve (micro valve for short) is one of the key components of the micro fluid control system, is an indispensable important component in the micro fluid system, and is also an important component for controlling the on-off and flow direction of the micro fluid. Its performance directly affects the operation of the entire microfluidic control system. With the wide application of micro valves in various fields, the precision requirement for the micro valves is higher and higher.
Disclosure of Invention
The invention aims to provide a pneumatic auxiliary extraction device, which solves the problems of low extraction efficiency and low reaction speed of the traditional multiphase liquid, is different from the traditional reactor, and has the outstanding advantages that through designing an auxiliary structure in a liquid pipeline, control micro valves at two sides and a pneumatic micro mixing chamber, and structurally, designing a liquid channel and a pneumatic device up and down, a better mixing effect can be achieved, the liquid-liquid extraction efficiency can be greatly improved, and the extraction time can be greatly shortened.
The technical scheme of the invention is as follows: a pneumatic auxiliary extraction device comprises a liquid channel, a liquid inlet I, two channel electromagnetic valves, two pneumatic control pipeline micro valves I, a pneumatic control electromagnetic valve I, a chip, a liquid outlet, two pneumatic control pipeline micro valves II, a pneumatic control micro mixing chamber, a pneumatic control electromagnetic valve II, an electromagnetic valve control line, a liquid inlet II and a glass substrate;
the chip is placed on a glass substrate, a liquid inlet I, a liquid inlet II and a liquid outlet are arranged on the chip, a liquid channel is arranged in the chip, one end of the liquid channel is provided with two branch channels, the liquid inlet I and the liquid inlet II are respectively communicated with one end of the liquid channel through the branch channels, the upper side and the lower side of one end of the liquid channel are respectively provided with a channel electromagnetic valve, the other end of the liquid channel is communicated with the liquid outlet, a pneumatic control micro mixing chamber is arranged below the liquid channel, the upper end and the lower end of the liquid channel on the two sides of the pneumatic control micro mixing chamber are respectively provided with a pneumatic control pipeline micro valve I and a pneumatic control pipeline micro valve II, a pneumatic control electromagnetic valve I and a pneumatic control electromagnetic valve II are arranged in the chip, the pneumatic control electromagnetic valve I and the pneumatic control electromagnetic valve II are respectively positioned above and below the liquid channel, and the pneumatic control electromagnetic valve I controls the pneumatic control micro valve I and the pneumatic control pipeline micro valve II on the upper end of the liquid channel on the two sides of the pneumatic control micro mixing chamber through an electromagnetic control line And the pneumatic control solenoid valve II respectively controls a pneumatic control pipeline micro valve II at the lower end of the liquid channel at two sides of the pneumatic control micro mixing chamber through a solenoid valve control line.
Be equipped with auxiliary structure in the liquid passage, auxiliary structure includes more than one semi-circular arch, arranges respectively on liquid passage's upper and lower inner wall, and the protruding of the auxiliary structure that is located the inner wall is downward, and the protruding of the auxiliary structure that is located the inner wall is upwards down, pneumatic control pipeline micro valve I is the same with pneumatic control pipeline micro valve II's structure, all includes controller I, more than one gas duct, more than one diaphragm, controller I is located the liquid passage outside, more than one gas duct, more than one diaphragm all are located liquid passage, just more than one diaphragm is located the top of more than one gas duct respectively, pneumatic control pipeline micro valve I and pneumatic control pipeline micro valve II relative arrangement, that is the gas duct of pneumatic control pipeline micro valve I and the gas duct of pneumatic control pipeline micro valve II arrange conversely, pneumatic control pipeline micro valve I, More than one gas pipeline and more than one diaphragm of the pneumatic control pipeline micro valve II are respectively positioned between more than one semicircular bulges of the auxiliary structures on the upper inner wall and the lower inner wall of the liquid channel.
The little mixing chamber of gas accuse includes two little air chambers I, two little air chambers II, two controllers II, pass through the pipe connection between two little air chambers I, pass through the pipe connection between two little air chambers II, and be equipped with air chamber entry I on one of them little air chamber I, the entrance of air chamber entry I is equipped with controller II, is equipped with air chamber entry II on one of them little air chamber II, and the entrance of air chamber entry II is equipped with controller II, controller II of the entrance of air chamber entry I passes through the solenoid valve control line and is connected with gas accuse solenoid valve I, controller II of the entrance of air chamber entry II is connected with gas accuse solenoid valve II through the solenoid valve control line, the thickness h of two little air chambers I, two little air chambers II2Are all 0.35mm, the two micro air chambers I and II are spherical when being filled with the air drum, and the volume is 1mm3。
The chip, the two micro air chambers I and the two micro air chambers II are all made of PDMS polydimethylsiloxane materials, the material is good in light transmission, the flowing characteristic of fluid can be observed conveniently in an experiment, biocompatibility is good, chemical inertia is good, the material is high in toughness, elasticity is good, and durability and pressure resistance are high. The device is simple to use and low in cost, and is a polymer material widely applied to the fields of microfluidics and the like.
The chip is 45mm long, 15mm wide and 5mm thick.
The diameters of the liquid inlet I, the liquid inlet II and the liquid outlet are all 0.5mm, and the width d of the liquid channel2Is 0.5mm and has a height h20.35mm, the length of the air-controlled micro-mixing chamber is 4mm, and the width d3Is 3mm and high h30.35mm and the thickness of the glass substrate is 0.1 mm.
The two pneumatic control pipeline micro valves I and the two pneumatic control pipeline micro valves II are 7mm in length, 0.3mm in width and 0.3mm in height.
The distance between the controller I of the pneumatic control pipeline micro valve I and the controller I of the pneumatic control pipeline micro valve II and the liquid channel is 1-2 mm.
The invention also aims to provide a method for auxiliary extraction by using the device, which comprises the following specific steps: firstly, injecting a water phase into a liquid inlet I, then injecting an organic phase into a liquid inlet II after the water phase is filled with a device, wherein the two inlet liquid phases respectively contain different chemical substances and can react with each other, the reaction efficiency of the two inlet liquid phases can be improved in a liquid channel by controlling the flow and the speed of the liquid inlet I and the liquid inlet II, channel electromagnetic valves on two sides of the liquid channel control the flow in the liquid channel after the two phases of liquid are mixed, electromagnets of the two channel electromagnetic valves attract each other after the channel electromagnetic valves on two sides of the liquid channel are electrified, so that the upper wall surface and the lower wall surface of the liquid channel are squeezed, the flow in the liquid channel is controlled, the air control electromagnetic valve I simultaneously controls a controller II at the inlets of two air control pipeline micro valves I and a controller II at the inlet of an air chamber inlet II, alternately electrifying the pneumatic control solenoid valve I and the pneumatic control solenoid valve II, namely when the two pneumatic control pipeline micro valves I and the air chamber inlet I work, the controller II at the inlets of the two pneumatic control pipeline micro valves II and the air chamber inlet II does not work, at the moment, more than one air pipeline of the two pneumatic control pipeline micro valves I is filled with air, more than one diaphragm is bulged downwards, the two micro air chambers I are filled with air, when the controller II at the inlets of the two pneumatic control pipeline micro valves II and the air chamber inlet II works, the two pneumatic control pipeline micro valves I and the air chamber inlet I do not work, at the moment, more than one air pipeline of the two pneumatic control pipeline micro valves II is filled with air, more than one diaphragm is bulged upwards, the two micro air chambers II are filled with air, more than one diaphragm is bulged alternately and forms vortexes and disturbances at two sides of the liquid channel with an auxiliary structure, in addition, the two micro air chambers I, II are filled with air, the controller II is filled with air, and the controller II is filled with the air, After the two micro air chambers II are filled with gas, the liquid channel above the micro air chambers II is deformed, so that the extraction efficiency between liquids is accelerated, and a better two-phase liquid extraction effect is achieved.
The invention firstly injects water phase into a liquid inlet I2, and then injects organic phase into a liquid inlet II 12 after the water phase is filled with a device, the two inlet liquid phases respectively contain different chemical substances and can react with each other, the reaction efficiency of the two inlet liquid phases can be improved in a liquid channel 1 by controlling the flow and the speed of the liquid inlet I2 and the liquid inlet II 12, channel electromagnetic valves 3 are arranged at two sides of the liquid channel after the two-phase liquid is mixed, wherein electromagnets in the channel electromagnetic valves 3 are connected with direct current, and the electromagnets at two sides of the liquid channel 1 are mutually attracted after being electrified, so that a chip film on the wall surface of the liquid channel is extruded, the flow of the liquid channel 1 is controlled, the flow of the channel is limited, the flow of the channel is reduced, and better micro-valve throttling effect can be achieved.
Pipeline auxiliary structures 14 are arranged on two sides in the liquid channel 1, the extraction efficiency of the device is improved by adding the pipeline auxiliary structures 14 to a mixing pipeline from a liquid inlet pipeline to the interior of a liquid outlet of the liquid channel 1, a small distance behind each auxiliary structure generates vortex and disturbance, so that stable laminar flow is greatly disturbed, and the disturbance accelerates the diffusion process of target molecules in a water phase and an organic phase from high concentration to low concentration. Therefore, the semicircular auxiliary structure not only promotes the molecular motion of the target molecules in the vertical direction in each liquid phase, but also enhances the transfer process of the target molecules at the phase interface, thereby remarkably improving the extraction efficiency of liquid-liquid extraction.
And controlling the gas in the two micro gas chambers I17 and II 18 of the pneumatic control micro mixing chamber 9, thereby promoting the vortex and disturbance of the circulating liquid in the liquid channel 1 above the pneumatic control micro mixing chamber 9 and enhancing the transfer process of the target molecules at the phase interface.
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention can efficiently improve the extraction efficiency of the two-phase liquid, can well control the flow of the two-phase liquid by arranging the channel electromagnetic valve on the liquid pipeline, limits the flow of the fluid in the channel, reduces the flow of the pipeline and can achieve better throttling effect of the micro valve.
(2) According to the invention, the auxiliary structures are arranged in two sides of the liquid pipeline, each two semicircular bulges of the auxiliary structures correspond to one gas pipeline, gas in the gas pipelines can be controlled by controlling the pneumatic control electromagnetic valve I and the pneumatic control electromagnetic valve II, and the pneumatic control electromagnetic valves I and the pneumatic control electromagnetic valves II are alternately electrified, so that the gas in the gas pipelines on two sides in the liquid pipeline is alternately filled, the diaphragms on two sides are alternately bulged, a strong turbulence effect is achieved, and the reaction efficiency between two phases of liquid is greatly improved.
(3) According to the invention, the pneumatic control micro mixing chamber is arranged below the liquid pipeline, and the gas in the pneumatic control micro mixing chamber is used, so that the efficiency of liquid-liquid extraction in the upper liquid channel is improved, and the extraction time is shortened.
(4) The chip is made of PDMS (polydimethylsiloxane) material, the material has good light transmission, good biocompatibility and good chemical inertness, and the material has high toughness and good elasticity.
(5) The device is simple to use and low in cost, and is a polymer material widely applied to the fields of microfluidics and the like.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic diagram of the auxiliary structure in the liquid channel, and the pneumatic control pipeline micro valve I and the pneumatic control pipeline micro valve II for air supply;
FIG. 3 is a schematic diagram of the pneumatic control pipeline micro valve I and the pneumatic control pipeline micro valve II when the pneumatic control pipeline micro valve I and the pneumatic control pipeline micro valve II are not ventilated;
FIG. 4 is a schematic diagram of a pneumatically controlled micro-mixing chamber;
the reference numbers in the figures: 1-liquid channel, 2-liquid inlet I, 3-channel electromagnetic valve, 4-pneumatic control pipeline micro valve I, 5-pneumatic control electromagnetic valve I, 6-chip, 7-liquid outlet, 8-pneumatic control pipeline micro valve II, 9-pneumatic control micro mixing chamber, 10-pneumatic control electromagnetic valve II, 11-electromagnetic valve control line, 12-liquid inlet II, 13-glass substrate, 14-auxiliary structure, 15-diaphragm, 16-gas pipeline, 17-micro gas chamber I, 18-micro gas chamber II, 19-gas chamber inlet I, 20-gas chamber inlet II, 21-controller I, 22-controller II.
Detailed Description
The invention is further described with reference to the following figures and specific examples.
Example 1: as shown in fig. 1, the pneumatic auxiliary extraction device comprises a liquid channel 1, a liquid inlet I2, two channel electromagnetic valves 3, two pneumatic control pipeline micro valves I4, a pneumatic control electromagnetic valve I5, a chip 6, a liquid outlet 7, two pneumatic control pipeline micro valves II 8, a pneumatic control micro mixing chamber 9, a pneumatic control electromagnetic valve II 10, an electromagnetic valve control line 11, a liquid inlet II 12 and a glass substrate 13;
the chip 6 is placed on a glass substrate 13, a liquid inlet I2, a liquid inlet II 12 and a liquid outlet 7 are arranged on the chip 6, a liquid channel 1 is arranged in the chip 6, two branch channels are arranged at one end of the liquid channel 1, the liquid inlet I2 and the liquid inlet II 12 are respectively communicated with one end of the liquid channel 1 through the branch channels, a channel electromagnetic valve 3 is respectively arranged at the upper side and the lower side of one end of the liquid channel 1, the other end of the liquid channel 1 is communicated with the liquid outlet 7, a pneumatic control micro mixing chamber 9 is arranged below the liquid channel 1, a pneumatic control pipeline micro valve I4 and a pneumatic control pipeline micro valve II 8 are respectively arranged at the upper end and the lower end of the liquid channel 1 at two sides of the pneumatic control micro mixing chamber 9, a pneumatic control electromagnetic valve I5 and an pneumatic control electromagnetic valve II 10 are arranged in the chip 6, and the pneumatic control electromagnetic valve I5 and the pneumatic control electromagnetic valve II 10 are respectively positioned above and below the liquid channel 1, and the pneumatic control solenoid valve I5 respectively controls a pneumatic control pipeline micro valve I4 at the upper end of the liquid channel 1 at two sides of the pneumatic control micro mixing chamber 9 through a solenoid valve control line 11, and the pneumatic control solenoid valve II 10 respectively controls a pneumatic control pipeline micro valve II 8 at the lower end of the liquid channel 1 at two sides of the pneumatic control micro mixing chamber 9 through a solenoid valve control line 11.
An auxiliary structure 14 is arranged in the liquid channel 1, as shown in fig. 2, the auxiliary structure 14 comprises a plurality of semicircular bulges which are respectively arranged on the upper inner wall and the lower inner wall of the liquid channel 1, the two sides of the semicircular bulges are uniformly distributed in a crossed manner, the bulge of the auxiliary structure 14 positioned on the upper inner wall faces downwards, the bulge of the auxiliary structure 14 positioned on the lower inner wall faces upwards, the structure of the pneumatic control pipeline micro valve I4 pneumatic control pipeline micro valve II 8 is the same, as shown in fig. 3, the auxiliary structure comprises controllers I21, 12 gas pipelines 16 and 12 membranes 15, the controller I21 is positioned outside the liquid channel 1, the 12 gas pipelines 16 and 12 membranes 15 are positioned in the liquid channel 1, the 12 membranes 15 are respectively positioned above the 12 gas pipelines 16, the pneumatic control pipeline micro valve I4 and the pneumatic control pipeline micro valve II 8 are oppositely arranged, namely the gas pipeline 16 of the pneumatic control pipeline micro valve I4 and the gas pipeline 16 of the pneumatic control pipeline micro valve II 8 are oppositely arranged, the pneumatic control pipeline micro valve I4, the gas pipeline 16 of the pneumatic control pipeline micro valve II 8 and the diaphragm 15 are respectively positioned between two adjacent semicircular bulges of the auxiliary structure 14 on the upper inner wall and the lower inner wall of the liquid channel 1.
As shown in fig. 4, the air-controlled micro mixing chamber 9 comprises two micro air chambers I17, two micro air chambers II 18 and two controllers II 22, the two micro air chambers I17 are connected through a pipeline, the two micro air chambers II 18 are connected through a pipeline, an air chamber inlet I19 is formed in one micro air chamber I17, a controller II 22 is arranged at an inlet of the air chamber inlet I19, an air chamber inlet II 20 is formed in one micro air chamber II 18, a controller II 22 is arranged at an inlet of the air chamber inlet II 20, the controller II 22 at the inlet of the air chamber inlet I19 is connected with an air-controlled electromagnetic valve I5 through an electromagnetic valve control line 11, the controller II 22 at the inlet of the air chamber inlet II 20 is connected with an air-controlled electromagnetic valve II 10 through an electromagnetic valve control line 11, and the thicknesses h of the two micro air chambers I17 and the two micro air chambers II 182Are all 0.35mm, the two micro air chambers I17 and II 18 are spherical when being filled with air bubbles, and the volume is 1mm3。
The chip 6, the two micro air chambers I17 and the two micro air chambers II 18 are all made of PDMS polydimethylsiloxane materials.
The chip 6 is 45mm long, 15mm wide and 5mm thick.
The diameters of the liquid inlet I2, the liquid inlet II 12 and the liquid outlet 7 are all 0.5mm, and the width d of the liquid channel 12Is 0.5mm and has a height h30.35mm, the length of the air-controlled micro-mixing chamber 9 is 4mm, and the width d3Is 3mm and high h30.35mm and the glass substrate 13 has a thickness of 0.1 mm.
The two pneumatic control pipeline micro valves I4 and II 8 are 7mm in length, 0.3mm in width and 0.3mm in height.
The distance between the controller I21 of the pneumatic control pipeline micro valve I4 and the controller I21 of the pneumatic control pipeline micro valve II 8 and the liquid channel 1 is 1-2 mm.
The steps of the device of the embodiment for auxiliary extraction are as follows: firstly, injecting a water phase into a liquid inlet I2, injecting an organic phase into a liquid inlet II 12 after the water phase is filled in a device, wherein the two inlet liquid phases respectively contain different chemical substances and can react with each other, the reaction efficiency of the two inlet liquid phases can be improved in a liquid channel 1 by controlling the flow and the speed of the liquid inlet I2 and the liquid inlet II 12, the flow in the liquid channel 1 is controlled by channel electromagnetic valves 3 at two sides of the liquid channel 1 after the two-phase liquid is mixed, and electromagnets of the two channel electromagnetic valves 3 are mutually attracted after the channel electromagnetic valves 3 at two sides of the liquid channel 1 are electrified, so that the upper wall surface and the lower wall surface of the liquid channel 1 are squeezed, the flow in the liquid channel 1 is controlled, and the liquid channel 1 is provided with an auxiliary structure from an inlet to an outlet to increase and disturb the mixing of the two-phase liquid except for a micro air chamber 9. The pneumatic control solenoid valve I5 simultaneously controls the two pneumatic control pipeline micro valves I4 and the controller 22 at the inlet of the air chamber inlet I19, the pneumatic control solenoid valve II 10 simultaneously controls the two pneumatic control pipeline micro valves II 8 and the controller 22 at the inlet of the air chamber inlet II 20, the pneumatic control solenoid valve I5 and the pneumatic control solenoid valve II 10 are alternately electrified, namely when the two pneumatic control pipeline micro valves I4 and the air chamber inlet I19 work, the controllers 22 at the inlets of the two pneumatic control pipeline micro valves II 8 and the air chamber inlet II 20 do not work, at the moment, each air pipeline 16 of the two pneumatic control pipeline micro valves I4 is filled with air, each diaphragm 15 is bulged downwards, the two micro air chambers I17 are filled with air, when the controllers II 22 at the inlets of the two pneumatic control pipeline micro valves II 8 and the air chamber inlet II 20 work, the two pneumatic control pipeline micro valves I4 and the air chamber inlet I19 do not work, at the moment, each air pipeline 16 of the two pneumatic control pipeline micro valves II 8 is filled with air, each diaphragm 15 is upwards bloated, and two micro air chambers II 18 are full of gas, and each diaphragm 15 is bloated in turn and constitutes liquid channel 1 both sides vortex and disturbance with auxiliary structure 14, and in addition, two micro air chambers I17, two micro air chambers II 18 produce ascending thrust to liquid channel 1 above it after being full of gas, make liquid channel 1 velocity of flow diminish, reach better two-phase liquid extraction effect.
The streamline and vector distribution of the fluid in the microchannel with the auxiliary structure that promotes laminar extraction efficiency by promoting mixing inside each liquid phase and solute exchange at the two-phase interface was analyzed by COMSOL Multiphysics finite element simulation software. Through increase auxiliary structure and air control unit in the laminar flow extraction microchip, can greatly improve the extraction efficiency of liquid-liquid laminar flow extraction.
While the present invention has been described in detail with reference to the embodiments shown in the drawings, the present invention is not limited to the embodiments, and various changes and modifications can be made within the knowledge of those skilled in the art without departing from the spirit of the present invention.
Claims (9)
1. A pneumatic auxiliary extraction device is characterized by comprising a liquid channel (1), a liquid inlet I (2), two channel electromagnetic valves (3), two pneumatic control pipeline micro valves I (4), a pneumatic control electromagnetic valve I (5), a chip (6), a liquid outlet (7), two pneumatic control pipeline micro valves II (8), a pneumatic control micro mixing chamber (9), a pneumatic control electromagnetic valve II (10), an electromagnetic valve control line (11), a liquid inlet II (12) and a glass substrate (13);
the chip (6) is placed on a glass substrate (13), a liquid inlet I (2), a liquid inlet II (12) and a liquid outlet (7) are arranged on the chip (6), a liquid channel (1) is arranged in the chip (6), two branch channels are arranged at one end of the liquid channel (1), the liquid inlet I (2) and the liquid inlet II (12) are respectively communicated with one end of the liquid channel (1) through the branch channels, channel electromagnetic valves (3) are respectively arranged at the upper side and the lower side of one end of the liquid channel (1), the other end of the liquid channel (1) is communicated with the liquid outlet (7), an air control micro mixing chamber (9) is arranged below the liquid channel (1), an air control pipeline micro valve I (4) and an air control pipeline micro valve II (8) are respectively arranged at the upper end and the lower end of the liquid channel (1) at the two sides of the air control micro mixing chamber (9), the chip (6) is internally provided with a pneumatic control solenoid valve I (5) and a pneumatic control solenoid valve II (10), the pneumatic control solenoid valve I (5) and the pneumatic control solenoid valve II (10) are respectively positioned above and below the liquid channel (1), the pneumatic control solenoid valve I (5) respectively controls a pneumatic control pipeline micro valve I (4) at the upper end of the liquid channel (1) at two sides of the pneumatic control micro mixing chamber (9) through a solenoid valve control line (11), and the pneumatic control solenoid valve II (10) respectively controls a pneumatic control pipeline micro valve II (8) at the lower end of the liquid channel (1) at two sides of the pneumatic control micro mixing chamber (9) through a solenoid valve control line (11).
2. A pneumatic auxiliary extraction device according to claim 1, characterized in that: the liquid channel (1) is internally provided with an auxiliary structure (14), the auxiliary structure (14) comprises more than one semicircular bulge which is respectively arranged on the upper inner wall and the lower inner wall of the liquid channel (1), the bulge of the auxiliary structure (14) positioned on the upper inner wall is downward, the bulge of the auxiliary structure (14) positioned on the lower inner wall is upward, the pneumatic control pipeline micro valve I (4) and the pneumatic control pipeline micro valve II (8) have the same structure and respectively comprise a controller I (21), more than one gas pipeline (16) and more than one membrane (15), the controller I (21) is positioned outside the liquid channel (1), the more than one gas pipeline (16) and the more than one membrane (15) are respectively positioned in the liquid channel (1), the more than one membrane (15) are respectively positioned above the more than one gas pipeline (16), and the pneumatic control pipeline micro valve I (4) and the pneumatic control pipeline micro valve II (8) are oppositely arranged, namely, a gas pipeline (16) of the pneumatic control pipeline micro valve I (4) and a gas pipeline (16) of the pneumatic control pipeline micro valve II (8) are arranged oppositely, and the gas pipeline (16) and the diaphragm (15) of the pneumatic control pipeline micro valve I (4) and the pneumatic control pipeline micro valve II (8) are respectively positioned between two adjacent semicircular bulges of the auxiliary structure (14) on the upper inner wall and the lower inner wall of the liquid channel (1).
3. A pneumatic auxiliary extraction device according to claim 1, characterized in that: the pneumatic control micro mixing chamber (9) comprises two micro air chambers I (17), two micro air chambers II (18) and two controllers II (22), the two micro air chambers I (17) are connected through a pipeline, the two micro air chambers II (18) are connected through a pipeline, an air chamber inlet I (19) is formed in one micro air chamber I (17), the controller II (22) is arranged at an inlet of the air chamber inlet I (19), an air chamber inlet II (20) is formed in one micro air chamber II (18), the controller II (22) is arranged at an inlet of the air chamber inlet II (20), the controller II (22) at the inlet of the air chamber inlet I (19) is connected with the pneumatic control electromagnetic valve I (5) through an electromagnetic valve control line (11), the controller II (22) at the inlet of the air chamber inlet II (20) is connected with the pneumatic control electromagnetic valve II (10) through the electromagnetic valve control line (11), the thickness h of the two micro air chambers I (17) and II (18)2Are all 0.35mm, the two micro air chambers I (17) and II (18) are spherical when being filled with air bubbles, and the volumes are both 1mm3。
4. A pneumatic auxiliary extraction device according to claim 3, characterized in that: the chip (6), the two micro air chambers I (17) and the two micro air chambers II (18) are all made of PDMS polydimethylsiloxane materials.
5. A pneumatic auxiliary extraction device according to claim 1, characterized in that: the chip (6) is 45mm long, 15mm wide and 5mm thick.
6. A pneumatic auxiliary extraction device according to claim 1, characterized in that: the diameters of the liquid inlet I (2), the liquid inlet II (12) and the liquid outlet (7) are all 0.5mm, and the width d of the liquid channel (1)2Is 0.5mm and has a height h20.35mm, the length of the air-controlled micro-mixing chamber (9) is 4mm, and the width d3Is 3mm and high h30.35mm, the thickness h of the glass substrate (13)1Is 0.1 mm.
7. A pneumatic auxiliary extraction device according to claim 1, characterized in that: the length of each of the two pneumatic control pipeline micro valves I (4) and the length of each of the two pneumatic control pipeline micro valves II (8) are both 7mm, the width of each pneumatic control pipeline micro valve I is 0.3mm, and the height of each pneumatic control pipeline micro valve II is 0.3 mm.
8. A pneumatic auxiliary extraction device according to claim 2, characterized in that: the distance between the controller I (21) of the pneumatic control pipeline micro valve I (4) and the controller I (21) of the pneumatic control pipeline micro valve II (8) and the liquid channel (1) is 1-2 mm.
9. The method for auxiliary extraction of any one of claims 1 to 8, comprising the following steps: firstly, injecting a water phase into a liquid inlet I (2), after the water phase is filled in a device, then injecting an organic phase into a liquid inlet II (12), wherein the two inlet liquid phases respectively contain different chemical substances and can react with each other, the reaction efficiency of the two inlet liquid phases can be improved in a liquid channel (1) by controlling the flow and the speed of the liquid inlet I (2) and the liquid inlet II (12), the flow in the liquid channel (1) is controlled by channel electromagnetic valves (3) at the two sides of the liquid channel (1) after the two-phase liquid is mixed, electromagnets of the two channel electromagnetic valves (3) are mutually attracted after the channel electromagnetic valves (3) at the two sides of the liquid channel (1) are electrified, so that the upper wall surface and the lower wall surface of the liquid channel (1) are extruded, the flow in the liquid channel (1) is controlled, the pneumatic control electromagnetic valve I (5) simultaneously controls two pneumatic control pipeline micro valves I (4) and a controller II (22) at the inlet of a gas chamber inlet I (19), the pneumatic control solenoid valve II (10) controls the two pneumatic control pipeline micro valves II (8) and the controller II (22) at the inlet of the air chamber inlet II (20) at the same time, the pneumatic control solenoid valve I (5) and the pneumatic control solenoid valve II (10) are electrified alternately, namely when the two pneumatic control pipeline micro valves I (4) and the air chamber inlet I (19) work, the two pneumatic control pipeline micro valves II (8) and the controller II (22) at the inlet of the air chamber inlet II (20) do not work, at the moment, more than one gas pipeline (16) of the two pneumatic control pipeline micro valves I (4) is filled with gas, more than one diaphragm (15) is bulged downwards, the two micro air chambers I (17) are filled with gas, and when the two pneumatic control pipeline micro valves II (8) and the controller II at the inlet of the air chamber inlet II (20) work, the two pneumatic control pipeline micro valves I (4) and the air chamber inlet I (19) do not work, at the moment, more than one gas pipeline (16) of the two pneumatic control pipeline micro valves II (8) is filled with gas, more than one diaphragm (15) is bulged upwards, the two micro air chambers II (18) are filled with gas, more than one diaphragm (15) is bulged alternatively and forms vortex and disturbance on two sides of the liquid channel (1) with the auxiliary structure (14), in addition, the two micro air chambers I (17) and the two micro air chambers II (18) are filled with gas and then generate upward thrust on the liquid channel (1) above the micro air chambers I and II, so that the flow rate of the liquid channel (1) is reduced, and a better two-phase liquid extraction effect is achieved.
Priority Applications (1)
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| CN102459565A (en) * | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | Fluidic devices with diaphragm valves |
| CN103861668A (en) * | 2012-12-17 | 2014-06-18 | 中国科学院沈阳自动化研究所 | Microfluidic chip based on pneumatic micro pumps and micro mixer |
| CN108144659A (en) * | 2017-11-22 | 2018-06-12 | 昆明理工大学 | Based on chip lab microflow control technique micro-structure assisted extraction device and method |
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| CN102459565A (en) * | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | Fluidic devices with diaphragm valves |
| CN103861668A (en) * | 2012-12-17 | 2014-06-18 | 中国科学院沈阳自动化研究所 | Microfluidic chip based on pneumatic micro pumps and micro mixer |
| CN108144659A (en) * | 2017-11-22 | 2018-06-12 | 昆明理工大学 | Based on chip lab microflow control technique micro-structure assisted extraction device and method |
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