CN107970847B - Plane bending passive micro mixer with double T-shaped inlet structure - Google Patents
Plane bending passive micro mixer with double T-shaped inlet structure Download PDFInfo
- Publication number
- CN107970847B CN107970847B CN201711253614.0A CN201711253614A CN107970847B CN 107970847 B CN107970847 B CN 107970847B CN 201711253614 A CN201711253614 A CN 201711253614A CN 107970847 B CN107970847 B CN 107970847B
- Authority
- CN
- China
- Prior art keywords
- unit
- liquid drop
- discrete phase
- liquid
- phase inlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
- B01F33/3022—Micromixers the materials to be mixed flowing in the form of droplets the components being formed by independent droplets which are alternated, the mixing of the components being achieved by diffusion between droplets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3034—Micromixers using induced convection or movement in the mixture to mix or move the fluids without mechanical means, e.g. thermodynamic instability, strong gradients, etc.
Abstract
The invention discloses a plane bending passive micro mixer with a double-T-shaped inlet structure, which belongs to the field of micro total analysis systems and nano particle preparation. The liquid drop generating unit is formed by optimizing a double-T-shaped inlet structure, and a necking and a flaring are arranged on two sides of the first component intersection port, so that stable generation of liquid drops is ensured; and a bent fusion structure is arranged at the position of the liquid drop fusion, so that the two components can generate the fusion liquid drop more stably. The liquid drop micro mixer is formed by a plurality of mixing unit arrays, and a straight channel structure is arranged at the tail part, so that the outlet unit is far away from the main body of the micro mixer, the manufacturing difficulty of the channel is reduced, and the reliability and the durability of the mixer are ensured. The invention further improves the stability and mixing efficiency of the droplet micromixer, and is beneficial to promoting the development of droplet micromixer technology.
Description
Technical Field
The invention belongs to the field of micro total analysis systems and nano particle preparation, mainly relates to the technologies of droplet micromixing, droplet generation, droplet fusion and the like, and provides a plane bending passive micromixer with a double T-shaped inlet structure.
Background
The microfluidics integrates functional units of sample preparation, mixing, separation, reaction, detection and the like which are usually involved in the biological and chemical fields, and the controllable fluid penetrates through the whole system formed by the micro-channel, so that the similar functions of the conventional biochemical laboratory are finally realized. The micro-fluidic chip technology has the advantages of small volume, high efficiency, low cost, easy integration and the like, and has wide application prospect in the fields of biology and chemistry. The micro mixer is an important component of the microfluidic technology and is widely applied to the fields of biological analysis, chemical synthesis, clinical test and the like. The micro-mixing of the liquid drops is to encapsulate reactant solute in the liquid drops through an interface between two phases so as to prevent the wall surface of a channel from being polluted. The channel structure of the microfluidic chip is in a micron-scale, fluid in the channel is usually in a laminar flow state, and the research focus in the field is to improve the mixing efficiency and reduce the volume of a mixer.
The invention belongs to a passive droplet micromixer, and the mixing process is controlled by the morphological characteristics of a microchannel. Compared with an active micro mixer, the passive micro mixer is easy to process and more convenient to use. The core problem of the technology is to optimize the structure of the passive micro mixer, further improve the mixing efficiency and reduce the volume.
The generation mode of micro-droplets, the distribution state of components in the droplets and the flow state all have important influence on the droplet mixing process, and the optimization of the droplet generation structure of the mixer is a key factor in the field. The double-T-shaped inlet structure enables the two components to be fused to form liquid drops to be mixed, and reaction is prevented from occurring before the liquid drops are generated. On the basis of a double-T-shaped inlet structure, the two sides of the intersection structure of the first component discrete phase channel are respectively provided with a sudden shrinkage structure and a sudden expansion structure, so that the uniformity of the size of liquid drops is further improved; a fusion bend is added at the intersection structure of the second component discrete phase channel, so that the liquid drop fusion process is more stable. The channel structure adopted by the invention has very important value in the field of droplet microfluidics.
Disclosure of Invention
The invention is based on a double-T-shaped inlet structure micro mixer, and improves the uniformity of the size of liquid drops and the stability of fusion by improving a first component intersection structure and a two-component fusion structure. The improved double-T-shaped inlet has the advantages of simple structure, high mixing efficiency and small volume of a mixing channel, and can uniformly and stably generate mixed liquid drops in a downstream micro mixer.
In order to achieve the above object, the present invention adopts a technical solution of a planar bending passive micromixer with a double T-shaped inlet structure, which comprises a continuous phase inlet unit 2, two discrete phase inlet units 1, a droplet generation unit 3, a droplet micromixer 4, and an outlet unit 5. The two discrete phase inlet units 1 and the continuous phase inlet unit 2 are connected by a droplet generation unit 3, and the droplet generation unit 3 is connected by a droplet micromixer 4 to an outlet unit 5.
The continuous phase inlet unit 2 is disposed upstream of the droplet generating unit 3, the first discrete phase inlet unit 1 is disposed midstream of the droplet generating unit 3, and the second discrete phase inlet unit 1 is disposed downstream of the droplet generating unit 3.
The continuous phase fluid is injected from the continuous phase inlet unit 2, and the two discrete phase fluids of different compositions are injected from the two discrete phase inlet units 1, respectively. At the intersection where the first discrete phase inlet unit 1 and the droplet generation unit 3 are connected, the discrete phase fluid of the first component is sheared by the continuous phase to form droplets, and the droplets move along the droplet generation unit 3 and are fused with the discrete phase droplets of the second component at the downstream to form droplets to be mixed. After the mixed liquid drops pass through the liquid drop micro mixer 4, the solute inside the liquid drop micro mixer 4 is fully mixed with the continuous phase fluid, and flows out from the outlet unit 5.
Continuous phase entry unit 2 is circular liquid storage tank structure to for guaranteeing channel structure's stability, prevent that too high pressure drop from leading to the passageway to break, circular liquid storage tank passes through the arc throat structure and is connected along liquid droplet generation unit 3 with the liquid droplet. The droplet generation unit 3 has a straight channel structure, so that the droplet generation process of the discrete phase fluid of the first component is stable and continuous. The arc-shaped craters and the droplets have the same cross-sectional height along the droplet generation unit 3, and the cross-sectional shape is rectangular. The two discrete phase inlet cells 1 are identical in structural form, and the sectional height of the discrete phase inlet cell 1 is smaller than that of the continuous phase inlet cell 2.
In order to ensure the stability of the generation of the discrete phase fluid of the first component, a necking and a flaring are arranged on two sides of an intersection channel, which is formed by connecting the first discrete phase inlet unit 1 and the liquid drop along the liquid drop generating unit 3, the necking is arranged at the joint of the first discrete phase inlet unit 1 and the intersection channel, and the flaring is arranged at the joint of the intersection channel and the liquid drop along the liquid drop generating unit 3. The second discrete phase inlet unit 1 is connected with the droplet generation unit 3 in the same manner; a fusion curve is arranged at the intersection where the second discrete phase inlet unit 1 and the liquid drop are connected along the liquid drop generating unit 3, and the fusion curve is used for ensuring the stability of the fusion process of the continuous phase liquid drop and the discrete phase liquid drop.
The droplet micromixer 4 is a droplet mixing unit, and the droplet micromixer 4 has a disk structure with a plane curvature. The droplet micromixer 4 and the droplet generation unit 3 and the outlet unit 5 are connected by a straight channel of rectangular cross section.
The outlet unit 5 includes a connection flare and a liquid reservoir, and the droplet micromixer 4 is connected to the liquid reservoir through the connection flare.
The mixer is formed from polydimethylsiloxane silicone.
The invention has the following advantages after adopting the technical scheme:
1. the distribution form of the components in the liquid drops and the flow distribution form ensure that the liquid drops have higher mixing efficiency in the downstream mixing process; the two components begin to contact after the liquid drops are formed, and the influence of wall surface modification or blockage and the like caused by products is effectively avoided.
2. A bend fusion structure is adopted at the intersection of the second component, and the capability of breaking a liquid film is improved by using the inertia force, so that the two components can be stably fused into liquid drops to be mixed.
3. The liquid storage tanks with larger diameters are adopted at the continuous phase inlet unit, the two discrete phase inlet units and the outlet unit, so that the stable flowing of the fluid into and out of the microfluidic chip is ensured. The liquid storage tank is connected with the straight channel section through the arc-shaped necking and flaring, so that the fluctuation of a flow field is reduced, and liquid drops can be generated and flow out more stably.
4. The denser plane bending micro-channel is adopted, so that the overall size of the micro-fluidic chip is effectively reduced, and the micro-fluidic chip is more miniaturized.
5. The two discrete phase inlet units are of T-shaped structures, and the two T-shaped structures are used for ensuring the stability and continuity of the discrete liquid injected by the micro mixer and improving the mixing effect of the micro mixer.
Drawings
FIG. 1 is a schematic structural view of a planar curved passive micromixer with a double T-shaped inlet structure according to the present invention;
FIG. 2 is a schematic three-dimensional structure of the planar passive micro-mixer;
in the figure: 1. a discrete phase inlet unit; 2. a continuous phase inlet unit; 3. a droplet generation unit; 4. a droplet mixing unit; 5. an outlet unit.
Detailed Description
As shown in fig. 1-2, a plane bending passive micromixer of a double T-shaped inlet structure includes a continuous phase inlet unit 2, two discrete phase inlet units 1, a droplet generation unit 3, a droplet micromixer 4, and an outlet unit 5. The two discrete phase inlet units 1 and the continuous phase inlet unit 2 are connected by a droplet generation unit 3, and the droplet generation unit 3 is connected by a droplet micromixer 4 to an outlet unit 5.
The continuous phase inlet unit 2 is disposed upstream of the droplet generating unit 3, the first discrete phase inlet unit 1 is disposed midstream of the droplet generating unit 3, and the second discrete phase inlet unit 1 is disposed downstream of the droplet generating unit 3.
The continuous phase fluid is injected from the continuous phase inlet unit 2, and the two discrete phase fluids of different compositions are injected from the two discrete phase inlet units 1, respectively. At the intersection where the first discrete phase inlet unit 1 and the droplet generation unit 3 are connected, the discrete phase fluid of the first component is sheared by the continuous phase to form droplets, and the droplets move along the droplet generation unit 3 and are fused with the discrete phase droplets of the second component at the downstream to form droplets to be mixed. After the mixed liquid drops pass through the liquid drop micro mixer 4, the solute inside the liquid drop micro mixer 4 is fully mixed with the continuous phase fluid, and flows out from the outlet unit 5.
Continuous phase entry unit 2 is circular liquid storage tank structure to for guaranteeing channel structure's stability, prevent that too high pressure drop from leading to the passageway to break, circular liquid storage tank passes through the arc throat structure and is connected along liquid droplet generation unit 3 with the liquid droplet. The droplet generation unit 3 has a straight channel structure, so that the droplet generation process of the discrete phase fluid of the first component is stable and continuous. The arc-shaped craters and the droplets have the same cross-sectional height along the droplet generation unit 3, and the cross-sectional shape is rectangular. The two discrete phase inlet cells 1 are identical in structural form, and the sectional height of the discrete phase inlet cell 1 is smaller than that of the continuous phase inlet cell 2.
In order to ensure the stability of the generation of the discrete phase fluid of the first component, a necking and a flaring are arranged on two sides of an intersection channel, which is formed by connecting the first discrete phase inlet unit 1 and the liquid drop along the liquid drop generating unit 3, the necking is arranged at the joint of the first discrete phase inlet unit 1 and the intersection channel, and the flaring is arranged at the joint of the intersection channel and the liquid drop along the liquid drop generating unit 3. The second discrete phase inlet unit 1 is connected with the droplet generation unit 3 in the same manner; a fusion curve is arranged at the intersection where the second discrete phase inlet unit 1 and the liquid drop are connected along the liquid drop generating unit 3, and the fusion curve is used for ensuring the stability of the fusion process of the continuous phase liquid drop and the discrete phase liquid drop.
The droplet micromixer 4 is a droplet mixing unit, and the droplet micromixer 4 has a disk structure with a plane curvature. The droplet micromixer 4 and the droplet generation unit 3 and the outlet unit 5 are connected by a straight channel of rectangular cross section.
The outlet unit 5 includes a connection flare and a liquid reservoir, and the droplet micromixer 4 is connected to the liquid reservoir through the connection flare.
The mixer is processed by polydimethylsiloxane organosilicon, the transfer of channel structure patterns and the solidification of the polydimethylsiloxane are realized on a monocrystalline silicon wafer by an injection molding method, and then the solidified polydimethylsiloxane is separated from the silicon wafer. And punching a hole on the cured polydimethylsiloxane according to the position of the inlet and the outlet of the relative channel, and carrying out irreversible bonding on the hole and the cured polydimethylsiloxane bottom plate through a corona machine so as to completely seal the channel of the micro mixer. And finally, installing interfaces at the positions of four reserved holes on the cured polydimethylsiloxane, and connecting a plastic conduit to finish the preparation of experimental part packaging.
The plane bending passive micromixer with the double T-shaped inlet structure shown in figure 1 is composed of two discrete phase inlet units, a continuous phase inlet unit, a droplet generation unit, a droplet mixing unit and an outlet unit.
The diameters of the liquid storage tanks of the two discrete phase inlet units, the continuous phase inlet unit and the outlet unit of the micro mixer are all 2mm, and the radius of the arc-shaped necking is 2 mm. And two sides of an upstream intersection structure of the liquid drop generating unit are provided with a necking and a flaring with an oblique angle of 30 degrees, and an intersection straight channel is 280 microns long. The downstream intersection structure is provided with a curved fusion structure with a corner of 30 degrees and a radius of curvature of 300 μm. The micro-mixer droplet mixer was arranged by an array of 3 droplet mixing units, each composed of a straight channel of 4.6mm and a semicircular curved channel with a radius of curvature of 300 μm. The depth of each structure of the channel unit is 100 μm, the structure width of the main channel is 200 μm, and the width of the discrete phase inlet channel is 100 μm.
When the continuous phase liquid generating device works, continuous phase fluid flows in from the liquid storage tank of the continuous phase inlet unit, passes through the arc-shaped necking and then enters the liquid drop generating unit. Two discrete phase fluids with different components respectively flow into the liquid storage tanks of the two discrete phase inlet units. At the upstream discrete phase intersection structure, the first component discrete phase is extruded by the continuous phase to form liquid drops, and after passing through the first section of straight channel structure, the first component discrete phase meets the second component discrete phase in the curve fusion structure and is fused into liquid drops to be mixed. After the droplets are sufficiently mixed in the droplet micromixer, the droplets flow out of the microfluidic chip from the outlet unit.
Claims (6)
1. A plane bending passive micro mixer with a double T-shaped inlet structure is characterized in that: the mixer comprises a continuous phase inlet unit (2), two discrete phase inlet units (1), a droplet generation unit (3), a droplet micromixer (4) and an outlet unit (5); the two discrete phase inlet units (1) are connected with the continuous phase inlet unit (2) through a liquid drop generating unit (3), and the liquid drop generating unit (3) is connected with the outlet unit (5) through a liquid drop micromixer (4);
the continuous phase inlet unit (2) is arranged at the upstream of the liquid drop generating unit (3), the first discrete phase inlet unit (1) is arranged at the midstream of the liquid drop generating unit (3), and the second discrete phase inlet unit (1) is arranged at the downstream of the liquid drop generating unit (3); in order to ensure the stability of the generation of the discrete phase fluid of the first component, a necking and a flaring are arranged on two sides of an intersection channel, which is formed by connecting the first discrete phase inlet unit (1) and the liquid drop along the liquid drop generating unit (3), the necking is arranged at the joint of the first discrete phase inlet unit (1) and the intersection channel, and the flaring is arranged at the joint of the intersection channel and the liquid drop along the liquid drop generating unit (3); the second discrete phase inlet unit (1) is connected with the liquid drop generation unit (3) in the same form; a fusion bend is arranged at the intersection where the second discrete phase inlet unit (1) and the liquid drop are connected along the liquid drop generating unit (3), and the fusion bend is used for ensuring the stability of the fusion process of the continuous phase liquid drop and the discrete phase liquid drop.
2. The planar bending passive micromixer of a double T-inlet configuration in accordance with claim 1, wherein: the continuous phase fluid is injected from a continuous phase inlet unit (2), and the two discrete phase fluids with different components are respectively injected from two discrete phase inlet units (1); at the intersection where the first discrete phase inlet unit (1) and the droplet generation unit (3) are connected, the discrete phase fluid of the first component is subjected to continuous phase shearing action to form droplets, and the droplets move along the droplet generation unit (3) and are fused with the discrete phase droplets of the second component at the downstream to form droplets to be mixed; after the mixed liquid drops pass through the liquid drop micro mixer (4), the solute in the liquid drop micro mixer (4) is fully mixed with the continuous phase fluid, and the mixed liquid drops flow out from the outlet unit (5).
3. The planar bending passive micromixer of a double T-inlet configuration in accordance with claim 1, wherein: the continuous phase inlet unit (2) is of a circular liquid storage tank structure, and in order to ensure the stability of a channel structure and prevent the channel from cracking caused by overhigh pressure drop, the circular liquid storage tank is connected with the liquid drop generation unit (3) through an arc-shaped necking structure; the liquid drop is in a straight channel structure along the liquid drop generating unit (3), so that the liquid drop generating process of the discrete phase fluid of the first component is stable and continuous; the arc-shaped necking and the liquid drops have the same cross-sectional height along the liquid drop generating unit (3), and the cross-sectional shapes are all rectangular; the two discrete phase inlet units (1) are identical in structural form, and the sectional height of each discrete phase inlet unit (1) is smaller than that of each continuous phase inlet unit (2).
4. The planar bending passive micromixer of a double T-inlet configuration in accordance with claim 1, wherein: the liquid drop micro mixer (4) is a liquid drop mixing unit, and the liquid drop micro mixer (4) is of a disc type structure with a plane bending; the liquid drop micromixer (4) is connected with the liquid drop generating unit (3) and the outlet unit (5) through straight channels with rectangular sections.
5. The planar bending passive micromixer of a double T-inlet configuration in accordance with claim 1, wherein: the outlet unit (5) comprises a connecting flaring and a liquid storage tank, and the liquid drop micro mixer (4) is connected with the liquid storage tank through the connecting flaring.
6. The planar bending passive micromixer of a double T-inlet configuration in accordance with claim 1, wherein: the mixer is formed from polydimethylsiloxane silicone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711253614.0A CN107970847B (en) | 2017-12-02 | 2017-12-02 | Plane bending passive micro mixer with double T-shaped inlet structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711253614.0A CN107970847B (en) | 2017-12-02 | 2017-12-02 | Plane bending passive micro mixer with double T-shaped inlet structure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107970847A CN107970847A (en) | 2018-05-01 |
| CN107970847B true CN107970847B (en) | 2020-10-27 |
Family
ID=62008840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711253614.0A Active CN107970847B (en) | 2017-12-02 | 2017-12-02 | Plane bending passive micro mixer with double T-shaped inlet structure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107970847B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108993338A (en) * | 2018-07-02 | 2018-12-14 | 烟台大学 | It is a kind of for synthesizing the micro-reaction device and method of ferriferrous oxide nano powder |
| EP3613498A1 (en) * | 2018-08-24 | 2020-02-26 | Université de Liège | Microfluidic module for co-encapsulation in droplets |
| JP2021048336A (en) * | 2019-09-20 | 2021-03-25 | 三菱電機株式会社 | Processing liquid generating method, processing liquid generating mechanism, semiconductor manufacturing apparatus and semiconductor manufacturing method |
| CN111804353B (en) * | 2020-07-14 | 2021-07-30 | 浙江大学 | Device and method for realizing micro-droplet passive fusion |
| CN113996363A (en) * | 2021-12-03 | 2022-02-01 | 郑州轻工业大学 | Micro-droplet reagent injection device and method based on focusing acoustic surface waves |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101201452A (en) * | 2007-12-03 | 2008-06-18 | 西北工业大学 | Micro optical chip based on light fluid and preparation method thereof |
| CN101718795A (en) * | 2008-09-22 | 2010-06-02 | 中国科学院大连化学物理研究所 | Microfluidic chip liquid drop control method based on pneumatic micro valve |
| CN104203382A (en) * | 2012-02-08 | 2014-12-10 | 哈佛学院院长及董事 | Droplet formation using fluid breakup |
| CN105017068A (en) * | 2015-07-06 | 2015-11-04 | 清华大学 | System and method for synthesizing cyclohexanone-oxime by micro-reactor |
| CN105170207A (en) * | 2015-09-29 | 2015-12-23 | 北京工业大学 | Micro-droplet control chip based on branch structure |
| CN105536896A (en) * | 2015-12-13 | 2016-05-04 | 北京工业大学 | Microfluidic chip with outer-convex lower wall face |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7010391B2 (en) * | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
-
2017
- 2017-12-02 CN CN201711253614.0A patent/CN107970847B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101201452A (en) * | 2007-12-03 | 2008-06-18 | 西北工业大学 | Micro optical chip based on light fluid and preparation method thereof |
| CN101718795A (en) * | 2008-09-22 | 2010-06-02 | 中国科学院大连化学物理研究所 | Microfluidic chip liquid drop control method based on pneumatic micro valve |
| CN104203382A (en) * | 2012-02-08 | 2014-12-10 | 哈佛学院院长及董事 | Droplet formation using fluid breakup |
| CN105017068A (en) * | 2015-07-06 | 2015-11-04 | 清华大学 | System and method for synthesizing cyclohexanone-oxime by micro-reactor |
| CN105170207A (en) * | 2015-09-29 | 2015-12-23 | 北京工业大学 | Micro-droplet control chip based on branch structure |
| CN105536896A (en) * | 2015-12-13 | 2016-05-04 | 北京工业大学 | Microfluidic chip with outer-convex lower wall face |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107970847A (en) | 2018-05-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107970847B (en) | Plane bending passive micro mixer with double T-shaped inlet structure | |
| CN106140340B (en) | Micro-fluidic chip based on flow focusing type microchannel synthesis micro emulsion drop | |
| US8563325B1 (en) | Coaxial microreactor for particle synthesis | |
| JP4193561B2 (en) | Microchannel structure, microparticle manufacturing method using the same, and solvent extraction method using microchannel structure | |
| CN103736528B (en) | Microfluidic chip for mixing reagent and preparing micro-droplets and micro-liquid column | |
| CN104826674B (en) | Reverse-Y shaped channel microfluid chip for generating droplets | |
| Shahriari et al. | Flow regime mapping of high inertial gas–liquid droplet microflows in flow-focusing geometries | |
| CN107583551A (en) | A kind of plane passive type micro-mixer of stepped passageway processing font baffle plate | |
| Li et al. | Geometric optimization of liquid–liquid slug flow in a flow-focusing millifluidic device for synthesis of nanomaterials | |
| CN113058669A (en) | Coaxial focusing micro-channel integrated device and method capable of being customized according to requirements | |
| CN106215988B (en) | A kind of double branch roads realize the microchannel of microlayer model splitting function twice | |
| CN108525715B (en) | Micro-channel structure, micro-fluidic chip and method for quantitatively wrapping microspheres by liquid drops | |
| Lim et al. | Vertical squeezing route Taylor flow with angled microchannel junctions | |
| CN108993622B (en) | Micro-fluidic chip for realizing collision of different combined liquid drops | |
| Liao et al. | Ultrasonic fabrication of micro nozzles from a stack of PVDF foils for generating and characterizing microfluidic dispersions | |
| CN108993337A (en) | A kind of integrating device of drop fluid micro-reactor | |
| CN213193496U (en) | Passive micro mixer | |
| CN105214546A (en) | A kind of concussion jetting type micro-mixer based on Pulsating Flow | |
| CN101716473B (en) | Chip-in micro-mixer and preparation method thereof | |
| CN108212236B (en) | Micro-fluidic chip for realizing synchronous movement and fusion of liquid drop pairs/bubble pairs | |
| CN216458933U (en) | Centrifugal force-based high-flux stepped emulsification microfluidic droplet preparation chip | |
| JP4973721B2 (en) | Microparticle structure and method for producing microparticles using the same | |
| CN209362517U (en) | A kind of intraluminal fluid dripping is for chip structure | |
| CN110975775A (en) | High-flux three-dimensional microfluid mixing device based on dean flow effect and mixing method thereof | |
| CN216322013U (en) | Novel micro-fluidic chip of compound passageway |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |