CN204816577U - Novel microbubble / liquid drop generates regulation and control device - Google Patents
Novel microbubble / liquid drop generates regulation and control device Download PDFInfo
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- CN204816577U CN204816577U CN201520561407.1U CN201520561407U CN204816577U CN 204816577 U CN204816577 U CN 204816577U CN 201520561407 U CN201520561407 U CN 201520561407U CN 204816577 U CN204816577 U CN 204816577U
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Abstract
The utility model discloses a novel microbubble / liquid drop generates regulation and control device, including micro -injection pump and syringe, microchip and collector, the last syringe that is provided with of micro -injection pump, the syringe uses the rubber tube to be connected with the microchip entry, and micro -injection pump and syringe have threely, and with the three entry linkage of microchip, the microchip exports to be connected with collector use rubber tube respectively. The utility model discloses a micro -injection pump dominant discharge combines the access structure control bubble of microchip big or small, has improved the production and the emulsifying efficiency of microbubble / liquid drop greatly, has reduced the occupation space of microchip, the cost is reduced.
Description
Technical field
The utility model belongs to micro-chemical technology field, particularly relates to a kind of novel microbubble/drop formation regulation device.
Background technology
In recent years, micro-Chemical Engineering Technology has become the cutting edge technology of chemical field, and it has, and high efficiency, controllability are strong, miniaturized, flexible for installation, handling safety, be easy to the advantages such as industry is amplified and production process is continuous.Compared with conventional apparatus, the power consumption of macro work is lower, and specific yield is higher; The features such as minute yardstick, bigger serface, volume are little, contact range is wide can strengthen mass transfer and diabatic process, make the reaction under some specific condition smooth, therefore, be used widely in fields such as food industry, chemical analysis, drug research, materials synthesis, crystallization, emulsification, protein screenings.Bubble and drop often occur in the application process of microflow control technique, and the sub-bubble (sub-drop) that bubble (drop) is broken into two or more is further the effective ways improving bubble (drop) production efficiency.
The microchip structure broken for bubble (drop) can be divided into: 1. microchannel of diverging.2. the microchannel of reducing type.3. containing the microchannel of barrier.
A bubble (drop) can be broken into two or more by above-mentioned three kinds of microchannels at one time, but is difficult to the simple and direct manipulation realizing sub-bubble size and frequency.And fork microchannel takes up space comparatively large, and the microchannel containing barrier is difficult to processing and causes practicality poor.
A kind of new-type microchip structure of current needs can overcome the defect that existing structure exists, and regulates and controls, effectively improve the production efficiency of microbubble (drop) with simpler and more direct method antithetical phrase bubble size and frequency.
Utility model content
In order to solve problems of the prior art, the utility model provides a kind of novel microbubble/drop formation regulation device, overcomes the problem of microbubble in prior art/droplet rupture technical size and the bad manipulation of frequency.
The technical solution of the utility model is:
A kind of novel microbubble/drop formation regulation device, comprise micro-injection pump and syringe, microchip and collector, micro-injection pump is provided with syringe, syringe and microchip entrance use sebific duct to be connected, micro-injection pump and syringe have three, be connected with three entrances of microchip respectively, microchip outlet uses sebific duct to be connected with collector.
Described microchip is formed by a square duct and a T-shaped channels intersect, microchip entrance has three, square duct is provided with continuous phase first entrance, one end, T-shaped channel branches place is provided with continuous phase second entrance, T-shaped passage two ends are respectively equipped with decentralized photo entrance and exit, described square duct and T-shaped passage cross focal position are main channel to the straight channel exported, and continuous phase second entrance is subchannel to the interface channel of main channel; Wide and the height in cross section, microchip main channel is all less than 1mm; The entrance length of decentralized photo and continuous phase is no less than 10mm; The channel cross-section size of continuous phase second entrance is less than main channel size; Continuous phase second entrance is not less than 10mm apart from the distance of cross focal position, and is not less than 10mm apart from the distance of outlet.
A kind of novel microbubble/drop formation regulate and control method, comprises the steps:
(1) solution pretreatment: first carry out suction filtration to solution, filters out the impurity in solution, in order to avoid blocking channel;
(2) ready solution is connected with microchannel respectively by micro-injection transport pump by the debugging of device: a.; B. microchip outlet is connected with collector; C. the air-tightness of check system, checks the situation with or without leakage; D. start micro-injection pump, set diameter and the liquid phase volume flow of injection needle tube, start to drive liquid;
(3) generation of microbubble and regulation and control: continuous phase and the import department of decentralized photo shown in microchip enter, with one voice locate to form bubble/drop at cross, and the continuous phase second entrance input continuous phase at T-shaped bifurcation mouth place, be convenient to the voidage regulating bubble/drop, and cutting is again carried out to bubble size.
Described step (3) enters continuous phase in microchip generating apparatus and decentralized photo is immiscible gas-liquid two-phase or liquid-liquid diphase.
Described step (3) continuous phase fluid and microchip wall wetability good.
The liquid phase fluid of described continuous phase and decentralized photo is Newtonian fluid or shear shinning type non-newtonian fluid.
Described Newtonian fluid is water, alcohol solution, ionic liquid, aromatic series liquid or alkanes liquid.
Described shear shinning type non-newtonian fluid is the macromolecular compound aqueous solution.
The beneficial effects of the utility model are: the utility model apparatus and method complete the generation of microbubble/drop in the cross focusing structure of microchip; In the T-shaped bifurcation mouth of microchip, complete regulating and controlling again microbubble/drop size; Cutting is again carried out to the microbubble/drop generated, meets the requirements such as follow-up emulsification, reaction.Control flow by micro-injection pump, the channel design in conjunction with microchip controls Air Bubble Size, substantially increases production and the emulsifying power of microbubble/drop, reduces taking up room of microchip, reduce cost.The utility model apparatus and method make the control manipulation of microbubble/drop more simplify and improve control accuracy, add controllability.
Accompanying drawing explanation
Fig. 1 the utility model apparatus structure schematic diagram;
Microchip structure schematic diagram in Fig. 2 the utility model device;
Wherein: 1. the first micro-injection pump; 2. the second micro-injection pump; 3. the 3rd micro-injection pump; 4. high-speed camera instrument; 5. computer; 6. microchip; 7. collector; 8. cold light source; 9. continuous phase first entrance; 10. decentralized photo entrance; 11. continuous phase second entrances; 12. outlets.
Detailed description of the invention
Below in conjunction with drawings and Examples, the utility model is described in further detail.
As shown in Figure 1-2, the utility model microbubble/drop formation regulation device, comprise micro-injection pump and syringe, microchip 6 and collector 7, micro-injection pump 1,2,3 is provided with syringe, syringe uses sebific duct to be connected with microchip entrance 9,10,11, and microchip outlet 12 uses sebific duct to be connected with collector 7.
Described microchip is formed by a square duct and a T-shaped channels intersect, microchip entrance has three, square duct is provided with continuous phase first entrance 9, one end, T-shaped channel branches place is provided with continuous phase second entrance 11, T-shaped passage two ends are respectively equipped with decentralized photo entrance 10 and outlet 12, described square duct and T-shaped passage cross focal position are main channel to the straight channel exported, and continuous phase second entrance is subchannel to the interface channel of main channel; Wide and the height in cross section, microchip main channel is all less than 1mm; The entrance length of decentralized photo and continuous phase is no less than 10mm; The channel cross-section size of continuous phase second entrance is less than main channel size; Continuous phase second entrance is not less than 10mm apart from the distance of cross focal position, and is not less than 10mm apart from the distance of outlet.
Embodiment 1
Regulate and control a method for microbubble size, comprise the steps:
Under normal temperature, water and glycerine are put in pretreatment beaker by the mass ratio of 1:1, stir 10-60min.Obtained glycerine water solution connects Buchner funnel and bottle,suction, carries out suction filtration via vavuum pump, altogether suction filtration three times.With two syringes, ready glycerine water solution is sucked, and two syringes are positioned on micro-injection pump.Syringe is connected with nitrogen cylinder, opens nitrogen cylinder and by Stress control at 0.7MPa, close steel cylinder after making syringe be full of nitrogen, and the syringe that nitrogen is housed is positioned on micro-injection pump.Syringe and microchip entrance use sebific duct to be connected, and microchip outlet uses sebific duct to be connected with collector.Regulate cold light source, relative position between microchip and high-speed camera instrument, to ensure to obtain enough pictures clearly.Start micro-injection pump, set diameter and the liquid phase volume flow of injection needle tube.Start to drive liquid.Gather after flowing is stable and preserve image.After each change flow, need gather again after flowing is stable and preserve image.Continuous phase and decentralized photo enter from microchip import department respectively, with one voice locate to form bubble at first cross, and liquid phase can enter at T-shaped bifurcation mouth place to be convenient to regulate the voidage of bubble or make bubbles burst, and exit, microchannel is the microbubble of required size.
Embodiment 2
Regulate and control a method for microbubble size, comprise the steps:
Under normal temperature, water and SDS (lauryl sodium sulfate) are put in pretreatment beaker by the mass ratio of 1000:3, stir 10-60min.The obtained SDS aqueous solution connects Buchner funnel and bottle,suction, carries out suction filtration via vavuum pump, altogether suction filtration three times.With two 60ml syringes, the ready SDS aqueous solution is sucked, and two syringes are positioned on micro-injection pump.60ml syringe is connected with nitrogen cylinder, opens nitrogen cylinder and by Stress control at 0.7MPa, close steel cylinder after making syringe be full of nitrogen, and the syringe that nitrogen is housed is positioned on micro-injection pump.Syringe and microchip entrance use sebific duct to be connected, and microchip outlet uses sebific duct to be connected with collector.Regulate cold light source, relative position between microchip and high-speed camera instrument, to ensure to obtain enough pictures clearly.Start micro-injection pump, set diameter and the liquid phase volume flow of injection needle tube.Start to drive liquid.Gather after flowing is stable and preserve image.After each change flow, need gather again after flowing is stable and preserve image.Continuous phase and decentralized photo enter from microchip import department respectively, with one voice locate to form bubble at first cross, and liquid phase can enter at T-shaped bifurcation mouth place to be convenient to regulate the voidage of bubble or make bubbles burst, and exit, microchannel is the microbubble of required size.
Embodiment 3
Regulate and control a method for microlayer model size, comprise the steps:
Under normal temperature, water and SDS (lauryl sodium sulfate) are put in pretreatment beaker by the mass ratio of 1000:3, stir 10-60min.The obtained SDS aqueous solution connects Buchner funnel and bottle,suction, carries out suction filtration via vavuum pump, altogether suction filtration three times.With two 60ml syringes, the ready SDS aqueous solution is sucked, and two syringes are positioned on micro-injection pump.With a 60ml syringe, cyclohexane is sucked, and syringe is positioned on micro-injection pump.Syringe and microchip entrance use sebific duct to be connected, and microchip outlet uses sebific duct to be connected with collector.Regulate cold light source, relative position between microchip and high-speed camera instrument, to ensure to obtain enough pictures clearly.Start micro-injection pump, set diameter and the liquid phase volume flow of injection needle tube.Start to drive liquid.Gather after flowing is stable and preserve image.After each change flow, need gather again after flowing is stable and preserve image.Continuous phase and decentralized photo enter from microchip import department respectively, with one voice locate to form microlayer model at first cross, and continuous phase can enter at T-shaped bifurcation mouth place to be convenient to regulate the voidage of drop or make droplet rupture, and exit, microchannel is the microlayer model of required size.
Embodiment 4
Regulate and control a method for microlayer model size, comprise the steps:
Under normal temperature, water and CMC (sodium carboxymethylcellulose) are put in pretreatment beaker by the mass ratio of 1000:3, stir 6-10h.The obtained CMC aqueous solution connects Buchner funnel and bottle,suction, carries out suction filtration via vavuum pump, altogether suction filtration three times.With two 60ml syringes, the ready CMC aqueous solution is sucked, and two syringes are positioned on micro-injection pump.With a 60ml syringe, cyclohexane is sucked, and syringe is positioned on micro-injection pump.Syringe and microchip entrance use sebific duct to be connected, and microchip outlet uses sebific duct to be connected with collector.Regulate cold light source, relative position between microchip and high-speed camera instrument, to ensure to obtain enough pictures clearly.Start micro-injection pump, set diameter and the liquid phase volume flow of injection needle tube.Start to drive liquid.Gather after flowing is stable and preserve image.After each change flow, need gather again after flowing is stable and preserve image.Continuous phase and decentralized photo enter from microchip import department respectively, with one voice locate to form microlayer model at first cross, and continuous phase can enter at T-shaped bifurcation mouth place to be convenient to regulate the voidage of drop or make droplet rupture, and exit, microchannel is the microlayer model of required size.
Although be described preferred embodiment of the present utility model by reference to the accompanying drawings above; but the utility model is not limited to above-mentioned detailed description of the invention; above-mentioned detailed description of the invention is only schematic; be not restrictive; those of ordinary skill in the art is under enlightenment of the present utility model; do not departing under the ambit that the utility model aim and claim protect, can also make a lot of form, these all belong within protection domain of the present utility model.
Claims (2)
1. novel microbubble/drop formation regulation device, it is characterized in that, comprise micro-injection pump and syringe, microchip and collector, micro-injection pump is provided with syringe, syringe and microchip entrance use sebific duct to be connected, micro-injection pump and syringe have three, are connected respectively with three entrances of microchip, and microchip outlet uses sebific duct to be connected with collector.
2. novel microbubble/drop formation regulation device according to claim 1, it is characterized in that, described microchip is formed by a square duct and a T-shaped channels intersect, microchip entrance has three, square duct is provided with continuous phase first entrance, one end, T-shaped channel branches place is provided with continuous phase second entrance, T-shaped passage two ends are respectively equipped with decentralized photo entrance and exit, described square duct and T-shaped passage cross focal position are main channel to the straight channel exported, and continuous phase second entrance is subchannel to the interface channel of main channel; Wide and the height in cross section, microchip main channel is all less than 1mm; The entrance length of decentralized photo and continuous phase is no less than 10mm; The channel cross-section size of continuous phase second entrance is less than main channel size; Continuous phase second entrance is not less than 10mm apart from the distance of cross focal position, and is not less than 10mm apart from the distance of outlet.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520561407.1U CN204816577U (en) | 2015-07-30 | 2015-07-30 | Novel microbubble / liquid drop generates regulation and control device |
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| CN201520561407.1U CN204816577U (en) | 2015-07-30 | 2015-07-30 | Novel microbubble / liquid drop generates regulation and control device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105013547A (en) * | 2015-07-30 | 2015-11-04 | 天津大学 | Novel microbubble/liquid drop generation regulation and control device and novel microbubble/liquid drop generation regulation and control method |
| CN105498875A (en) * | 2016-01-27 | 2016-04-20 | 杭州霆科生物科技有限公司 | Centrifugal micro-fluidic chip for preparing liquid drops |
| CN105618167A (en) * | 2016-01-27 | 2016-06-01 | 杭州霆科生物科技有限公司 | Centrifugal microfluidic chip for preparing droplets in high-throughput manner |
| CN108393100A (en) * | 2017-02-08 | 2018-08-14 | 上海小海龟科技有限公司 | Reaction system occurs and collects for a kind of microlayer model |
-
2015
- 2015-07-30 CN CN201520561407.1U patent/CN204816577U/en not_active Withdrawn - After Issue
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105013547A (en) * | 2015-07-30 | 2015-11-04 | 天津大学 | Novel microbubble/liquid drop generation regulation and control device and novel microbubble/liquid drop generation regulation and control method |
| CN105498875A (en) * | 2016-01-27 | 2016-04-20 | 杭州霆科生物科技有限公司 | Centrifugal micro-fluidic chip for preparing liquid drops |
| CN105618167A (en) * | 2016-01-27 | 2016-06-01 | 杭州霆科生物科技有限公司 | Centrifugal microfluidic chip for preparing droplets in high-throughput manner |
| CN108393100A (en) * | 2017-02-08 | 2018-08-14 | 上海小海龟科技有限公司 | Reaction system occurs and collects for a kind of microlayer model |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20151202 Effective date of abandoning: 20160928 |
|
| C25 | Abandonment of patent right or utility model to avoid double patenting |