CN202129066U - Microflow-controlled microballoon preparation device - Google Patents
Microflow-controlled microballoon preparation device Download PDFInfo
- Publication number
- CN202129066U CN202129066U CN201120198980U CN201120198980U CN202129066U CN 202129066 U CN202129066 U CN 202129066U CN 201120198980 U CN201120198980 U CN 201120198980U CN 201120198980 U CN201120198980 U CN 201120198980U CN 202129066 U CN202129066 U CN 202129066U
- Authority
- CN
- China
- Prior art keywords
- microchannel
- micro
- channel
- continuous phase
- microballoon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The utility model discloses a micro-flow-controlled micro-balloon preparation device which comprises a micro-channel chip, a micro-fluid driving device and a micro-balloon collector, wherein the micro-channel chip integrates a dispersed phase micro-channel and a continuous phase micro-channel, the dispersed phase micro-channel is a micro-channel with a fractal tree structure, the micro-channel with the fractal tree structure comprises a main channel and at least one level of branch channel, an entrance of the main channel is connected with a dispersed phase fluid injector, a connecting channel is arranged on a tail level of branch channel, an exit of the connecting channel is positioned in the continuous phase micro-channel, a dispersed phase main channel generates more branches by bifurcate act, and the structure is similar to optimization of a fluid distributor, so that the device can effectively reduce the flowing pressure drop of fluid in the micro-channels, and simultaneously, uniformly distributes flow rate and flow speed of liquid in every level of channel, so as to ensure that the homogeneity of size of micro-balloons is high; and tree-shaped channels are provided with a plurality of outlets, so that the device greatly improves the micro-balloon production rate.
Description
Technical field
The utility model relates to a kind of microballoon preparation facilities based on microflow control technique, and what be specifically related to is a kind ofly to have a tree characteristic microchannel microballoon preparation facilities for what improve that the microballoon preparation efficiency designs.
Background technology
Microballoon is meant that medicine disperses or is attracted in macromolecule, the polymer substrate and the microparticulate system that forms.At present, method for preparing polymer micro commonly used has: emulsion polymerization, dispersion copolymerization method, seeding polymerization method, suspension polymerization, microsuspension polymerization method, spray drying process, template etc.Common unit prepares that microballoon exists usually that reagent consumption is big, complex process, technology length consuming time, not high, the first-class problems of the big or small inequality of microballoon of microballoon sphericity that make.For this reason, press for the novel preparation facilities of development polymer microballoon, make that can effectively improve microballoon produces preparation efficiency, can reduce reagent consumption again, optimize the preparation process.
Microflow control technique is a kind of optimization approach of polymer microballoon preparation.An important component part is the microchannel in the micro fluidic device, and the structure of microchannel and shape have material impact to the micro fluidic device performance.Existing micro-fluidic chip mostly adopts is the simple coflow flow control apparatus that declines; Have only a preparation passage, thereby the productivity ratio of preparation process is not high, the preparation process is consuming time longer; Though in the laboratory, obtained distinguished effect, be difficult to be applied in the large-scale industrial production.The method of boosting productivity generally is with the parallel connection of a plurality of preparation passages, but under minute yardstick, and fluid distributes and often is difficult to accomplish evenly when flowing, thereby may cause the shape, not of uniform size of each passage microballoon preparation, has influence on the monodispersity of product.For this reason, the utility model is edified by bionical thought, and trees such as human body medium vessels, tracheae and lymphatic vessel are applied to microchannel design, so reach make full use of the micro-fluidic chip space, production efficiency is high, the microballoon sphericity is high and uniform purpose.
Summary of the invention
The technical problem that solves:
The utility model technical problem to be solved is to the above-mentioned existing coflow not high shortcoming of flow control apparatus productivity ratio that declines; And a kind of novel microfluidic chip structure with fractal tree-shaped characteristic microchannel is provided, this structure microballoon preparation facilities can significantly improve the microballoon preparation efficiency under the condition that guarantees microballoon sphericity and dimensional homogeneity.
The purpose of the utility model is a kind of microballoon preparation facilities based on microflow control technique of design; Have integrated and advantage miniaturization; The decentralized photo passage of this device is fractal tree, has realized that fluid distributes fully uniformly, makes the preparation process of microballoon obtain optimization; Improve preparation efficiency, realized scale, the serialization production of high controllability.
Technical scheme:Go up the technical problem that exists for solving current microballoon preparation facilities design, the technical scheme that the utility model adopts is:
A kind of micro-fluidic microballoon preparation facilities; Form by microchannel chip, microfluid drive and microballoon gatherer; Described microfluid drive comprises dispersed phase fluid syringe and continuous phase fluid syringe; Described microchannel chip is integrated decentralized photo microchannel and continuous phase microchannel, the arrival end in described decentralized photo microchannel connects described dispersed phase fluid syringe, and the arrival end in described continuous phase microchannel connects described continuous phase fluid syringe; The exit of chip connects described microballoon gatherer in described microchannel; It is characterized in that: described decentralized photo microchannel is fractal tree microchannel, and this fractal tree microchannel comprises main channel and one-level branched bottom at least, and the inlet of described main channel connects described dispersed phase fluid syringe; On described final stage branched bottom, interface channel is set, the outlet of this interface channel is positioned at described continuous phase microchannel.
Described decentralized photo microchannel has fractal tree-shaped architectural feature; Be made up of main channel and branched bottom, the main channel is the 0th grade (being decentralized photo liquid inlet) of fractal tree, generates the 1st grade of branched bottom by main channel bifurcated effect; Angle of the crossing α between the superior and the subordinate microchannel is 180 degree; The 1st grade branched bottom generates the 2nd grade of branched bottom through the bifurcated effect then, and Zhou Erfu follows, and generates the 3rd, 4,5 ....
nThe level branched bottom.Like this, the afterbody of the tree of generation will have 2
n Individual microchannel.This means that the interface channel that connects levels has 2
n Individual.Fractal structure with reference to human respiratory designs fractal tree-shaped microchannel, and the ratio of the hydraulic diameter of described the superior and the subordinate branched bottom does
N -1/
Δ (
NBe every grade branched bottom number, N=2, diametral dimension
ΔGet greater than 7/3 and smaller or equal to 3 real number), the length ratio of described the superior and the subordinate branched bottom does
N -1/
d (length dimension
dGet greater than 1 and less than 2 real number).The branched bottom that it is pointed out that each grade all has identical shaped and physical dimension, and then has effectively guaranteed the complete uniform distribution function of dispersed phase fluid, thereby the microballoon that reaches preparation has the high and big or small homogeneous characteristic of sphericity.In addition, the decentralized photo microchannel adopts fractal structure to arrange that each microchannel chip has 2
n Individual interface channel, the space utilization that has improved the microchannel chip greatly makes can generate 2 simultaneously at every turn
n Individual microballoon makes the production efficiency of microballoon obtain increasing substantially.
Described decentralized photo microchannel and continuous phase microchannel spatially are parallel laminar arrangement up and down, and the decentralized photo microchannel is positioned at the top, is fractal tree-shaped structural configuration; The continuous phase microchannel is positioned at the below, is flat and arranges.The final stage passage of decentralized photo microchannel connects through communication passage and continuous phase microchannel perpendicular to plane, decentralized photo microchannel.
During use, decentralized photo that has configured and continuous phase liquid are contained respectively in the said syringe, used liquid flow in propeller or the syringe pump injector-actuated.Through the flow velocity of conciliation with proportioning propeller or syringe pump; Make decentralized photo liquid be able to be become monodispersed microballoon by the continuous phase liquid shear in said interface channel exit; And, can obtain qualified microballoon through solidifying drying at last along with continuous phase liquid flows out to the said microballoon gatherer from said continuous phase channel outlet.
The technical scheme of the utility model is: edified by bionical thought, trees such as human body medium vessels, tracheae and lymphatic vessel are applied to the microchannel design, designed the micro-fluidic microballoon preparation facilities with fractal tree.The decentralized photo main channel produces increasing branch through the bifurcated effect; This structure is similar to the fluid distributor of having optimized; The flow and the flow velocity that distribute liquid in each grade passage in can the fluid-flow pressure drop in effectively reducing the microchannel uniformly guarantee that the microballoon dimensional homogeneity that makes is high; And tree-shaped passage has a plurality of outlets, has improved the microballoon productivity ratio of microballoon preparation facilities greatly.Therefore, the design arrangement of the micro-fluidic microballoon preparation facilities of fractal tree has reached energy-conservation and purpose High-efficient Production.
Each passage of described decentralized photo passage (being made up of main channel and branched bottom and interface channel) is sprawled with planar fashion and is come; The 0th grade of passage (main channel) is the 0th grade of fractal tree; End at the 0th grade of passage generates two the 1st grade of branched bottoms through the bifurcated effect; Angle of the crossing α between the superior and the subordinate microchannel is 180 degree, generates four the 2nd grade of branched bottoms through the bifurcated effect then at the end of two the 1st grade branched bottom, and the angle of the crossing α between the superior and the subordinate microchannel also is 180 degree; Zhou Erfu follows, and generates the 3rd, 4,5 ....
nThe level branched bottom.Like this, the afterbody of the tree of generation will have 2
n Individual microchannel.At last, be connected with interface channel at final stage channel end and import in the continuous phase passage.The cross sectional shape of passages at different levels and exit passageway all can be arbitrary shapes such as circle, rectangle, trapezoidal, thread-shaped.
In research, find, in the branched structure human respiratory fractal structure characteristic
nRelation between level passage hydraulic diameter and the next stage hydraulic diameter does
D n /
D N-1 =N -Δ (
DBe hydraulic diameter,
NBe every grade branched bottom number,
N=2, diametral dimension
ΔGet greater than 7/3 and smaller or equal to 3 real number).Experiment showed, in a large number and work as
Δ=1/3 o'clock, fluid laminar flow flow resistance was got minimum of a value, when
Δ=7/3 o'clock, the fluid turbulent flow resistance was got minimum of a value.Make tree the length dimension not occur interlocking between planar fashion layout and the passage
dShould get greater than 1 and less than 2 real number.
It is to be noted; May bring certain pressure drop loss although flow at tree-shaped passage bifurcated; But, it should be noted that fractal channel has the peptizaiton of fluid flow, its similar in fact one optimization disperser of flowing; This structure can make each unit fluid dispersion flows, and flow resistance equals concentrating of decentralized photo liquid outlet diameter than diameter and flows little.The fractal distribution characteristic that passage hydraulic diameter that the decentralized photo passage is not at the same level and length are such can realize the optimization that the flow pumps merit consumes in the pipe.And fractal tree-shaped passage has a plurality of fluid issuings, and the flow of each fluid issuing and speed obtained the distribution of homogeneous, has improved the space availability ratio of micro-fluidic chip and the preparation efficiency of microballoon greatly.
Described micro-fluidic chip is according to differences such as condition of work, fluid properties; Size can be controlled at several square centimeters of effects; Material can select for use silicon chip, glass, silicon rubber, plastic or other material as substrate, through methods such as etching, photoetching or die processing microchannel.
The fractal tree-shaped micro-fluidic microballoon preparation facilities that the utility model provides; Said decentralized photo passage and continuous phase inner fluid passage can use any fluid working substance as required; Flowing of continuous phase can become concurrent flow with the flow arrangement of decentralized photo main channel; Also can be arranged to cross-current, no matter flow direction how in the continuous phase passage, the production process of said microballoon preparation facilities is unaffected.
The utility model provides a kind of novel micro-fluidic microballoon preparation facilities of efficient, integrated fractal tree.In said device uses; Dispersed phase fluid gets into the decentralized photo passage from the decentralized photo inlet; Be diverted to each decentralized photo channel branch rapidly, in this aspect, reach uniform quality and speed and distribute, flow into the decentralized photo exit passageway from fractal tree tip then; Then get in the continuous phase fluid, cut into monodispersed microballoon by the effect of continuous phase fluid through viscous force.Compare with traditional passage that is arranged in parallel, the passage of fractal tree improves useful space utilization rate greatly, because its flow resistance is little, has reduced the consumption of pump merit in addition, and this is for realizing that the efficient production microballoon is useful.
Beneficial effect:
The fractal tree-shaped micro-fluidic microballoon preparation facilities that the utility model is novel; The arrangement of fractal tree-shaped microchannel has made full use of the space of micro-fluidic chip; And the flow of each decentralized photo microchannel fluid issuing and speed complete and homogeneous are divided and are joined; Improve the space availability ratio of micro-fluidic chip and the preparation efficiency of microballoon, also helped the consumption that reduces the pump merit.More than these factors, not only make whole micro-fluidic microballoon preparation facilities compact to design rationally, can also reach efficient production and purpose of energy saving in the productivity ratio that reduces raising microballoon under certain energy consumption condition.
Description of drawings:
The fractal tree-shaped micro-fluidic microballoon preparation facilities sketch map of Fig. 1.
Fig. 2 micro-fluidic chip vertical view.
Fig. 3 microfluidic chip structure sketch map one.
Fig. 4 microfluidic chip structure sketch map two.
The fractal tree-shaped channel design sketch map of Fig. 5.
1. decentralized photo syringes among the figure; 2. continuous phase syringe; 3. fractal tree-shaped micro-fluidic chip; 4. collection ware; 5. connecting pipe; 6. main channel (the 0th grade of passage); 7. branched bottom; 8. interface channel; 9. tree flow channel network, i.e. decentralized photo passage; 10. flat interface channel, i.e. continuous phase passage; 11. the 1st grade of passage; 12. the 2nd grade of passage; 13. 3rd level passage; 14. the 4th grade of passage; 15. the 5th grade of passage; 16. microballoon.
The specific embodiment:
Carry out detailed description further below in conjunction with accompanying drawing:
Fig. 1 has provided the utility model sketch map; A kind of have a micro-fluidic microballoon preparation facilities of fractal tree-shaped characteristic, and concrete structure comprises: chief component such as decentralized photo syringe 1, continuous phase syringe 2, micro-fluidic chip (integrated decentralized photo passage and pancake continuous phase passage with fractal tree) 3, microballoon gatherer 4, tube connector 5.
Fig. 2 has provided said micro-fluidic chip vertical view; The decentralized photo passage has fractal tree; Sprawl with the mode on plane and to come; Decentralized photo liquid is driven inflow main channel 6 (the 0th grade of passage of fractal tree) through connecting pipeline by syringe pump from syringe, be assigned to uniformly in the next stage branched bottom 7 (the 1st grade of passage of fractal tree) at the branch point place and go.Decentralized photo liquid finally is assigned to 2 uniformly through branch points at different levels
n (
nBe fractal tree-shaped channel level number) in the individual branched bottom, and flow into to be sheared in the continuous phase liquid through interface channel 8 at n level passage place end and become microballoon.
Fig. 3 and Fig. 4 have provided the microfluidic chip structure sketch map under the different angles, and said fractal tree-shaped micro-fluidic chip is processed by substrate, and substrate material can be selected silicon chip, glass, silicon rubber, plastics or the like as required.Decentralized photo passage and each one deck of continuous phase passage, wherein fractal tree-shaped structural flow is moved channel network 9, i.e. decentralized photo passage; Be arranged on the inboard of substrate upper surface; It is inboard that the continuous phase passage is arranged on basic lower surface, and the continuous phase channel cross-section is a rectangle, is shaped as flat.The outlet of the interface channel that the final stage passage of the decentralized photo passage of fractal tree is connecting is distributed in the continuous phase passage vacantly.
The structure of the structure of fractal tree-shaped microchannel, upper strata and branch at different levels and interface channel and branch at different levels are as shown in Figure 5, and described tree microchannel is sprawled with planar fashion and come, and the microchannel network contains 2 grades at least, and every grade of passage is connecting the bifurcated number
N=2 next stage passage, the angle of the crossing between the superior and the subordinate's runner
αBe 180 °, in order to obtain optimum flow effect, hydraulic diameters at different levels and length generate according to certain proportionate relationship in the branched structure.According to fractal theory, hydraulic diameters at different levels and length satisfy certain relation in the designing requirement branched structure, and the diameter ratio of the superior and the subordinate's branched bottom does
N -1/
Δ ,
NBe every grade branched bottom number, N=2, diametral dimension
ΔGet greater than 7/3 and smaller or equal to 3 real number; The length ratio of branch of the superior and the subordinate runner does
N -1/
d , the length dimension
dGet greater than 1 and smaller or equal to 2 real number.The passage progression of fractal tree-shaped passage is smaller or equal to 10 integer more than or equal to 2.
Decentralized photo liquid flows into the main channel (the 0th grade of passage) 6 of said tree passage from said decentralized photo syringe 1 under the driving of syringe pump, successively through the 1st, 2
nThe level passage finally is assigned to 2 fully uniformly
n In the individual n level passage 15, get into interface channel 8 then, become microballoon by the continuous phase liquid shear in the exit of interface channel.
Continuous phase liquid flows into the said continuous phase path 10 from said continuous phase syringe 2 under the driving of syringe pump; Near through shearing force 8 outlets of said interface channel effect cuts into decentralized photo liquid and is monodispersed microballoon, and carrying secretly microballoon from the outlet of continuous phase path 10 through tube connector 5 inflow microballoon gatherers 4.
Claims (6)
1. micro-fluidic microballoon preparation facilities; Form by microchannel chip, microfluid drive and microballoon gatherer; Described microfluid drive comprises dispersed phase fluid syringe and continuous phase fluid syringe; Described microchannel chip is integrated decentralized photo microchannel and continuous phase microchannel, the arrival end in described decentralized photo microchannel connects described dispersed phase fluid syringe, and the arrival end in described continuous phase microchannel connects described continuous phase fluid syringe; The exit of chip connects described microballoon gatherer in described microchannel; It is characterized in that: described decentralized photo microchannel is fractal tree microchannel, and this fractal tree microchannel comprises main channel and one-level branched bottom at least, and the inlet of described main channel connects described dispersed phase fluid syringe; On described final stage branched bottom, interface channel is set, the outlet of this interface channel is positioned at described continuous phase microchannel.
2. micro-fluidic microballoon preparation facilities according to claim 1 is characterized in that: described decentralized photo microchannel and continuous phase microchannel are two-layer being arranged in parallel up and down, and described continuous phase microchannel is platypelloid type rectangle microchannel.
3. micro-fluidic microballoon preparation facilities according to claim 1 is characterized in that: described decentralized photo microchannel is two-layer, and described continuous phase microchannel is one deck and occupy in the middle of the two-layer decentralized photo microchannel.
4. the micro-fluidic microballoon preparation facilities of tree according to claim 1 is characterized in that: described fractal tree microchannel is sprawled with planar fashion and is come, and every grade of passage is connecting the bifurcated number
N=2 next stage passage, the angle of the crossing α between the superior and the subordinate microchannel are 180 degree.
5. micro-fluidic microballoon preparation facilities according to claim 4 is characterized in that: the ratio of the hydraulic diameter of the superior and the subordinate's branched bottom of described fractal tree fluid channel network does
N -1/
Δ , diametral dimension wherein
ΔGet greater than 7/3 and smaller or equal to 3 real number, the length ratio of described the superior and the subordinate branched bottom does
N -1/
d , length dimension wherein
dGet greater than 1 and less than 2 real number.
6. micro-fluidic microballoon preparation facilities according to claim 4 is characterized in that: the passage progression of described fractal tree-shaped passage for more than or equal to 2 smaller or equal to 10 integer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120198980U CN202129066U (en) | 2011-06-14 | 2011-06-14 | Microflow-controlled microballoon preparation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120198980U CN202129066U (en) | 2011-06-14 | 2011-06-14 | Microflow-controlled microballoon preparation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202129066U true CN202129066U (en) | 2012-02-01 |
Family
ID=45517852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201120198980U Expired - Fee Related CN202129066U (en) | 2011-06-14 | 2011-06-14 | Microflow-controlled microballoon preparation device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202129066U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102284262A (en) * | 2011-06-14 | 2011-12-21 | 东南大学 | Microfluidic microsphere preparation device |
| WO2019227105A1 (en) * | 2018-05-25 | 2019-11-28 | The General Hospital Corporation | Additive manufacture of complex implantable living devices |
| US11534530B2 (en) | 2015-08-14 | 2022-12-27 | The General Hospital Corporation | Systems for and methods for using biomimetic structures providing communication in living tissue |
-
2011
- 2011-06-14 CN CN201120198980U patent/CN202129066U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102284262A (en) * | 2011-06-14 | 2011-12-21 | 东南大学 | Microfluidic microsphere preparation device |
| US11534530B2 (en) | 2015-08-14 | 2022-12-27 | The General Hospital Corporation | Systems for and methods for using biomimetic structures providing communication in living tissue |
| WO2019227105A1 (en) * | 2018-05-25 | 2019-11-28 | The General Hospital Corporation | Additive manufacture of complex implantable living devices |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102284262A (en) | Microfluidic microsphere preparation device | |
| CN102389730A (en) | Double-emulsion preparation chip | |
| CN107999155A (en) | Micro-fluidic chip and its control method, drop formation device and microballoon preparation facilities | |
| CN103386333A (en) | Micro-fluidic liquid drop production chip | |
| CN103638852B (en) | A kind of synthesizing jet-flow Valveless piezoelectric micro-mixer | |
| CN104069757B (en) | Dual-microemulsion rapid preparation device | |
| CN103923816B (en) | A kind of cell capture array based on microflow control technique | |
| CN109261036B (en) | Microstructure mixer for mixing high-viscosity fluid | |
| CN103386336A (en) | Microfluidic chip for producing droplets with concentration gradients | |
| CN103454126A (en) | Adjustable liquid droplet generating device | |
| CN105126687B (en) | A kind of passive micro-mixer of separating-closing type | |
| CN202129066U (en) | Microflow-controlled microballoon preparation device | |
| CN106622407A (en) | Capillary microfluidic control device for solid core package, and preparation method thereof | |
| CN106190779A (en) | Unicellular separation based on micro-fluidic chip and containment device and method | |
| CN103386337A (en) | Microfluidic chip for producing multicomponent droplets | |
| CN105921188A (en) | Microfluidic device capable of rapidly preparing emulsion in multiple dimensions | |
| CN205886751U (en) | Flow mixer passively declines | |
| CN208340745U (en) | A kind of microballoon quickly prepares collection micro-fluidic chip | |
| CN106140050B (en) | Reactor unit and double-side type microreactor system | |
| CN208356802U (en) | Microfluidic chip liquid drop generating means | |
| CN207899465U (en) | Micro-fluidic chip, drop formation device and microballoon preparation facilities | |
| CN201823514U (en) | Gravity-driven microfluid device for preparing monodispersed emulsion | |
| CN104741049B (en) | Microsphere manufacture device | |
| CN202237837U (en) | Double emulsion preparation chip | |
| CN101920183A (en) | Microchannel reactor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120201 Termination date: 20140614 |
|
| EXPY | Termination of patent right or utility model |