CN208340745U - A kind of microballoon quickly prepares collection micro-fluidic chip - Google Patents
A kind of microballoon quickly prepares collection micro-fluidic chip Download PDFInfo
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- CN208340745U CN208340745U CN201820107856.2U CN201820107856U CN208340745U CN 208340745 U CN208340745 U CN 208340745U CN 201820107856 U CN201820107856 U CN 201820107856U CN 208340745 U CN208340745 U CN 208340745U
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Abstract
A kind of microballoon quickly prepares collection micro-fluidic chip, is made of upper cover plate, continuous phase layer, porous layer, disperse phase layer, lower plate；Porous layer is equipped with the array hole with boss；Continuous phase layer is located at the side of porous layer, and disperse phase layer is located at the other side of porous layer；Continuous phase layer includes continuous phase channel, continuous phase pond, solution hybrid channel, microballoon separated structure；Continuous phase pond is connected to continuous phase channel；Solution hybrid channel is connected to continuous phase pond；Microballoon separated structure is made of microballoon channel, waste liquid capillary channel, waste liquid affluent channel；Microballoon channel is connected to solution hybrid channel；Waste liquid capillary channel is distributed in the two sides in microballoon channel and is connected to microballoon channel；Waste liquid affluent channel has two, and is connected to by waste liquid capillary channel with microballoon channel；Disperse phase layer includes dispersed phase channel, dispersed phase pond.A kind of microballoon provided by the utility model, which quickly prepares collection micro-fluidic chip, to generate sodium alginate micro ball to fast and stable.
Description
Technical field
The utility model relates to micro-fluidic chip fields, prepare collection device more particularly to a kind of microballoon.
Background technique
Microballoon is a kind of technology of the manipulation very low volume fluids to grow up on micro-fluidic chip in recent years, and microballoon is used
Have the advantages that 1) sample consumption is atomic, substantially reduces screening cost in screening；2) ball is wrapped up by oil, with the external world without substance
It exchanges, the stable reaction conditions in ball, as a result reliably.At present, most common microballoon generation is to utilize sodium alginate
Drop is reacted with calcium chloride drop can generate microballoon.
Micro-fluidic chip is an emerging technology platform, on one piece several square centimeters of chip, completes conventional chemical
Or the various operations of biology laboratory.Using sodium alginate soln as dispersed phase, calcium chloride solution makes seaweed as continuous phase
Acid sodium solution reacts after forming drop with calcium chloride solution, generates calcium alginate microsphere.But existing micro-fluidic chip generates
The method of calcium alginate microsphere is still difficult to realize realize in a micro-fluidic chip while generating large batch of alginate
Microballoon, therefore in the occasion that the microballoon that alginate microsphere is applied to larger flux is synthesized or screened, it is difficult to meet efficient
The demand of rate batch production alginate microsphere.Therefore, it is necessary to a kind of methods for more efficiently preparing alginate microcapsules.
Summary of the invention
The purpose of this utility model is to design a kind of microballoon preparation facilities based on microflow control technique, this microballoon preparation facilities
Have the advantages that integration and miniaturization, realize substantially uniformity fluid distribution so that the preparation process of microballoon obtained it is excellent
Change, improves preparation efficiency, realize scale, the continuous production of high controllability.
A kind of microballoon quickly prepares collection micro-fluidic chip, it is characterised in that by upper cover plate 1, continuous phase layer 2, porous layer 3,
Disperse phase layer 4, lower plate 5 form.
The porous layer 3 is equipped with the array hole 31 with boss；The continuous phase layer 2 is located at the upside of porous layer 3, institute
The disperse phase layer 4 stated is located at the downside of porous layer 3；The continuous phase layer 2 includes continuous phase channel 21, continuous phase pond 22, molten
Liquid hybrid channel 23, microballoon separated structure 24；The continuous phase pond 22 is connected to continuous phase channel 21；The solution mixing
Channel 23 is connected to continuous phase pond 22.
The microballoon separated structure 24 is by microballoon channel 241, waste liquid capillary channel 242,243 groups of waste liquid affluent channel
At；The microballoon separating mechanism 24 from continuous phase for separating microballoon.The microballoon channel 241 leads to snakelike
Road 23 is connected to；The waste liquid capillary channel 242 is distributed in the two sides in microballoon channel 241 and is connected to microballoon channel 241, described
Waste liquid affluent channel 243 have two, and be connected to 241 with microballoon channel by waste liquid capillary channel 242；The waste liquid capillary
The width in channel 242 answers the small diameter for being formed by microballoon.Continuous phase and the mixing liquid of microballoon enter in microballoon channel 241,
Waste liquid capillary channel 242 can stop microballoon to enter and continuous phase is allowed to enter, to reach the effect of separation microballoon and continuous phase
Fruit.
The disperse phase layer 4 includes dispersed phase channel 41, dispersed phase pond 42；The dispersed phase pond 42 is communicated with dispersion
Road 41 is connected.
It is quickly prepared in collection micro-fluidic chip to enable dispersed phase and continuous phase to inject a kind of microballoon, it is described
Dispersed phase channel 41 should be connected to the chip external world with continuous phase channel 21.
With the flowing of dispersed phase, in continuous phase pond 22 and dispersed phase pond 42 between pressure difference can change, in order to
Ensure that drop successively and can be generated uniformly, it should be ensured that porous layer 3 is indeformable, and porous layer 3 should be high rigidity material.
Boss is viscid on porous layer 3 when dispersed phase is flowed out from array hole 31 in order to prevent.The utility model has the advantages that this is practical new
A kind of microballoon of type quickly prepares collection micro-fluidic chip, and the arrangement of microchannel takes full advantage of the sky of micro-fluidic chip
Between, and the flow of each dispersed phase microchannel fluid outlets and the distribution of speed complete and homogeneousization, improve micro-fluidic chip
The preparation efficiency of space utilization rate and microballoon also helps the consumption for reducing pump work.The above factor not only makes entire micro-
Flow control microballoon preparation facilities is compact to design rationally, moreover it is possible to which the productivity that microballoon is improved in the case where reducing certain energy consumption condition reaches
Efficient preparation and energy-efficient purpose.
Detailed description of the invention
A kind of Fig. 1 microballoon provided by the utility model quickly prepares the structural schematic diagram for collecting micro-fluidic chip.
A kind of Fig. 2 microballoon provided by the utility model, which is quickly prepared, collects micro-fluidic chip continuous phase layer top view.
A kind of Fig. 3 microballoon provided by the utility model, which is quickly prepared, to be collected microfluidic chip liquid drop and generates partial view.
Wherein, 1. upper cover plates, 2. continuous phase layers, 21. continuous phase channels, 22. continuous phase ponds, 23. solution hybrid channels,
24. microballoon separated structure, 241. microballoon channels, 242. waste liquid capillary channels, 243. waste liquid affluent channel, 3. porous layer, 31. gusts
Arrange hole, 4. disperse phase layers, 41. dispersed phase channels, 42. dispersed phase pond, 5. lower plate
Specific embodiment
In order to make those skilled in the art more fully understand the technical solution of the utility model, below with reference to specific implementation
The utility model is described in further detail for example.
As shown in Figure 1, Figure 2 and a kind of microballoon of Fig. 3 quickly prepares collection micro-fluidic chip by upper cover plate 1, continuous phase layer 2, porous
Layer 3, disperse phase layer 4, lower plate 5 form.
The porous layer 3 is equipped with the array hole 31 with boss；The continuous phase layer 2 is located at the upside of porous layer 3, institute
The disperse phase layer 4 stated is located at the downside of porous layer 3；The continuous phase layer 2 includes continuous phase channel 21, continuous phase pond 22, molten
Liquid hybrid channel 23, microballoon separated structure 24；The continuous phase pond 22 is connected to continuous phase channel 21；The solution mixing
Channel 23 is connected to continuous phase pond 22.
The microballoon separated structure 24 is by microballoon channel 241, waste liquid capillary channel 242,243 groups of waste liquid affluent channel
At；The microballoon separating mechanism 24 from continuous phase for separating microballoon.The microballoon channel 241 leads to snakelike
Road 23 is connected to；The waste liquid capillary channel 242 is distributed in the two sides in microballoon channel 241 and is connected to microballoon channel 241, described
Waste liquid affluent channel 243 have two, and be connected to 241 with microballoon channel by waste liquid capillary channel 242；The waste liquid capillary
The width in channel 242 answers the small diameter for being formed by microballoon.Continuous phase and the mixing liquid of microballoon enter in microballoon channel 241,
Waste liquid capillary channel 242 can stop microballoon to enter and continuous phase is allowed to enter, to reach the effect of separation microballoon and continuous phase
Fruit.
The disperse phase layer 4 includes dispersed phase channel 41, dispersed phase pond 42；The dispersed phase pond 42 is communicated with dispersion
Road 41 is connected.
It is quickly prepared in collection micro-fluidic chip to enable dispersed phase and continuous phase to inject a kind of microballoon, it is described
Dispersed phase channel 41 should be connected to the chip external world with continuous phase channel 21.
With the flowing of dispersed phase and continuous phase, in continuous phase pond 22 and dispersed phase pond 42 between pressure difference can change
Become, in order to ensure drop successively and can be generated uniformly, it should be ensured that porous layer 3 is indeformable, and porous layer 3 should be high rigidity
Material.
Boss on array hole is viscid on porous layer 3 when dispersed phase is flowed out from array hole 31 in order to prevent.In use,
Dispersed phase (sodium alginate soln) by syringe pump inject dispersed phase channel 41, and be full of dispersed phase pond 42, subsequent dispersed phase from
Continuous phase pond 22 is flowed into array hole 31；Continuous phase injects continuous phase channel 21, continuous phase (calcium chloride solution) by syringe pump
It flows through continuous phase pond 22 and the dispersed phase flowed out in array hole 31 is cut into microlayer model.Dispersed phase microlayer model and continuous phase reaction
Generate microballoon.The mixing liquid of microballoon and continuous phase flows through solution hybrid channel 23, microballoon fast reaction in serpentine channel 23
Complete the reaction process of continuous phase and dispersed phase.The mixing liquid of microballoon and continuous phase flows into microballoon channel 241, and continuous phase passes through
Waste liquid capillary channel 242 enters waste liquid affluent channel 243 and flows out micro-fluidic chip, realizes microballoon with continuous phase separation.
The basic principles and main features and advantage of the utility model have been shown and described above.The technical staff of the industry
It should be appreciated that the present utility model is not limited to the above embodiments, the above embodiments and description only describe this
The principle of utility model, on the premise of not departing from the spirit and scope of the utility model, the utility model also has various change
And improvement, these various changes and improvements fall within the scope of the claimed invention.The utility model requires protection scope
It is defined by the appending claims and its equivalent thereof.
Claims (2)
1. a kind of microballoon quickly prepares collection micro-fluidic chip, it is characterised in that by upper cover plate, continuous phase layer, porous layer, dispersion
Phase layer, lower plate composition；The porous layer is equipped with the array hole with boss；The continuous phase layer is located at the upper of porous layer
Side, the disperse phase layer are located at the downside of porous layer；The continuous phase layer includes continuous phase channel, continuous phase pond, solution
Hybrid channel, microballoon separated structure；The continuous phase pond is connected to continuous phase channel；The solution hybrid channel and continuous
The connection of phase pond；The microballoon separated structure is made of microballoon channel, waste liquid capillary channel, waste liquid affluent channel；Described is micro-
Ball channel is connected to solution hybrid channel；The waste liquid capillary channel is distributed in the two sides in microballoon channel and connects with microballoon channel
It is logical；The waste liquid affluent channel has two, and is connected to by waste liquid capillary channel with microballoon channel；The disperse phase layer packet
Include dispersed phase channel, dispersed phase pond；The dispersed phase pond is connected to dispersed phase channel.
2. a kind of microballoon according to claim 1 quickly prepares collection micro-fluidic chip, it is characterized in that the dispersed phase
Channel should all be connected to continuous phase channel with the chip external world.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201820107856.2U CN208340745U (en) | 2018-01-22 | 2018-01-22 | A kind of microballoon quickly prepares collection micro-fluidic chip |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820107856.2U CN208340745U (en) | 2018-01-22 | 2018-01-22 | A kind of microballoon quickly prepares collection micro-fluidic chip |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110029063A (en) * | 2019-03-04 | 2019-07-19 | 杭州电子科技大学 | A kind of double-deck microlayer model co-culture device and its application method with concentration gradient |
| CN110639450A (en) * | 2019-09-29 | 2020-01-03 | 山东大学 | Device and method for preparing calcium alginate microspheres by using microreactor and application of device |
| CN112844501A (en) * | 2019-11-28 | 2021-05-28 | 中国科学院大连化学物理研究所 | Multi-liquid-core hydrogel microcapsule chip based on double aqueous phases and application thereof |
| CN115624928A (en) * | 2022-11-01 | 2023-01-20 | 贵州大学 | Micro-reaction equipment for preparing nano cuprous iodide and using method |
-
2018
- 2018-01-22 CN CN201820107856.2U patent/CN208340745U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110029063A (en) * | 2019-03-04 | 2019-07-19 | 杭州电子科技大学 | A kind of double-deck microlayer model co-culture device and its application method with concentration gradient |
| CN110639450A (en) * | 2019-09-29 | 2020-01-03 | 山东大学 | Device and method for preparing calcium alginate microspheres by using microreactor and application of device |
| CN112844501A (en) * | 2019-11-28 | 2021-05-28 | 中国科学院大连化学物理研究所 | Multi-liquid-core hydrogel microcapsule chip based on double aqueous phases and application thereof |
| CN115624928A (en) * | 2022-11-01 | 2023-01-20 | 贵州大学 | Micro-reaction equipment for preparing nano cuprous iodide and using method |
| CN115624928B (en) * | 2022-11-01 | 2024-04-12 | 贵州大学 | Micro-reaction equipment for preparing nano cuprous iodide and use method |
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Granted publication date: 20190108 Termination date: 20200122 |