CN104941541A - System and method for preparing microcapsules - Google Patents
System and method for preparing microcapsules Download PDFInfo
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- CN104941541A CN104941541A CN201510282879.8A CN201510282879A CN104941541A CN 104941541 A CN104941541 A CN 104941541A CN 201510282879 A CN201510282879 A CN 201510282879A CN 104941541 A CN104941541 A CN 104941541A
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Abstract
The present invention provides a system and a method for preparing microcapsules, and relates to the technical field of materials. The system comprises a drive power supply, a piezoelectric ceramic, a bracket, a microfluidic chip, a micro pump, a micro spraying nozzle and a wall material reaction vessel. The method further comprises: injecting at least a solution to be prepared to the preparing system; emulsifying the injected solution to be prepared, such that the solution is in the micro-droplet form; and jetting the obtained solution having the micro-droplet form into the wall material solution so as to form the microcapsules through the reaction. According to the present invention, the microfluidic chip technology and the micro-jetting technology are firstly combined to carry out the metronomic microcapsule preparation, such that the mixing uniformity of the single component or multi-component solution and the capsule wall solution is enhanced, and the assurance is provided for the metronomic jetting of the microcapsules; and the microcapsule component configuration is flexible, wherein only the number of the inlet channels on the microfluidic chip and the channel geometry are changed so as to flexibly configure the number of the microcapsule components.
Description
Technical field
The present invention relates to field of material technology, be specifically related to a kind of system and method preparing microcapsules.
Background technology
Capsule or microcapsules reactor have broad application prospects in organic chemistry, analytical chemistry, molecular biology, pharmaceutical chemistry, polymer chemistry, nano material preparation with the structure of its uniqueness, the special microenvironment that can provide.Its core concept be structure one by the cyst membrane of molecular recognition and form containing the capsule internal cavity of reaction medium there is the eucaryotic cell structure being similar to organism, in microcapsules, active culture, propagation can be carried out to particulate, reduce external source environment to atomic impact, as cell particle.Along with the development of bio-microcapsule, can the bioactivators such as cell, enzyme, protein and nucleic acid be encapsulated in selective through in film.Because cyst wall has sieving actoion, some guest molecules also optionally can be made to enter capsule, and react in capsule and material, and shield other guest molecules.Multi-component biological structure microcapsules; can by multiple biomaterial as enzyme, protein, nucleic acid etc. be integrated in microcapsules; and separation protection is carried out to them; this multiple component structure not only can expand the function of single capsule; the a certain component of alternative release or multiple component in use, by the separation of the Induction Control component of external field environment thus initiation reaction further.And in multicomponent microcapsules reactor, Multi component reaction is controlled in smaller micro-space, compared with the reaction compartment of routine, reactant has higher concentration in the space that this is special, thus reaction speed can be promoted widely, meanwhile, the motion of reactant and reaction intermediate molecule is subject to great restriction in small space, causes it on micron even nanometer level, form certain orientation and ordered arrangement.
For a long time, Chinese scholars all constantly puts forward various plans, and some scientific research institutions and company also carry out large quantity research and experiment to this both at home and abroad, achieves some achievements.The preparation method of current microcapsules is mainly self-assembly method and emulsion process.Self assembly and emulsion process all have certain limitation.Self-assembling technique needs many more manipulations, and once-through operation generally can only encapsulate a kind of component, when needs encapsulation various ingredients especially active component, in order to protect the activity of each component, there is complex operation, the low inferior problem of packaging efficiency.And emulsion process is comparatively large by the restriction ratio of fluent material, at present can only enclosing liquid material, the encapsulation for solid matter is difficult to realize.
Univ Michigan-Ann Arbor USA reports the method for one " shoulder to shoulder " high pressure EFI, two or three different material can be attached in same particle, prepare the anisotropy nano particle with three-phase structure.Method has certain requirement to fluid electric conductivity, and for active material, utilizes high pressure EFI, can bring a series of problem.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of system and method preparing microcapsules, self-assembling technique complicated operation problem can be solved, the problem that emulsion process is difficult to packaging solid material can be solved, the problem that high pressure electroblowing process shoulder to shoulder impacts material activity can also be solved
For realizing above object, the present invention is achieved by the following technical programs:
A kind of microcapsules preparation system, it is characterized in that: comprise driving power, piezoelectric ceramics, support, micro-fluidic chip, Micropump, mini sprinkler and wall material reaction vessels, described driving power is for powering to described piezoelectric ceramics, described piezoelectric ceramics, described micro-fluidic chip and described mini sprinkler are all arranged on described support, described Micropump is for pumping into solution to described micro-fluidic chip, and described wall material reaction vessels is for receiving solution and reacting.
Wherein, described micro-fluidic chip comprises substrate channel layer and cover layer, and described cover layer is positioned at above described substrate channel layer, by adhered by double sided plaster or thermocompression bonding.Described micro-fluidic chip is made up of thermoplastic high molecular polymer, for polymethyl methacrylate, Merlon, polyethylene, polypropylene, polyvinyl chloride, polystyrene wherein any one.
Wherein, described Micropump is at least provided with 3.Described mini sprinkler adopts borosilicate glass to make, and end is taper, and its internal diameter is 10 μm-200 μm.
A kind of microcapsule preparation method, comprises the following steps:
S1: inject at least one solution to be prepared in preparation system;
S2: emulsification is carried out to the solution to be prepared injected, makes solution be microlayer model form;
S3: be injected into by the solution of the microlayer model form obtained in wall material solution, forms microcapsules by reaction.
In described step S1, described solution to be prepared is single component solutions or Multi component.In described step S3, described wall material solution is undertaken formulated by sodium alginate deionized water.In described step S3, the microcapsules of formation are one pack system microcapsules or multicomponent microcapsules.
The invention provides a kind of system and method preparing microcapsules, first microfluidic chip technology is combined with micro-injection technology, carry out the microcapsules preparation of beat.Beat microcapsules, uniform particle sizes, good stability, preparation speed is directly proportional to beat frequency.
After first component solution and wall material solution being mixed to form emulsion, prepare microcapsules again, in the present invention, the preparation of emulsion and the preparation of microcapsules realize continuously, one-shot forming.
By the active disturbance of pulsed drive, and the shape of T-shaped and U-shaped microchannel, in microfluidic channel, enhance the uniformity that one-component or multicomponent mix with capsule wall solution, the beatization for microcapsules is sprayed and is provided guarantee.
Microcapsule Ingredient flexible configuration, as long as after the access road quantity on micro-fluidic chip and channel geometries are changed, just can the number of flexible configuration microcapsule Ingredient.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is one pack system microcapsules preparation system structured flowchart of the present invention;
Fig. 2 is one-component microcapsules micro-fluidic chip encapsulation figure of the present invention;
Fig. 3 is bi-component microcapsules preparation system structured flowchart of the present invention;
Fig. 4 is of the present invention couple of component microcapsules micro-fluidic chip encapsulation figure;
Fig. 5 is multicomponent microcapsules preparation system structured flowchart of the present invention;
Fig. 6 is many components microcapsules micro-fluidic chip encapsulation figure of the present invention;
Fig. 7 is micro-fluidic chip A-D interface part of the present invention and installation diagram.
In figure 1, driving power, 2, holder, 3, piezoelectric ceramics, 4, connecting bolt, 5, support, 6, screw, 7, micro-fluidic chip, 8, mini sprinkler holding screw, 9, mini sprinkler, 10, wall material solution vessel, 11, silica gel hose, 12, polymethyl methacrylate annulus, 13, double faced adhesive tape annulus, A, wall material solution inlet, B, the first core material solution entrance, C, the second core material solution entrance, D, the 3rd core material solution entrance.
Detailed description of the invention
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the accompanying drawing in the embodiment of the present invention, technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.In the present invention, the wall material of microcapsules reacts with sodium alginate soln and calcium chloride solution and is generated as example.
The preparation of embodiment 1 one-component microcapsules
First prepare one pack system micro-fluidic chip 7, be then used for exporting by inserting in micro-fluidic chip 7 in mini sprinkler 9, and by shower nozzle holding screw 8, mini sprinkler fixed, with UV glue optic-solidified adhesive end-blocking mouth; Be fixed in chip mounting bracket 5 plane by 4 screws 6 in the corner of micro-fluidic chip 7, mounting bracket 5 afterbody is connected by connecting bolt with piezoelectric ceramics 3, is fixed on by piezoelectric ceramics 3 on holder 2, is connected by piezoelectric ceramics 3 with driving power 1.Single component solutions is pumped into micro-fluidic chip 7 by Micropump first core material solution entrance B from chip, and wall material sodium alginate soln is pumped into micro-fluidic chip 7 Micropump by Micropump from wall material solution inlet A and is connected with each feeder connection by silica gel hose 11; The wall material solution vessel 10 containing wall material solution are placed below mini sprinkler 9, open Micropump and drive power supply for piezoelectric ceramics 1 works simultaneously, single component solutions is emulsified in wrapping of two side material sodium alginate soln, after Continuous Flow emulsion is all full of mini sprinkler, close Micropump, and driving power 1 is worked on, emulsification fine liquid drop spray is formed microcapsules by mini sprinkler 9 to wall material solution vessel 10.
The preparation of embodiment 2 pairs of component microcapsules
First prepare bi-component micro-fluidic chip 7, be then used for exporting by inserting in micro-fluidic chip 7 in mini sprinkler 9, and by shower nozzle holding screw 8, mini sprinkler fixed, with UV glue optic-solidified adhesive end-blocking mouth; Be fixed in chip mounting bracket 5 plane by 4 screws 6 in the corner of micro-fluidic chip 7, mounting bracket 5 afterbody is connected by connecting bolt with piezoelectric ceramics 3, is fixed on by piezoelectric ceramics 3 on holder 2, is connected by piezoelectric ceramics 3 with driving power 1.By two-constituent solution by Micropump respectively from chip the first core material solution entrance B and the second core material solution entrance C pump into micro-fluidic chip 7, wall material sodium alginate soln pumps into micro-fluidic chip 7 by Micropump from wall material solution inlet A, and Micropump is connected with each feeder connection by silica gel hose 11; The wall material solution vessel 10 containing wall material solution are placed below mini sprinkler 9, open Micropump and drive power supply for piezoelectric ceramics 1 works simultaneously, two-constituent solution is first mixed, mixed liquor is emulsified in wrapping of two side material sodium alginate soln, after Continuous Flow emulsion is all full of mini sprinkler, close Micropump, and driving power 1 is worked on, emulsification fine liquid drop spray is formed microcapsules by mini sprinkler 9 to wall material solution vessel 10.
The preparation of embodiment 3 three component microcapsules
First prepare bi-component micro-fluidic chip 7, be then used for exporting by inserting in micro-fluidic chip 7 in mini sprinkler 9, and by shower nozzle holding screw 8, mini sprinkler fixed, with UV glue optic-solidified adhesive end-blocking mouth; Be fixed in chip mounting bracket 5 plane by 4 screws 6 in the corner of micro-fluidic chip 7, mounting bracket 5 afterbody is connected by connecting bolt with piezoelectric ceramics 3, is fixed on by piezoelectric ceramics 3 on holder 2, is connected by piezoelectric ceramics 3 with driving power 1.By three components solution by Micropump respectively from chip the first core material solution entrance B, the second core material solution entrance C, the 3rd core material solution entrance D pump into micro-fluidic chip 7, wall material sodium alginate soln pumps into micro-fluidic chip 7 by Micropump from wall material solution inlet A entrance, and Micropump is connected with each feeder connection by silica gel hose 11; The wall material solution vessel 10 containing wall material solution are placed below mini sprinkler 9, open Micropump and drive power supply for piezoelectric ceramics 1 works simultaneously, three components solution is first mixed, mixed liquor is emulsified in wrapping of two side material sodium alginate soln, after Continuous Flow emulsion is all full of mini sprinkler, close Micropump, and driving power 1 is worked on, emulsification fine liquid drop spray is formed microcapsules by mini sprinkler 9 to wall material solution vessel 10.
The invention provides a kind of system and method preparing microcapsules in sum, first microfluidic chip technology is combined with micro-injection technology, carry out the microcapsules preparation of beat.Beat microcapsules, uniform particle sizes, good stability, preparation speed is directly proportional to beat frequency.
After first component solution and wall material solution being mixed to form emulsion, prepare microcapsules again, in the present invention, the preparation of emulsion and the preparation of microcapsules realize continuously, one-shot forming.
By the active disturbance of pulsed drive, and the shape of T-shaped and U-shaped microchannel, in microfluidic channel, enhance the uniformity that one-component or multicomponent mix with capsule wall solution, the beatization for microcapsules is sprayed and is provided guarantee.
Microcapsule Ingredient flexible configuration, as long as after the access road quantity on micro-fluidic chip and channel geometries are changed, just can the number of flexible configuration microcapsule Ingredient.
It should be noted that, in this article, the such as relational terms of first and second grades and so on is only used for an entity or operation to separate with another entity or operating space, and not necessarily requires or imply the relation that there is any this reality between these entities or operation or sequentially.And, term " comprises ", " comprising " or its any other variant are intended to contain comprising of nonexcludability, thus make to comprise the process of a series of key element, method, article or equipment and not only comprise those key elements, but also comprise other key elements clearly do not listed, or also comprise by the intrinsic key element of this process, method, article or equipment.When not more restrictions, the key element limited by statement " comprising ... ", and be not precluded within process, method, article or the equipment comprising described key element and also there is other identical element.
Above embodiment only in order to technical scheme of the present invention to be described, is not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (9)
1. a microcapsules preparation system, it is characterized in that: comprise driving power, piezoelectric ceramics, support, micro-fluidic chip, Micropump, mini sprinkler and wall material reaction vessels, described driving power is for powering to described piezoelectric ceramics, described piezoelectric ceramics, described micro-fluidic chip and described mini sprinkler are all arranged on described support, described Micropump is for pumping into solution to described micro-fluidic chip, and described wall material reaction vessels is for receiving solution and reacting.
2. microcapsules preparation system as claimed in claim 1, it is characterized in that: described micro-fluidic chip comprises substrate channel layer and cover layer, described cover layer is positioned at above described substrate channel layer, by adhered by double sided plaster or thermocompression bonding.
3. the microcapsules preparation system as described in claim 1 and 2, it is characterized in that: described micro-fluidic chip is made up of thermoplastic high molecular polymer, for polymethyl methacrylate, Merlon, polyethylene, polypropylene, polyvinyl chloride, polystyrene wherein any one.
4. microcapsules preparation system as claimed in claim 1, is characterized in that: described Micropump is at least provided with 3.
5. microcapsules preparation system as claimed in claim 1, is characterized in that: described mini sprinkler adopts borosilicate glass to make, and end is taper, and its internal diameter is 10 μm-200 μm.
6. a microcapsule preparation method, is characterized in that comprising the following steps:
S1: inject at least one solution to be prepared in preparation system;
S2: emulsification is carried out to the solution to be prepared injected, makes solution be microlayer model form;
S3: be injected into by the solution of the microlayer model form obtained in wall material solution, forms microcapsules by reaction.
7. microcapsule preparation method as claimed in claim 6, it is characterized in that: in described step S1, described solution to be prepared is single component solutions or Multi component.
8. microcapsule preparation method as claimed in claim 6, it is characterized in that: in described step S3, described wall material solution is undertaken formulated by sodium alginate deionized water.
9. microcapsule preparation method as claimed in claim 6, it is characterized in that: in described step S3, the microcapsules of formation are one pack system microcapsules or multicomponent microcapsules.
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Cited By (9)
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| CN105363503A (en) * | 2015-11-02 | 2016-03-02 | 华东理工大学 | Multicomponent micro droplet microfluidic chip and processing method thereof |
| CN105381826A (en) * | 2015-11-25 | 2016-03-09 | 太原理工大学 | Preparation method of microfluidic three-dimensional gel chip model |
| CN106109440A (en) * | 2016-06-17 | 2016-11-16 | 安徽理工大学 | A kind of micro-fluidic chip and the preparation method of alginate magnetic microsphere |
| CN107916261A (en) * | 2017-12-28 | 2018-04-17 | 贠婷婷 | Probiotics preparation method is coated with before a kind of fermentation based on microflow control technique |
| CN108354181A (en) * | 2018-03-23 | 2018-08-03 | 刘洪明 | A kind of preparation method and system of three probiotic microcapsules |
| CN109261089A (en) * | 2018-09-28 | 2019-01-25 | 常州工学院 | A kind of manufacturing device and method of the composite micro-capsule based on compound micro- spray |
| WO2019148577A1 (en) * | 2018-02-02 | 2019-08-08 | 成都优创复材科技有限公司 | Method for preparing microcapsule containing pure polyamine and microdroplet forming device thereof |
| CN112871102A (en) * | 2021-04-16 | 2021-06-01 | 中国矿业大学 | Control method for preparing phase-change capsules on large scale based on microfluidics |
| CN114099459A (en) * | 2021-09-30 | 2022-03-01 | 国科温州研究院(温州生物材料与工程研究所) | Prebiotics and metazoan composite microcapsule for treating enteritis and preparation method thereof |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105363503B (en) * | 2015-11-02 | 2017-10-03 | 华东理工大学 | Multicomponent microlayer model micro-fluidic chip and its processing method |
| CN105363503A (en) * | 2015-11-02 | 2016-03-02 | 华东理工大学 | Multicomponent micro droplet microfluidic chip and processing method thereof |
| CN105381826A (en) * | 2015-11-25 | 2016-03-09 | 太原理工大学 | Preparation method of microfluidic three-dimensional gel chip model |
| CN105381826B (en) * | 2015-11-25 | 2017-08-11 | 太原理工大学 | A kind of preparation method of micro-fluidic three dimensional gel chip model |
| CN106109440B (en) * | 2016-06-17 | 2019-08-23 | 安徽理工大学 | A kind of preparation method of micro-fluidic chip and alginate magnetic microsphere |
| CN106109440A (en) * | 2016-06-17 | 2016-11-16 | 安徽理工大学 | A kind of micro-fluidic chip and the preparation method of alginate magnetic microsphere |
| CN107916261A (en) * | 2017-12-28 | 2018-04-17 | 贠婷婷 | Probiotics preparation method is coated with before a kind of fermentation based on microflow control technique |
| CN107916261B (en) * | 2017-12-28 | 2020-07-21 | 贠婷婷 | Preparation method of pre-fermentation coated probiotics based on micro-fluidic technology |
| WO2019148577A1 (en) * | 2018-02-02 | 2019-08-08 | 成都优创复材科技有限公司 | Method for preparing microcapsule containing pure polyamine and microdroplet forming device thereof |
| CN108354181A (en) * | 2018-03-23 | 2018-08-03 | 刘洪明 | A kind of preparation method and system of three probiotic microcapsules |
| CN109261089A (en) * | 2018-09-28 | 2019-01-25 | 常州工学院 | A kind of manufacturing device and method of the composite micro-capsule based on compound micro- spray |
| CN112871102A (en) * | 2021-04-16 | 2021-06-01 | 中国矿业大学 | Control method for preparing phase-change capsules on large scale based on microfluidics |
| CN114099459A (en) * | 2021-09-30 | 2022-03-01 | 国科温州研究院(温州生物材料与工程研究所) | Prebiotics and metazoan composite microcapsule for treating enteritis and preparation method thereof |
| CN114099459B (en) * | 2021-09-30 | 2023-02-24 | 国科温州研究院(温州生物材料与工程研究所) | Prebiotics and metazoan composite microcapsule for treating enteritis and preparation method thereof |
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Application publication date: 20150930 |