CN105056820A - Microstructure device adopting series amplification - Google Patents
Microstructure device adopting series amplification Download PDFInfo
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- CN105056820A CN105056820A CN201510405884.3A CN201510405884A CN105056820A CN 105056820 A CN105056820 A CN 105056820A CN 201510405884 A CN201510405884 A CN 201510405884A CN 105056820 A CN105056820 A CN 105056820A
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Abstract
The invention belongs to the technical field of multi-phase fluid micro-dispersion, and particularly relates to a microstructure device adopting series amplification. The microstructure device comprises a micro-channel substrate, a main channel and bypass channels, wherein the main channel is arranged on the micro-channel substrate, and the bypass channels are arranged on one or two sides of the main channel and are perpendicular to the main channel; capillary tubes are embedded in the bypass channels and throats are formed at junctions of the capillary tubes and the main channel; a continuous-phase fluid inlet tube is arranged at an upstream inlet of the main channel and a two-phase fluid outlet tube is arranged at a downstream outlet. The formed microstructure device adopting series amplification realizes scale amplification of the droplet and bubble breaking process under the jetting flow pattern and is simple in structure, convenient to manufacture and not easy to block, the mono-dispersed droplet and bubble generation frequency is substantially increased, and the microstructure device can be well applied to gas-liquid and liquid-liquid systems.
Description
Technical field
The invention belongs to heterogeneous fluid differential to fall apart technical field, particularly a kind of micro-structural device amplified of connecting.
Background technology
Single dispersing micro-dimension drop and bubble have in the chemical industry such as food, biological detection, pharmacy and cosmetics to be applied extremely widely.In conventional procedure, the drop utilizing heterogeneous shear flow to obtain and bubble size distribution is wider, energy loss is serious, is difficult to carry out regulating and controlling and efficiency utilization.In recent years, characteristic size obtains the concern of people at the micro-structured devices of below 1mm, can realize the controlled synthesis of single dispersing micro-dimension drop and bubble in micro-structural device, is convenient to the regulation and control realizing drop and bubble labyrinth.But present stage is micro-fluidic, particularly the micro-dispersion technology of heterogeneous fluid be often limited in single stage channel, the scale of single dispersing micro-dimension drop and bubble is prepared and is faced larger technology barrier, and there is larger gap between industrial requirements.
Present stage, the scale preparation of micro-dimension drop and bubble depends on the quantity amplification in parallel of micro-structured devices, and achieves preliminary commercial Application.But to manufacture craft, shunting means requires that higher, flow distribution of fluid is comparatively complicated, the less stable of operation, basic research and industry reality are all in the urgent need to the scale preparation method of more efficiently controlled single dispersing micro-dimension drop and bubble.
The present invention proposes the series connection structure for amplifying based on micro-structured devices first, prepared by the scale achieving single dispersing drop, bubble and particle, and the controllability that micro-structural device is amplified in described series connection is strong, stability is high.
Summary of the invention
The object of this invention is to provide a kind of micro-structural device amplified of connecting, concrete technical scheme is as follows:
Connect amplify a micro-structural device, described micro-structural device is by microchannel substrate 1, and main channel 3 and bypass channel 4 form;
Described microchannel substrate 1 is arranged the cross structure rectangular channel of series connection as main channel 3, the one or both sides of main channel 3 are provided with bypass channel 4, and bypass channel 4 is perpendicular to main channel 3; Bypass channel 3 is embedded in capillary, and capillary is closely connected with microchannel substrate 1, and forms reducing with main channel 3 in intersection, and reducing series connection forms staggered ladder-type structure;
The upstream entrance place of main channel 3 arranges continuous phase fluid inlet tube 2, and continuous phase fluid inlet tube 2 seals with microchannel substrate 1 and is connected; The lower exit place of main channel 3 arranges two-phase fluid outlet 5, and two-phase fluid outlet 5 seals with microchannel substrate 1 and is connected.
The cascaded structure that described bypass channel 4 interlocks up and down for footpath or the cascaded structure that radial direction is upwards interlocked.
Described bypass channel 4 directly picks out microchannel substrate 1, or described bypass channel 4 collect after pick out microchannel substrate 1 through distributing passage 6 by higher level.
Described main channel 3 corner is arc or right angle.
The width of described main channel 3 and bypass channel 4 is 300 ~ 1300 μm, and the degree of depth is 300 ~ 1300 μm; The capillary of described embedding bypass channel 4 and main channel 3 are 10 ~ 300 μm in the radial width of the reducing that intersection is formed; The spacing of described reducing is 500 ~ 5000 μm.
The series connection progression of described reducing series connection is 2 ~ 20 grades.
Described capillary inner diameter is 50 ~ 1000 μm, and external diameter is not less than the degree of depth of bypass channel 4 and main channel 3.
The material of described capillary is glass, quartz glass, stainless steel or polytetrafluoroethylene (PTFE).
The material of described microchannel substrate (1) is polymethyl methacrylate, dimethyl silicone polymer, glass, stainless steel, silicon chip, polytetrafluoroethylene (PTFE) or photosensitive resin.
Beneficial effect of the present invention is: the adjustment of micro-structural device by two-phase mutually when channel design is amplified in series connection of the present invention, based on the shear action of continuous phase to decentralized photo, achieve the scale preparation of 1-100 μm of single dispersing micro-dimension drop and bubble under jetting flow pattern.Micro-structured devices amplified, this apparatus structure is simple, easy to make, not easily block, significantly improve the generated frequency of single dispersing drop and bubble than traditional parallel connection; Applicability is strong, and gas-liquid, liquid liquid system are all applicable; A kind of low cost, high efficiency micro-structural amplifying device.
Accompanying drawing explanation
Fig. 1 is that the present invention connects one of the structural representation of the micro-structural device amplified.
Fig. 2 is the enlarged drawing of the place of A shown in Fig. 1 (reducing place).
Fig. 3 is that the present invention connects the structural representation two of micro-structural device amplified.
Detailed description of the invention
The invention provides a kind of micro-structural device amplified of connecting, below in conjunction with the drawings and specific embodiments, the present invention will be further described.
Connect amplify a micro-structural device, as shown in figures 1 and 3, above-mentioned two figure are respectively the present invention's two kinds of typical structural styles to the structure of described micro-structural device.
In device shown in Fig. 1, there is the cascaded structure that footpath interlocks up and down in the passage that microchannel substrate is arranged, and Fig. 1 denotes two kinds of different decentralized photo injection modes (upside: decentralized photo distributes after channel allocation through higher level and injects main channel respectively; Downside: decentralized photo directly injects main channel), two kinds of input modes all can realize object of the present invention.
Fig. 2 is the enlarged drawing of the place of A shown in Fig. 1 (reducing place), and in shown device, the capillary and the main channel that embed bypass channel form throat structure in intersection.
In device shown in Fig. 3, there is radial upwards staggered cascaded structure in the passage that microchannel substrate is arranged, Fig. 3 denotes the input mode that decentralized photo directly injects main channel.
In figure, the concrete meaning of each label is as follows: 1-microchannel substrate, 2-continuous phase fluid inlet tube, 3-main channel, 4-bypass channel, 5-two-phase fluid outlet, 6-higher level distribute passage.
Embodiment 1
Using polymethyl methacrylate (PMMA) as the material of microchannel substrate 1, the hierarchy structure of main channel 3 is 750 microns, and the hierarchy structure of bypass channel 4 is 750 microns, and main channel 3 and bypass channel 4 are rectangular channel.The radial width of reducing 200 microns, main channel 3 has ten grades of reducings, 1500 microns, reducing interval.The tack quartz capillary of external diameter 750 microns, internal diameter 530 microns is embedded bypass channel 4, and front end is concordant with wall on the upside of main channel, upstream 3.As shown in Figure 1, both sides, main channel 3 all adopt distributes through higher level the decentralized photo injection mode (Fig. 1 upper structure) injecting main channel 3 after passage 6 distributes to channel design.
Utilize teflon hose continuous phase to be injected, and two-phase fluid is collected.Add lauryl sodium sulfate sodium sulphate (SDS, 0.01wt%-2wt%) or softex kw (CTAB, 0.01wt%-2wt%) etc. the aqueous solution of water soluble surfactant active is as continuous phase, add the glycerine (mass fraction in continuous phase is 1 ~ 70wt%) of different quality concentration to regulate continuous phase viscosity, continuous phase viscosity is 1mPas ~ 500mPas.N-hexane, as decentralized photo, utilizes syringe pump decentralized photo to be injected higher level and distributes passage 6, and dispersed phase fluid injects bypass channel 4 respectively after distributing.Regulate two phase flow can obtain average-size 1-100 micron, standard deviation be not more than 5% micro-dimension single dispersing n-hexane droplet cluster.
Embodiment 2
Material using stainless steel as microchannel substrate 1, the hierarchy structure of main channel 3 is 300 microns, and the hierarchy structure of bypass channel 4 is 300 microns, and main channel 3 and bypass channel 4 are rectangular channel.The radial width of reducing is 10 microns, and main channel 3 has ten grades of reducings, 500 microns, reducing interval.The tack stainless steel capillary of external diameter 300 microns, internal diameter 50 microns is embedded bypass channel 4, and capillary front end is concordant with wall on the upside of main channel, upstream 3.Channel design as shown in Figure 3, adopts the mode directly injected to inject decentralized photo (Fig. 3 upper structure) to main channel 3 on the upside of main channel 3.
Utilize teflon hose continuous phase to be injected, and two-phase fluid is collected.Add lauryl sodium sulfate sodium sulphate (SDS, 0.01wt%-2wt%) or softex kw (CTAB, 0.01wt%-2wt%) etc. the aqueous solution of water soluble surfactant active is as continuous phase, add the glycerine (mass fraction in continuous phase is 1 ~ 70wt%) of different quality concentration to regulate continuous phase viscosity, continuous phase viscosity is 1mPas ~ 500mPas.Nitrogen, as decentralized photo, utilizes ten channel injection pump/ten cover mass flowmenters respectively ten strands of decentralized photos to be injected continuous phase from bypass channel 4.Regulate that two phase flow can obtain that average-size is 5 ~ 50 microns, standard deviation be not more than 5% minute yardstick monodisperse bubble group.
Embodiment 3
Material using polytetrafluoroethylene (PTFE) as microchannel substrate 1, the hierarchy structure of main channel 3 is 1300 microns, and the hierarchy structure of bypass channel 4 is 1300 microns, and main channel 3 and bypass channel 4 are rectangular channel.The radial width of reducing is 300 microns, and main channel 3 has ten grades of reducings, 5000 microns, reducing interval.The stainless steel capillary of external diameter 1300 microns, internal diameter 1000 microns is embedded bypass channel 4, and capillary front end is concordant with wall on the upside of main channel, upstream 3.Channel design as shown in Figure 3, adopts the mode directly injected to inject decentralized photo (Fig. 3 upper structure) to main channel on the upside of main channel 3.
Utilize teflon hose continuous phase to be injected, and two-phase fluid is collected.Add lauryl sodium sulfate sodium sulphate (SDS, 0.01wt%-2wt%) or softex kw (CTAB, 0.01wt%-2wt%) etc. the aqueous solution of water soluble surfactant active is as continuous phase, add the polyvinyl alcohol (PVA of different quality concentration, mass fraction in continuous phase is 1 ~ 10wt%) to regulate continuous phase viscosity, continuous phase viscosity is 1mPas ~ 500mPas.Normal octane, as decentralized photo, utilizes syringe pump decentralized photo to be injected higher level and distributes passage 6, and dispersed phase fluid injects bypass channel 4 respectively after distributing.Regulate two phase flow, average-size 1-100 micron can be obtained, standard deviation be not more than 5% micro-dimension single dispersing normal octane droplet cluster.
Embodiment 4
Using dimethyl silicone polymer (PDMS) as the material of microchannel substrate 1, the hierarchy structure of main channel 3 is 810 microns, and the hierarchy structure of bypass channel 4 is 810 microns, and main channel 3 and bypass channel 4 are square rectangular channel.The radial width of reducing is 250 microns, and main channel 3 has two-stage reducing, 1500 microns, reducing interval.The tack stainless steel capillary of external diameter 810 microns, internal diameter 510 microns is embedded bypass channel 4, and capillary front end is concordant with wall on the upside of main channel, upstream 3.Channel design as shown in Figure 1, adopts the mode directly injected to inject decentralized photo (Fig. 1 lower structure) to main channel 3 on the upside of main channel 3.
Utilize teflon hose continuous phase to be injected, and two-phase fluid is collected.Add sorbitol anhydride oleate (Span80,0.01wt%-2wt%) or sorbitan trioleate (Span85,0.01wt%-2wt%) etc. the dodecane/mineral oil/corn oil of oil soluble surfactant is as continuous phase, and continuous phase viscosity is 1mPas ~ 100mPas.Nitrogen, as decentralized photo, utilizes ten channel injection pumps respectively ten strands of decentralized photos to be injected continuous phase from bypass channel 4.Regulate that two phase flow can obtain that average-size is 5 ~ 100 microns, standard deviation be not more than 3% minute yardstick monodisperse bubble.
Embodiment 5
Material using silicon chip as microchannel substrate 1, the hierarchy structure of main channel 3 is 750 microns, and the hierarchy structure of bypass channel 4 is 750 microns, and main channel 3 and bypass channel 4 are square rectangular channel.The radial width of reducing 200 microns, main channel 3 has 20 grades of reducings, 2000 microns, reducing interval.Be 1250 microns by external diameter, internal diameter is that the capillary glass tube of 1000 microns embeds bypass channel 4, capillary front end is concordant with on the upside of main channel, upstream 3.As shown in Figure 3, both sides, main channel 3 all adopt distributes through higher level the decentralized photo injection mode (Fig. 1 upper structure) injecting main channel 3 after passage 6 distributes to channel design.
Utilize teflon hose continuous phase to be injected, and two-phase fluid is collected.Add sorbitol anhydride oleate (Span80,0.01wt%-2wt%) or sorbitan trioleate (Span85,0.01wt%-2wt%) etc. the dodecane/mineral oil/corn oil of oil soluble surfactant is as continuous phase, and continuous phase viscosity is 1mPas ~ 100mPas.Water, as decentralized photo, utilizes syringe pump decentralized photo to be injected higher level and distributes passage 6, and dispersed phase fluid injects bypass channel 4 respectively after distributing.Regulate that two phase flow can obtain that average-size is 1 ~ 100 micron, standard deviation be not more than 3% minute yardstick single dispersing water droplet.
Embodiment 6
Material using glass as microchannel substrate 1, the hierarchy structure of main channel 3 is 750 microns, and the hierarchy structure of bypass channel 4 is 750 microns, and main channel 3 and bypass channel 4 are square rectangular channel.The radial width of reducing 200 microns, main channel 3 has ten Pyatyi reducings, 1600 microns, reducing interval.Be 750 microns by external diameter, internal diameter is that the capillary glass tube of 600 microns embeds bypass channel 4, capillary front end is concordant with on the upside of main channel, upstream 3.Channel design as shown in Figure 3, adopts the mode directly injected to inject decentralized photo (Fig. 3 upper structure) to main channel 3 on the upside of main channel.
Utilize teflon hose continuous phase to be injected, utilize the quartz capillary embedded to be collected by two-phase fluid.Add lauryl sodium sulfate (SDS, 0.01wt%-2wt%) or softex kw (CTAB, 0.01wt%-2wt%) etc. the aqueous solution of water soluble surfactant active is as continuous phase, add the PVP (polyvinylpyrrolidone of different quality concentration, mass fraction in continuous phase is 0.1 ~ 10wt%) to regulate continuous phase viscosity, continuous phase viscosity is 1mPas ~ 700mPas, (the solution composition: styrene 48wt%-98.9wt% of styrene prepolymer solution, divinylbenzene 1wt%-50wt%, azodiisobutyronitrile 0.1wt%-2wt%, styrene prepolymer solution can be obtained heat 1-5min in 90 DEG C of water-baths after) as decentralized photo, ten channel injection pumps are utilized respectively ten strands of decentralized photos to be injected continuous phase from bypass channel 4.Regulate that two phase flow can obtain that average-size is 2 ~ 100 microns, standard deviation be not more than 3% minute yardstick single dispersing drop.Microlayer model group carried out thermal-initiated polymerization, obtains average-size 0.2 ~ 50 micron, standard deviation is not more than polystyrene microsphere in 3%, micro-sphere structure is complete, have good stability.
Embodiment 7
Material using photosensitive resin as microchannel substrate 1, the hierarchy structure of main channel 3 is 300 microns, and the hierarchy structure of bypass channel 4 is 300 microns, and main channel 3 and bypass channel 4 are square rectangular channel.The radial width of reducing 200 microns, main channel 3 has ten grades of reducings, 2000 microns, reducing interval.Be 200 microns by external diameter, internal diameter is that the polytetrafluoroethylene (PTFE) syringe needle of 50 microns embeds bypass channel 4 and stretches out to side, main channel 3, capillary front end is concordant with on the upside of main channel, upstream 3.As shown in Figure 1, both sides, main channel all adopt distributes through higher level the decentralized photo injection mode (Fig. 1 upper structure) injecting main channel 3 after passage 6 distributes to channel design.
Utilize teflon hose continuous phase to be injected, and utilize quartz glass capillary two-phase to be collected.Add the n-octyl alcohol solution of the oil soluble surfactants such as span-20, span-40, span-60, span-80, span-85, tween-20 and tween-80 (mass concentration is 0.1wt%-5wt%) as continuous phase, be dissolved with the aqueous solution of shitosan (mass fraction in decentralized photo is 1wt% ~ 5wt%) and acetic acid (mass fraction in decentralized photo is 1wt% ~ 5wt%) as decentralized photo, utilize syringe pump decentralized photo to be injected higher level and distribute passage 6, dispersed phase fluid injects bypass channel 4 respectively after distributing.Regulate two phase flow, the shitosan monomer droplet group that average-size is 30 ~ 100 microns can be obtained, after thermal-initiated polymerization, obtain the single dispersing chitosan microball that average-size is 10 ~ 50 microns.Micro-sphere structure is complete, have good stability.
As can be seen from the above embodiments, the present invention has the advantages such as structure is simple, easy to make, the generated frequency of not easily blocking, significantly raising single dispersing drop and bubble, by arranging two phase flow, control reducing spacing distance can obtain monodispersed microscale droplets and bubble, and the batch of the scale preparation and microballoon production that are specially adapted to 1 ~ 100 micron of minute yardstick single dispersing drop and bubble amplifies.
The present invention is not departing under its spirit and substantive characteristics prerequisite, multiple detailed description of the invention can be had, be to be understood that above-described embodiment is not limited to above-mentioned any details, and should be widely interpreted in the spirit and scope that claims define, therefore, all drop on claim border and scope in or with the change of these borders and scope equivalence with revise and all attempt to be included in accessory claim.
Claims (10)
1. connect amplify a micro-structural device, it is characterized in that, described micro-structural device by microchannel substrate (1), main channel (3) and bypass channel (4) composition;
Described microchannel substrate (1) is arranged the cross structure rectangular channel of series connection as main channel (3), the one or both sides of main channel (3) are provided with bypass channel (4), and bypass channel (4) is perpendicular to main channel (3); Bypass channel (4) is embedded in capillary, and capillary is closely connected with microchannel substrate (1), and forms reducing with main channel (3) in intersection, and reducing series connection forms staggered ladder-type structure;
The upstream entrance place of main channel (3) arranges continuous phase fluid inlet tube (2), and continuous phase fluid inlet tube (2) seals with microchannel substrate (1) and is connected; The lower exit place of main channel (3) arranges two-phase fluid outlet (5), and two-phase fluid outlet (5) seals with microchannel substrate (1) and is connected.
2. micro-structural device according to claim 1, is characterized in that, the cascaded structure that described bypass channel (4) interlocks up and down for footpath.
3. micro-structural device according to claim 1, is characterized in that, described bypass channel (4) is radial upwards staggered cascaded structure.
4. micro-structural device according to claim 1, is characterized in that, described bypass channel (4) directly picks out microchannel substrate (1).
5. micro-structural device according to claim 2, is characterized in that, picks out microchannel substrate (1) after described bypass channel (4) collects through distributing passage (6) by higher level.
6. micro-structural device according to claim 1, is characterized in that, described main channel (3) corner is arc or right angle.
7. micro-structural device according to claim 1, is characterized in that, the width of described main channel (3) and bypass channel (4) is 300 ~ 1300 μm, and the degree of depth is 300 ~ 1300 μm; The capillary of described embedding bypass channel (4) and main channel (3) are 10 ~ 300 μm in the radial width of the reducing that intersection is formed; The spacing of described reducing is 500 ~ 5000 μm.
8. micro-structural device according to claim 1, is characterized in that, the series connection progression of described reducing series connection is 2 ~ 20 grades.
9. micro-structural device according to claim 1, is characterized in that, described capillary inner diameter is 50 ~ 1000 μm, and external diameter is not less than the degree of depth of bypass channel (4) and main channel (3); Material is glass, quartz glass, stainless steel or polytetrafluoroethylene (PTFE).
10. micro-structural device according to claim 1, is characterized in that, the material of described microchannel substrate (1) is polymethyl methacrylate, dimethyl silicone polymer, glass, stainless steel, silicon chip, polytetrafluoroethylene (PTFE) or photosensitive resin.
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| CN112588331A (en) * | 2020-11-16 | 2021-04-02 | 苏州艾达仕电子科技有限公司 | Method for synthesizing composite conductive material by droplet microfluidics and microfluidic synthesis chip |
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| CN115228515A (en) * | 2021-04-23 | 2022-10-25 | 中国石油化工股份有限公司 | Series-connection domain limiting device and method for regulating and controlling size distribution of dispersed phases in multiphase system |
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