CN105496942A - 一种高溶解性姜黄素液晶的制备方法 - Google Patents
一种高溶解性姜黄素液晶的制备方法 Download PDFInfo
- Publication number
- CN105496942A CN105496942A CN201510951415.1A CN201510951415A CN105496942A CN 105496942 A CN105496942 A CN 105496942A CN 201510951415 A CN201510951415 A CN 201510951415A CN 105496942 A CN105496942 A CN 105496942A
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- Prior art keywords
- curcumin
- liquid crystal
- add
- mixed liquor
- warming
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 title claims abstract description 147
- 229940109262 curcumin Drugs 0.000 title claims abstract description 79
- 235000012754 curcumin Nutrition 0.000 title claims abstract description 79
- 239000004148 curcumin Substances 0.000 title claims abstract description 79
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 title claims abstract description 79
- 239000004973 liquid crystal related substance Substances 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 241000234314 Zingiber Species 0.000 claims abstract description 14
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 14
- 235000008397 ginger Nutrition 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 claims abstract description 11
- 229960002632 acarbose Drugs 0.000 claims abstract description 11
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 9
- 150000001413 amino acids Chemical class 0.000 claims abstract description 8
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 238000010792 warming Methods 0.000 claims description 18
- 238000000605 extraction Methods 0.000 claims description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- -1 curcumin compound Chemical class 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 239000000725 suspension Substances 0.000 claims description 12
- 235000001014 amino acid Nutrition 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000012044 organic layer Substances 0.000 claims description 6
- 230000010355 oscillation Effects 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 238000013517 stratification Methods 0.000 claims description 6
- 239000003814 drug Substances 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 230000007547 defect Effects 0.000 abstract description 4
- 230000000144 pharmacologic effect Effects 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 2
- 229940122393 Hyaluronidase inhibitor Drugs 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000009084 cardiovascular function Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 241000187844 Actinoplanes Species 0.000 description 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 description 1
- 235000014375 Curcuma Nutrition 0.000 description 1
- 244000164439 Curcuma angustifolia Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810741351.6A CN108743538A (zh) | 2015-12-19 | 2015-12-19 | 可提高药物生物利用度的姜黄素液晶 |
CN201510951415.1A CN105496942B (zh) | 2015-12-19 | 2015-12-19 | 一种高溶解性姜黄素液晶的制备方法 |
CN201810741345.0A CN108727175A (zh) | 2015-12-19 | 2015-12-19 | 药物生物利用度较高的高溶解性姜黄素液晶 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510951415.1A CN105496942B (zh) | 2015-12-19 | 2015-12-19 | 一种高溶解性姜黄素液晶的制备方法 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810741351.6A Division CN108743538A (zh) | 2015-12-19 | 2015-12-19 | 可提高药物生物利用度的姜黄素液晶 |
CN201810741345.0A Division CN108727175A (zh) | 2015-12-19 | 2015-12-19 | 药物生物利用度较高的高溶解性姜黄素液晶 |
Publications (2)
Publication Number | Publication Date |
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CN105496942A true CN105496942A (zh) | 2016-04-20 |
CN105496942B CN105496942B (zh) | 2019-04-30 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510951415.1A Active CN105496942B (zh) | 2015-12-19 | 2015-12-19 | 一种高溶解性姜黄素液晶的制备方法 |
CN201810741345.0A Pending CN108727175A (zh) | 2015-12-19 | 2015-12-19 | 药物生物利用度较高的高溶解性姜黄素液晶 |
CN201810741351.6A Pending CN108743538A (zh) | 2015-12-19 | 2015-12-19 | 可提高药物生物利用度的姜黄素液晶 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810741345.0A Pending CN108727175A (zh) | 2015-12-19 | 2015-12-19 | 药物生物利用度较高的高溶解性姜黄素液晶 |
CN201810741351.6A Pending CN108743538A (zh) | 2015-12-19 | 2015-12-19 | 可提高药物生物利用度的姜黄素液晶 |
Country Status (1)
Country | Link |
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CN (3) | CN105496942B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107772479A (zh) * | 2017-11-28 | 2018-03-09 | 吉安市御美丽健康产业股份有限公司 | 一种提高免疫力的乌鸡肽保健食品及其制备方法 |
CN109453148A (zh) * | 2018-12-12 | 2019-03-12 | 湖南湘源美东医药科技有限公司 | 一种姜黄素共晶组合物及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011069051A1 (en) * | 2009-12-04 | 2011-06-09 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions |
CN104622812A (zh) * | 2013-11-14 | 2015-05-20 | 崔景朝 | 复方姜黄脂质立方液晶纳米粒及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103570517B (zh) * | 2013-11-01 | 2016-08-17 | 湖南科源生物制品有限公司 | 一种提取分离姜黄素的方法 |
-
2015
- 2015-12-19 CN CN201510951415.1A patent/CN105496942B/zh active Active
- 2015-12-19 CN CN201810741345.0A patent/CN108727175A/zh active Pending
- 2015-12-19 CN CN201810741351.6A patent/CN108743538A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011069051A1 (en) * | 2009-12-04 | 2011-06-09 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions |
CN104622812A (zh) * | 2013-11-14 | 2015-05-20 | 崔景朝 | 复方姜黄脂质立方液晶纳米粒及其制备方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107772479A (zh) * | 2017-11-28 | 2018-03-09 | 吉安市御美丽健康产业股份有限公司 | 一种提高免疫力的乌鸡肽保健食品及其制备方法 |
CN109453148A (zh) * | 2018-12-12 | 2019-03-12 | 湖南湘源美东医药科技有限公司 | 一种姜黄素共晶组合物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN108727175A (zh) | 2018-11-02 |
CN108743538A (zh) | 2018-11-06 |
CN105496942B (zh) | 2019-04-30 |
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Effective date of registration: 20190410 Address after: 100086 room 1302, block B, casting tower, 6 South Avenue, Haidian District, Beijing, 6 Applicant after: BEIJING ZHITAO SCIENCE & TECHNOLOGY CO., LTD. Address before: 213164 No. 90 Changjiang Road, Xinbei District, Changzhou, Jiangsu (thousand red biochemical pharmacy) Applicant before: Chou Yingchao |
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Effective date of registration: 20210112 Address after: 610000 liugan Road, Chengdu cross strait science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Patentee after: CHENGDU SNS BIOTECHNOLOGY Co.,Ltd. Address before: 100086 room 1302, block B, casting tower, 6 South Avenue, Haidian District, Beijing, 6 Patentee before: BEIJING ZHITAO SCIENCE & TECHNOLOGY Co.,Ltd. |