CN105456938A - Foot soaking powder for treating erythromelalgia and preparation method thereof - Google Patents

Abstract

The invention discloses foot soaking powder for treating erythromelalgia and a preparation method thereof. The foot soaking powder is mainly prepared from the following components in a certain weight ratio: exocarpium benincasae, folium eriobotryae, turtle shell, rose flowers, turmeric, bamboo shavings, polygonum cuspidatum, semen arecae, cornu bubali, phaseolus calcaratus, polygonum multiflorum, cortex mori radicis and peppermint. The foot soaking powder has functions of inducing diuresis, diminishing swelling, warming meridians, promoting qi circulation, purging heat and removing stagnation, and has the advantages of good curative effect and no side effect when being used for treating erythromelalgia.

Description

A kind of powder for dipping feet for the treatment of erythromelalgia and preparation method thereof

Technical field

The present invention relates to a kind of powder for dipping feet for the treatment of erythromelalgia and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Erythromelalgia is a kind of rare vascular conditions, it is characterized by paroxysmal acra skin temperature to raise, erubescence, swelling, produce violent burning pain, especially with sole, toes for work, when ambient temperature increases, then scorching hot aggravation, be more common in youth of both sexes, belong to the traditional Chinese medical science " pyretic arthralgia " " blood stasis " category.Because current Western medicine cannot treat erythromelalgia fast and effectively, therefore there is great demand in the Chinese medicine product of people to treatment erythroderma, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of test, finally have developed the powder for dipping feet for the treatment of erythroderma, thus completes the present invention.

Object of the present invention is just to provide a kind of powder for dipping feet for the treatment of erythroderma.

Another object of the present invention just there is provided the preparation method of this powder for dipping feet.

The present invention selects Exocarpium Benincasae, Folium Eriobotryae, Carapax Trionycis, Flos Rosae Rugosae, Rhizoma Curcumae Longae, Caulis Bambusae In Taenia, Rhizoma Polygoni Cuspidati, Semen Arecae, Cornu Bubali, Semen Phaseoli, Radix Polygoni Multiflori, Cortex Mori, Herba Menthae, Cortex Magnoliae Officinalis, Fructus Psoraleae, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Semen Sinapis Albae, Ramulus Cinnamomi, Caulis Spatholobi, Bulbus Lilii, Folium Sennae to combine, made by these drug regimens each efficacy of drugs produce synergism, thus play effect for the treatment of erythroderma.Wherein select Exocarpium Benincasae to be because its nature and flavor are sweet, cool, enter spleen, lung two warp, have the function that diuretic disappears kind, harness the river swollen, diarrhoea, carbuncle.Select Folium Eriobotryae to be because its nature and flavor are bitter, cool, attach to the lung and stomach meridians, have lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm, control lung-heat phlegmatic cough, hemoptysis, epistaxis, gastric heat is vomitted the sound of vomiting.Carapax Trionycis is selected to be because its nature and flavor are salty, flat, enter liver, spleen channel, have replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, the function of hard masses softening and resolving, control consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly ， mass in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, little Jing Epilepsy.Flos Rosae Rugosae is selected to be because its property sweet and slightly bitter taste, temperature, resolving depression of regulating the flow of vital energy, and the function of blood scattered silt, treating the liver peratodynia, new lingering pathogenic wind numbness, spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.Select Rhizoma Curcumae Longae to be that temperature, enters spleen, Liver Channel, have removing blood stasis, circulation of qi promoting, stimulate the menstrual flow, the function of pain relieving, control trusted subordinate's feeling of fullness distending pain, brachialgia ， mass in the abdomen, women's blood stasis amenorrhea because its nature and flavor are worked hard, puerperal, the stasis of blood stopped stomachache, injury from falling down, carbuncle.Select Caulis Bambusae In Taenia to be because its nature and flavor are sweet, cool, enter stomach, gallbladder meridian, have heat clearing away, removing heat from blood, reduce phlegm, the function of emesis, control dysphoria with smothery sensation vomiting, singultus, expectorant heat syndrome cough is breathed heavily, and spits blood, epistaxis, metrorrhagia, malignant histocytosis, fetal movement ， Jing Epilepsy.Select Rhizoma Polygoni Cuspidati to be because its nature and flavor are bitter, flat, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis ， lumps in the chest and abdomen, anal fistula hematochezia, injury from falling down, scalds, malignant boil tinea disease.Select Semen Arecae to be because its nature and flavor toil, temperature, enters spleen, stomach, large intestine channel, has parasite killing, removing mass, the therapeutic method to keep the adverse QI flowing downwards, the function of row water, control malnutrition due to parasitic infestation, dyspepsia, abdominal distention, and heavy after dysentery, malaria, edema, beriberi, accumulation of phlegm in the hypochondrium ， Disorder ties.Select Cornu Bubali to be because its nature and flavor hardship is salty, cold, have the function of heat clearing away, removing heat from blood, removing toxic substances, control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.Semen Phaseoli is selected to be because the sweet acid of its nature and flavor, flat, enter the heart, small intestine meridian, have diuretic to dehumidify, and blood evacuation of pus, the function of subduing swelling and detoxicating, harnesses the river swollen, beriberi, jaundice, and dysentery, has blood in stool, carbuncle.Radix Polygoni Multiflori is selected to be that tepor, enters liver, kidney channel, have tonifying liver, kidney tonifying, nourish blood, the function of dispeling the wind because its property bitter but sweet flavor is puckery, control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Select Cortex Mori to be that cold, enter lung, spleen channel, have eliminating pathogen from the lung for relieving asthma, the function of line water detumescence, controls dyspnea and cough due to lung-heat because its nature and flavor are sweet, spit blood, edema, beriberi, dysuria.Select Herba Menthae to be because its nature and flavor are pungent, cool, enter lung, Liver Channel, have dispelling wind, heat radiation, ward off dirty, the function of removing toxic substances, controls affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Select Cortex Magnoliae Officinalis to be because its nature and flavor toil, temperature, enter spleen, stomach, large intestine channel, have warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, the function of expectorant, control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.Fructus Psoraleae is because its nature and flavor are pungent, temperature.Enter kidney channel.Reinforcing the kidney and supporting YANG.Control cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.Select Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, control stagnant, the function of strengthening the spleen and stomach, control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Select Folium Nelumbinis to be because its nature and flavor are pained, flat, enter the heart, liver, spleen channel, have clearing away summer-heat and eliminating dampness, sending up the lucid YANG, the function of hemostasis, control diarrhea due to summer heat and dampness, dizzy, aqueous vapor edema, thunder-headache, spit blood, epistaxis, metrorrhagia, has blood in stool, puerperal blood faints.Select Semen Sinapis Albae to be that temperature, enters lung, stomach warp, have promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, the function of removing obstruction in the collateral to relieve pain, control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain because its nature and flavor are pungent, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Select Ramulus Cinnamomi to be because its property acrid-sweet flavor, temperature, enter bladder, the heart, lung meridian, have diaphoresis expelling pathogenic factors from muscles, the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Caulis Spatholobi to be because its property bitter but sweet flavor, temperature, enters the heart, spleen two warp, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Bulbus Lilii to be because its property sweet and slightly bitter taste, flat, enter the heart, lung meridian, have nourishing the lung to arrest cough, the function of clearing away heart-fire for tranquillization, control pulmonary tuberculosis chronic cough, cough and spit expectorant blood, after calentura, waste heat is unclear, and fidgets due to deficiency is palpitated with fear, staring spells, beriberi edema.Folium Sennae is selected to be because its nature and flavor sweetness and bitterness, cold, enter large intestine channel, have the function of the intestinal stasis relieving that purges heat, control constipation with heat retention, stagnant abdominal distention.

Detailed description of the invention

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each grouping all has good therapeutic effect within the scope of following weight:

Exocarpium Benincasae 10-20g, Folium Eriobotryae 10-20g, Carapax Trionycis 4-10g, Flos Rosae Rugosae 5-15g,

Rhizoma Curcumae Longae 5-12g, Caulis Bambusae In Taenia 5-15g, Rhizoma Polygoni Cuspidati 5-15g, Semen Arecae 4-12g,

Cornu Bubali 4-10g, Semen Phaseoli 10-20g, Radix Polygoni Multiflori 4-10g, Cortex Mori 5-15g,

Herba Menthae 10-20g, Cortex Magnoliae Officinalis 5-15g, Fructus Psoraleae 5-12g, Endothelium Corneum Gigeriae Galli 4-12g,

Folium Nelumbinis 10-20g, Semen Sinapis Albae 5-15g, Ramulus Cinnamomi 10-20g, Caulis Spatholobi 5-15g,

Bulbus Lilii 10-20g, Folium Sennae 4-12g.

Be preferably:

Exocarpium Benincasae 16g, Folium Eriobotryae 15g, Carapax Trionycis 6g, Flos Rosae Rugosae 10g,

Rhizoma Curcumae Longae 8g, Caulis Bambusae In Taenia 12g, Rhizoma Polygoni Cuspidati 8g, Semen Arecae 7g,

Cornu Bubali 6g, Semen Phaseoli 12g, Radix Polygoni Multiflori 8g, Cortex Mori 10g,

Herba Menthae 16g, Cortex Magnoliae Officinalis 10g, Fructus Psoraleae 9g, Endothelium Corneum Gigeriae Galli 8g,

Folium Nelumbinis 16g, Semen Sinapis Albae 10g, Ramulus Cinnamomi 15g, Caulis Spatholobi 10g,

Bulbus Lilii 15g, Folium Sennae 9g.

Preparation method of the present invention is as follows

One, get the raw materials ready

1, Exocarpium Benincasae: get crude drug, removing impurity and rotten person of going rotten, wash quickly is clean, stripping and slicing or silk, dry, and sieve removes chip;

2, Folium Eriobotryae: brush away fine hair, washes, and slightly moistens, and shredding is dried;

3, Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;

4, Flos Rosae Rugosae: cut off impurity, extracts anthocaulus and the base of a fruit;

5, Rhizoma Curcumae Longae: pick decontamination, is soaked in water, and picks up, and runs through rear section, dries;

6, Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;

7, Rhizoma Polygoni Cuspidati: spring and autumn excavates, cutting, dries;

8, Semen Arecae: pick decontamination, soaks with clear water, changes water, to soaking, pick up by temperature situation, and section, dries;

9, Cornu Bubali: rive, with hot-water soak, pulls out, and pound sheet, dries;

10, Semen Phaseoli: get crude drug, removing impurity, the used time smashs to pieces;

11, Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;

12, Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;

13, Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;

14, Cortex Magnoliae Officinalis: be soaked in water and pull out, scrapes off rough bark after running through, and clean, shredding, dries;

15, Fructus Psoraleae: most impurity of winnowing with a dustpan, cleans, dries;

16, Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;

17, Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dry;

18, Semen Sinapis Albae: former medicine is winnowed with a dustpan most impurity, and fry to buff, micro-have fragrance and get final product;

19, Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;

20, Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;

21, Bulbus Lilii: pick decontamination, black lobe, ash disposal of winnowing with a dustpan is considered to be worth doing;

22, Folium Sennae: get crude drug, except discarding stalk, impurity;

Two, prepare

1, described Exocarpium Benincasae, Folium Eriobotryae, Carapax Trionycis, Flos Rosae Rugosae, Rhizoma Curcumae Longae, Caulis Bambusae In Taenia, Rhizoma Polygoni Cuspidati, Semen Arecae, Cornu Bubali, Semen Phaseoli, Radix Polygoni Multiflori, Cortex Mori, Herba Menthae, Cortex Magnoliae Officinalis, Fructus Psoraleae, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Semen Sinapis Albae, Ramulus Cinnamomi, Caulis Spatholobi, Bulbus Lilii, Folium Sennae are decocted with water twice, add water 8 times amount for the first time, decoct 1.5 hours, add water 6 times amount for the second time, decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

2, the filtrate of filtration is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

3, dry extract is broken into fine powder, sieves and obtain powder for dipping feet.

The present invention has line water detumescence, warming the meridian and promoting blood circulation, the intestinal stasis relieving that purges heat are invigorated blood circulation, the function of blood stasis dispelling, is used for the treatment of erythromelalgia instant effect, good effect, has no side effect.

Detailed description of the invention:

Set forth beneficial effect of the present invention further below by way of test example, these tests comprise animal toxicity test and the test of overweight people's observation of curative effect of medicine of the present invention.

[test example 1] animal toxicity test of the present invention

Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, first exposes skin by rabbit abdominal part hair removing, then the medicated powder furnishing pasty state configured is spread upon rabbit abdominal part baring skin place, then twine with gauze and tie up, every day coating 2 times, continuous coating 5 days, observe every day administration reaction, result shows that rabbit is movable, diet is normal, and medicine is without bad toxic and side effects.

[test example 2] test observation of curative effect of the present invention

1, physical data

Overweight people's test example adds up to 43 people.

2, diagnostic criteria

Suffering limb erubescence, swelling, has the scorching hot pain of acute fragility, and more so, acra often has paroxysmal temperature to raise to vola toes.

3, Therapeutic Method

(1) get the hot water of basin 40 degrees centigrade at every turn;

(2) by the powder for dipping feet prepared by weight 1:100 pour in basin water and stir;

(3) both feet are put into basin and soak 30-40 minute, every twice-daily, continuous dipping 30 days, three days, interval, then steep 30 days.

4, efficacy assessment standard

Effective: erythromelalgia is eliminated, recovery from illness;

Take a turn for the better: skin turgor disappears, burning sensation pain relief, and suffering limb progressively takes a turn for the better;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, use the present invention to treat erythromelalgia totally 43 examples, effective 37 examples of result, obvious effective rate is 86.05%, and take a turn for the better 4 examples, and improvement rate is 9.30%, and invalid 2 examples, total effective rate is 95.35%.

Claims (3)

1. treat a powder for dipping feet for erythromelalgia, it is characterized in that: it is made up of the raw material in following weight range:

Exocarpium Benincasae 10-20g, Folium Eriobotryae 10-20g, Carapax Trionycis 4-10g, Flos Rosae Rugosae 5-15g,

Rhizoma Curcumae Longae 5-12g, Caulis Bambusae In Taenia 5-15g, Rhizoma Polygoni Cuspidati 5-15g, Semen Arecae 4-12g,

Cornu Bubali 4-10g, Semen Phaseoli 10-20g, Radix Polygoni Multiflori 4-10g, Cortex Mori 5-15g,

Herba Menthae 10-20g, Cortex Magnoliae Officinalis 5-15g, Fructus Psoraleae 5-12g, Endothelium Corneum Gigeriae Galli 4-12g,

Folium Nelumbinis 10-20g, Semen Sinapis Albae 5-15g, Ramulus Cinnamomi 10-20g, Caulis Spatholobi 5-15g,

Bulbus Lilii 10-20g, Folium Sennae 4-12g.

2. powder for dipping feet according to claim 1, wherein the consumption of each raw material is:

Exocarpium Benincasae 16g, Folium Eriobotryae 15g, Carapax Trionycis 6g, Flos Rosae Rugosae 10g,

Rhizoma Curcumae Longae 8g, Caulis Bambusae In Taenia 12g, Rhizoma Polygoni Cuspidati 8g, Semen Arecae 7g,

Cornu Bubali 6g, Semen Phaseoli 12g, Radix Polygoni Multiflori 8g, Cortex Mori 10g,

Herba Menthae 16g, Cortex Magnoliae Officinalis 10g, Fructus Psoraleae 9g, Endothelium Corneum Gigeriae Galli 8g,

Folium Nelumbinis 16g, Semen Sinapis Albae 10g, Ramulus Cinnamomi 15g, Caulis Spatholobi 10g,

Bulbus Lilii 15g, Folium Sennae 9g.

3. the preparation method of powder for dipping feet according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Exocarpium Benincasae: get crude drug, removing impurity and rotten person of going rotten, wash quickly is clean, stripping and slicing or silk, dry, and sieve removes chip;

(2) Folium Eriobotryae: brush away fine hair, washes, and slightly moistens, and shredding is dried;

(3) Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;

(4) Flos Rosae Rugosae: cut off impurity, extracts anthocaulus and the base of a fruit;

(5) Rhizoma Curcumae Longae: pick decontamination, is soaked in water, and picks up, and runs through rear section, dries;

(6) Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;

(7) Rhizoma Polygoni Cuspidati: spring and autumn excavates, cutting, dries;

(8) Semen Arecae: pick decontamination, soaks with clear water, changes water, to soaking, pick up by temperature situation, and section, dries;

(9) Cornu Bubali: rive, with hot-water soak, pulls out, and pound sheet, dries;

(10) Semen Phaseoli: get crude drug, removing impurity, the used time smashs to pieces;

(11) Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;

(12) Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;

(13) Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;

(14) Cortex Magnoliae Officinalis: be soaked in water and pull out, scrapes off rough bark after running through, and clean, shredding, dries;

(15) Fructus Psoraleae: most impurity of winnowing with a dustpan, cleans, dries;

(16) Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;

(17) Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dry;

(18) Semen Sinapis Albae: former medicine is winnowed with a dustpan most impurity, and fry to buff, micro-have fragrance and get final product;

(19) Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;

(20) Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;

(21) Bulbus Lilii: pick decontamination, black lobe, ash disposal of winnowing with a dustpan is considered to be worth doing;

(22) Folium Sennae: get crude drug, except discarding stalk, impurity;

(2) prepare

(1) described Exocarpium Benincasae, Folium Eriobotryae, Carapax Trionycis, Flos Rosae Rugosae, Rhizoma Curcumae Longae, Caulis Bambusae In Taenia, Rhizoma Polygoni Cuspidati, Semen Arecae, Cornu Bubali, Semen Phaseoli, Radix Polygoni Multiflori, Cortex Mori, Herba Menthae, Cortex Magnoliae Officinalis, Fructus Psoraleae, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Semen Sinapis Albae, Ramulus Cinnamomi, Caulis Spatholobi, Bulbus Lilii, Folium Sennae are decocted with water twice, add water 8 times amount for the first time, decoct 1.5 hours, add water 6 times amount for the second time, decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate of filtration is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into fine powder, then sieves and get final product.