CN105381467A - 具有叶酸靶向pH-还原双重响应的抗肿瘤活性的两亲嵌段聚合物及其制备和应用 - Google Patents
具有叶酸靶向pH-还原双重响应的抗肿瘤活性的两亲嵌段聚合物及其制备和应用 Download PDFInfo
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- CN105381467A CN105381467A CN201510869595.9A CN201510869595A CN105381467A CN 105381467 A CN105381467 A CN 105381467A CN 201510869595 A CN201510869595 A CN 201510869595A CN 105381467 A CN105381467 A CN 105381467A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
- C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
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CN201510869595.9A CN105381467B (zh) | 2015-12-01 | 2015-12-01 | 具有叶酸靶向pH-还原双重响应的抗肿瘤活性的两亲嵌段聚合物及其制备和应用 |
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CN201510869595.9A CN105381467B (zh) | 2015-12-01 | 2015-12-01 | 具有叶酸靶向pH-还原双重响应的抗肿瘤活性的两亲嵌段聚合物及其制备和应用 |
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CN105381467A true CN105381467A (zh) | 2016-03-09 |
CN105381467B CN105381467B (zh) | 2018-08-10 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106883397A (zh) * | 2017-01-22 | 2017-06-23 | 江西科技师范大学 | Fa‑p85‑pcl叶酸靶向共聚物及其制备方法与应用 |
CN106883394A (zh) * | 2017-01-22 | 2017-06-23 | 江西科技师范大学 | Fa‑f127‑pcl叶酸靶向共聚物及其制备方法与应用 |
CN108341967A (zh) * | 2018-03-26 | 2018-07-31 | 温岭汉德高分子科技有限公司 | 一种基于多糖的还原响应自解聚接枝聚合物及其制备方法、用途 |
CN108524529A (zh) * | 2018-03-27 | 2018-09-14 | 苏州大学 | 基于两性离子及叶酸靶向的酸敏感性阿霉素前药及其制备方法与应用 |
CN109303768A (zh) * | 2018-09-30 | 2019-02-05 | 中国林业科学研究院林产化学工业研究所 | 一种负载漆酚的pH响应性两亲共聚物胶束的制备方法 |
CN109550055A (zh) * | 2017-09-25 | 2019-04-02 | 烟台药物研究所 | 一种还原响应释放原药的紫衫烷类两亲性聚合物药物前体及其制备方法和应用 |
CN112107542A (zh) * | 2020-09-03 | 2020-12-22 | 西北师范大学 | 具有肿瘤pH和H2O2特异性激活抗肿瘤活性多功能聚合物胶束及制备方法 |
CN113912841A (zh) * | 2021-10-22 | 2022-01-11 | 清华大学深圳国际研究生院 | 一种pH和Redox双响应两嵌段两亲性聚合物前药及其制备方法 |
CN116444709A (zh) * | 2023-04-19 | 2023-07-18 | 合肥医工医药股份有限公司 | 一种新型pH响应/高缓冲能力的高分子聚合物及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103923281A (zh) * | 2014-04-11 | 2014-07-16 | 西北师范大学 | 可还原降解的两亲嵌段共聚物及其制备和作为药物载体的应用 |
CN105061701A (zh) * | 2015-02-04 | 2015-11-18 | 西北师范大学 | 含有腙键的具有靶向抗肿瘤活性的嵌段共聚物及其制备和作为抗肿瘤药物载体的应用 |
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2015
- 2015-12-01 CN CN201510869595.9A patent/CN105381467B/zh not_active Expired - Fee Related
Patent Citations (2)
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CN103923281A (zh) * | 2014-04-11 | 2014-07-16 | 西北师范大学 | 可还原降解的两亲嵌段共聚物及其制备和作为药物载体的应用 |
CN105061701A (zh) * | 2015-02-04 | 2015-11-18 | 西北师范大学 | 含有腙键的具有靶向抗肿瘤活性的嵌段共聚物及其制备和作为抗肿瘤药物载体的应用 |
Non-Patent Citations (1)
Title |
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陈玉祥: "《分子药剂学》", 31 January 2010 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106883394A (zh) * | 2017-01-22 | 2017-06-23 | 江西科技师范大学 | Fa‑f127‑pcl叶酸靶向共聚物及其制备方法与应用 |
CN106883397B (zh) * | 2017-01-22 | 2018-09-11 | 江西科技师范大学 | Fa-p85-pcl叶酸靶向共聚物及其制备方法与应用 |
CN106883394B (zh) * | 2017-01-22 | 2018-10-09 | 江西科技师范大学 | Fa-f127-pcl叶酸靶向共聚物及其制备方法与应用 |
CN106883397A (zh) * | 2017-01-22 | 2017-06-23 | 江西科技师范大学 | Fa‑p85‑pcl叶酸靶向共聚物及其制备方法与应用 |
CN109550055A (zh) * | 2017-09-25 | 2019-04-02 | 烟台药物研究所 | 一种还原响应释放原药的紫衫烷类两亲性聚合物药物前体及其制备方法和应用 |
CN108341967B (zh) * | 2018-03-26 | 2021-09-24 | 温岭汉德高分子科技有限公司 | 一种基于多糖的还原响应自解聚接枝聚合物及其制备方法、用途 |
CN108341967A (zh) * | 2018-03-26 | 2018-07-31 | 温岭汉德高分子科技有限公司 | 一种基于多糖的还原响应自解聚接枝聚合物及其制备方法、用途 |
CN108524529A (zh) * | 2018-03-27 | 2018-09-14 | 苏州大学 | 基于两性离子及叶酸靶向的酸敏感性阿霉素前药及其制备方法与应用 |
CN109303768A (zh) * | 2018-09-30 | 2019-02-05 | 中国林业科学研究院林产化学工业研究所 | 一种负载漆酚的pH响应性两亲共聚物胶束的制备方法 |
CN109303768B (zh) * | 2018-09-30 | 2020-11-27 | 中国林业科学研究院林产化学工业研究所 | 一种负载漆酚的pH响应性两亲共聚物胶束的制备方法 |
CN112107542A (zh) * | 2020-09-03 | 2020-12-22 | 西北师范大学 | 具有肿瘤pH和H2O2特异性激活抗肿瘤活性多功能聚合物胶束及制备方法 |
CN113912841A (zh) * | 2021-10-22 | 2022-01-11 | 清华大学深圳国际研究生院 | 一种pH和Redox双响应两嵌段两亲性聚合物前药及其制备方法 |
CN116444709A (zh) * | 2023-04-19 | 2023-07-18 | 合肥医工医药股份有限公司 | 一种新型pH响应/高缓冲能力的高分子聚合物及其制备方法 |
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Inventor after: Yuan Jianchao Inventor after: Luo Wenbo Inventor after: Song Kairun Inventor after: Zhang Dan Inventor after: Ma Min Inventor after: Yuan Yingzhi Inventor before: Yuan Jianchao Inventor before: Song Kairun Inventor before: Luo Wenbo Inventor before: Zhang Danhua Inventor before: Ma Min Inventor before: Yuan Yingzhi |
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Granted publication date: 20180810 Termination date: 20181201 |