CN105378070A - 由多能干细胞产生的光感受器和光感受器祖细胞 - Google Patents

由多能干细胞产生的光感受器和光感受器祖细胞 Download PDF

Info

Publication number
CN105378070A
CN105378070A CN201480022584.0A CN201480022584A CN105378070A CN 105378070 A CN105378070 A CN 105378070A CN 201480022584 A CN201480022584 A CN 201480022584A CN 105378070 A CN105378070 A CN 105378070A
Authority
CN
China
Prior art keywords
cells
photoreceptor
progenitor cells
preparation
photoreceptor progenitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480022584.0A
Other languages
English (en)
Chinese (zh)
Inventor
R·P·兰扎
卢世江
汪维
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ocata Treatment Co
Original Assignee
Ocata Treatment Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocata Treatment Co filed Critical Ocata Treatment Co
Priority to CN202411157822.0A priority Critical patent/CN118995611A/zh
Publication of CN105378070A publication Critical patent/CN105378070A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts or implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/062Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0623Stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0696Artificially induced pluripotent stem cells, e.g. iPS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids
    • C12N2500/33Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/105Insulin-like growth factors [IGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/13Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/155Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/235Leukemia inhibitory factor [LIF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/33Insulin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/385Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
CN201480022584.0A 2013-03-15 2014-03-14 由多能干细胞产生的光感受器和光感受器祖细胞 Pending CN105378070A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411157822.0A CN118995611A (zh) 2013-03-15 2014-03-14 由多能干细胞产生的光感受器和光感受器祖细胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361793168P 2013-03-15 2013-03-15
US61/793,168 2013-03-15
PCT/US2014/029790 WO2014145108A1 (en) 2013-03-15 2014-03-14 Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202411157822.0A Division CN118995611A (zh) 2013-03-15 2014-03-14 由多能干细胞产生的光感受器和光感受器祖细胞

Publications (1)

Publication Number Publication Date
CN105378070A true CN105378070A (zh) 2016-03-02

Family

ID=51537881

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201480022584.0A Pending CN105378070A (zh) 2013-03-15 2014-03-14 由多能干细胞产生的光感受器和光感受器祖细胞
CN202411157822.0A Pending CN118995611A (zh) 2013-03-15 2014-03-14 由多能干细胞产生的光感受器和光感受器祖细胞

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202411157822.0A Pending CN118995611A (zh) 2013-03-15 2014-03-14 由多能干细胞产生的光感受器和光感受器祖细胞

Country Status (14)

Country Link
US (5) US20160030490A1 (https=)
EP (2) EP4292600A3 (https=)
JP (4) JP6581966B2 (https=)
KR (3) KR102527507B1 (https=)
CN (2) CN105378070A (https=)
AU (4) AU2014233403B2 (https=)
CA (2) CA2906815A1 (https=)
DK (1) DK2970903T3 (https=)
ES (1) ES2970720T3 (https=)
FI (1) FI2970903T3 (https=)
HK (1) HK1222205A1 (https=)
IL (5) IL307568A (https=)
PT (1) PT2970903T (https=)
WO (1) WO2014145108A1 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108795864A (zh) * 2018-05-24 2018-11-13 中山大学中山眼科中心 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法
CN109486766A (zh) * 2018-11-26 2019-03-19 中山大学 一种泪腺干细胞、泪腺干细胞的培养体系和培养方法
CN111712564A (zh) * 2017-10-17 2020-09-25 新加坡国立大学 用于产生视网膜祖细胞的系统和方法
CN112608883A (zh) * 2020-12-25 2021-04-06 武汉睿健医药科技有限公司 一种光感受器神经元细胞的化学诱导方法
CN113272422A (zh) * 2018-09-07 2021-08-17 赫贝细胞股份有限公司 用于无载体3d球体悬浮培养中视网膜神经元生成的方法和组合物
CN113388582A (zh) * 2021-06-21 2021-09-14 香港再生医学有限公司 促使iPSC分化为外周神经干细胞的方法及培养基和系统
WO2022134031A1 (zh) * 2020-12-25 2022-06-30 武汉睿健医药科技有限公司 一种光感受器神经元细胞的化学诱导方法
CN113930476B (zh) * 2015-03-23 2024-11-12 安斯泰来再生医药协会 改进的人视网膜色素(rpe)细胞和感光祖细胞的效能测定

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
EP4292600A3 (en) 2013-03-15 2024-04-10 Astellas Institute for Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
TWI711455B (zh) * 2015-05-13 2020-12-01 臺北榮民總醫院 多層視網膜細胞移植物
CN108697641A (zh) 2015-08-18 2018-10-23 安斯泰来再生医药协会 临床制剂
SG11201801770VA (en) * 2015-09-08 2018-04-27 Sumitomo Dainippon Pharma Co Ltd Method for producing retinal pigment epithelial cells
CN105567635A (zh) * 2016-02-21 2016-05-11 中国医科大学附属第一医院 一种改良的Neurobasal B27培养基、制备方法及应用
WO2017173064A1 (en) 2016-03-30 2017-10-05 Asterias Biotherapeutics, Inc. Oligodendrocyte progenitor cell compositions
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
KR102638492B1 (ko) * 2017-02-17 2024-02-19 쏘흐본느 유니베흐시테 망막 전구 세포, 망막 색소 상피 세포 및 신경 망막 세포를 얻기 위한 피더-비의존적(Feeder-free) 방법
GB201703058D0 (en) * 2017-02-24 2017-04-12 Ucl Business Plc Biomarkers
WO2018164240A1 (ja) 2017-03-08 2018-09-13 大日本住友製薬株式会社 網膜色素上皮細胞の製造方法
US12090252B2 (en) 2017-09-14 2024-09-17 Riken Method for producing retinal tissues
CA3075883A1 (en) * 2017-09-14 2019-03-21 Riken Method for amplifying cone photoreceptors or rod photoreceptors using dorsalization signal transmitter or ventralization signal transmitter
JP2021521792A (ja) 2018-04-20 2021-08-30 フジフィルム セルラー ダイナミクス,インコーポレイテッド 眼球細胞の分化方法及びその使用
US12365872B2 (en) 2018-09-19 2025-07-22 Lineage Cell Therapeutics, Inc. Methods for differentiating pluripotent stem cells in dynamic suspension culture
KR20260020476A (ko) 2019-01-23 2026-02-11 아스테리아스 바이오세라퓨틱스, 인크. 인간 만능 줄기 세포로부터의 배측-유래된 희소돌기아교세포 전구 세포
BR112022024064A2 (pt) * 2020-05-29 2023-01-31 Fujifilm Cellular Dynamics Inc Bicamada de epitélio pigmentado da retina e fotorreceptores e uso dos mesmos
US20230201267A1 (en) * 2020-05-29 2023-06-29 FUJIFILM Cellular Dynamics, Inc. Retinal pigmented epithelium and photoreceptor dual cell aggregates and methods of use thereof
KR102525093B1 (ko) * 2021-04-16 2023-04-27 가톨릭대학교 산학협력단 사람 신경능 유래 코 하비갑개 줄기세포를 유효성분으로 포함하는 망막변성질환 예방 또는 치료용 약학적 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110081719A1 (en) * 2009-08-24 2011-04-07 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
US20110223140A1 (en) * 2009-10-06 2011-09-15 Snu R&Db Foundation Method for differentiation into retinal cells from stem cells
CN102204930A (zh) * 2004-01-23 2011-10-05 先进细胞技术公司 用于治疗视网膜变性病的改良模式

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750196B1 (en) 1995-03-27 2004-06-15 Acorda Therapeutics Methods of treating disorders of the eye
US20030166276A1 (en) 2000-10-16 2003-09-04 Melissa Carpenter Cultures of human CNS neural stem cells
AU3964799A (en) 1998-04-24 1999-11-16 University Of Nebraska Board Of Regents Compositions and methods for the characterization and transplantation of mammalian retinal stem cells
CA2377906A1 (en) 1999-07-16 2001-01-25 Prescient Neuropharma Inc. Methods for producing and preparing cells for cell therapy
WO2002074176A1 (en) 2001-03-16 2002-09-26 University Of Washington Methods for modulating neural activity in the retina
CA2452233A1 (en) 2001-03-26 2002-10-03 Zymogenetics, Inc. Method of inducing proliferation of retinal stem cells
AU2003249227A1 (en) 2002-07-12 2004-02-02 University Of Washington Methods and systems for extended in vitro culture of neuronal cells
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
WO2005123902A1 (ja) 2004-06-18 2005-12-29 Riken 無血清浮遊培養による胚性幹細胞の神経分化誘導法
WO2006044204A2 (en) * 2004-10-05 2006-04-27 University Of Georgia Research Foundation, Inc. Neuronal progenitors from feeder-free human embryonic stem cell culture
US7541186B2 (en) 2006-02-22 2009-06-02 University Of Washington Method of generating human retinal progenitors from embryonic stem cells
US20100136537A1 (en) 2006-10-10 2010-06-03 The Regents Of The University Of Michigan Photoreceptor precursor cells
EP2128244A4 (en) 2007-01-18 2012-05-09 Riken PROCESS FOR INDUCTION / DIFFERENTIATION TO A PHOTOREZEPTORZELLE
JP5787370B2 (ja) 2009-11-05 2015-09-30 国立研究開発法人理化学研究所 幹細胞の分化誘導方法
ES2542226T3 (es) 2010-04-28 2015-08-03 Technische Universität Dresden Método para producir células progenitoras retinianas polarizadas a partir de células madre pluripotentes y su diferenciación para dar células del epitelio pigmentario retiniano
CA2835215C (en) 2011-05-18 2023-10-10 The Regents Of The University Of California Non-immortal human retinal cell compositions, method for preparing them, and their use for treating retinal diseases
EP2784152B1 (en) 2011-11-25 2019-04-10 Sumitomo Chemical Company, Limited Methods for producing retinal tissue and retina-related cell
SG11201407768QA (en) 2012-04-24 2015-01-29 Brigham & Womens Hospital Generating pluripotent cells de novo
US9458428B2 (en) * 2012-06-05 2016-10-04 The Regents Of The University Of California Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells
CN104508125B (zh) 2012-06-08 2020-06-16 住友化学株式会社 用于产生睫状边缘带样结构的方法
US20140004086A1 (en) 2012-06-29 2014-01-02 Tissue Genesis Inc. Formation of cell aggregates
US20160175361A1 (en) 2014-03-14 2016-06-23 Advanced Cell Technology, Inc. Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
EP4292600A3 (en) 2013-03-15 2024-04-10 Astellas Institute for Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US20160175362A1 (en) 2014-03-14 2016-06-23 Ocata Therapeutics, Inc. Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
EP2796545A1 (en) 2013-04-26 2014-10-29 Université Pierre et Marie Curie (Paris 6) Methods for obtaining retinal progenitors, retinal pigmented epithelial cells and neural retinal cells
KR102278978B1 (ko) 2013-08-23 2021-07-19 스미또모 가가꾸 가부시끼가이샤 망막 조직 및 망막 관련 세포의 제조 방법
EP3070162B1 (en) 2013-11-11 2019-09-18 Sumitomo Chemical Company, Limited Method for producing retinal pigment epithelial cells
JP6495830B2 (ja) 2013-12-11 2019-04-03 住友化学株式会社 毛様体周縁部様構造体の製造法
WO2015109148A1 (en) 2014-01-16 2015-07-23 The Johns Hopkins University Methods for forming three-dimensional human retinal tissue in vitro
KR102368751B1 (ko) 2014-01-17 2022-03-03 스미또모 가가꾸 가부시끼가이샤 모양체 주연부 간세포의 제조 방법
GB201402692D0 (en) 2014-02-16 2014-04-02 Univ Newcastle Synthetic retina
EP3211071B1 (en) 2014-10-24 2021-05-05 Sumitomo Dainippon Pharma Co., Ltd. Production method for retinal tissue
WO2016160718A1 (en) 2015-03-27 2016-10-06 University Of Washington Methods for treatment of retinal disease by photoreceptor gene expression modulation
US12385008B2 (en) 2015-09-08 2025-08-12 Sumitomo Pharma Co., Ltd. Method for producing retinal tissue
US11371003B2 (en) 2016-02-05 2022-06-28 Wisconsin Alumni Research Foundation Photoreceptor scaffold for in vitro modeling and transplantation therapy
WO2017176810A1 (en) 2016-04-04 2017-10-12 Biotime, Inc. Pluripotent stem cell-derived 3d retinal tissue and uses thereof
SG11201809201UA (en) 2016-04-22 2018-11-29 Sumitomo Dainippon Pharma Co Ltd Method for producing retinal tissue
JP7048585B2 (ja) 2016-09-22 2022-04-05 ソルボンヌ・ユニヴェルシテ 網膜変性疾患の処置に使用するための光遺伝学的に形質転換した光受容体前駆細胞
US10973855B2 (en) 2016-10-10 2021-04-13 Small Kent W Methods for treating macular degeneration
MY199613A (en) 2016-11-25 2023-11-09 Riken Cell population for transplantation and method for producing same
US20200138563A1 (en) 2017-01-13 2020-05-07 The Johns Hopkins University Retina regeneration with a tissue-and-technology prosthesis
KR102638492B1 (ko) 2017-02-17 2024-02-19 쏘흐본느 유니베흐시테 망막 전구 세포, 망막 색소 상피 세포 및 신경 망막 세포를 얻기 위한 피더-비의존적(Feeder-free) 방법
GB201703058D0 (en) 2017-02-24 2017-04-12 Ucl Business Plc Biomarkers
EP3656852B1 (en) 2017-07-20 2025-09-03 Riken Method for maturation of retinal tissue containing continuous epithelium
JP2020530839A (ja) 2017-07-31 2020-10-29 バイオタイム インコーポレイテッド 疾患または外傷性損傷を原因とする視覚喪失を回復させるまたは予防するための組成物および方法
JP2020530459A (ja) 2017-08-10 2020-10-22 ユニヴァーシティ オブ ワシントン 網膜の疾患を処置するための光受容体遺伝子のモジュレーターであるフォトレギュリン3
US12090252B2 (en) 2017-09-14 2024-09-17 Riken Method for producing retinal tissues
CA3075883A1 (en) 2017-09-14 2019-03-21 Riken Method for amplifying cone photoreceptors or rod photoreceptors using dorsalization signal transmitter or ventralization signal transmitter
GB201800546D0 (en) 2018-01-12 2018-02-28 Ucl Business Plc Treatment
US12497591B2 (en) 2018-03-07 2025-12-16 Sorbonne Universite Compositions and methods for efficient amplification of retinal progenitors cells
US20210228741A1 (en) 2018-04-27 2021-07-29 University Of Washington Methods and compositions to stimulate retinal regeneration
US20210317403A1 (en) 2018-05-09 2021-10-14 The Regents Of The University Of Colorado, A Body Corporate Stem cell-derived cell cultures, stem cell-derived three dimensional tissue products, and methods of making and using the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102204930A (zh) * 2004-01-23 2011-10-05 先进细胞技术公司 用于治疗视网膜变性病的改良模式
US20110081719A1 (en) * 2009-08-24 2011-04-07 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
US20110223140A1 (en) * 2009-10-06 2011-09-15 Snu R&Db Foundation Method for differentiation into retinal cells from stem cells
CN102712900A (zh) * 2009-10-06 2012-10-03 首尔大学校产学协力团 干细胞分化成为视网膜细胞的方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CARLA B.MELLOUGH等: "Efficient Stage-Specific Differentiation of Human Pluripotent Stem Cells Toward Retinal Photoreceptor Cells", 《STEM CELLS》 *
JASON S.MEYER等: "Modeling early retinal development with human embryonic and induced pluripotent stem cells", 《PNAS》 *
LAMBA等: "Generation,purification and transplantation of photoreceptors derived from human induced pluripotent stem cells.", 《PLOS ONE》 *
SWAROOP等: "Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.", 《NATURE REVIEWS NEUROSCIENCE》 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113930476B (zh) * 2015-03-23 2024-11-12 安斯泰来再生医药协会 改进的人视网膜色素(rpe)细胞和感光祖细胞的效能测定
CN111712564A (zh) * 2017-10-17 2020-09-25 新加坡国立大学 用于产生视网膜祖细胞的系统和方法
CN111712564B (zh) * 2017-10-17 2023-10-20 新加坡国立大学 用于产生视网膜祖细胞的系统和方法
CN108795864A (zh) * 2018-05-24 2018-11-13 中山大学中山眼科中心 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法
CN108795864B (zh) * 2018-05-24 2021-08-24 中山大学中山眼科中心 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法
CN113272422A (zh) * 2018-09-07 2021-08-17 赫贝细胞股份有限公司 用于无载体3d球体悬浮培养中视网膜神经元生成的方法和组合物
CN113272422B (zh) * 2018-09-07 2025-01-07 赫贝细胞股份有限公司 用于无载体3d球体悬浮培养中视网膜神经元生成的方法和组合物
CN109486766A (zh) * 2018-11-26 2019-03-19 中山大学 一种泪腺干细胞、泪腺干细胞的培养体系和培养方法
CN112608883A (zh) * 2020-12-25 2021-04-06 武汉睿健医药科技有限公司 一种光感受器神经元细胞的化学诱导方法
WO2022134031A1 (zh) * 2020-12-25 2022-06-30 武汉睿健医药科技有限公司 一种光感受器神经元细胞的化学诱导方法
CN112608883B (zh) * 2020-12-25 2023-02-24 武汉睿健医药科技有限公司 一种光感受器神经元细胞的化学诱导方法
CN113388582A (zh) * 2021-06-21 2021-09-14 香港再生医学有限公司 促使iPSC分化为外周神经干细胞的方法及培养基和系统

Also Published As

Publication number Publication date
KR20160002779A (ko) 2016-01-08
AU2014233403B2 (en) 2019-08-01
IL294897B2 (en) 2024-03-01
AU2025283562A1 (en) 2026-01-15
IL266775A (en) 2019-07-31
EP4292600A3 (en) 2024-04-10
IL276173B2 (en) 2023-02-01
EP2970903A1 (en) 2016-01-20
KR20210070394A (ko) 2021-06-14
IL294897B1 (en) 2023-11-01
KR102527507B1 (ko) 2023-04-28
JP2020031635A (ja) 2020-03-05
CN118995611A (zh) 2024-11-22
AU2014233403A1 (en) 2015-10-08
EP2970903B1 (en) 2023-12-13
DK2970903T3 (da) 2024-02-19
JP2024053564A (ja) 2024-04-15
HK1222205A1 (zh) 2017-06-23
JP6581966B2 (ja) 2019-09-25
AU2019253874A1 (en) 2019-11-14
US10307444B2 (en) 2019-06-04
US12558380B2 (en) 2026-02-24
IL266775B (en) 2020-08-31
AU2022201986A1 (en) 2022-04-14
CA3177943A1 (en) 2014-09-18
IL307568A (en) 2023-12-01
US20220347228A1 (en) 2022-11-03
WO2014145108A1 (en) 2014-09-18
US20190321414A1 (en) 2019-10-24
JP2016515382A (ja) 2016-05-30
US20190290701A1 (en) 2019-09-26
IL294897A (en) 2022-09-01
PT2970903T (pt) 2024-02-26
KR102263956B1 (ko) 2021-06-11
IL276173A (en) 2020-09-30
AU2022201986B2 (en) 2025-09-18
FI2970903T3 (fi) 2024-03-13
ES2970720T3 (es) 2024-05-30
IL241177A0 (en) 2015-11-30
CA2906815A1 (en) 2014-09-18
IL241177B (en) 2019-06-30
IL276173B (en) 2022-10-01
KR20230058556A (ko) 2023-05-03
HK1218931A1 (en) 2017-03-17
US20140294778A1 (en) 2014-10-02
JP2022023092A (ja) 2022-02-07
EP4292600A2 (en) 2023-12-20
US20160030490A1 (en) 2016-02-04
JP7245752B2 (ja) 2023-03-24
EP2970903A4 (en) 2016-11-16

Similar Documents

Publication Publication Date Title
JP7245752B2 (ja) 多能性幹細胞から生成された光受容体および光受容体前駆体
JP7263293B2 (ja) 網膜神経節細胞およびその前駆体
HK40119302A (zh) 由多能干细胞产生的光感受器和光感受器祖细胞
HK40097681A (en) Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
HK40064920A (en) Retinal ganglion cells and progenitors thereof
HK1218931B (en) Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: Massachusetts, USA

Applicant after: OCATA THERAPEUTICS, Inc.

Address before: Massachusetts, USA

Applicant before: Ocata Treatment Co.

COR Change of bibliographic data
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1222205

Country of ref document: HK

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20160302