CN105378055A - 用于通过顺序、自动提供葡萄糖分批补料发酵所供养的小球藻属物种的方法 - Google Patents
用于通过顺序、自动提供葡萄糖分批补料发酵所供养的小球藻属物种的方法 Download PDFInfo
- Publication number
- CN105378055A CN105378055A CN201480039481.5A CN201480039481A CN105378055A CN 105378055 A CN105378055 A CN 105378055A CN 201480039481 A CN201480039481 A CN 201480039481A CN 105378055 A CN105378055 A CN 105378055A
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- China
- Prior art keywords
- glucose
- carbon back
- back source
- algae
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- Pending
Links
- 238000000855 fermentation Methods 0.000 title claims abstract description 44
- 230000004151 fermentation Effects 0.000 title claims abstract description 44
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims description 90
- 239000008103 glucose Substances 0.000 title claims description 90
- 238000000034 method Methods 0.000 title claims description 38
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 67
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 59
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 claims abstract description 15
- 230000036284 oxygen consumption Effects 0.000 claims abstract description 13
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 9
- 239000001301 oxygen Substances 0.000 claims abstract description 9
- 230000004044 response Effects 0.000 claims abstract description 6
- 241000195645 Auxenochlorella protothecoides Species 0.000 claims description 11
- 230000007423 decrease Effects 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 150000001721 carbon Chemical class 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 235000007089 Chlorella vulgaris Nutrition 0.000 claims description 6
- 240000009108 Chlorella vulgaris Species 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 235000019439 ethyl acetate Nutrition 0.000 claims description 3
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 3
- 239000002028 Biomass Substances 0.000 description 16
- 239000000843 powder Substances 0.000 description 10
- 241000195493 Cryptophyta Species 0.000 description 9
- 230000001580 bacterial effect Effects 0.000 description 9
- 239000006052 feed supplement Substances 0.000 description 9
- 150000002632 lipids Chemical class 0.000 description 9
- 238000003756 stirring Methods 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 230000012010 growth Effects 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 229930002875 chlorophyll Natural products 0.000 description 4
- 235000019804 chlorophyll Nutrition 0.000 description 4
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 230000000630 rising effect Effects 0.000 description 4
- 239000011435 rock Substances 0.000 description 4
- 240000002900 Arthrospira platensis Species 0.000 description 3
- 235000016425 Arthrospira platensis Nutrition 0.000 description 3
- 241000196251 Ulva arasakii Species 0.000 description 3
- 235000009392 Vitis Nutrition 0.000 description 3
- 241000219095 Vitis Species 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 230000029553 photosynthesis Effects 0.000 description 3
- 238000010672 photosynthesis Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 241000206754 Palmaria palmata Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 238000010923 batch production Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002303 glucose derivatives Chemical class 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000005070 ripening Effects 0.000 description 2
- 229940082787 spirulina Drugs 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000832151 Chlorella regularis Species 0.000 description 1
- 241000195654 Chlorella sorokiniana Species 0.000 description 1
- 241000206609 Porphyra Species 0.000 description 1
- 241000206572 Rhodophyta Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229940011019 arthrospira platensis Drugs 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 239000002551 biofuel Substances 0.000 description 1
- 230000006860 carbon metabolism Effects 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 230000011748 cell maturation Effects 0.000 description 1
- 210000003763 chloroplast Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000001921 dulse Substances 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000009229 glucose formation Effects 0.000 description 1
- 230000009569 heterotrophic growth Effects 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1357387 | 2013-07-26 | ||
| FR1357387A FR3008991B1 (fr) | 2013-07-26 | 2013-07-26 | Procede de fermentation de chlorelles en mode discontinu alimente par apports sequentiels et automatises en glucose |
| PCT/FR2014/051943 WO2015011428A1 (fr) | 2013-07-26 | 2014-07-25 | Procédé de fermentation de chlorelles en mode discontinu alimente par apports séquentiels et automatises en glucose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105378055A true CN105378055A (zh) | 2016-03-02 |
Family
ID=49322647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480039481.5A Pending CN105378055A (zh) | 2013-07-26 | 2014-07-25 | 用于通过顺序、自动提供葡萄糖分批补料发酵所供养的小球藻属物种的方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20160326483A1 (enExample) |
| EP (1) | EP3024924B1 (enExample) |
| JP (1) | JP2016524923A (enExample) |
| KR (1) | KR20160036037A (enExample) |
| CN (1) | CN105378055A (enExample) |
| BR (1) | BR112016000650B1 (enExample) |
| ES (1) | ES2744424T3 (enExample) |
| FR (1) | FR3008991B1 (enExample) |
| MX (1) | MX367466B (enExample) |
| WO (1) | WO2015011428A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107794225A (zh) * | 2016-08-31 | 2018-03-13 | 国家开发投资公司 | 一种微藻培养方法 |
| CN108624516A (zh) * | 2017-03-20 | 2018-10-09 | 华东理工大学 | 一种提高发酵细胞中的代谢产物量及制备idms标准品的方法 |
| CN111099740A (zh) * | 2018-10-26 | 2020-05-05 | 中国石油化工股份有限公司 | 一种化能自养微生物培养过程的补料控制方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX361324B (es) | 2013-03-29 | 2018-11-20 | Corbion Biotech Inc | Metodo de enriquecimiento proteico de la biomasa de microalgas. |
| KR20160045066A (ko) | 2013-08-23 | 2016-04-26 | 로께뜨프레르 | 산소의 가용성을 제어하여 나쁜 특색을 갖지 않는, 지질이 풍부한 미세조류의 바이오매스 미분의 산업적 생산 방법 |
| MX391883B (es) | 2016-02-08 | 2025-03-21 | Corbion Biotech Inc | Procedimiento de enriquecimiento con proteínas de una biomasa de microalgas. |
| CN108485983B (zh) * | 2018-06-04 | 2021-07-30 | 海南源泉生物科技有限公司 | 一种用于规模化高密度培育绿藻的培养基及其培养方法 |
| EP3604222A1 (en) * | 2018-07-30 | 2020-02-05 | Evonik Operations GmbH | Process for the purification of hydrogen cyanide |
| CN115698251A (zh) * | 2020-05-21 | 2023-02-03 | 阿贝拉实验室公司 | 需氧发酵系统及使用其的方法 |
| KR102876588B1 (ko) * | 2022-09-26 | 2025-10-27 | 경북대학교 산학협력단 | 바이오매스 생산 증대를 위한 클로렐라속 균주의 배양방법 |
| KR102876584B1 (ko) * | 2022-09-26 | 2025-10-27 | 경북대학교 산학협력단 | 신규한 클로렐라 속 균주 및 이를 이용한 바이오디젤 제조방법 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1359224A1 (en) * | 2002-05-01 | 2003-11-05 | Ato B.V. | A process for production of polyunsaturated fatty acids by marine microorganisms |
| CN101230364A (zh) * | 2008-02-25 | 2008-07-30 | 清华大学 | 一种利用异养小球藻高密度发酵生产生物柴油的方法 |
| WO2014074769A2 (en) * | 2012-11-09 | 2014-05-15 | Heliae Development, Llc | Methods of culturing microorganisms in non-axenic mixotrophic conditions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2932791B2 (ja) * | 1990-11-30 | 1999-08-09 | 味の素株式会社 | 微生物好気培養における炭素源濃度の制御方法及び装置 |
| BR9105208A (pt) * | 1990-11-30 | 1992-07-21 | Ajinomoto Kk | Processo para o cultivo aerobico de um microorganismo em uma cultura alimentada em batelada,cultura continua ou cultura continua com reciclagem de celulas,aparelho para controlar a concentracao da fonte de carbono do substrato e processo para produzir l-lisina por fermentacao |
| JP5768341B2 (ja) * | 2010-08-04 | 2015-08-26 | 東ソー株式会社 | Ｆｃ結合性タンパク質の製造方法 |
-
2013
- 2013-07-26 FR FR1357387A patent/FR3008991B1/fr active Active
-
2014
- 2014-07-25 CN CN201480039481.5A patent/CN105378055A/zh active Pending
- 2014-07-25 JP JP2016528595A patent/JP2016524923A/ja not_active Ceased
- 2014-07-25 KR KR1020167001323A patent/KR20160036037A/ko not_active Withdrawn
- 2014-07-25 WO PCT/FR2014/051943 patent/WO2015011428A1/fr not_active Ceased
- 2014-07-25 MX MX2016000473A patent/MX367466B/es active IP Right Grant
- 2014-07-25 ES ES14755879T patent/ES2744424T3/es active Active
- 2014-07-25 US US14/911,078 patent/US20160326483A1/en not_active Abandoned
- 2014-07-25 EP EP14755879.5A patent/EP3024924B1/fr active Active
- 2014-07-25 BR BR112016000650-0A patent/BR112016000650B1/pt active IP Right Grant
-
2018
- 2018-04-26 US US15/963,945 patent/US20180312798A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1359224A1 (en) * | 2002-05-01 | 2003-11-05 | Ato B.V. | A process for production of polyunsaturated fatty acids by marine microorganisms |
| CN101230364A (zh) * | 2008-02-25 | 2008-07-30 | 清华大学 | 一种利用异养小球藻高密度发酵生产生物柴油的方法 |
| WO2014074769A2 (en) * | 2012-11-09 | 2014-05-15 | Heliae Development, Llc | Methods of culturing microorganisms in non-axenic mixotrophic conditions |
Non-Patent Citations (2)
| Title |
|---|
| XIUFENG LI 等: "Large-Scale Biodiesel Production From Microalga Chlorella protothecoides Through Heterotrophic Cultivation in Bioreactors", 《BIOTECHNOLOGY AND BIOENGINEERING》 * |
| 马千然: "发酵罐高密度异养培养小球藻的研究", 《广东化工》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107794225A (zh) * | 2016-08-31 | 2018-03-13 | 国家开发投资公司 | 一种微藻培养方法 |
| CN107794225B (zh) * | 2016-08-31 | 2022-09-13 | 国投生物科技投资有限公司 | 一种微藻培养方法 |
| CN108624516A (zh) * | 2017-03-20 | 2018-10-09 | 华东理工大学 | 一种提高发酵细胞中的代谢产物量及制备idms标准品的方法 |
| CN108624516B (zh) * | 2017-03-20 | 2022-08-26 | 华东理工大学 | 一种提高发酵细胞中的代谢产物量及制备idms标准品的方法 |
| CN111099740A (zh) * | 2018-10-26 | 2020-05-05 | 中国石油化工股份有限公司 | 一种化能自养微生物培养过程的补料控制方法 |
| CN111099740B (zh) * | 2018-10-26 | 2022-06-07 | 中国石油化工股份有限公司 | 一种化能自养微生物培养过程的补料控制方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015011428A1 (fr) | 2015-01-29 |
| ES2744424T3 (es) | 2020-02-25 |
| FR3008991A1 (fr) | 2015-01-30 |
| US20160326483A1 (en) | 2016-11-10 |
| EP3024924A1 (fr) | 2016-06-01 |
| FR3008991B1 (fr) | 2016-11-04 |
| BR112016000650B1 (pt) | 2022-04-19 |
| MX367466B (es) | 2019-08-22 |
| MX2016000473A (es) | 2016-04-07 |
| KR20160036037A (ko) | 2016-04-01 |
| JP2016524923A (ja) | 2016-08-22 |
| BR112016000650A2 (enExample) | 2017-07-25 |
| US20180312798A1 (en) | 2018-11-01 |
| EP3024924B1 (fr) | 2019-07-24 |
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