CN105377855B - 合成双氢青蒿素及青蒿素衍生物的方法和装置 - Google Patents

合成双氢青蒿素及青蒿素衍生物的方法和装置 Download PDF

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Publication number
CN105377855B
CN105377855B CN201480040034.1A CN201480040034A CN105377855B CN 105377855 B CN105377855 B CN 105377855B CN 201480040034 A CN201480040034 A CN 201480040034A CN 105377855 B CN105377855 B CN 105377855B
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reactor
alkyl
qinghaosu
post
solution
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Chinese (zh)
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CN105377855A (zh
Inventor
D·科佩茨基
D·T·麦奎德
P·H·泽贝格尔
K·吉尔摩
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/245—Stationary reactors without moving elements inside placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480040034.1A 2013-07-15 2014-07-14 合成双氢青蒿素及青蒿素衍生物的方法和装置 Active CN105377855B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13176539.8A EP2826779A1 (fr) 2013-07-15 2013-07-15 Procédé et appareil pour la synthèse de dihydroartémisinine et de dérivés d'artémisinine
EP13176539.8 2013-07-15
PCT/EP2014/065053 WO2015007693A1 (fr) 2013-07-15 2014-07-14 Procédé et appareil de synthèse de dihydroartémisinine et de dérivés d'artémisinine

Publications (2)

Publication Number Publication Date
CN105377855A CN105377855A (zh) 2016-03-02
CN105377855B true CN105377855B (zh) 2018-04-10

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CN201480040034.1A Active CN105377855B (zh) 2013-07-15 2014-07-14 合成双氢青蒿素及青蒿素衍生物的方法和装置

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Country Link
US (1) US9802952B2 (fr)
EP (2) EP2826779A1 (fr)
CN (1) CN105377855B (fr)
AP (1) AP2016009026A0 (fr)
WO (1) WO2015007693A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2540365B (en) * 2015-07-14 2019-12-11 Thermo Fisher Scient Bremen Gmbh Control of gas flow
EP3210667A1 (fr) 2016-02-29 2017-08-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Dispositif à écoulement modulaire continu
CN107383048B (zh) * 2017-08-11 2019-09-03 昆药集团股份有限公司 一种青蒿素类衍生物、其合成及应用
CN112705149B (zh) * 2019-10-25 2022-10-21 中国石油化工股份有限公司 一种内衬石英反应器
CN112694482B (zh) * 2020-12-29 2022-04-01 张家港威胜生物医药有限公司 利用微通道反应器制备青蒿琥酯的方法
CN114832753B (zh) * 2022-06-08 2023-09-12 河北诚信集团有限公司 连续制备原甲酸酯的装置及方法
CN115385929A (zh) * 2022-09-16 2022-11-25 延边大学 一种二氢青蒿素类衍生物、制备方法及应用
CN115738384B (zh) * 2022-12-13 2024-05-28 中国科学院过程工程研究所 一种离子液体@SiO2材料选择性分离青蒿素/青蒿烯的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102887907A (zh) * 2011-07-22 2013-01-23 江苏斯威森生物医药工程研究中心有限公司 以青蒿素为原料单反应釜法制备β-蒿乙醚的新工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750356B1 (en) 2002-12-02 2004-06-15 Council Of Scientific And Industrial Research Single pot conversion of artemisinin into arteether
WO2008087666A1 (fr) 2007-01-19 2008-07-24 Almet Corporation Procédé de préparation d'un dérivé éther de l'artémisinine
WO2008087667A1 (fr) 2007-01-19 2008-07-24 Almet Corporation Procédé de préparation d'artésunate à partir d'artémisinine
US9150535B2 (en) 2011-08-29 2015-10-06 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method and device for the synthesis of artemisinin
GB2494676A (en) * 2011-09-15 2013-03-20 Univ Warwick Reduction of artemisinin to dihydroartemisinin and suitable apparatus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102887907A (zh) * 2011-07-22 2013-01-23 江苏斯威森生物医药工程研究中心有限公司 以青蒿素为原料单反应釜法制备β-蒿乙醚的新工艺

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
正交实验法研究双氢青蒿素的制备工艺;江剑芳等;《应用化工》;20081031;第37卷(第10期);1175-1178 *

Also Published As

Publication number Publication date
AP2016009026A0 (en) 2016-02-29
EP2826779A1 (fr) 2015-01-21
EP3022208B1 (fr) 2017-06-14
EP3022208A1 (fr) 2016-05-25
CN105377855A (zh) 2016-03-02
US9802952B2 (en) 2017-10-31
WO2015007693A1 (fr) 2015-01-22
US20160145265A1 (en) 2016-05-26

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