CN108503528B - 一种抗凝血药物替卡格雷中间体原料的合成方法 - Google Patents
一种抗凝血药物替卡格雷中间体原料的合成方法 Download PDFInfo
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- CN108503528B CN108503528B CN201810453564.9A CN201810453564A CN108503528B CN 108503528 B CN108503528 B CN 108503528B CN 201810453564 A CN201810453564 A CN 201810453564A CN 108503528 B CN108503528 B CN 108503528B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
- C07C29/34—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups by condensation involving hydroxy groups or the mineral ester groups derived therefrom, e.g. Guerbet reaction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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CN201810453564.9A CN108503528B (zh) | 2018-05-14 | 2018-05-14 | 一种抗凝血药物替卡格雷中间体原料的合成方法 |
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CN201810453564.9A CN108503528B (zh) | 2018-05-14 | 2018-05-14 | 一种抗凝血药物替卡格雷中间体原料的合成方法 |
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CN108503528A CN108503528A (zh) | 2018-09-07 |
CN108503528B true CN108503528B (zh) | 2021-02-09 |
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CN201810453564.9A Expired - Fee Related CN108503528B (zh) | 2018-05-14 | 2018-05-14 | 一种抗凝血药物替卡格雷中间体原料的合成方法 |
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GT199800109A (es) * | 1997-08-06 | 2000-01-13 | Derivados de n-sulfonilglicinalquiniloxifenetilamida microbicidas. | |
JP5341754B2 (ja) * | 2007-06-14 | 2013-11-13 | 田辺三菱製薬株式会社 | アミン化合物及びその医薬用途 |
CN103739483B (zh) * | 2013-12-23 | 2015-05-20 | 王桂霞 | 一种反式-(1r,2r)-2-(3,4-二氟苯基)-1-环丙烷甲酸的制备方法 |
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SE01 | Entry into force of request for substantive examination | ||
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CB03 | Change of inventor or designer information |
Inventor after: Wei Li Inventor after: Ni Runyan Inventor before: Ni Runyan |
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CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20210120 Address after: 273100 room 108, unit 4, building 5, No.3 Tianhua Road, Qufu City, Jining City, Shandong Province Applicant after: Wei Li Address before: 9 / F, building D, 398 Ruoshui Road, Dushuhu high school district, Suzhou Industrial Park, Jiangsu Province 215123 Applicant before: SUZHOU GENESPOTS BIOTECHNOLOGY Co.,Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210209 Termination date: 20210514 |
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CF01 | Termination of patent right due to non-payment of annual fee |