CN108503508B - 一种抗凝血药物替卡格雷原料中间体的合成方法 - Google Patents
一种抗凝血药物替卡格雷原料中间体的合成方法 Download PDFInfo
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- CN108503508B CN108503508B CN201810453592.0A CN201810453592A CN108503508B CN 108503508 B CN108503508 B CN 108503508B CN 201810453592 A CN201810453592 A CN 201810453592A CN 108503508 B CN108503508 B CN 108503508B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
- C07C29/34—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups by condensation involving hydroxy groups or the mineral ester groups derived therefrom, e.g. Guerbet reaction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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CN201810453592.0A CN108503508B (zh) | 2018-05-14 | 2018-05-14 | 一种抗凝血药物替卡格雷原料中间体的合成方法 |
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CN201810453592.0A CN108503508B (zh) | 2018-05-14 | 2018-05-14 | 一种抗凝血药物替卡格雷原料中间体的合成方法 |
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CN108503508A CN108503508A (zh) | 2018-09-07 |
CN108503508B true CN108503508B (zh) | 2021-02-02 |
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GT199800109A (es) * | 1997-08-06 | 2000-01-13 | Derivados de n-sulfonilglicinalquiniloxifenetilamida microbicidas. | |
JP5341754B2 (ja) * | 2007-06-14 | 2013-11-13 | 田辺三菱製薬株式会社 | アミン化合物及びその医薬用途 |
CN103739483B (zh) * | 2013-12-23 | 2015-05-20 | 王桂霞 | 一种反式-(1r,2r)-2-(3,4-二氟苯基)-1-环丙烷甲酸的制备方法 |
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Effective date of registration: 20210113 Address after: 510000 Building 1, No.6 Dongbo Road, Guangzhou Economic and Technological Development Zone, Guangdong Province Applicant after: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Address before: 9 / F, building D, 398 Ruoshui Road, Dushuhu high school district, Suzhou Industrial Park, Jiangsu Province 215123 Applicant before: SUZHOU GENESPOTS BIOTECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20221110 Address after: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Patentee after: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Patentee after: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Patentee after: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Patentee after: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Patentee after: Euphorbia Biological Medicine Co.,Ltd. Address before: 510000 Building 1, No.6 Dongbo Road, Guangzhou Economic and Technological Development Zone, Guangdong Province Patentee before: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. |
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Effective date of registration: 20221226 Address after: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Patentee after: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Patentee after: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Patentee after: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Patentee after: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Patentee after: Euphorbia Biological Medicine Co.,Ltd. Patentee after: Guangdong Ruishi Pharmaceutical Technology Co.,Ltd. Address before: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Patentee before: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Patentee before: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Patentee before: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Patentee before: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Patentee before: Euphorbia Biological Medicine Co.,Ltd. |