JP5918624B2 - 光学活性含フッ素5,6−ジヒドロピリドン誘導体及びその製造方法 - Google Patents
光学活性含フッ素5,6−ジヒドロピリドン誘導体及びその製造方法 Download PDFInfo
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- JP5918624B2 JP5918624B2 JP2012113895A JP2012113895A JP5918624B2 JP 5918624 B2 JP5918624 B2 JP 5918624B2 JP 2012113895 A JP2012113895 A JP 2012113895A JP 2012113895 A JP2012113895 A JP 2012113895A JP 5918624 B2 JP5918624 B2 JP 5918624B2
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- Prior art keywords
- optically active
- trifluoromethyl
- reaction
- ethoxy
- chloride
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 11
- OXRRHYRRQWIHIV-UHFFFAOYSA-N 2,3-dihydro-1h-pyridin-6-one Chemical class O=C1NCCC=C1 OXRRHYRRQWIHIV-UHFFFAOYSA-N 0.000 title claims description 6
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims description 5
- 239000011737 fluorine Substances 0.000 title claims description 5
- 229910052731 fluorine Inorganic materials 0.000 title claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 239000002841 Lewis acid Substances 0.000 claims description 6
- 150000007517 lewis acids Chemical class 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 4
- 150000001993 dienes Chemical class 0.000 claims description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
- VNDYJBBGRKZCSX-UHFFFAOYSA-L zinc bromide Chemical compound Br[Zn]Br VNDYJBBGRKZCSX-UHFFFAOYSA-L 0.000 description 13
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 12
- 239000012043 crude product Substances 0.000 description 11
- 239000000047 product Substances 0.000 description 9
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 8
- UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 description 8
- 239000002904 solvent Substances 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 238000005481 NMR spectroscopy Methods 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 229940102001 zinc bromide Drugs 0.000 description 6
- GETTZEONDQJALK-UHFFFAOYSA-N (trifluoromethyl)benzene Chemical compound FC(F)(F)C1=CC=CC=C1 GETTZEONDQJALK-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- SHALBPKEGDBVKK-VOTSOKGWSA-N danishefsky's diene Chemical compound CO\C=C\C(=C)O[Si](C)(C)C SHALBPKEGDBVKK-VOTSOKGWSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 238000006077 hetero Diels-Alder cycloaddition reaction Methods 0.000 description 4
- 239000011592 zinc chloride Substances 0.000 description 4
- 235000005074 zinc chloride Nutrition 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000012044 organic layer Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- FRPBQTFQWOFMEI-UHFFFAOYSA-N 2-(difluoromethyl)-1-(1-phenylethyl)-2,3-dihydropyridin-4-one Chemical class C=1C=CC=CC=1C(C)N1C=CC(=O)CC1C(F)F FRPBQTFQWOFMEI-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- FJHBSKREQMGGHN-UHFFFAOYSA-N C1C(NC(=CC1=O)CCC2=CC=CC=C2)C(F)(F)F Chemical compound C1C(NC(=CC1=O)CCC2=CC=CC=C2)C(F)(F)F FJHBSKREQMGGHN-UHFFFAOYSA-N 0.000 description 2
- AECUJXXWYGCHGN-UHFFFAOYSA-N CCOCC(C1=CC=CC=C1)N2C=CC(=O)CC2C(F)(F)F Chemical class CCOCC(C1=CC=CC=C1)N2C=CC(=O)CC2C(F)(F)F AECUJXXWYGCHGN-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- IDIMFLKKUCXTDH-UHFFFAOYSA-N tert-butyl 4-oxo-2-(trifluoromethyl)-2,3-dihydropyridine-1-carboxylate Chemical class C(C)(C)(C)OC(=O)N1C(CC(C=C1)=O)C(F)(F)F IDIMFLKKUCXTDH-UHFFFAOYSA-N 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- ZMLPZCGHASSGEA-UHFFFAOYSA-M zinc trifluoromethanesulfonate Chemical compound [Zn+2].[O-]S(=O)(=O)C(F)(F)F ZMLPZCGHASSGEA-UHFFFAOYSA-M 0.000 description 2
- CITILBVTAYEWKR-UHFFFAOYSA-L zinc trifluoromethanesulfonate Substances [Zn+2].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F CITILBVTAYEWKR-UHFFFAOYSA-L 0.000 description 2
- -1 α-methylbenzyl Chemical group 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- LWILBNUCDOFKEF-UHFFFAOYSA-N 1-(1-phenylethyl)-2-(trifluoromethyl)-2,3-dihydropyridin-4-one Chemical class C=1C=CC=CC=1C(C)N1C=CC(=O)CC1C(F)(F)F LWILBNUCDOFKEF-UHFFFAOYSA-N 0.000 description 1
- JVTSHOJDBRTPHD-UHFFFAOYSA-N 2,2,2-trifluoroacetaldehyde Chemical compound FC(F)(F)C=O JVTSHOJDBRTPHD-UHFFFAOYSA-N 0.000 description 1
- HLEPWSHQXFPJSP-UHFFFAOYSA-N 2-(oxomethylidene)piperidin-4-one Chemical compound O=C=C1CC(=O)CCN1 HLEPWSHQXFPJSP-UHFFFAOYSA-N 0.000 description 1
- NAXDEFXCCITWEU-UHFFFAOYSA-N 2-(trifluoromethyl)piperidine Chemical class FC(F)(F)C1CCCCN1 NAXDEFXCCITWEU-UHFFFAOYSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- CZBBUOXUTITZAI-UHFFFAOYSA-N 2-ethoxy-1-phenylethanamine Chemical compound CCOCC(N)C1=CC=CC=C1 CZBBUOXUTITZAI-UHFFFAOYSA-N 0.000 description 1
- OBOSXEWFRARQPU-UHFFFAOYSA-N 2-n,2-n-dimethylpyridine-2,5-diamine Chemical compound CN(C)C1=CC=C(N)C=N1 OBOSXEWFRARQPU-UHFFFAOYSA-N 0.000 description 1
- IWWDWOYKHMTHSL-UHFFFAOYSA-N 4-methoxybuta-1,3-dien-2-yl(trimethyl)silane Chemical compound COC=CC(=C)[Si](C)(C)C IWWDWOYKHMTHSL-UHFFFAOYSA-N 0.000 description 1
- KEDNSMBVYXSBFC-UHFFFAOYSA-N 6-bromo-2-chloroquinoline-4-carbonyl chloride Chemical compound C1=C(Br)C=C2C(C(=O)Cl)=CC(Cl)=NC2=C1 KEDNSMBVYXSBFC-UHFFFAOYSA-N 0.000 description 1
- RASDWYUCTFOJQS-UHFFFAOYSA-N 6-methyl-2,3-dihydro-1h-pyridin-4-one Chemical class CC1=CC(=O)CCN1 RASDWYUCTFOJQS-UHFFFAOYSA-N 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- 229910052693 Europium Inorganic materials 0.000 description 1
- GNXGTKAMKLQVOQ-UHFFFAOYSA-N FC(C1NC=CC(C1)=O)(F)F Chemical class FC(C1NC=CC(C1)=O)(F)F GNXGTKAMKLQVOQ-UHFFFAOYSA-N 0.000 description 1
- QMXOFBXZEKTJIK-UHFFFAOYSA-N Glycinol Natural products C1=C(O)C=C2OCC3(O)C4=CC=C(O)C=C4OC3C2=C1 QMXOFBXZEKTJIK-UHFFFAOYSA-N 0.000 description 1
- MPZQTUXRABUJPR-UHFFFAOYSA-N [Sm+3].CC[O-].CC[O-].CC[O-] Chemical compound [Sm+3].CC[O-].CC[O-].CC[O-] MPZQTUXRABUJPR-UHFFFAOYSA-N 0.000 description 1
- MEMUCXUKCBNISQ-UHFFFAOYSA-N acetonitrile;trifluoroborane Chemical compound CC#N.FB(F)F MEMUCXUKCBNISQ-UHFFFAOYSA-N 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- JOAPBVRQZQYKMS-UHFFFAOYSA-N buta-1,3-dien-2-yloxy(trimethyl)silane Chemical compound C[Si](C)(C)OC(=C)C=C JOAPBVRQZQYKMS-UHFFFAOYSA-N 0.000 description 1
- UQGOYQLRRBTVFM-UHFFFAOYSA-N buta-1,3-dienoxy(trimethyl)silane Chemical compound C[Si](C)(C)OC=CC=C UQGOYQLRRBTVFM-UHFFFAOYSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- VYLVYHXQOHJDJL-UHFFFAOYSA-K cerium trichloride Chemical compound Cl[Ce](Cl)Cl VYLVYHXQOHJDJL-UHFFFAOYSA-K 0.000 description 1
- WYKVRFMTWIPDPJ-UHFFFAOYSA-N cerium(3+) ethanolate Chemical compound [Ce+3].CC[O-].CC[O-].CC[O-] WYKVRFMTWIPDPJ-UHFFFAOYSA-N 0.000 description 1
- FCSYOKKSVLQUBC-UHFFFAOYSA-N cerium(3+);methanolate Chemical compound [Ce+3].[O-]C.[O-]C.[O-]C FCSYOKKSVLQUBC-UHFFFAOYSA-N 0.000 description 1
- PHSMPGGNMIPKTH-UHFFFAOYSA-K cerium(3+);trifluoromethanesulfonate Chemical compound [Ce+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F PHSMPGGNMIPKTH-UHFFFAOYSA-K 0.000 description 1
- MOOUSOJAOQPDEH-UHFFFAOYSA-K cerium(iii) bromide Chemical compound [Br-].[Br-].[Br-].[Ce+3] MOOUSOJAOQPDEH-UHFFFAOYSA-K 0.000 description 1
- WQAJKGNQVZTJAE-UHFFFAOYSA-M chloro(diethoxy)alumane Chemical compound [Cl-].CCO[Al+]OCC WQAJKGNQVZTJAE-UHFFFAOYSA-M 0.000 description 1
- IFMWVBVPVXRZHE-UHFFFAOYSA-M chlorotitanium(3+);propan-2-olate Chemical compound [Cl-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-] IFMWVBVPVXRZHE-UHFFFAOYSA-M 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- ODWTVGWVVYTUKA-UHFFFAOYSA-M dimethoxyalumanylium;chloride Chemical compound [Cl-].CO[Al+]OC ODWTVGWVVYTUKA-UHFFFAOYSA-M 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- CCUCUHRUAPGBHB-UHFFFAOYSA-N ethanolate europium(3+) Chemical compound [Eu+3].CC[O-].CC[O-].CC[O-] CCUCUHRUAPGBHB-UHFFFAOYSA-N 0.000 description 1
- WHBCBPWZXZZZPD-UHFFFAOYSA-N ethanolate ytterbium(3+) Chemical compound [Yb+3].CC[O-].CC[O-].CC[O-] WHBCBPWZXZZZPD-UHFFFAOYSA-N 0.000 description 1
- NPAJGHOZGYPSTK-UHFFFAOYSA-N ethanolate;lanthanum(3+) Chemical compound [La+3].CC[O-].CC[O-].CC[O-] NPAJGHOZGYPSTK-UHFFFAOYSA-N 0.000 description 1
- QMYQAWPIPPLING-UHFFFAOYSA-N ethanolate;scandium(3+) Chemical compound [Sc+3].CC[O-].CC[O-].CC[O-] QMYQAWPIPPLING-UHFFFAOYSA-N 0.000 description 1
- KEQVPIDOPAGWCP-UHFFFAOYSA-N ethanolate;yttrium(3+) Chemical compound [Y+3].CC[O-].CC[O-].CC[O-] KEQVPIDOPAGWCP-UHFFFAOYSA-N 0.000 description 1
- ASBGGHMVAMBCOR-UHFFFAOYSA-N ethanolate;zirconium(4+) Chemical compound [Zr+4].CC[O-].CC[O-].CC[O-].CC[O-] ASBGGHMVAMBCOR-UHFFFAOYSA-N 0.000 description 1
- 239000004210 ether based solvent Substances 0.000 description 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 description 1
- QEDFUJZRPHEBFG-UHFFFAOYSA-K europium(3+);tribromide Chemical compound Br[Eu](Br)Br QEDFUJZRPHEBFG-UHFFFAOYSA-K 0.000 description 1
- TWNOVENTEPVGEJ-UHFFFAOYSA-K europium(3+);trifluoromethanesulfonate Chemical compound [Eu+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F TWNOVENTEPVGEJ-UHFFFAOYSA-K 0.000 description 1
- NNMXSTWQJRPBJZ-UHFFFAOYSA-K europium(iii) chloride Chemical compound Cl[Eu](Cl)Cl NNMXSTWQJRPBJZ-UHFFFAOYSA-K 0.000 description 1
- MEANOSLIBWSCIT-UHFFFAOYSA-K gadolinium trichloride Chemical compound Cl[Gd](Cl)Cl MEANOSLIBWSCIT-UHFFFAOYSA-K 0.000 description 1
- KGOKDPWKDBWITQ-UHFFFAOYSA-K gadolinium(3+);tribromide Chemical compound Br[Gd](Br)Br KGOKDPWKDBWITQ-UHFFFAOYSA-K 0.000 description 1
- DYOBTPTUHDTANY-UHFFFAOYSA-K gadolinium(3+);trifluoromethanesulfonate Chemical compound [Gd+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F DYOBTPTUHDTANY-UHFFFAOYSA-K 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- PSCMQHVBLHHWTO-UHFFFAOYSA-K indium(iii) chloride Chemical compound Cl[In](Cl)Cl PSCMQHVBLHHWTO-UHFFFAOYSA-K 0.000 description 1
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 description 1
- RCFZUDZONKPRJX-UHFFFAOYSA-N lanthanum(3+) methanolate Chemical compound [La+3].[O-]C.[O-]C.[O-]C RCFZUDZONKPRJX-UHFFFAOYSA-N 0.000 description 1
- WGJJZRVGLPOKQT-UHFFFAOYSA-K lanthanum(3+);trifluoromethanesulfonate Chemical compound [La+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F WGJJZRVGLPOKQT-UHFFFAOYSA-K 0.000 description 1
- XKUYOJZZLGFZTC-UHFFFAOYSA-K lanthanum(iii) bromide Chemical compound Br[La](Br)Br XKUYOJZZLGFZTC-UHFFFAOYSA-K 0.000 description 1
- ICAKDTKJOYSXGC-UHFFFAOYSA-K lanthanum(iii) chloride Chemical compound Cl[La](Cl)Cl ICAKDTKJOYSXGC-UHFFFAOYSA-K 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 description 1
- 229910001623 magnesium bromide Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- ZEIWWVGGEOHESL-UHFFFAOYSA-N methanol;titanium Chemical compound [Ti].OC.OC.OC.OC ZEIWWVGGEOHESL-UHFFFAOYSA-N 0.000 description 1
- PXAINRSJFSAUAN-UHFFFAOYSA-N methanolate samarium(3+) Chemical compound [Sm+3].[O-]C.[O-]C.[O-]C PXAINRSJFSAUAN-UHFFFAOYSA-N 0.000 description 1
- GAZQTPCOHATOHJ-UHFFFAOYSA-N methanolate;scandium(3+) Chemical compound [Sc+3].[O-]C.[O-]C.[O-]C GAZQTPCOHATOHJ-UHFFFAOYSA-N 0.000 description 1
- WVLGTKBIJRAYME-UHFFFAOYSA-N methanolate;yttrium(3+) Chemical compound [Y+3].[O-]C.[O-]C.[O-]C WVLGTKBIJRAYME-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical group OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- ICKYUJFKBKOPJT-UHFFFAOYSA-K samarium(3+);tribromide Chemical compound Br[Sm](Br)Br ICKYUJFKBKOPJT-UHFFFAOYSA-K 0.000 description 1
- DDCWGUIPLGMBPO-UHFFFAOYSA-K samarium(3+);trifluoromethanesulfonate Chemical compound [Sm+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F DDCWGUIPLGMBPO-UHFFFAOYSA-K 0.000 description 1
- BHXBZLPMVFUQBQ-UHFFFAOYSA-K samarium(iii) chloride Chemical compound Cl[Sm](Cl)Cl BHXBZLPMVFUQBQ-UHFFFAOYSA-K 0.000 description 1
- APPHYFNIXVIIJR-UHFFFAOYSA-K scandium bromide Chemical compound Br[Sc](Br)Br APPHYFNIXVIIJR-UHFFFAOYSA-K 0.000 description 1
- HZXJVDYQRYYYOR-UHFFFAOYSA-K scandium(iii) trifluoromethanesulfonate Chemical compound [Sc+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F HZXJVDYQRYYYOR-UHFFFAOYSA-K 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- PUGUQINMNYINPK-UHFFFAOYSA-N tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCN(C(=O)CCl)CC1 PUGUQINMNYINPK-UHFFFAOYSA-N 0.000 description 1
- ROUYFJUVMYHXFJ-UHFFFAOYSA-N tert-butyl 4-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(=O)CC1 ROUYFJUVMYHXFJ-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- JMXKSZRRTHPKDL-UHFFFAOYSA-N titanium ethoxide Chemical compound [Ti+4].CC[O-].CC[O-].CC[O-].CC[O-] JMXKSZRRTHPKDL-UHFFFAOYSA-N 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- VXUYXOFXAQZZMF-UHFFFAOYSA-N titanium(IV) isopropoxide Chemical compound CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C VXUYXOFXAQZZMF-UHFFFAOYSA-N 0.000 description 1
- AJSTXXYNEIHPMD-UHFFFAOYSA-N triethyl borate Chemical compound CCOB(OCC)OCC AJSTXXYNEIHPMD-UHFFFAOYSA-N 0.000 description 1
- AHZJKOKFZJYCLG-UHFFFAOYSA-K trifluoromethanesulfonate;ytterbium(3+) Chemical compound [Yb+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F AHZJKOKFZJYCLG-UHFFFAOYSA-K 0.000 description 1
- JPJIEXKLJOWQQK-UHFFFAOYSA-K trifluoromethanesulfonate;yttrium(3+) Chemical compound [Y+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F JPJIEXKLJOWQQK-UHFFFAOYSA-K 0.000 description 1
- UAEJRRZPRZCUBE-UHFFFAOYSA-N trimethoxyalumane Chemical compound [Al+3].[O-]C.[O-]C.[O-]C UAEJRRZPRZCUBE-UHFFFAOYSA-N 0.000 description 1
- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- CKLHRQNQYIJFFX-UHFFFAOYSA-K ytterbium(III) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Yb+3] CKLHRQNQYIJFFX-UHFFFAOYSA-K 0.000 description 1
- QNLXXQBCQYDKHD-UHFFFAOYSA-K ytterbium(iii) bromide Chemical compound Br[Yb](Br)Br QNLXXQBCQYDKHD-UHFFFAOYSA-K 0.000 description 1
- 229940105965 yttrium bromide Drugs 0.000 description 1
- DUNKXUFBGCUVQW-UHFFFAOYSA-J zirconium tetrachloride Chemical compound Cl[Zr](Cl)(Cl)Cl DUNKXUFBGCUVQW-UHFFFAOYSA-J 0.000 description 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
[項1] 下記式(1)
[項3] ルイス酸存在下、反応を行うことを特徴とする項2に記載の製造方法
を提供するものである。
本発明の反応後の後処理としては、衆知の処理で問題ないが、例えば、水を添加、ジクロロメタンで抽出、有機層を合わせて硫酸ナトリウムで乾燥、ろ過、濃縮することにより粗製物を得、必要に応じてシリカゲルカラムクロマトグラフィー等で精製しても良い。
攪拌子を備えた50mlのナス型フラスコを窒素置換した後、これに臭化亜鉛(438mg、1.95mmol)、ジクロロメタン(6ml)及びトリフルオロメチル (S)−2−エトキシ−1−フェニルエチル−1−イミン(300mg、1.30mmol)を仕込み、室温下、30分攪拌した。次いでこれに、1−メトキシ−3−トリメチルシリルオキシ−1,3−ブタジエン(447mg、2.60mmol)を10分かけて滴下し、さらに同温度で16時間反応を行った。
1H−NMR(400MHz,CDCl3)δ1.20(t,3H,J=6.80Hz)、2.54(d,2H,J=9.2Hz)、3.20−4.30(m,6H)、5.60(d,1H,J=1.60Hz)、7.00−7.45(m,6H)ppm。
13C−NMR(100.6MHz,CDCl3)δ15.18、33.19、59.17(d,J=29.68Hz)、66.15、67.03、72.95、99.74、126.79、128.00、128.61(q,J=286.50Hz)、129.03、129.24、149.96、188.75ppm。
19F−NMR(376MHz,CDCl3)δ−75.57(d,J=7.52Hz)ppm。
Minorδ−73.03(d,J=7.52Hz)ppm。
実施例1と同じ反応装置を用い、トリフルオロメチル (S)−2−エトキシ−1−フェニルエチル−1−イミン(300mg、1.30mmol)に替えてトリフルオロメチル (R)−2−エトキシ−1−フェニルエチル−1−イミン(300mg、1.30mmol)を用いた以外実施例1と同じ操作を行い、粗製物(484mg)を得た。得られた粗製物をベンゾトリフルオリドを内標準として用いた19F−NMRでの定量により、目的物の生成量162mg、収率42%、主生成物/異性体比=97.4/2.6(mol/mol)であった。
1H−NMR(400MHz,CDCl3)δ1.20(t,3H,J=6.80Hz)、2.54(d,2H,J=9.2Hz)、3.20−4.30(m,6H)、5.60(d,1H,J=1.60Hz)、7.00−7.45(m,6H)ppm。
13C−NMR(100.6MHz,CDCl3)δ15.18、33.19、59.17(d,J=29.68Hz)、66.15、67.03、72.95、99.74、126.79、128.00、128.61(q,J=286.50Hz)、129.03、129.24、149.96、188.75ppm。
19F−NMR(376MHz,CDCl3)δ−75.57(d,J=7.52Hz)ppm。
Minorδ−73.03(d,J=7.52Hz)ppm。
実施例1で用いた臭化亜鉛(438mg、1.95mmol)に替えて、塩化亜鉛(265mg、1.95mmol)を用いた以外、実施例1と同じ反応操作を行い、粗製物(377mg)を得た。得られた粗製物をベンゾトリフルオリドを内標準として用いた19F−NMRでの定量により、目的物の生成量152mg、収率39%、主生成物/異性体比=97.9/2.1(mol/mol)であった。
実施例1で用いた臭化亜鉛(438mg、1.95mmol)に替えて、ヨウ化亜鉛(621mg、1.95mmol)を用いた以外、実施例1と同じ反応操作を行い、粗製物(445mg)を得た。得られた粗製物をベンゾトリフルオリドを内標準として用いた19F−NMRでの定量により、目的物の生成量157mg、収率41%、主生成物/異性体比=97.0/3.0(mol/mol)であった。
実施例5〜13
実施例1と同じ反応装置を用い、表1中に示した条件下、反応を行った。結果を表1中に示した。
Claims (2)
- 下記式(3)
で表されるトリフルオロメチル (S)−1−フェニル−2−エトキシエチル−1−イミンまたは下記式(4)
で表されるトリフルオロメチル (R)−1−フェニル−2−エトキシエチル−1−イミンと下記式(5)
で表されるジエンを反応させ、次いで酸で処理することを特徴とする、
式(1)
または式(2)
で表される光学活性含フッ素5,6−ジヒドロピリドン誘導体の製造方法。 - ルイス酸存在下、反応を行うことを特徴とする請求項1に記載の製造方法。
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