CN105377815B - 氨基吡啶衍生物或其药用可接受盐和包括相同活性成分的药物组合物 - Google Patents

氨基吡啶衍生物或其药用可接受盐和包括相同活性成分的药物组合物 Download PDF

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CN105377815B
CN105377815B CN201480033183.5A CN201480033183A CN105377815B CN 105377815 B CN105377815 B CN 105377815B CN 201480033183 A CN201480033183 A CN 201480033183A CN 105377815 B CN105377815 B CN 105377815B
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trimethylpyridine
cancer
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hydroxyls
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CN105377815A (zh
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程炳善
金贞爱
南泰圭
李贤芝
金东局
姜宥拉
宾宰辉
陈裕真
苏希尔·钱德拉·蕾格米
加雅·高塔姆
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Industry Academic Cooperation Foundation of Yeungnam University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K9/20—Pills, tablets, discs, rods
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201480033183.5A 2013-04-19 2014-04-21 氨基吡啶衍生物或其药用可接受盐和包括相同活性成分的药物组合物 Active CN105377815B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
KR20130043613 2013-04-19
KR10-2013-0043613 2013-04-19
KR10-2014-0046135 2014-04-17
KR1020140046135A KR101612179B1 (ko) 2013-04-19 2014-04-17 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 암질환 예방 또는 치료용 약학조성물
KR1020140046133A KR101652577B1 (ko) 2013-04-19 2014-04-17 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물
KR10-2014-0046133 2014-04-17
KR10-2014-0046134 2014-04-17
KR1020140046134A KR101663864B1 (ko) 2013-04-19 2014-04-17 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 염증성 장질환의 예방 또는 치료용 약학조성물
PCT/KR2014/003450 WO2014171801A1 (ko) 2013-04-19 2014-04-21 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 약학조성물

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Publication Number Publication Date
CN105377815A CN105377815A (zh) 2016-03-02
CN105377815B true CN105377815B (zh) 2018-06-12

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US (1) US9802897B2 (https=)
EP (1) EP2987786B1 (https=)
JP (1) JP6502919B2 (https=)
KR (3) KR101663864B1 (https=)
CN (1) CN105377815B (https=)
WO (1) WO2014171801A1 (https=)

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KR101415742B1 (ko) * 2011-12-21 2014-07-04 영남대학교 산학협력단 6―아미노피리딘―3―올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물
US9889139B2 (en) 2011-12-21 2018-02-13 Research Cooperation Foundation Of Yeungnam University Method of treating inflammatory bowel disease comprising administering a pharmaceutical composition comprising a 6-aminopyridin-3-ol compound or a pharmaceutically acceptable salt thereof as an active ingredient to a subject
US10604487B2 (en) 2016-01-14 2020-03-31 Research Cooperation Foundation Of Yeungnam University Pyridinol derivative or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient
KR101983788B1 (ko) * 2016-12-01 2019-05-30 서울대학교산학협력단 아미드 유도체 화합물, 이의 입체이성질체, 또는 이의 약학적으로 허용 가능한 염, 및 이를 포함하는 피부 노화 억제, 주름 개선, 또는 피부 상처 치료용 약학적 또는 화장료 조성물
KR20180083994A (ko) * 2017-01-13 2018-07-24 영남대학교 산학협력단 피리딘올 유도체 또는 이의 약제학적 허용 가능한 염 및 이를 유효성분으로 함유하는 자가면역 질환의 예방 또는 치료용 약학 조성물
KR102117083B1 (ko) * 2018-10-30 2020-05-29 계명대학교 산학협력단 벤조헤테로사이클 화합물 및 이를 유효성분으로 함유하는 암질환 예방 또는 치료용 조성물
KR102426921B1 (ko) * 2019-09-24 2022-07-29 주식회사 이노보테라퓨틱스 헤테로아릴아미도피리딘올 유도체 및 이를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 약학적 조성물
KR20220140177A (ko) 2021-04-09 2022-10-18 경북대학교 산학협력단 혈관신생 관련 대사질환 치료용 약학적 조성물

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JP6502919B2 (ja) 2019-04-17
WO2014171801A1 (ko) 2014-10-23
EP2987786A4 (en) 2016-12-28
CN105377815A (zh) 2016-03-02
EP2987786A1 (en) 2016-02-24
JP2016516812A (ja) 2016-06-09
US20160068489A1 (en) 2016-03-10
KR101663864B1 (ko) 2016-10-07
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