CN105339346B - Neoseptin：小分子佐剂 - Google Patents

Neoseptin：小分子佐剂 Download PDF

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Publication number
CN105339346B
CN105339346B CN201480023040.6A CN201480023040A CN105339346B CN 105339346 B CN105339346 B CN 105339346B CN 201480023040 A CN201480023040 A CN 201480023040A CN 105339346 B CN105339346 B CN 105339346B
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China
Prior art keywords
mmol
equiv
etoac
compound
hexanes
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Expired - Fee Related
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CN201480023040.6A
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English (en)
Chinese (zh)
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CN105339346A (zh
Inventor
B.伯伊特勒
D.L.伯杰
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TAXAS SYSTEM, University of, Regents of
Scripps Research Institute
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TAXAS SYSTEM, University of, Regents of
Scripps Research Institute
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN201480023040.6A 2013-02-25 2014-02-25 Neoseptin：小分子佐剂 Expired - Fee Related CN105339346B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361768712P 2013-02-25 2013-02-25
US61/768712 2013-02-25
PCT/US2014/018380 WO2014131023A1 (en) 2013-02-25 2014-02-25 Neoseptins: small molecule adjuvants

Publications (2)

Publication Number Publication Date
CN105339346A CN105339346A (zh) 2016-02-17
CN105339346B true CN105339346B (zh) 2017-03-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480023040.6A Expired - Fee Related CN105339346B (zh) 2013-02-25 2014-02-25 Neoseptin：小分子佐剂

Country Status (7)

Country Link
US (1) US9649373B2 (enExample)
EP (1) EP2958889B1 (enExample)
JP (1) JP6356160B2 (enExample)
CN (1) CN105339346B (enExample)
AU (1) AU2014218598B2 (enExample)
CA (1) CA2902342C (enExample)
WO (1) WO2014131023A1 (enExample)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
US10037382B2 (en) 2012-10-29 2018-07-31 Kyocera Corporation Surface acoustic wave sensor
US10131683B2 (en) 2014-07-17 2018-11-20 Molecular Templates, Inc. TH-302 solid forms and methods related thereto
ES2896960T3 (es) 2015-03-10 2022-02-28 Obi Pharma Inc Agentes alquilantes del ADN para su uso en el tratamiento del cáncer
CN112142692A (zh) * 2015-04-02 2020-12-29 深圳艾欣达伟医药科技有限公司 硝基苄基衍生物抗癌试剂
JP7327900B2 (ja) 2015-06-24 2023-08-16 スレッシュホールド ファーマシューティカルズ， インコーポレイテッド アジリジン含有ｄｎａアルキル化剤
US20180327364A1 (en) * 2015-11-13 2018-11-15 Brandeis University Mtor inhibitors and methods of use thereof
CN109641878B (zh) 2016-06-29 2021-09-14 斯克里普斯研究学院 Diprovocim：一类有效的tlr激动剂
US11673891B2 (en) 2017-11-14 2023-06-13 Dana-Farber Cancer Institute, Inc. Imidazopyrimidine compounds and uses thereof
EP3710007A4 (en) 2017-11-14 2021-12-15 Children's Medical Center Corporation USE OF IMIDAZOPYRIMIDINE TO MODULATE A HUMAN IMMUNE RESPONSE

Citations (5)

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Publication number Priority date Publication date Assignee Title
US20050004144A1 (en) * 2003-04-14 2005-01-06 Regents Of The University Of California Combined use of IMPDH inhibitors with toll-like receptor agonists
WO2007005583A1 (en) * 2005-06-30 2007-01-11 Eisai Co., Ltd. Compounds for preparing immunological adjuvant
WO2007024707A2 (en) * 2005-08-22 2007-03-01 The Regents Of The University Of California Tlr agonists
CN102015651A (zh) * 2008-03-03 2011-04-13 Irm责任有限公司 作为tlr活性调节剂的化合物和组合物
US20120148660A1 (en) * 2007-02-07 2012-06-14 Regents Of The University Of California, San Diego Ucsd Technology Transfer Office Conjugates of synthetic tlr agonists and uses therefor

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US4031083A (en) 1975-10-24 1977-06-21 Yeda Research And Development Co., Ltd. Cephalosporin antibiotics
US4045438A (en) 1975-10-24 1977-08-30 Yeda Research And Development Co. Ltd. Cephalosporin antibiotics
WO2008008264A2 (en) * 2006-07-07 2008-01-17 The Board Of Trustees Of The Leland Stanford Junior University Selective caspase inhibitors
US10369204B2 (en) * 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
MX2011008067A (es) * 2009-01-30 2011-08-17 Idera Pharmaceuticals Inc Novedosos agonistas sinteticos del receptor 9 tipo toll.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004144A1 (en) * 2003-04-14 2005-01-06 Regents Of The University Of California Combined use of IMPDH inhibitors with toll-like receptor agonists
WO2007005583A1 (en) * 2005-06-30 2007-01-11 Eisai Co., Ltd. Compounds for preparing immunological adjuvant
WO2007024707A2 (en) * 2005-08-22 2007-03-01 The Regents Of The University Of California Tlr agonists
US20120148660A1 (en) * 2007-02-07 2012-06-14 Regents Of The University Of California, San Diego Ucsd Technology Transfer Office Conjugates of synthetic tlr agonists and uses therefor
CN102015651A (zh) * 2008-03-03 2011-04-13 Irm责任有限公司 作为tlr活性调节剂的化合物和组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Design, Synthesis, and Evaluation of an α-Helix Mimetic Library Targeting Protein-Protein Interactions;Alex Shaginian et al.;《Journal of the American Chemical Society》;20090331;第131卷(第15期);第5564-5572页 *

Also Published As

Publication number Publication date
CN105339346A (zh) 2016-02-17
WO2014131023A1 (en) 2014-08-28
AU2014218598B2 (en) 2016-08-04
JP6356160B2 (ja) 2018-07-11
US9649373B2 (en) 2017-05-16
CA2902342A1 (en) 2014-08-28
EP2958889A1 (en) 2015-12-30
EP2958889B1 (en) 2017-03-22
EP2958889A4 (en) 2016-07-27
US20160000907A1 (en) 2016-01-07
CA2902342C (en) 2017-10-17
AU2014218598A1 (en) 2015-09-10
JP2016513128A (ja) 2016-05-12

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