CA2902342C - Neoseptins: small molecule adjuvants - Google Patents

Neoseptins: small molecule adjuvants Download PDF

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Publication number
CA2902342C
CA2902342C CA2902342A CA2902342A CA2902342C CA 2902342 C CA2902342 C CA 2902342C CA 2902342 A CA2902342 A CA 2902342A CA 2902342 A CA2902342 A CA 2902342A CA 2902342 C CA2902342 C CA 2902342C
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CA
Canada
Prior art keywords
mmol
equiv
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rule
substitute sheet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2902342A
Other languages
English (en)
French (fr)
Other versions
CA2902342A1 (en
Inventor
Bruce Beutler
Dale L. Boger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
University of Texas System
Original Assignee
Scripps Research Institute
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute, University of Texas System filed Critical Scripps Research Institute
Publication of CA2902342A1 publication Critical patent/CA2902342A1/en
Application granted granted Critical
Publication of CA2902342C publication Critical patent/CA2902342C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA2902342A 2013-02-25 2014-02-25 Neoseptins: small molecule adjuvants Expired - Fee Related CA2902342C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361768712P 2013-02-25 2013-02-25
US61/768,712 2013-02-25
PCT/US2014/018380 WO2014131023A1 (en) 2013-02-25 2014-02-25 Neoseptins: small molecule adjuvants

Publications (2)

Publication Number Publication Date
CA2902342A1 CA2902342A1 (en) 2014-08-28
CA2902342C true CA2902342C (en) 2017-10-17

Family

ID=51391916

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2902342A Expired - Fee Related CA2902342C (en) 2013-02-25 2014-02-25 Neoseptins: small molecule adjuvants

Country Status (7)

Country Link
US (1) US9649373B2 (enExample)
EP (1) EP2958889B1 (enExample)
JP (1) JP6356160B2 (enExample)
CN (1) CN105339346B (enExample)
AU (1) AU2014218598B2 (enExample)
CA (1) CA2902342C (enExample)
WO (1) WO2014131023A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10037382B2 (en) 2012-10-29 2018-07-31 Kyocera Corporation Surface acoustic wave sensor
US10131683B2 (en) 2014-07-17 2018-11-20 Molecular Templates, Inc. TH-302 solid forms and methods related thereto
JP6704421B2 (ja) 2015-03-10 2020-06-03 アセンタウィッツ ファーマシューティカルズ リミテッド Ｄｎａアルキル化剤
US10829437B2 (en) * 2015-04-02 2020-11-10 Obi Pharma, Inc. Nitrobenzyl derivatives of anti-cancer agents
AU2016282785A1 (en) 2015-06-24 2018-02-15 Immunogenesis, Inc. Aziridine containing DNA alkylating agents
US20180327364A1 (en) * 2015-11-13 2018-11-15 Brandeis University Mtor inhibitors and methods of use thereof
JP6964298B2 (ja) * 2016-06-29 2021-11-10 ザ スクリプス リサーチ インスティテュート ジプロボシム：新規かつ強力なクラスのｔｌｒアゴニスト
US11730810B2 (en) 2017-11-14 2023-08-22 Children's Medical Center Corporation Composition comprising an antigen and a substituted imidazo[1,2-a]pyrimidine for enhancing human immune response
WO2019099564A1 (en) 2017-11-14 2019-05-23 Children's Medical Center Corporation Novel imidazopyrimidine compounds and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031083A (en) 1975-10-24 1977-06-21 Yeda Research And Development Co., Ltd. Cephalosporin antibiotics
US4045438A (en) 1975-10-24 1977-08-30 Yeda Research And Development Co. Ltd. Cephalosporin antibiotics
WO2005016235A2 (en) * 2003-04-14 2005-02-24 The Regents Of The University Of California Combined use of impdh inhibitors with toll-like receptor agonists
JP5214446B2 (ja) * 2005-06-30 2013-06-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 免疫アジュバントの調製のための化合物
JP2009504803A (ja) * 2005-08-22 2009-02-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｔｌｒアゴニスト
JP2009542689A (ja) * 2006-07-07 2009-12-03 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 選択的カスパーゼ阻害剤
ES2456964T3 (es) 2007-02-07 2014-04-24 The Regents Of The University Of California Conjugados de agonistas de TLR sintéticos y usos de los mismos
ES2546213T3 (es) * 2008-03-03 2015-09-21 Novartis Ag Compuestos y composiciones como moduladores de la actividad de TLR
WO2010037402A1 (en) * 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
RU2011135993A (ru) * 2009-01-30 2013-03-10 Идера Фармасьютикалз, Инк. Новые синтетические агонисты tlr9

Also Published As

Publication number Publication date
JP6356160B2 (ja) 2018-07-11
WO2014131023A1 (en) 2014-08-28
JP2016513128A (ja) 2016-05-12
EP2958889A1 (en) 2015-12-30
AU2014218598A1 (en) 2015-09-10
CA2902342A1 (en) 2014-08-28
US9649373B2 (en) 2017-05-16
EP2958889A4 (en) 2016-07-27
CN105339346B (zh) 2017-03-08
CN105339346A (zh) 2016-02-17
EP2958889B1 (en) 2017-03-22
AU2014218598B2 (en) 2016-08-04
US20160000907A1 (en) 2016-01-07

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