CN105326967A - Medicinal preparation used for treating acute cholecystitis - Google Patents

Medicinal preparation used for treating acute cholecystitis Download PDF

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CN105326967A
CN105326967A CN201510874731.3A CN201510874731A CN105326967A CN 105326967 A CN105326967 A CN 105326967A CN 201510874731 A CN201510874731 A CN 201510874731A CN 105326967 A CN105326967 A CN 105326967A
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acute cholecystitis
treatment
herba
pharmaceutical preparation
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王菊明
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Suzhou Fengling Pharmaceutical Co Ltd
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Suzhou Fengling Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/428—Trichosanthes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/51—Gentianaceae (Gentian family)
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    • A61K36/57—Magnoliaceae (Magnolia family)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention belongs to the field of Chinese herba preparations and particularly provides a medicinal preparation used for treating acute cholecystitis. The medicinal preparation is prepared from 20 parts of delavay parnassia herb, 25 parts of wisteria roots, 22 parts of vallisneria natans, 20 parts of plumbago indica, 18 parts of salivia chinensis, 20 parts of fructus forsythiae, 25 parts of gentian, 25 parts of pericarpium citri reticulatae, 20 parts of endothelium corneum gigeriae galli, 20 parts of rhizoma corydalis, 20 parts of magnolia officinalis, 25 parts of polygonum cuspidatum, 20 parts of fructus aurantii, 15 parts of fructus trichosanthis, 15 parts of lygodium japonicum and 5 parts of liquorice. The preparation can treat acute cholecystitis.

Description

A kind of pharmaceutical preparation being used for the treatment of acute cholecystitis
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of acute cholecystitis and its preparation method and application.
Background technology
Acute cholecystitis refers to the gallbladder inflammation because bacteria attack gallbladder wall or cystic duct block and cause, and be a kind of common biliary tract disease, how caused by calculus, non-lithogenous acute cholecystitis only accounts for 4% ~ 8% of acute cholecystitis.Acute cholecystitis is because of its specificity sign and Radiologic imaging, and recall rate is relatively high, but still there is many disputes in the choose opportunities of Therapeutic Principle especially operative treatment.For this reason, be bursting to and develop the needs that more medicines for the treatment of acute cholecystitis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of acute cholecystitis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of acute cholecystitis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Parnassiae Delavayi 20 parts, Radix wisteriae sinensis 25 parts, Herba vallisneriae Spiralis 22 parts, Herba plumbaginis indicae 20 parts, Cortex Moutan 18 parts, Fructus Forsythiae 20 parts, Radix Gentianae 25 parts, Pericarpium Citri Reticulatae 25 parts, Endothelium Corneum Gigeriae Galli 20 parts, Rhizoma Corydalis 20 parts, Cortex Magnoliae Officinalis 20 parts, Rhizoma Polygoni Cuspidati 25 parts, Fructus Aurantii 20 parts, Fructus Trichosanthis 15 parts, Spora Lygodii 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of acute cholecystitis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of acute cholecystitis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment acute cholecystitis medicine being used for the treatment of acute cholecystitis.
Herba Parnassiae Delavayi is that saxifragaceae plant is dashed forward every the herb of Herba parnassiae.Clearing heat and moistening lung, reducing swelling and alleviating pain.Control pulmonary tuberculosis, parotitis, lymphadenitis, laryngitis, leucorrhea, hot carbuncle toxin, traumatic injury.
Radix wisteriae sinensis is the root of leguminous plant Caulis wisteriae sinensis.Control grain pathogenic wind, reinforcing the heart.
Herba plumbaginis indicae is stem and leaf and the flower of Plumbaginaceae plant Herba plumbaginis indicae.Removing blood stasis stimulates the menstrual flow; Reducing swelling and alleviating pain; To dispel the wind cestode.
Herba vallisneriae Spiralis is the herb of feverfew gold waist arrow.Heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, nourishing muscle and tendon and blood.For acute and chronic bronchitis, pharyngitis, tonsillitis, arthralgia; External treatment traumatic hemorrhage.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: acute cholecystitis disease is many because invading liver in damp and hot, pyretic toxicity, foul heresy, causes the liver failing to maintain the normal flow of QI, functional activity of QI being not smooth.Herba Parnassiae Delavayi of the present invention, Radix wisteriae sinensis, Herba vallisneriae Spiralis, Herba plumbaginis indicae, Cortex Moutan, Fructus Forsythiae heat-clearing and toxic substances removing, depressed liver-energy dispersing and function of gallbladder promoting are monarch drug, Radix Gentianae, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Rhizoma Corydalis, Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Fructus Aurantii, Fructus Trichosanthis, Spora Lygodii eliminating heat pathogen by purging the bowels are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, depressed liver-energy dispersing and function of gallbladder promoting, eliminating heat pathogen by purging the bowels treatment acute cholecystitis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Parnassiae Delavayi 20g, Radix wisteriae sinensis 25g, Herba vallisneriae Spiralis 22g, Herba plumbaginis indicae 20g, Cortex Moutan 18g, Fructus Forsythiae 20g, Radix Gentianae 25g, Pericarpium Citri Reticulatae 25g, Endothelium Corneum Gigeriae Galli 20g, Rhizoma Corydalis 20g, Cortex Magnoliae Officinalis 20g, Rhizoma Polygoni Cuspidati 25g, Fructus Aurantii 20g, Fructus Trichosanthis 15g, Spora Lygodii 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Parnassiae Delavayi 20g, Radix wisteriae sinensis 25g, Herba vallisneriae Spiralis 22g, Herba plumbaginis indicae 20g, Cortex Moutan 18g, Fructus Forsythiae 20g, Radix Gentianae 25g, Pericarpium Citri Reticulatae 25g, Endothelium Corneum Gigeriae Galli 20g, Rhizoma Corydalis 20g, Cortex Magnoliae Officinalis 20g, Rhizoma Polygoni Cuspidati 25g, Fructus Aurantii 20g, Fructus Trichosanthis 15g, Spora Lygodii 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Herba Parnassiae Delavayi 20g, Radix wisteriae sinensis 25g, Herba vallisneriae Spiralis 22g, Herba plumbaginis indicae 20g, Cortex Moutan 18g, Fructus Forsythiae 20g, Radix Gentianae 25g, Pericarpium Citri Reticulatae 25g, Endothelium Corneum Gigeriae Galli 20g, Rhizoma Corydalis 20g, Cortex Magnoliae Officinalis 20g, Rhizoma Polygoni Cuspidati 25g, Fructus Aurantii 20g, Fructus Trichosanthis 15g, Spora Lygodii 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation treatment acute cholecystitis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation acute cholecystitis case 60 example, 25 ~ 47 years old age.
4.2 diagnostic criterias: according to the guideline of clinical investigations of cholecystitis " new Chinese medicine treatment " (" Chen Haozhu. practical internal medicine. People's Health Publisher, 2002:1900-1901 ") formulate following standard: 1. many because of oils and fats meal, tired rear onset suddenly, upper right abdomen constant pain, paroxysmal is aggravated, and can radiate by shoulder to the right; Normal companion's Nausea and vomiting, heating, minority has jaundice; 2. upper right abdominal pressure pain, muscle tonus, or have rebound tenderness, Fei Shi does not levy the positive, sometimes can beat and enlargement, tenderness gallbladder; 3. Leukocyte Counts increases, and liver function can have mile abnormality; 4. ultrasound investigation can show that gallbladder increases, or sees cholelithiasis light group and sound shadow etc.; 5. x-ray checks that plain abdominal radiograph may be shown in the gallbladder shade of enlargement, the visible radiopaque calculus of minority.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule one month is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: the side of body (abdomen) pain waits transference cure, and temperature recovery is normal, routine blood test check total white blood cells recovers normal, and ultrasound diagnosis is without exception; Effective: symptom, sign disappear, body temperature, hemogram recover normal, and B ultrasonic gallbladder image obviously improves; Effective: the symptoms such as the side of body (abdomen) pain alleviate or disappear, and body temperature is also tending towards normal, though routine blood test and B ultrasonic check are improved, does not recover normal completely; Invalid: symptom is not improved, routine blood test and ultrasound diagnosis still belong to abnormal.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Effective Effectively Invalid Total effective rate (%)
Treatment group 30 3 8 15 4 86.7
Blank group 30 0 2 1 27 10
Visible, the medicine that the present invention obtains can safe and effective treatment acute cholecystitis, and has no side effect.

Claims (4)

1. one kind is used for the treatment of the pharmaceutical preparation of acute cholecystitis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Parnassiae Delavayi 20 parts, Radix wisteriae sinensis 25 parts, Herba vallisneriae Spiralis 22 parts, Herba plumbaginis indicae 20 parts, Cortex Moutan 18 parts, Fructus Forsythiae 20 parts, Radix Gentianae 25 parts, Pericarpium Citri Reticulatae 25 parts, Endothelium Corneum Gigeriae Galli 20 parts, Rhizoma Corydalis 20 parts, Cortex Magnoliae Officinalis 20 parts, Rhizoma Polygoni Cuspidati 25 parts, Fructus Aurantii 20 parts, Fructus Trichosanthis 15 parts, Spora Lygodii 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of acute cholecystitis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of acute cholecystitis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment acute cholecystitis medicine of acute cholecystitis according to claim 1.
CN201510874731.3A 2015-12-03 2015-12-03 Medicinal preparation used for treating acute cholecystitis Withdrawn CN105326967A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104800800A (en) * 2015-04-26 2015-07-29 臧孝国 Traditional Chinese medicine composition for treating cervical spondylosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104800800A (en) * 2015-04-26 2015-07-29 臧孝国 Traditional Chinese medicine composition for treating cervical spondylosis

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Title
李薇青等: "中西医结合治疗胆囊炎63例观察", 《实用中医药杂志》 *

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