CN105326649B - 一种变色胶囊 - Google Patents
一种变色胶囊 Download PDFInfo
- Publication number
- CN105326649B CN105326649B CN201510858165.7A CN201510858165A CN105326649B CN 105326649 B CN105326649 B CN 105326649B CN 201510858165 A CN201510858165 A CN 201510858165A CN 105326649 B CN105326649 B CN 105326649B
- Authority
- CN
- China
- Prior art keywords
- capsule
- toner
- microcapsules
- core
- containing toner
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 48
- 238000002845 discoloration Methods 0.000 title claims abstract description 22
- 239000003094 microcapsule Substances 0.000 claims abstract description 28
- 239000011162 core material Substances 0.000 claims abstract description 23
- 239000011257 shell material Substances 0.000 claims abstract description 15
- 230000005661 hydrophobic surface Effects 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims abstract description 4
- 230000002776 aggregation Effects 0.000 claims abstract description 3
- 238000004220 aggregation Methods 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 8
- 239000000516 sunscreening agent Substances 0.000 claims description 8
- 206010011732 Cyst Diseases 0.000 claims description 7
- 208000031513 cyst Diseases 0.000 claims description 7
- 239000001856 Ethyl cellulose Substances 0.000 claims description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 6
- 229920001249 ethyl cellulose Polymers 0.000 claims description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 229920002521 macromolecule Polymers 0.000 claims description 5
- 239000004014 plasticizer Substances 0.000 claims description 5
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000011787 zinc oxide Substances 0.000 claims description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims 2
- 229940058015 1,3-butylene glycol Drugs 0.000 claims 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920001817 Agar Polymers 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920001800 Shellac Polymers 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- 229920002494 Zein Polymers 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims 1
- 229940081735 acetylcellulose Drugs 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 229940023476 agar Drugs 0.000 claims 1
- UHHXUPJJDHEMGX-UHFFFAOYSA-K azanium;manganese(3+);phosphonato phosphate Chemical compound [NH4+].[Mn+3].[O-]P([O-])(=O)OP([O-])([O-])=O UHHXUPJJDHEMGX-UHFFFAOYSA-K 0.000 claims 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 claims 1
- 235000019437 butane-1,3-diol Nutrition 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 239000006229 carbon black Substances 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 1
- 229910052804 chromium Inorganic materials 0.000 claims 1
- 239000011651 chromium Substances 0.000 claims 1
- VQWFNAGFNGABOH-UHFFFAOYSA-K chromium(iii) hydroxide Chemical compound [OH-].[OH-].[OH-].[Cr+3] VQWFNAGFNGABOH-UHFFFAOYSA-K 0.000 claims 1
- 239000011258 core-shell material Substances 0.000 claims 1
- 229960004667 ethyl cellulose Drugs 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- HNMCSUXJLGGQFO-UHFFFAOYSA-N hexaaluminum;hexasodium;tetrathietane;hexasilicate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].S1SSS1.S1SSS1.[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] HNMCSUXJLGGQFO-UHFFFAOYSA-N 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229960002900 methylcellulose Drugs 0.000 claims 1
- 239000010445 mica Substances 0.000 claims 1
- 229910052618 mica group Inorganic materials 0.000 claims 1
- 238000010422 painting Methods 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229960000292 pectin Drugs 0.000 claims 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229940075065 polyvinyl acetate Drugs 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229940068984 polyvinyl alcohol Drugs 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 229950003779 propiram Drugs 0.000 claims 1
- ZBAFFZBKCMWUHM-UHFFFAOYSA-N propiram Chemical compound C=1C=CC=NC=1N(C(=O)CC)C(C)CN1CCCCC1 ZBAFFZBKCMWUHM-UHFFFAOYSA-N 0.000 claims 1
- 229960003351 prussian blue Drugs 0.000 claims 1
- 239000013225 prussian blue Substances 0.000 claims 1
- 239000004208 shellac Substances 0.000 claims 1
- 229940113147 shellac Drugs 0.000 claims 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
- 235000013874 shellac Nutrition 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 235000015424 sodium Nutrition 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- -1 sorbierite Chemical compound 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 229940032147 starch Drugs 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 230000000475 sunscreen effect Effects 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
- 235000013799 ultramarine blue Nutrition 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- 239000005019 zein Substances 0.000 claims 1
- 229940093612 zein Drugs 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 239000002537 cosmetic Substances 0.000 abstract description 15
- 239000000843 powder Substances 0.000 abstract description 9
- 239000003086 colorant Substances 0.000 abstract description 5
- 230000005660 hydrophilic surface Effects 0.000 abstract description 2
- 238000004381 surface treatment Methods 0.000 abstract description 2
- 239000000725 suspension Substances 0.000 description 7
- 239000000839 emulsion Substances 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000010094 polymer processing Methods 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- AXPZIVKEZRHGAS-UHFFFAOYSA-N 3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one Chemical compound [O-][N+](=O)C1=CC=CC=C1OCC1OC(=O)C(CC=2C=CC=CC=2)C1 AXPZIVKEZRHGAS-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N ferrosoferric oxide Chemical compound O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/10—Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/12—Face or body powders for grooming, adorning or absorbing
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Developing Agents For Electrophotography (AREA)
Abstract
本发明提供一种变色胶囊，所述变色胶囊包括丸芯和丸壳；其中，丸芯材料包括含有色粉1的微胶囊，丸壳材料包括含有色粉2的微胶囊；通过将含有色粉1的微胶囊聚集起来作为丸芯，在所述丸芯上喷雾盘涂含有色粉2的微胶囊作为丸壳制得。本发明变色胶囊将色粉真实颜色掩埋起来，只有当受到外力作用胶囊结构破坏时，丸芯和丸壳的颜色才混合在一起，获得稳定的颜色，具有完美的变色效果；且本发明可以对粉体进行疏水和亲水表面处理，进而使粉体能在各种化妆品基质中稳定，提高了匹配度，拓宽了应用前景。
Description
本发明属于微胶囊领域，具体涉及一种变色胶囊。
背景技术
众所周知，微胶囊是指对囊芯材料进行包埋处理而制备成的一种固体微粒产品，其作为近年来的热门技术，已在诸多领域均有应用。如用于提高囊芯物本身的稳定性、用于提高囊芯物在应用环境的匹配度，用于掩盖囊芯物真实的颜色和气味，亦或用于达到定时、定点的控制释放功效等。
现有的化妆品产品，使用过程中在皮肤上呈现的颜色，多为产品外观自身的颜色；如现有的BB霜产品在皮肤上涂抹时呈现出来的颜色，即为自身外观所呈现的象牙白色至浅棕色，没有给消费者带来意想不到的变色效果。不仅如此，因在化妆品体系中匹配度不高，有些颜料和粉体的应用受到了限制；如有些颜料和粉体属于亲水性物质，其在亲油性基料中就存在不匹配的问题，进而会使得粉体和颜料在油性基料中分散性差，颜色展现缓慢，颜色不稳定，直接导致“浮白”、花妆现象的产生，而存在着一定的缺陷。
发明内容
针对现有技术存在的上述不足，本发明是针对现有化妆产品不具有变色效果，且部分颜料和粉体与化妆品基料不匹配，容易造成颜色展现缓慢、颜色不稳定、“浮白”和花妆现象的技术问题，提供一种既具有变色效果、又能使颜料和粉体与化妆品基质相匹配的变色胶囊。
为了解决上述技术问题，本发明采用如下技术方案：一种变色胶囊，包括丸芯和丸壳；其中，丸芯材料包括含有色粉1的微胶囊，丸壳材料包括含有色粉2的微胶囊；通过将含有色粉1的微胶囊聚集起来作为丸芯，在所述丸芯上喷雾盘涂含有色粉2的微胶囊作为丸壳制得。
相比现有技术，本发明具有如下有益效果：
1、本发明变色防晒微胶囊采用微胶囊技术，将色粉、防晒剂和活性成分包埋起来，使其在化妆品基料中浸泡时不会受到基料环境的不良影响，有效保护了色粉、防晒剂和活性成分的性质，且不会使囊芯材料泄露或直接暴露在化妆品基料中造成基料着色。
2、本发明制得的变色胶囊丸壳可以在不同的化妆品基质中溶胀软化，但不会导致溶解、破坏外形、囊芯泄露的现象发生；在化妆品基质中溶胀软化的变色胶囊，在受到外界摩擦力涂抹作用时，胶囊结构可以被破坏，丸芯材料外漏，使丸芯和丸壳混合均匀，内外颜色混合达到变色效果，且协同发挥滋润皮肤、遮盖和防晒的功效。
3、本发明变色胶囊通过微胶囊技术，掩饰丸芯真实的颜色；当通过涂抹，使胶囊结构破坏时，又会瞬间展现出丸芯色粉所具有的色彩，并在10s之内获得稳定的颜色，给消费者带来意想不到的变色效果。
4、本发明通过微胶囊技术，可以包裹对化妆品基质有较高亲和力的颜料，避免出现基料着色的问题。
5、本发明对包裹的囊芯材料没有亲油、亲水性质上的限定；且可以对色粉、防晒剂和活性成分进行亲水表面处理或疏水表面处理，使色粉、防晒剂和活性成分可以在各种化妆品基质中稳定地分散，提高了粉体与化妆品基质的匹配度，拓宽了应用面。
6、本发明变色胶囊通过色粉、防晒剂和活性成分的协同配合作用，达到了变色、缓放活性成分、提高SPF防晒值的效果。
具体实施方式
下面结合实施例对本发明作进一步详细说明，下述实施例中使用的原料如无特殊说明，均为常用市售产品。
实施例1：
本实施例变色胶囊的直径为100~200 μm，具体成分配方如下所示：
如上所示，本实施例以乙基纤维素和羟丙基甲基纤维素作为复合壁材；其中乙基纤维素是一种水不溶解的成膜剂，可以溶解在70%浓度以上乙醇水溶液中，也可以溶解在一些油脂例如蓖麻油中。羟丙基甲基纤维素是一种水易溶的成膜材料，不溶解于油，但能溶解在70%的乙醇水溶液中。所以选择70%的乙醇水溶液，作为乙基纤维素和羟丙基甲基纤维素的共同溶剂。通过调节乙基纤维素和羟丙基甲基纤维素的比例，并且加入塑化剂，本实施例囊壁材料可以在化妆品基质中溶胀软化，并不溶解。
本实施例所有的色粉和粉体都是经过聚二甲基硅氧烷疏水表面处理，本实施例变色胶囊具体采用如下制备方法实现：
（1）将乙基纤维素和羟丙基甲基纤维素，按1:1的质量比称量，混合溶解在70%的乙醇水溶液中，混合均匀；
（2）向步骤（1）混合均匀的溶液中，加入增塑剂PEG600和1,3-丁二醇，制成囊壁材料溶液（A）；
（3）向囊壁材料溶液（A）中，加入活性成分维生素E，再加入聚二甲基硅氧烷处理后的氧化铁红、氧化铁黄、氧化铁黑的混合色粉，搅拌均匀，使各成分匀质分散在囊壁材料溶液中，得到一个混悬液（B），混悬液（B）的固形物含量约为35%。
（4）用喷雾干燥法，将混悬液（B）进行喷雾干燥，得到微胶囊1（C），微胶囊1（C）直径大约10-20微米。
（5）用混悬液（B）作为粘合剂，使用流化床切线喷雾制丸机，将混悬液（B）喷雾干燥到微胶囊1（C）上，使微胶囊1（C）团聚成直径70-150微米的颗粒（E）；
（6）按与步骤（1）、（2）和（3）相同的方法，制得聚二甲基硅氧烷处理的钛白粉和氧化锌的混悬液（F），并将混悬液（F）喷雾盘涂到颗粒（E）上，形成一个白色的外壳，得到直径约100-200微米的变色胶囊（G）。
实施例2
该变色胶囊（G）外观是近白色的细小颗粒，可以直接分散到下面硅油包水的乳液里面。变色胶囊（G）在乳液基质中浸泡几天以后变得柔软，但是形状仍保持完整，使消费者在涂抹破坏胶囊结构时，完全感觉不到颗粒感。变色胶囊（G）被涂抹破坏结构后，瞬间释放包裹的色粉，使囊壳和丸芯含有的色粉一同发挥作用，在皮肤上混合快速的呈现肉色，达到变色的效果；不仅如此，同时释放的还有具有防晒效果的钛白粉和氧化锌，以及营养成分维生素 E，带来了防晒和滋润肌肤的效果。本实施例中所有的色粉都是经过聚二甲基硅氧烷疏水处理过的，与硅油包水的乳液有极佳的相容性，可以使色粉在乳液中稳定地分散，使变色混合效果可以快速而均匀地完成，呈现极佳的颜色效果和遮盖力。
本实施例变色胶囊（G）可以添加入硅油包水BB霜乳液中，含有变色胶囊G的硅油包水BB霜乳液具体成分配方如下所示：
表2 成分和配方
本发明中列举的其他常温下易溶于水的高分子成膜材料、常温下不溶于或微溶于水的高分子成膜材料均具有网状交联包裹效果，进而都可以制备成微胶囊的囊壁；列举的其他增塑剂均可以使囊壳不同的化妆品基质中溶胀软化，进而均具有溶胀软化效果；列举的其他色粉都可以发挥其色彩功效；列举的其他活性成分均可以实现其活性功能。即采用任一本发明中所列举的各类物质，均可以制备成本发明变色胶囊，实现本发明的目的，故再此不一一赘述。
最后说明的是，以上实施例仅用以说明本发明的技术方案而非限制，尽管申请人参照较佳实施例对本发明进行了详细说明，本领域的普通技术人员应当理解，对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的宗旨和范围的，均应涵盖在本发明的权利要求范围当中。
Claims (3)
1.一种变色胶囊，其特征在于，包括丸芯和丸壳；其中，丸芯材料包括含有色粉1的微胶囊，丸壳材料包括含有色粉2的微胶囊；通过将含有色粉1的微胶囊聚集起来作为丸芯，在所述丸芯上喷雾盘涂含有色粉2的微胶囊作为丸壳制得；所述含有色粉1的微胶囊和含有色粉2的微胶囊均为核壳结构的微胶囊；
其中，所述微胶囊的囊壁材料包括常温下易溶于水的高分子成膜材料和常温下不溶于或微溶于水的高分子成膜材料中的一种或多种，囊芯材料包括色粉、活性成分和物理防晒剂中的一种或多种；所述常温下易溶于水的高分子成膜材料包括甲基纤维素、羧甲基纤维素钠、聚维酮、羟乙基纤维素、羟乙基甲基纤维素、羟丙基甲基纤维素、卡波姆、普鲁兰、葡聚糖、阿拉伯胶、果胶、角叉菜胶、海藻酸钠或瓜尔豆胶；所述常温下不溶于或微溶于水的高分子成膜材料包括乙基纤维素、甲基丙烯酸共聚物、虫胶、邻苯二甲酸醋酸纤维素、玉米朊、聚醋酸乙烯酯、醋酸纤维素、聚乙烯醇、琼脂、淀粉浆或明胶；
所述囊壁材料还包括一种或多种增塑剂；所述增塑剂包括甘油、丙二醇、聚乙二醇、聚丙二醇、1,3-丁二醇、戊二醇、山梨醇、甘露醇、木糖醇、柠檬酸三乙酯、邻苯二甲酸二乙酯或蓖麻油；所述色粉包括无机色粉或有机色淀；其中，所述无机色粉包括氧化铁、二氧化钛、氧化铬、氢氧化铬、群青蓝、群青紫、普鲁士蓝、锰紫、云母或碳黑；所述有机色淀包括D＆C系列色淀或FD＆C系列色淀；所述物理防晒剂包括钛白粉和氧化锌中的一种或多种；所述色粉、活性成分和物理防晒剂中的一种或多种还经过聚二甲基硅氧烷疏水表面处理或亲水表面处理。
2.根据权利要求1所述变色胶囊，其特征在于，所述含有色粉1的微胶囊和含有色粉2的微胶囊直径均为10~70 μm。
3.根据权利要求1所述变色胶囊，其特征在于，所述变色胶囊的直径为50~1000μm。
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510858165.7A CN105326649B (zh) | 2015-11-30 | 2015-11-30 | 一种变色胶囊 |
| PCT/CN2016/107503 WO2017092637A1 (zh) | 2015-11-30 | 2016-11-28 | 一种变色胶囊 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510858165.7A CN105326649B (zh) | 2015-11-30 | 2015-11-30 | 一种变色胶囊 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105326649A CN105326649A (zh) | 2016-02-17 |
| CN105326649B true CN105326649B (zh) | 2018-03-09 |
Family
ID=55277563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510858165.7A Active CN105326649B (zh) | 2015-11-30 | 2015-11-30 | 一种变色胶囊 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN105326649B (zh) |
| WO (1) | WO2017092637A1 (zh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102370804B1 (ko) * | 2016-09-30 | 2022-03-07 | (주)아모레퍼시픽 | 색소를 포함하는 캡슐을 함유하는 메이크업 화장료 조성물 |
| CN107098425A (zh) * | 2017-05-05 | 2017-08-29 | 中科众沃生态科技（武汉）有限公司 | 一种微胶囊净水剂及其制备方法 |
| CN107349112B (zh) * | 2017-05-27 | 2018-09-18 | 清远初曲智能科技有限公司 | 一种减少唇纹长效深层保湿滋润的变色唇膏及其制备方法 |
| CN107375020B (zh) * | 2017-05-27 | 2018-11-30 | 清远初曲智能科技有限公司 | 一种具有独立分散色粉微胶囊的瞬时融合护色唇膏 |
| CN107157836A (zh) * | 2017-05-27 | 2017-09-15 | 清远初曲智能科技有限公司 | 一种利用核壳结构进行色粉包埋的护色唇釉及其制备方法 |
| CN107349136B (zh) * | 2017-05-27 | 2018-07-20 | 清远初曲智能科技有限公司 | 一种防晕染及长时保持鲜艳呈色的变色唇釉及其制备方法 |
| CN109012520B (zh) * | 2018-07-18 | 2021-03-02 | 湖北工业大学 | 一种基于凝胶网络受限反溶剂制备核壳结构微胶囊的方法 |
| KR102204155B1 (ko) * | 2019-03-13 | 2021-01-18 | 한국콜마주식회사 | 캡슐의 색상이 변화하는 컬러레이션 화장료 조성물 |
| CN109793699A (zh) * | 2019-04-02 | 2019-05-24 | 生态环境部南京环境科学研究所 | 一种天麻面膜乳的制备方法 |
| CN109806215B (zh) * | 2019-04-10 | 2021-09-28 | 湖南素元生物科技有限公司 | 天麻面膜乳及其超声制备方法 |
| CN110917094A (zh) * | 2019-12-18 | 2020-03-27 | 成都潮蛹科技有限公司 | 一种带有抗蓝光和变色功效的粉底液及其制备方法 |
| CN112120943B (zh) * | 2020-09-04 | 2023-10-27 | 江西联锴科技有限公司 | 一种粉底用球形变色粒子 |
| CN112425771A (zh) * | 2020-11-30 | 2021-03-02 | 丽江三川实业集团有限公司 | 一种富硒食用菌含片及其制备方法 |
| CN116807938B (zh) * | 2023-07-06 | 2024-04-16 | 希肤科技（上海）有限公司 | 一种具有变色功能的复合面膜布及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104812359A (zh) * | 2012-11-30 | 2015-07-29 | 莱雅公司 | 变色组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4756906A (en) * | 1986-03-18 | 1988-07-12 | Minnesota Mining And Manufacturing Company | Cosmetic colorant compositions |
| CA2568006A1 (en) * | 2004-05-25 | 2005-12-08 | E-L Management Corp. | Novel color cosmetic compositions |
| WO2009138978A2 (en) * | 2008-05-12 | 2009-11-19 | Tagra Biotechnologies Ltd | Compositions for topical application comprising microencapsulated colorants |
| ES2378495T3 (es) * | 2009-07-17 | 2012-04-13 | Clariant Finance (Bvi) Limited | Composición de limpieza que cambia de color |
| WO2013107000A1 (en) * | 2012-01-17 | 2013-07-25 | L'oreal | Colour changing composition |
-
2015
- 2015-11-30 CN CN201510858165.7A patent/CN105326649B/zh active Active
-
2016
- 2016-11-28 WO PCT/CN2016/107503 patent/WO2017092637A1/zh active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104812359A (zh) * | 2012-11-30 | 2015-07-29 | 莱雅公司 | 变色组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017092637A1 (zh) | 2017-06-08 |
| CN105326649A (zh) | 2016-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105326649B (zh) | 一种变色胶囊 | |
| US8425940B2 (en) | Agent-encapsulating micro-and nanoparticles, methods for preparation of same and products containing same | |
| JP7198205B2 (ja) | 腸溶性硬質カプセル | |
| Phaechamud et al. | Chitosan citrate as film former: compatibility with water-soluble anionic dyes and drug dissolution from coated tablet | |
| TWI733910B (zh) | 含有包含色素的膠囊的化妝用化妝料組合物 | |
| CN112120943B (zh) | 一种粉底用球形变色粒子 | |
| KR101471447B1 (ko) | 코어씨드 및 감압-파괴성 벽층을 갖는 색상-변화 마이크로캡슐 및 이의 제조방법 | |
| TWI798184B (zh) | 包含色素的膠囊及其製備方法 | |
| US10813851B2 (en) | Color-changing microcapsule comprising pigment core and pressure breakable wall layer, and preparation method therefor | |
| CN108210415A (zh) | 一种辣椒红色素丝滑口红的加工方法 | |
| WO2024063039A1 (ja) | 酸化マグネシウムを含有する遮光性ハードカプセル | |
| EP3862021A1 (en) | Improved-strength hard capsule and production method for same | |
| Yoksan et al. | Fabrication, Characterization and In Vitro Release of Vitexin-Loaded Chitosan Nanoparticles | |
| TWI832471B (zh) | 具清除自由基及美白功效的粉團蓼微膠囊載體及其製備方法與用途 | |
| KR20180079655A (ko) | 화장료용 색소 또는 기능성 성분을 함유하는 다중캡슐 및 이의 제조방법 | |
| WO2008059522B1 (en) | Herbal gastrointenstinal controlled drug delivery dosage forms including pellets and process for their preparation | |
| CN107205952A (zh) | 包含可见珠的组合物 | |
| TW202415399A (zh) | 具清除自由基及美白功效的粉團蓼微膠囊載體及其製備方法與用途 | |
| JPS58118511A (ja) | 油類を加えてなるアキユアスコ−チング法 | |
| KR20200012558A (ko) | 쉘락을 이용한 손발톱용 저자극 매니큐어 조성물 및 그의 제조방법 | |
| US20170273887A1 (en) | Composite powder, method of producing thereof and cosmetic composition containing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 401519 Chongqing Hechuan Industrial Park weir village two Patentee after: Chongqing Xiaowan Biotechnology Co.,Ltd. Address before: 401519 Chongqing Hechuan Industrial Park weir village two Patentee before: CHONGQING XIAOWAN TRADE Co.,Ltd. |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20210324 Address after: No.17-1, China CITIC Bank building, No.5, yanghesan village, Jiangbei District, Chongqing 400020 Patentee after: Chongqing Dongsheng Precision Technology Co.,Ltd. Address before: 401519 community 2, Yankou village, Hechuan Industrial Park, Chongqing Patentee before: Chongqing Xiaowan Biotechnology Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230704 Address after: 401519 community 2, Yankou village, Hechuan Industrial Park, Chongqing Patentee after: Chongqing Xiaowan Biotechnology Co.,Ltd. Address before: No.17-1, China CITIC Bank building, No.5, yanghesan village, Jiangbei District, Chongqing 400020 Patentee before: Chongqing Dongsheng Precision Technology Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240325 Address after: No. 1, Building 20, No. 28 Yuefu Avenue, Fuxing Street, Liangjiang New Area, Beibei District, Chongqing, 400713 Patentee after: Pailechi (Chongqing) Biotechnology Co.,Ltd. Country or region after: China Address before: 401519 community 2, Yankou village, Hechuan Industrial Park, Chongqing Patentee before: Chongqing Xiaowan Biotechnology Co.,Ltd. Country or region before: China |
|
| TR01 | Transfer of patent right |