CN105308038B - Zeste增强子同源物2的抑制剂 - Google Patents
Zeste增强子同源物2的抑制剂 Download PDFInfo
- Publication number
- CN105308038B CN105308038B CN201480033093.6A CN201480033093A CN105308038B CN 105308038 B CN105308038 B CN 105308038B CN 201480033093 A CN201480033093 A CN 201480033093A CN 105308038 B CN105308038 B CN 105308038B
- Authority
- CN
- China
- Prior art keywords
- methyl
- oxo
- dihydropyridin
- dimethyl
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(C)(C)OC(N[C@](CC1)CC[C@]1C(*)N(C)OC)=O Chemical compound CC(C)(C)OC(N[C@](CC1)CC[C@]1C(*)N(C)OC)=O 0.000 description 27
- CQZPEBDZIWYWEL-UHFFFAOYSA-N Cc1c(N)[s]cc1C(OC)=O Chemical compound Cc1c(N)[s]cc1C(OC)=O CQZPEBDZIWYWEL-UHFFFAOYSA-N 0.000 description 2
- RQHHTQQZIPZYKU-DVZOWYKESA-N C/C=C(/CCN1CCOCC1)\c1c(C)c(C(NCC2=C(C)C=C(C)NC2=O)=O)c[s]1 Chemical compound C/C=C(/CCN1CCOCC1)\c1c(C)c(C(NCC2=C(C)C=C(C)NC2=O)=O)c[s]1 RQHHTQQZIPZYKU-DVZOWYKESA-N 0.000 description 1
- WEWBQPFPCRBHDO-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CC1c1c(C)c(C(NCC2=C(C)C=C(C)NC2=O)=O)c[s]1)=O Chemical compound CC(C)(C)OC(N(CC1)CC1c1c(C)c(C(NCC2=C(C)C=C(C)NC2=O)=O)c[s]1)=O WEWBQPFPCRBHDO-UHFFFAOYSA-N 0.000 description 1
- MNCXGBBUODZXES-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CC1c1c(C)c(C(OC)=O)c[s]1)=O Chemical compound CC(C)(C)OC(N(CC1)CC1c1c(C)c(C(OC)=O)c[s]1)=O MNCXGBBUODZXES-UHFFFAOYSA-N 0.000 description 1
- HFPTVKCVVCVGRX-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(c1c(C)c(C(OC)=O)c[s]1)O)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(c1c(C)c(C(OC)=O)c[s]1)O)=O HFPTVKCVVCVGRX-UHFFFAOYSA-N 0.000 description 1
- PCJPGNCABBDNJU-UHFFFAOYSA-N CC(C=C(C)N1)=C(CN)C1=O Chemical compound CC(C=C(C)N1)=C(CN)C1=O PCJPGNCABBDNJU-UHFFFAOYSA-N 0.000 description 1
- RQSIAANKDQCDHF-UHFFFAOYSA-N CC(CCC1)N1c1c(C)c(C(OC)=O)c[s]1 Chemical compound CC(CCC1)N1c1c(C)c(C(OC)=O)c[s]1 RQSIAANKDQCDHF-UHFFFAOYSA-N 0.000 description 1
- WQHDTHDJPDGYLZ-UHFFFAOYSA-N CC(N1)=CC(C(F)(F)F)=C(CN)C1=O Chemical compound CC(N1)=CC(C(F)(F)F)=C(CN)C1=O WQHDTHDJPDGYLZ-UHFFFAOYSA-N 0.000 description 1
- LQRSUXVZQNCRKZ-JHJOSGQCSA-N CCC([C@H](CC1)CC[C@@H]1N)c1c(C)c(C(NCC2=C(C)C=C(C)NC2=O)=O)c[s]1 Chemical compound CCC([C@H](CC1)CC[C@@H]1N)c1c(C)c(C(NCC2=C(C)C=C(C)NC2=O)=O)c[s]1 LQRSUXVZQNCRKZ-JHJOSGQCSA-N 0.000 description 1
- QWQOUCCBLMVBJR-YGQOYYDZSA-N CCC([C@H](CC1)CC[C@@H]1NC(OC(C)(C)C)=O)c1c(C)c(C(NCC2=C(C)C=C(C)NC2=O)=O)c[s]1 Chemical compound CCC([C@H](CC1)CC[C@@H]1NC(OC(C)(C)C)=O)c1c(C)c(C(NCC2=C(C)C=C(C)NC2=O)=O)c[s]1 QWQOUCCBLMVBJR-YGQOYYDZSA-N 0.000 description 1
- XSSOURWDDVTNJJ-TZYNXQCKSA-N CCCN(CCO)C(C)c1c(C)c(C(NC/C(/C(C)=O)=C(\C)/C=C(/C)\N)=O)c[s]1 Chemical compound CCCN(CCO)C(C)c1c(C)c(C(NC/C(/C(C)=O)=C(\C)/C=C(/C)\N)=O)c[s]1 XSSOURWDDVTNJJ-TZYNXQCKSA-N 0.000 description 1
- IELCIYCNIFXFHZ-UHFFFAOYSA-N CCN(C(CC1)CCC1N(C)C)c1c(C)c(C(NCC2=C(C)C=C(C)N(C)C2=N)=N)c[s]1 Chemical compound CCN(C(CC1)CCC1N(C)C)c1c(C)c(C(NCC2=C(C)C=C(C)N(C)C2=N)=N)c[s]1 IELCIYCNIFXFHZ-UHFFFAOYSA-N 0.000 description 1
- YYYMQDRNWZMSCA-UHFFFAOYSA-N CCN(C1CCOCC1)C(C1)=C(C)C(C(OC)=O)=C1Cl Chemical compound CCN(C1CCOCC1)C(C1)=C(C)C(C(OC)=O)=C1Cl YYYMQDRNWZMSCA-UHFFFAOYSA-N 0.000 description 1
- WAUYOOANGDXOEM-UHFFFAOYSA-N CCN(C1CCOCC1)c1c(C)c(C(OC)=O)c(C)[s]1 Chemical compound CCN(C1CCOCC1)c1c(C)c(C(OC)=O)c(C)[s]1 WAUYOOANGDXOEM-UHFFFAOYSA-N 0.000 description 1
- LXCAZKRXHNGVNM-UHFFFAOYSA-N CCN(CCC(C)C(C(C1C)SC=C1C(NCC1=C(C)C=C(C)NC1=O)=O)O)C(O)OC(C)(C)C Chemical compound CCN(CCC(C)C(C(C1C)SC=C1C(NCC1=C(C)C=C(C)NC1=O)=O)O)C(O)OC(C)(C)C LXCAZKRXHNGVNM-UHFFFAOYSA-N 0.000 description 1
- YTCDDVHOZLILNH-OKILXGFUSA-N CCN([C@H](CC1)CC[C@H]1N(C)C)c1c[s]c(C(OC)=O)c1C Chemical compound CCN([C@H](CC1)CC[C@H]1N(C)C)c1c[s]c(C(OC)=O)c1C YTCDDVHOZLILNH-OKILXGFUSA-N 0.000 description 1
- IDRCVWWYENNMTH-HNNXBMFYSA-N CC[C@@H](c1c(C)c(C(OC)=O)c[s]1)N(CC1)CC=C1N(C)C Chemical compound CC[C@@H](c1c(C)c(C(OC)=O)c[s]1)N(CC1)CC=C1N(C)C IDRCVWWYENNMTH-HNNXBMFYSA-N 0.000 description 1
- MQSUJFMBRLFJQD-OAHLLOKOSA-N CC[C@H](c1c(C)c(C(OC)=O)c[s]1)N(CC1)CCC1N(C)C Chemical compound CC[C@H](c1c(C)c(C(OC)=O)c[s]1)N(CC1)CCC1N(C)C MQSUJFMBRLFJQD-OAHLLOKOSA-N 0.000 description 1
- HUUPVABNAQUEJW-UHFFFAOYSA-N CN(CC1)CCC1=O Chemical compound CN(CC1)CCC1=O HUUPVABNAQUEJW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361817436P | 2013-04-30 | 2013-04-30 | |
| US61/817,436 | 2013-04-30 | ||
| US201361842038P | 2013-07-02 | 2013-07-02 | |
| US61/842,038 | 2013-07-02 | ||
| US201361907024P | 2013-11-21 | 2013-11-21 | |
| US61/907,024 | 2013-11-21 | ||
| US201461936460P | 2014-02-06 | 2014-02-06 | |
| US61/936,460 | 2014-02-06 | ||
| PCT/IB2014/061012 WO2014177982A1 (en) | 2013-04-30 | 2014-04-25 | Enhancer of zeste homolog 2 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105308038A CN105308038A (zh) | 2016-02-03 |
| CN105308038B true CN105308038B (zh) | 2018-05-29 |
Family
ID=50877537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480033093.6A Expired - Fee Related CN105308038B (zh) | 2013-04-30 | 2014-04-25 | Zeste增强子同源物2的抑制剂 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9505745B2 (https=) |
| EP (1) | EP2991980B1 (https=) |
| JP (1) | JP6373973B2 (https=) |
| KR (1) | KR20160003115A (https=) |
| CN (1) | CN105308038B (https=) |
| AU (1) | AU2014261075B2 (https=) |
| BR (1) | BR112015027527A2 (https=) |
| CA (1) | CA2910873A1 (https=) |
| CL (1) | CL2015003200A1 (https=) |
| DO (1) | DOP2015000270A (https=) |
| EA (1) | EA030196B1 (https=) |
| ES (1) | ES2717680T3 (https=) |
| HK (1) | HK1214815A1 (https=) |
| MX (1) | MX2015015144A (https=) |
| NZ (1) | NZ630205A (https=) |
| PE (1) | PE20151981A1 (https=) |
| PH (1) | PH12015502414A1 (https=) |
| SG (1) | SG11201508203TA (https=) |
| WO (1) | WO2014177982A1 (https=) |
| ZA (1) | ZA201507398B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ628762A (en) * | 2012-02-10 | 2016-07-29 | Constellation Pharmaceuticals Inc | Modulators of methyl modifying enzymes, compositions and uses thereof |
| KR20230156450A (ko) | 2012-10-15 | 2023-11-14 | 에피자임, 인코포레이티드 | 암을 치료하는 방법 |
| EP2991980B1 (en) * | 2013-04-30 | 2019-01-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
| KR20160030221A (ko) | 2013-07-10 | 2016-03-16 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 제스트 인핸서 상동체 2 억제제 |
| KR102352388B1 (ko) | 2014-02-06 | 2022-01-17 | 헵테얼즈 테라퓨틱스 리미티드 | 무스카린성 m1 수용체 및/또는 m4 수용체 작용제로서 바이사이클릭 아자 화합물 |
| CN107148419A (zh) * | 2014-10-28 | 2017-09-08 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | Zeste增强子同源物2抑制剂 |
| AR102767A1 (es) * | 2014-12-05 | 2017-03-22 | Lilly Co Eli | Inhibidores de ezh2 |
| UY36758A (es) * | 2015-06-30 | 2016-12-30 | Glaxosmithkline Ip No 2 Ltd | Inhibidores del potenciador del homólogo zeste 2 |
| WO2017035234A1 (en) | 2015-08-24 | 2017-03-02 | Epizyme, Inc. | Method for treating cancer |
| TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| EP3370725A4 (en) * | 2015-11-06 | 2019-07-03 | Epizyme, Inc. | PEDIATRIC DOSAGE FOR THE TREATMENT OF CANCER WITH AN EZH2 INHIBITOR |
| RS59763B1 (sr) | 2015-11-19 | 2020-02-28 | Jiangsu Hengrui Medicine Co | Derivati benzofurana, postupci njihove pripreme i njihova upotreba u medicini |
| CA3023157A1 (en) * | 2016-05-05 | 2017-11-09 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
| US20170337814A1 (en) * | 2016-05-20 | 2017-11-23 | Donald Edward Morgan | Safety alerting drivers device and system |
| WO2018045971A1 (zh) | 2016-09-07 | 2018-03-15 | 上海海和药物研究开发有限公司 | 吡啶并五元芳香环类化合物、其制备方法及用途 |
| WO2018125983A1 (en) | 2016-12-30 | 2018-07-05 | Mitobridge, Inc. | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (acmsd) inhibitors |
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| DK3746446T3 (da) | 2018-01-31 | 2022-06-27 | Mirati Therapeutics Inc | PRC2-inhibitorer |
| CA3104209A1 (en) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| US12421228B2 (en) | 2019-04-22 | 2025-09-23 | Mirati Therapeutics, Inc. | Naphthyridine derivatives as PRC2 inhibitors |
| TWI762939B (zh) * | 2019-05-31 | 2022-05-01 | 大陸商海思科醫藥集團股份有限公司 | Btk抑制劑環衍生物及其製備方法和藥學上的應用 |
| US12252493B2 (en) | 2019-06-05 | 2025-03-18 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as PRC2 inhibitors for treating cancer |
| JP2022545467A (ja) | 2019-08-22 | 2022-10-27 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法とｚｅｓｔｅホモログ２エンハンサー（ＥＺＨ２）阻害剤との併用療法および関連方法 |
| CN110964200A (zh) * | 2019-12-19 | 2020-04-07 | 新纳奇材料科技江苏有限公司 | 一种基于聚硅氧烷馏出物的羟基封端聚硅氧烷的制备方法 |
| WO2021129629A1 (zh) * | 2019-12-23 | 2021-07-01 | 四川海思科制药有限公司 | Zeste增强子同源物2抑制剂及其用途 |
| CN111233768B (zh) * | 2020-03-18 | 2021-08-03 | 徐州圣元化工有限公司 | 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法 |
| IL316768A (en) | 2022-05-25 | 2025-01-01 | Ikena Oncology Inc | MEK inhibitors and their uses |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140325A1 (en) * | 2010-05-07 | 2011-11-10 | Glaxosmithkline Llc | Indazoles |
| WO2012005805A1 (en) * | 2010-05-07 | 2012-01-12 | Glaxosmithkline Llc | Azaindazoles |
| WO2012118812A2 (en) * | 2011-02-28 | 2012-09-07 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| WO2012142513A1 (en) * | 2011-04-13 | 2012-10-18 | Epizyme, Inc. | Substituted benzene compounds |
| CN102970869A (zh) * | 2010-05-07 | 2013-03-13 | 葛兰素史密斯克莱有限责任公司 | 吲哚 |
| WO2013049770A2 (en) * | 2011-09-30 | 2013-04-04 | Glaxosmithkline Llc | Methods of treating cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080293716A1 (en) * | 2004-01-30 | 2008-11-27 | Smithkline Beecham Corporation | Chemical Compounds |
| MXPA06010520A (es) * | 2004-03-30 | 2007-03-26 | Chiron Corp | Derivados de tiofeno sustituidos como agentes anticancerosos. |
| US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
| AU2006325746A1 (en) | 2005-12-14 | 2007-06-21 | Bristol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| CN102471338B (zh) * | 2009-08-07 | 2014-07-02 | 默克专利有限公司 | 氮杂杂环化合物 |
| ES2607064T3 (es) | 2010-12-01 | 2017-03-29 | Glaxosmithkline Llc | Indoles |
| JO3363B1 (ar) | 2011-04-13 | 2019-03-13 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| NZ628762A (en) | 2012-02-10 | 2016-07-29 | Constellation Pharmaceuticals Inc | Modulators of methyl modifying enzymes, compositions and uses thereof |
| PT3184523T (pt) | 2012-04-13 | 2019-09-26 | Eisai R&D Man Co Ltd | Bromidrato de n-((4,6-dimetil-2-oxo-l,2-di-hidropiridin- 3-il)metil)-5-(etil(tetra-hidro-2h-piran-4-il)amino)-4- metil-4¿-(morfolinometil)-[l,1¿-bofenil]-3-carboxamida para utilização no tratamento de uma doença proliferativa celular do sistema hematológico |
| WO2013173441A2 (en) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
| EP2991980B1 (en) * | 2013-04-30 | 2019-01-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
-
2014
- 2014-04-25 EP EP14727619.0A patent/EP2991980B1/en active Active
- 2014-04-25 JP JP2016511152A patent/JP6373973B2/ja not_active Expired - Fee Related
- 2014-04-25 KR KR1020157033651A patent/KR20160003115A/ko not_active Ceased
- 2014-04-25 AU AU2014261075A patent/AU2014261075B2/en not_active Ceased
- 2014-04-25 SG SG11201508203TA patent/SG11201508203TA/en unknown
- 2014-04-25 CN CN201480033093.6A patent/CN105308038B/zh not_active Expired - Fee Related
- 2014-04-25 WO PCT/IB2014/061012 patent/WO2014177982A1/en not_active Ceased
- 2014-04-25 PE PE2015002298A patent/PE20151981A1/es not_active Application Discontinuation
- 2014-04-25 HK HK16102708.1A patent/HK1214815A1/zh unknown
- 2014-04-25 NZ NZ630205A patent/NZ630205A/en not_active IP Right Cessation
- 2014-04-25 US US14/787,866 patent/US9505745B2/en not_active Expired - Fee Related
- 2014-04-25 EA EA201592068A patent/EA030196B1/ru not_active IP Right Cessation
- 2014-04-25 BR BR112015027527A patent/BR112015027527A2/pt not_active IP Right Cessation
- 2014-04-25 MX MX2015015144A patent/MX2015015144A/es unknown
- 2014-04-25 ES ES14727619T patent/ES2717680T3/es active Active
- 2014-04-25 CA CA2910873A patent/CA2910873A1/en not_active Abandoned
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2015
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- 2015-10-19 PH PH12015502414A patent/PH12015502414A1/en unknown
- 2015-10-30 CL CL2015003200A patent/CL2015003200A1/es unknown
- 2015-10-30 DO DO2015000270A patent/DOP2015000270A/es unknown
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2016
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| WO2011140325A1 (en) * | 2010-05-07 | 2011-11-10 | Glaxosmithkline Llc | Indazoles |
| WO2012005805A1 (en) * | 2010-05-07 | 2012-01-12 | Glaxosmithkline Llc | Azaindazoles |
| CN102970869A (zh) * | 2010-05-07 | 2013-03-13 | 葛兰素史密斯克莱有限责任公司 | 吲哚 |
| WO2012118812A2 (en) * | 2011-02-28 | 2012-09-07 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| WO2012142513A1 (en) * | 2011-04-13 | 2012-10-18 | Epizyme, Inc. | Substituted benzene compounds |
| WO2013049770A2 (en) * | 2011-09-30 | 2013-04-04 | Glaxosmithkline Llc | Methods of treating cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2015000270A (es) | 2016-02-15 |
| JP2016517878A (ja) | 2016-06-20 |
| EA030196B1 (ru) | 2018-07-31 |
| EP2991980A1 (en) | 2016-03-09 |
| CA2910873A1 (en) | 2014-11-06 |
| SG11201508203TA (en) | 2015-11-27 |
| CN105308038A (zh) | 2016-02-03 |
| BR112015027527A2 (pt) | 2017-07-25 |
| AU2014261075B2 (en) | 2017-01-19 |
| JP6373973B2 (ja) | 2018-08-15 |
| EP2991980B1 (en) | 2019-01-02 |
| PH12015502414A1 (en) | 2016-02-22 |
| ES2717680T3 (es) | 2019-06-24 |
| NZ630205A (en) | 2017-03-31 |
| US9790212B2 (en) | 2017-10-17 |
| EA201592068A1 (ru) | 2016-05-31 |
| US20160102083A1 (en) | 2016-04-14 |
| WO2014177982A1 (en) | 2014-11-06 |
| CL2015003200A1 (es) | 2016-04-22 |
| US9505745B2 (en) | 2016-11-29 |
| US20170029412A1 (en) | 2017-02-02 |
| ZA201507398B (en) | 2017-01-25 |
| PE20151981A1 (es) | 2016-01-14 |
| HK1214815A1 (zh) | 2016-08-05 |
| KR20160003115A (ko) | 2016-01-08 |
| AU2014261075A1 (en) | 2015-11-05 |
| MX2015015144A (es) | 2016-02-18 |
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