CN105307675A - 使用抗il23抗体治疗克罗恩氏病的方法 - Google Patents

使用抗il23抗体治疗克罗恩氏病的方法 Download PDF

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Publication number
CN105307675A
CN105307675A CN201480015713.3A CN201480015713A CN105307675A CN 105307675 A CN105307675 A CN 105307675A CN 201480015713 A CN201480015713 A CN 201480015713A CN 105307675 A CN105307675 A CN 105307675A
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CN
China
Prior art keywords
antibody
day
disease
antibodies
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480015713.3A
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English (en)
Chinese (zh)
Inventor
W.潘
W.楚吉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
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Amgen Inc
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Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CN105307675A publication Critical patent/CN105307675A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
CN201480015713.3A 2013-03-15 2014-02-25 使用抗il23抗体治疗克罗恩氏病的方法 Pending CN105307675A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361789976P 2013-03-15 2013-03-15
US61/789976 2013-03-15
PCT/US2014/018308 WO2014143540A1 (en) 2013-03-15 2014-02-25 Methods for treating crohn's disease using an anti-il23 antibody

Publications (1)

Publication Number Publication Date
CN105307675A true CN105307675A (zh) 2016-02-03

Family

ID=50236361

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480015713.3A Pending CN105307675A (zh) 2013-03-15 2014-02-25 使用抗il23抗体治疗克罗恩氏病的方法

Country Status (17)

Country Link
US (5) US20160031983A1 (xx)
EP (2) EP2968486A1 (xx)
JP (4) JP2016516686A (xx)
KR (1) KR20150128859A (xx)
CN (1) CN105307675A (xx)
AP (1) AP2015008801A0 (xx)
AU (1) AU2014228553B2 (xx)
CA (1) CA2906384A1 (xx)
CL (1) CL2015002724A1 (xx)
EA (1) EA201591579A1 (xx)
HK (1) HK1220605A1 (xx)
IL (2) IL241343A0 (xx)
NZ (1) NZ712294A (xx)
PH (1) PH12015502133A1 (xx)
SG (2) SG11201507483PA (xx)
TN (1) TN2015000402A1 (xx)
WO (1) WO2014143540A1 (xx)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109071653A (zh) * 2016-03-29 2018-12-21 詹森生物科技公司 用增加的抗-il12和/或-23抗体给药间隔治疗牛皮癣
CN111956606A (zh) * 2020-08-31 2020-11-20 江苏荃信生物医药有限公司 包含高浓度抗人白介素23单克隆抗体的低粘度液体制剂
CN114641493A (zh) * 2019-08-21 2022-06-17 阿斯特捷利康合作创业有限责任公司 使用布雷库单抗治疗克罗恩病

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JO3244B1 (ar) 2009-10-26 2018-03-08 Amgen Inc بروتينات ربط مستضادات il – 23 البشرية
JP6126532B2 (ja) 2010-11-04 2017-05-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗ｉｌ−２３抗体
CN109206516A (zh) 2012-05-03 2019-01-15 勃林格殷格翰国际有限公司 抗IL-23p19抗体
US10507241B2 (en) 2014-07-24 2019-12-17 Boehringer Ingelheim International Gmbh Biomarkers useful in the treatment of IL-23A related diseases
TWI711629B (zh) 2014-09-03 2020-12-01 德商包林格因蓋爾漢國際股份有限公司 靶向IL-23A與TNF-α之化合物及其用途
AR102417A1 (es) 2014-11-05 2017-03-01 Lilly Co Eli Anticuerpos biespecíficos anti-tnf- / anti-il-23
JP2018507868A (ja) * 2015-02-26 2018-03-22 ジェネンテック， インコーポレイテッド インテグリンベータ７アンタゴニスト及びクローン病の治療方法
TWI733695B (zh) * 2015-09-18 2021-07-21 德商百靈佳殷格翰國際股份有限公司 治療發炎性疾病之方法
EP3677597A1 (en) * 2016-10-14 2020-07-08 Boehringer Ingelheim International GmbH Methods of treating diseases
EP3820897A2 (en) * 2018-07-13 2021-05-19 Astrazeneca Collaboration Ventures, LLC Treating ulcerative colitis with brazikumab
MX2021012848A (es) 2019-04-22 2021-12-10 Lilly Co Eli Mirikizumab para su uso en un metodo de tratamiento de la enfermedad de crohn.

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WO2011056600A1 (en) * 2009-10-26 2011-05-12 Amgen Inc. Human il-23 antigen binding proteins

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CA2613818C (en) 2005-06-30 2013-08-27 Centocor, Inc. Anti-il-23 antibodies, compositions, methods and uses
PL1937721T3 (pl) 2005-08-25 2010-12-31 Lilly Co Eli Przeciwciała anty-IL23
US20070050011A1 (en) 2005-08-26 2007-03-01 Medlogics Device Corporation Lumen-supporting stents and methods for creating lumen-supporting stents with various open/closed designs
SG165322A1 (en) 2005-08-31 2010-10-28 Schering Corp Engineered anti-il-23 antibodies
US7686047B2 (en) * 2005-11-04 2010-03-30 Roger Cleveland Golf Co., Inc. Golf club cover
EA035459B1 (ru) 2005-12-29 2020-06-19 Сентокор, Инк. Антитело против il-23p19
WO2007147019A2 (en) 2006-06-13 2007-12-21 Zymogenetics, Inc. Il-17 and il-23 antagonists and methods of using the same
PL2426144T3 (pl) 2007-02-23 2019-05-31 Merck Sharp & Dohme Przeciwciała Anty-IL-23p19 wytworzone metodą inżynierii genetycznej
EP2426145B1 (en) 2007-02-23 2017-01-18 Merck Sharp & Dohme Corp. Engineered anti-il-23p19 antibodies
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EP2331078B1 (en) 2008-08-27 2012-09-19 Merck Sharp & Dohme Corp. Lyophilized formulations of engineered anti-il-23p19 antibodies
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JP6126532B2 (ja) 2010-11-04 2017-05-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗ｉｌ−２３抗体
CA2821926A1 (en) * 2011-01-07 2012-07-12 Abbvie Inc. Anti-il-12/il-23 antibodies and uses thereof

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WO2011056600A1 (en) * 2009-10-26 2011-05-12 Amgen Inc. Human il-23 antigen binding proteins

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MARKUS F NEURATH ET AL: "IL-23:a master regulator in Crohn disease", 《NATURE MEDICINE》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109071653A (zh) * 2016-03-29 2018-12-21 詹森生物科技公司 用增加的抗-il12和/或-23抗体给药间隔治疗牛皮癣
CN114641493A (zh) * 2019-08-21 2022-06-17 阿斯特捷利康合作创业有限责任公司 使用布雷库单抗治疗克罗恩病
CN111956606A (zh) * 2020-08-31 2020-11-20 江苏荃信生物医药有限公司 包含高浓度抗人白介素23单克隆抗体的低粘度液体制剂
CN111956606B (zh) * 2020-08-31 2021-05-14 江苏荃信生物医药有限公司 包含高浓度抗人白介素23单克隆抗体的低粘度液体制剂

Also Published As

Publication number Publication date
US20180327490A1 (en) 2018-11-15
TN2015000402A1 (fr) 2017-01-03
NZ712294A (en) 2020-04-24
US20170218062A1 (en) 2017-08-03
CA2906384A1 (en) 2014-09-18
HK1220605A1 (zh) 2017-05-12
SG10201805015TA (en) 2018-07-30
CL2015002724A1 (es) 2016-03-28
EP2968486A1 (en) 2016-01-20
US20160031983A1 (en) 2016-02-04
AU2014228553A1 (en) 2015-10-08
JP2023012516A (ja) 2023-01-25
EP3693007A1 (en) 2020-08-12
SG11201507483PA (en) 2015-10-29
EA201591579A1 (ru) 2016-01-29
US20200283517A1 (en) 2020-09-10
AP2015008801A0 (en) 2015-10-31
JP2020073470A (ja) 2020-05-14
KR20150128859A (ko) 2015-11-18
AU2014228553B2 (en) 2019-01-24
IL275092A (en) 2020-07-30
JP2016516686A (ja) 2016-06-09
IL241343A0 (en) 2015-11-30
PH12015502133A1 (en) 2016-01-25
WO2014143540A1 (en) 2014-09-18
JP2021107397A (ja) 2021-07-29
US20200017581A1 (en) 2020-01-16

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