CN105250829A - Dispersible tablets with function of promoting digestion to eliminate stagnation and preparation method thereof - Google Patents
Dispersible tablets with function of promoting digestion to eliminate stagnation and preparation method thereof Download PDFInfo
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- CN105250829A CN105250829A CN201510798915.6A CN201510798915A CN105250829A CN 105250829 A CN105250829 A CN 105250829A CN 201510798915 A CN201510798915 A CN 201510798915A CN 105250829 A CN105250829 A CN 105250829A
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Abstract
The invention provides dispersible tablets with the function of promoting digestion to eliminate stagnation and a preparation method thereof. The dispersible tablets are prepared from the following raw materials by weight percent: 10-50% of traditional Chinese medicine extract, 10-80% of filling agent, 5-50% of internally added disintegrating agent, 5-15% of externally added disintegrating agent, 0.1-10% of flavoring agent, 0.1-20% of wetting agent and 0.05-20% of lubricating agent, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 100-300 parts of parched hawthorn fruit, 100-200 parts of fried medicated leaven, 100-150 parts of processed pinellia tuber, 50-150 parts of Indian buead, 50-150 parts of dried tangerine peel, 50-120 parts of fried malt and 50-150 parts of fried radish seed. The preparation method comprises the steps of material preparation, extraction, tablet preparation and packaging. The dispersible tablets with the function of promoting digestion to eliminate stagnation have the functions of promoting digestion, eliminating stagnation and harmonizing the stomach and are used for treating infantile dyspepsia symptoms, such as food retention and stagnation, abdominal fullness and distention, putrid belching and acid swallowing and inappetence.
Description
Technical field
the present invention relates to pharmaceutical technology sectors, particularly relate to a kind of dyspepsia and intestinal stasis relieving dispersible tablet and preparation method thereof.
Background technology
infantile dyspepsia common sympton has: upper abdominal pain, abdominal distention, flatulence, early full, belch, Nausea and vomiting, upper abdomen burning sensation etc., these Symptoms last exist or recurrent exerbation, but shortage characteristic, and seldom all occur, many there are one or several. simultaneouslyThese symptoms have impact on infant feed, and cause long-term nutrition Deficiency of Intake, infant malnutrition incidence rate is higher, and growth retardation also may occur.
for infantile dyspepsia, at present, the Western medicine for the treatment of infantile dyspepsia is a lot, and most drug therapeutic effect is poor, and treats into the shortcomings such as high, side effect is large, cure the symptoms, not the disease in addition, even affects patient health time serious.In addition, also have the Chinese medicine of a lot for the treatment of infantile dyspepsia, but most of compatibility is bad, there is the shortcomings such as the low and treatment cycle of therapeutic effect difference, cure rate is long.
Summary of the invention
the object of this invention is to provide a kind of dyspepsia and intestinal stasis relieving dispersible tablet and preparation method thereof, have help digestion, effect of intestinal stasis relieving, stomach function regulating, see food stagnation stagnation, distension and fullness in the abdomen, belching and acid regurgitation, loss of appetite for infantile dyspepsia disease.
object of the present invention is achieved through the following technical solutions:
a kind of dyspepsia and intestinal stasis relieving dispersible tablet, is prepared from by following percentage by weight by raw material,
chinese medicine extract 10-50%
filler 10-80%
inside with disintegrating agent 5-50%
additional disintegrating agent 5-15%
correctives 0.1-10%
wetting agent 0.1-20%
lubricant 0.05-20%;
in described Chinese medicine extract, raw materials by weight portion, Fructus Crataegi (parched to brown) 100-300 part, stir-fry Massa Medicata Fermentata 100-200 part, Rhizoma Pinelliae Preparata 100-150 part, Poria 50-150 part, Pericarpium Citri Reticulatae 50-150 part, Fructus Hordei Germinatus (parched) 50-120 part, Semen Raphani (parched) 50-150 part.
described a kind of dyspepsia and intestinal stasis relieving dispersible tablet, optimum weight percentage ratio pressed by raw material,
chinese medicine extract 40%
filler 30%
inside with disintegrating agent 25%
additional disintegrating agent 12%
correctives 5%
wetting agent 8%
lubricant 8%.
in described Chinese medicine extract, optimum weight number pressed by raw material, Fructus Crataegi (parched to brown) 200 parts, stir-fry Massa Medicata Fermentata 200 parts, Rhizoma Pinelliae Preparata 100 parts, 50 parts, Poria, Pericarpium Citri Reticulatae 100 parts, Fructus Hordei Germinatus (parched) 100 parts, Semen Raphani (parched) 50 parts.
described filler is the mixing of one or more in pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate.
with the mixing of one or more that disintegrating agent or additional disintegrating agent are in low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone in described.
described correctives is the mixing of one or more in aspartame, steviosin, citric acid, orange flavor.
described wetting agent is one or both the mixing in water, alcoholic solution.
described lubricant is the mixing of one or more in magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci.
described a kind of dyspepsia and intestinal stasis relieving dispersible tablet, its preparation method comprises:
step 1, to get the raw materials ready: by weight, choose the Fructus Crataegi (parched to brown) of high-quality, fry Massa Medicata Fermentata, Rhizoma Pinelliae Preparata, Poria, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus (parched), Semen Raphani (parched), clean and remove impurity, for subsequent use;
step 2, extraction: by weight, get above-mentioned seven taste Chinese medicines, decoct with water secondary, 10 times amount soak by water 1.5 hours for the first time, second time 8 times amount soak by water 1.5 hours, merges twice decocting liquid, filtering medicinal residues and impurity, be evaporated to the clear paste that relative density is 1.1-1.3, finally at 80 DEG C of drying under reduced pressure, obtain Chinese medicine extract;
step 3, preparation: Chinese medicine extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology granulate or use oscillating granulator granule, after granulate, add additional disintegrating agent, correctives, mix lubricant are even, with tabletting machine, make tablet;
step 4, packaging: according to tablet format, class wrapping, makes finished product.
in Chinese medicine extract: Fructus Crataegi (parched to brown), promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.Fry Massa Medicata Fermentata, invigorating the spleen and regulating the stomach, help digestion in adjusting.For weakness of the spleen and stomach, retention of food and drink, feeling of stuffiness in chest abdominal distention, food stagnation of child; Rhizoma Pinelliae Preparata, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For vomitting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus; Poria, promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability; Pericarpium Citri Reticulatae, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm; Fructus Hordei Germinatus (parched), promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, galactopoiesis relieving distension.Do not disappear for food stagnation, abdominal distention, insufficiency of the spleen lack of appetite; Semen Raphani (parched), help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm, for retention of food and drink, abdominal distention, constipation, stagnant dysentery.
beneficial effect of the present invention: a kind of dyspepsia and intestinal stasis relieving dispersible tablet of the present invention, have help digestion, effect of intestinal stasis relieving, stomach function regulating, see that food stagnation is stagnated for infantile dyspepsia disease, distension and fullness in the abdomen, belching and acid regurgitation, the patient of loss of appetite; Its dissolubility, favorable dispersibility, dissolution is high, and bioavailability is good, distribution in vivo is rapid, steady quality, and mouthfeel is good, taking convenience, can swallow, chew, containing sucking or taking with after aqueous dispersion, be more suitable for the patient of old people or children's, there is medicine stability good, packaging, transport, the advantages such as storage is convenient, its preparation method is simple, is applicable to commercial production.
the present invention is through two groups of clinical verifications, and wherein one group is treatment group, takes the present invention, taking the present invention every day once, 7 days is a course for the treatment of, and another group matched group takes removing food stagnancy ball, taking every day once, 7 days is a course for the treatment of, every group selection outpatient 100 example, wherein male 50 example, women 50 example, max age 70 years old, minimal ages 25 years old, clinical manifestation is acid regurgitation, flatulence, belch, Nausea and vomiting, and table one is for taking the contrasting data after the course for the treatment of:
table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of
the effective percentage for the treatment of group and matched group has notable difference, is not difficult to find out the significant curative effect in clinical practice of the present invention.
process characteristic of the present invention: 1, select raw material science, production technology is advanced, and its product is conveniently deposited and used; 2, product Chinese medicine composition is easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
Detailed description of the invention
embodiment 1
a kind of dyspepsia and intestinal stasis relieving dispersible tablet, is prepared from by following percentage by weight by raw material,
chinese medicine extract 10-50%
filler 10-80%
inside with disintegrating agent 5-50%
additional disintegrating agent 5-15%
correctives 0.1-10%
wetting agent 0.1-20%
lubricant 0.05-20%;
embodiment 2
in described Chinese medicine extract, raw materials by weight portion, Fructus Crataegi (parched to brown) 100-300 part, stir-fry Massa Medicata Fermentata 100-200 part, Rhizoma Pinelliae Preparata 100-150 part, Poria 50-150 part, Pericarpium Citri Reticulatae 50-150 part, Fructus Hordei Germinatus (parched) 50-120 part, Semen Raphani (parched) 50-150 part.
embodiment 3
described a kind of dyspepsia and intestinal stasis relieving dispersible tablet, optimum weight percentage ratio pressed by raw material,
chinese medicine extract 40%
filler 30%
inside with disintegrating agent 25%
additional disintegrating agent 12%
correctives 5%
wetting agent 8%
lubricant 8%.
embodiment 4
in described Chinese medicine extract, optimum weight number pressed by raw material, Fructus Crataegi (parched to brown) 200 parts, stir-fry Massa Medicata Fermentata 200 parts, Rhizoma Pinelliae Preparata 100 parts, 50 parts, Poria, Pericarpium Citri Reticulatae 100 parts, Fructus Hordei Germinatus (parched) 100 parts, Semen Raphani (parched) 50 parts.
embodiment 5
described filler is the mixing of one or more in pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate.
embodiment 6
with the mixing of one or more that disintegrating agent or additional disintegrating agent are in low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone in described.
embodiment 7
described correctives is the mixing of one or more in aspartame, steviosin, citric acid, orange flavor.
embodiment 8
described wetting agent is one or both the mixing in water, alcoholic solution.
embodiment 9
described lubricant is the mixing of one or more in magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci.
embodiment 10
a kind of dyspepsia and intestinal stasis relieving dispersible tablet, its preparation method comprises:
step 1, to get the raw materials ready: by weight, choose the Fructus Crataegi (parched to brown) of high-quality, fry Massa Medicata Fermentata, Rhizoma Pinelliae Preparata, Poria, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus (parched), Semen Raphani (parched), clean and remove impurity, for subsequent use;
step 2, extraction: by weight, get above-mentioned seven taste Chinese medicines, decoct with water secondary, 10 times amount soak by water 1.5 hours for the first time, second time 8 times amount soak by water 1.5 hours, merges twice decocting liquid, filtering medicinal residues and impurity, be evaporated to the clear paste that relative density is 1.1-1.3, finally at 80 DEG C of drying under reduced pressure, obtain Chinese medicine extract;
step 3, preparation: Chinese medicine extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology granulate or use oscillating granulator granule, after granulate, add additional disintegrating agent, correctives, mix lubricant are even, with tabletting machine, make tablet;
step 4, packaging: according to tablet format, class wrapping, makes finished product.
Claims (9)
1. a dyspepsia and intestinal stasis relieving dispersible tablet, is characterized in that: be prepared from by following percentage by weight by raw material,
Chinese medicine extract 10-50%
Filler 10-80%
Inside with disintegrating agent 5-50%
Additional disintegrating agent 5-15%
Correctives 0.1-10%
Wetting agent 0.1-20%
Lubricant 0.05-20%;
In described Chinese medicine extract, raw materials by weight portion, Fructus Crataegi (parched to brown) 100-300 part, stir-fry Massa Medicata Fermentata 100-200 part, Rhizoma Pinelliae Preparata 100-150 part, Poria 50-150 part, Pericarpium Citri Reticulatae 50-150 part, Fructus Hordei Germinatus (parched) 50-120 part, Semen Raphani (parched) 50-150 part.
2. a kind of dyspepsia and intestinal stasis relieving dispersible tablet according to claim 1, is characterized in that: raw material by optimum weight percentage ratio,
Chinese medicine extract 40%
Filler 30%
Inside with disintegrating agent 25%
Additional disintegrating agent 12%
Correctives 5%
Wetting agent 8%
Lubricant 8%.
3. a kind of dyspepsia and intestinal stasis relieving dispersible tablet according to claim 1-2 any one, it is characterized in that: in described Chinese medicine extract, optimum weight number pressed by raw material, Fructus Crataegi (parched to brown) 200 parts, stir-fry Massa Medicata Fermentata 200 parts, Rhizoma Pinelliae Preparata 100 parts, 50 parts, Poria, Pericarpium Citri Reticulatae 100 parts, Fructus Hordei Germinatus (parched) 100 parts, Semen Raphani (parched) 50 parts.
4. a kind of dyspepsia and intestinal stasis relieving dispersible tablet according to claim 1-2 any one, is characterized in that: described filler is the mixing of one or more in pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate.
5. a kind of dyspepsia and intestinal stasis relieving dispersible tablet according to claim 1-2 any one, is characterized in that: with the mixing of one or more that disintegrating agent or additional disintegrating agent are in low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone in described.
6. a kind of dyspepsia and intestinal stasis relieving dispersible tablet according to claim 1-2 any one, is characterized in that: described correctives is the mixing of one or more in aspartame, steviosin, citric acid, orange flavor.
7. a kind of dyspepsia and intestinal stasis relieving dispersible tablet according to claim 1-2 any one, is characterized in that: described wetting agent is one or both the mixing in water, alcoholic solution.
8. a kind of dyspepsia and intestinal stasis relieving dispersible tablet according to claim 1-2 any one, is characterized in that: described lubricant is the mixing of one or more in magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci.
9. a kind of dyspepsia and intestinal stasis relieving dispersible tablet according to claim 1-8 any one, is characterized in that: its preparation method comprises:
Step 1, to get the raw materials ready: by weight, choose the Fructus Crataegi (parched to brown) of high-quality, fry Massa Medicata Fermentata, Rhizoma Pinelliae Preparata, Poria, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus (parched), Semen Raphani (parched), clean and remove impurity, for subsequent use;
Step 2, extraction: by weight, get above-mentioned seven taste Chinese medicines, decoct with water secondary, 10 times amount soak by water 1.5 hours for the first time, second time 8 times amount soak by water 1.5 hours, merges twice decocting liquid, filtering medicinal residues and impurity, be evaporated to the clear paste that relative density is 1.1-1.3, finally at 80 DEG C of drying under reduced pressure, obtain Chinese medicine extract;
Step 3, preparation: Chinese medicine extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology granulate or use oscillating granulator granule, after granulate, add additional disintegrating agent, correctives, mix lubricant are even, with tabletting machine, make tablet;
Step 4, packaging: according to tablet format, class wrapping, makes finished product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510798915.6A CN105250829A (en) | 2015-11-19 | 2015-11-19 | Dispersible tablets with function of promoting digestion to eliminate stagnation and preparation method thereof |
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| CN201510798915.6A CN105250829A (en) | 2015-11-19 | 2015-11-19 | Dispersible tablets with function of promoting digestion to eliminate stagnation and preparation method thereof |
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Cited By (3)
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| CN105623995A (en) * | 2016-03-06 | 2016-06-01 | 胡伯虎 | Large-fruited Chinese hawthorn appetizer wine or drink and preparation method thereof |
| CN108578628A (en) * | 2018-06-26 | 2018-09-28 | 思南县人民医院 | A kind of Chinese medicine preparation and application and preparation method for children's having indigestion appetizing |
| CN109999149A (en) * | 2019-05-21 | 2019-07-12 | 葵花药业集团北京药物研究院有限公司 | A kind of preparation method of Chinese medicine composition and its preparation with reinforcing spleen to promote digestion effect |
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| CN1785373A (en) * | 2005-07-28 | 2006-06-14 | 江西汇仁药业有限公司 | Baohe fast dispetsion solid preparation and its preparation method |
| CN1733266A (en) * | 2005-07-29 | 2006-02-15 | 王衡新 | Chinese traditional medicine preparation for relieving food retention, resolving stagnation and harmonizing stomach, process for preparing the same and quality controlling method thereof |
| CN102886000A (en) * | 2012-11-05 | 2013-01-23 | 太极集团重庆中药二厂有限公司 | Preparation method of digestant pills |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105623995A (en) * | 2016-03-06 | 2016-06-01 | 胡伯虎 | Large-fruited Chinese hawthorn appetizer wine or drink and preparation method thereof |
| CN105623995B (en) * | 2016-03-06 | 2018-11-09 | 胡伯虎 | Large-fruited Chinese hawthorn aperitif and beverage and preparation method thereof |
| CN108578628A (en) * | 2018-06-26 | 2018-09-28 | 思南县人民医院 | A kind of Chinese medicine preparation and application and preparation method for children's having indigestion appetizing |
| CN109999149A (en) * | 2019-05-21 | 2019-07-12 | 葵花药业集团北京药物研究院有限公司 | A kind of preparation method of Chinese medicine composition and its preparation with reinforcing spleen to promote digestion effect |
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