CN105250189B - A kind of anti-acne maintenance essence cream and preparation method thereof - Google Patents
A kind of anti-acne maintenance essence cream and preparation method thereof Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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Abstract
The invention belongs to cosmetic technical field, being specifically related to a kind of anti-acne maintenance essence cream and preparation method thereof, essence cream includes starch ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract, Cortex Phellodendri extract, retinyl palmitate.The anti-acne composition of the present invention is obtained by screening, and the anti-acne composition that the present invention is new can effectively suppress propionibacterium acnes, is added in essence cream by anti-acne composition, and experimental study shows, has good therapeutical effect for acne.Stability study shows, essence cream of the present invention has more preferable stability.
Description
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of anti-acne maintenance essence cream and preparation method thereof.
Background technology
Acne is that a kind of pilosebaceous chronic inflammatory skin is sick, is mainly in face, chest and back,
Relatively common at adolescence, main morbidity form is comedo, acne.Acne has various skin
Damage form, including acne, pimple, pustule, tuberosity etc., therefore, acne is all department of dermatologry all the time
Commonly encountered diseases and frequently-occurring disease.The cause of disease of acne is complex, and modern medicine thinks that the pathogenesis of acne is main
Infect with hypersteatosis, pilosebaceous duct blocking, antibacterial and the factor such as inflammatory reaction is closely related.
The content of androgen particularly testosterone in descendant's body that adolesces raises rapidly, promotes that sebaceous gland is grown and produces
Raw a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage simultaneously, dyssebacia,
Form horn plug i.e. micropowder thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction, acne in hair follicle
The lipase that propionibacterium produces decomposes sebum and generates free fatty, simultaneously chemotactic inflammatory cell and medium,
Induce eventually and increase the weight of inflammatory reaction.It is long that acne has the course of disease, easily the feature of recurrence, and long-standing problem vast green grass or young crops
Juvenile.
At present, the method for the treatment of acne has a lot, how based on oral drugs, also includes minority external used medicine.
Oral mode mainly utilizes systemic blood circulation to carry out Formulations for systemic administration, to reach to treat effect of acne, typically
The course for the treatment of is longer, poor effect.External mode is many by smearing external used medicine or cosmetics are controlled at disease sites
Treating acne, medicine can be directly acted on human body face by cosmetic applying so that medicine fully connects with face
Touch and quickly penetrate into skin, effectively extending the time of contact of medicine and skin, improving the skin absorption to medicine
Degree, significantly shortens treatment cycle.
But, mostly containing the chemical composition such as hydrargyrum, fruit acid in the cosmetics for the treatment of acne in the market,
Easily causing the untoward reaction such as skin allergy, injured cutaneous tissue structure, therapeutic effect is unsatisfactory, for number
Although few Chinese herbal medicine cosmetic is nontoxic non-stimulated, but often therapeutic effect is single, only have sterilization,
Biocidal efficacies, it is impossible to detumescence and apocenosis and reparation impression in time, therapeutic effect is the best.Therefore, study new
The cosmetics of acne can be treated, significant for patients with acne.
Summary of the invention
For these reasons, applicant, through years of researches, obtains a kind of new essence with anti-acne effect
Hua Shuan (i.e. has the essence cream for the treatment of acne effect), and containing anti-acne composition in this essence cream, anti-acne becomes subpackage
Include: ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract
Thing, Cortex Phellodendri extract, retinyl palmitate.The anti-acne composition of the present invention is obtained by screening,
The anti-acne composition that the present invention is new can effectively suppress propionibacterium acnes, is added by anti-acne composition in essence cream,
Experimental study shows, has good therapeutical effect for acne.Stability study shows, elite of the present invention
Frost has more preferable stability.
The present invention is achieved through the following technical solutions.
A kind of essence cream, described essence cream includes anti-acne composition, and described anti-acne becomes to be grouped into: starch octene
Base succinic acid aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract, Cortex Phellodendri
Bark extract, retinyl palmitate.
Preferably anti-acne becomes to be grouped into: starch ocentyl succinic aluminum 2-3 weight portion, salicylic acid 1-2 weight
Part, PCA zinc 0.4-0.6 weight portion, zinc gluconate 0.1-0.3 weight portion, nicotiamide 0.05-0.15 weight
Part, mandarin orange peel extract 0.001-0.003 weight portion, Cortex Phellodendri extract 0.001-0.003 weight portion,
Retinyl palmitate 0.001 weight portion.
Described essence cream raw material of preparing includes: 1,3 butylene glycol, cetearyl alcohol, polydimethylsiloxane,
Isononyl isononanoate, PEG-45 stearate, sucrose stearate, glyceryl stearate, beta glucan,
Two (lauramide glutamine) L-Lysine sodium salt, sodium hydroxide, arginine, carbomer, Salix alba bark carry
Take thing, hydrolecithin, resveratrol, tremella polysaccharide, glycerol caprylate, Herba Artemisiae Scopariae flower extract, Huang
Virgin rubber, Natrulon H-10 laurate, pentetic acid five sodium, sodium chondroitin sulfate, adenosine triphosphate, hydrolysis are planted
Thing albumen, Citrus junos fruit extract, phytic acid, Flos Caryophylli extract, NAP, 1,2-
Propylene glycol, Cynara scolymus L (Cyhara cardunculus.) leaf extract, silver oxide, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, platinum powder,
Starch ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract
Thing, Cortex Phellodendri extract, retinyl palmitate.
Described essence cream raw material of preparing includes: 1,3 butylene glycol 8-10 weight portion, cetearyl alcohol 5-7 weight portion,
Polydimethylsiloxane 3-5 weight portion, isononyl isononanoate 2-4 weight portion, PEG-45 stearate 1-2
Weight portion, sucrose stearate 1-2 weight portion, glyceryl stearate 0.6-0.8 weight portion, beta glucan
0.4-0.6 weight portion, two (lauramide glutamine) L-Lysine sodium salt 0.4-0.6 weight portion, sodium hydroxide 0.4-0.5
Weight portion, arginine 0.3-0.5 weight portion, carbomer 0.3-0.5 weight portion, white willow peel extract 0.1-0.3
Weight portion, hydrolecithin 0.1-0.3 weight portion, resveratrol 0.05-0.15 weight portion, tremella polysaccharide
0.05-0.15 weight portion, glycerol caprylate 0.07-0.09 weight portion, Herba Artemisiae Scopariae flower extract 0.07-0.08 weight
Part, xanthan gum 0.04-0.06 weight portion, Natrulon H-10 laurate 0.02-0.04 weight portion, pentetic acid five
Sodium 0.01-0.02 weight portion, sodium chondroitin sulfate 0.01-0.02 weight portion, adenosine triphosphate 0.01-0.02 weight
Amount part, hydrolyzed vegetable protein 0.01-0.02 weight portion, Citrus junos fruit extract 0.004-0.006 weight portion, inositol
Six phosphoric acid 0.0015-0.0020 weight portions, Flos Caryophylli extract 0.001 weight portion, NAP
0.0001 weight portion, 1,2-propylene glycol 0.0005 weight portion, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004 weight portion, oxidation
Silver 0.000162 weight portion, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001 weight portion, Anthemis nobilis flower extract 0.0000075
Weight portion, platinum powder 0.00000002 weight portion, starch ocentyl succinic aluminum 2-3 weight portion, salicylic acid 1-2
Weight portion, PCA zinc 0.4-0.6 weight portion, zinc gluconate 0.1-0.3 weight portion, nicotiamide 0.05-0.15
Weight portion, mandarin orange peel extract 0.001-0.003 weight portion, Cortex Phellodendri extract 0.001-0.003 weight
Part, retinyl palmitate 0.001 weight portion.
The preparation method of described essence cream is:
(1) water intaking, 1,3 butylene glycol, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin,
Xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, suction vacuum emulsifying machine
In；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；
Add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinol
Cetylate, beta glucan, Citrus junos fruit extract, water, 1,3 butylene glycol, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolysis are planted
Thing albumen, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, oxygen
Change silver, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, in vain
Extract of willow bark, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, anti-
Bad hematic acid sodium phosphate, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1,3-PD, nicotiamide, continue
Continue and stir, be cooled to room temperature；Fill, to obtain final product.
Described starch ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange
The compositions of peel extract, Cortex Phellodendri extract and retinyl palmitate answering in acne-eliminating cosmetic
With.
Following is purchase producer and the lot number of part material of the present invention:
Detailed description of the invention
Below in conjunction with example, the present invention is elaborated.Following example do not limit the protection to the present invention
Scope.
Following test, is on the basis of repeatedly creative test, for the claimed content of the present invention,
The concluding test carried out.
One, screening test: the inhibitory action to propionibacterium acnes
Test 1 group: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, glucose
Acid zinc 0.2g.
Test 2 groups: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, glucose
Acid zinc 0.2g, nicotiamide 0.01g part, mandarin orange peel extract 0.002g.
Test 3 groups: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, glucose
Acid zinc 0.2g, nicotiamide 0.01g part, mandarin orange peel extract 0.002g, Cortex Phellodendri extract 0.002g,
Retinyl palmitate 0.001g.
Test 4 groups: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, glucose
Acid zinc 0.2g, nicotiamide 0.01g part, mandarin orange peel extract 0.02g, Cortex Phellodendri extract 0.02g, regard
Flavol cetylate 0.01g.
Test 5 groups: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, glucose
Acid zinc 0.2g, nicotiamide 0.01g part, mandarin orange peel extract 0.2g, Cortex Phellodendri extract 0.2g, regard Huang
Alcohol cetylate 0.1g.
Sample preparation: take above-mentioned test group raw material, adds 50mL deionized water, adds 50mL1,3-fourth
Glycol, mix homogeneously, standby.
Test method: collection of specimens: choose patients with acne skin lesion (pustule, typical acne), with iodine tincture, wine
After essence sterilization, with the acne extruder extrusion content of sterilization, move into stuart transporting culture medium immediately.
The cultivation of anaerobe, separate and identify: the specimen being inoculated on transporting culture medium is immediately fed into micro-life
Thing laboratory, is inoculated in THIO culture medium, uses airbag method, is placed in 37 DEG C of cultivation 72h in anaerobic jar, with
Methylene blue makees indicator, and palladium grain is catalyst.According to colonial morphology, microscopy is gram-positive bacteria, how in rod
Shape or tennis-racket-shaped, carry out preliminary identification, the then single bacterium colony of picking, turns 2 pieces of flat boards, and one piece is placed in and detests
In oxygen tank, the lower 37 DEG C of pure cultures of anaerobic condition；Another block is with 37 DEG C of aerobic cultivations；Observed result after 48h,
See occur on the flat board of Anaerobic culturel that form is homogeneous, canescence, the circle that tiny, diameter about 1mm is protruding,
The bacterium colony that edge is the neatest, without bacterial growth under aerobic cultivation；Bacterium colony is made microscopy, visible chromabacterium biolaceum under mirror,
Micro-bend in bar-shaped or shaft-like, can the blunt circle in one end, one end attenuates, and coloring is deep, and cell is single, can be paired
Arrangement or row are the shape such as " people ", " V ".Again through oxytolerant test, catalase test, indole test, department of biochemistry
Row test for identification is propionibacterium acnes.
Secondary culture P.acne is inoculated in LB fluid medium, after 37 DEG C of aerobic cultivation 24h, finds liquid
Muddiness, takes bacterium solution in a ring fluid medium and makees microscopy, and it has been observed that flat board after coating flat board 24h
Colonial morphology, Gram's staining and Microscopic observation characteristic of bacteria, the test of catalase test, indole test, oxytolerant,
Biochemical results is consistent with front.
Anaerobism drug sensitive test: inoculation: 1-2 colony inoculation of picking on LB plating medium, 37 DEG C
Aerobic cultivation 24h, rinses the purebred P.acne physiological saline solution of aerobic cultivation 24h, and flushing liquor is put into
In sterile test tube；Use Maxwell turbidimetry ratio turbid, need to shake 10-12 time before opacity tube, first than turbid extremely
3*108/ mL, then with normal saline dilution to 105-106/ mL is standby.LB plating medium is inoculated: by sterilizing
Swab stick dip bacterium solution, on tube wall squeeze go unnecessary bacterium solution, even spread on LB plating medium, and edge
Plate edge ring sweeps a circle, builds plate, is dried 2-3min.Aseptic steel bowl (a diameter of 6mm) is light
It is put on plating medium, fills it up with ready sample liquid, put into 37 DEG C of aerobic cultivation 24h, find nothing in plate
Bacterial growth, is shown in have inhibition zone to be formed after continuing 37 DEG C of aerobic cultivation 24h.
Survey antibacterial circle diameter, it is determined that result, 4 groups of antibacterial circle diameter values are averaged.Test group antimicrobial drug
Quick grade classification: inhibition zone diameter is Gao Min more than 20mm, quick in 10-20mm, is resistance to less than 10mm
Medicine.
Result of the test: be shown in Table 1.
Table 1 antibacterial Comparative result result
Conclusion (of pressure testing): above-mentioned result of the test shows, tests 1 group, tests 2 groups and do not produce fungistatic effect,
And after adding the mandarin orange peel extract of trace, Cortex Phellodendri extract and retinyl palmitate, in generation
Quick antibacterial (testing 3 groups), and strengthen mandarin orange peel extract, Cortex Phellodendri extract and retinol Palmic acid
Ester fungistatic effect does not produce significance change (quick in being still that), and therefore, our retention test 3 groups is for dispelling
Pox component.
Two, checking test: the experimental study to rabbit ear Acne Model therapeutical effect
Test 1 group: 1,3 butylene glycol 8g, cetearyl alcohol 5g, polydimethylsiloxane 3g, different n-nonanoic acid are different
Nonyl ester 2g, PEG-45 stearate 1g, sucrose stearate 1g, glyceryl stearate 0.6g, β-Portugal gather
Sugar 0.4g, two (lauramide glutamine) L-Lysine sodium salt 0.4g, sodium hydroxide 0.4g, arginine 0.3g,
Carbomer 0.3g, white willow peel extract 0.1g, hydrolecithin 0.1g, resveratrol 0.05g, Tremella are many
Sugar 0.05g, glycerol caprylate 0.07g, Herba Artemisiae Scopariae flower extract 0.07g, xanthan gum 0.04g, Natrulon H-10
Laurate 0.02g, pentetic acid five sodium 0.01g, sodium chondroitin sulfate 0.01g, adenosine triphosphate 0.01g,
Hydrolyzed vegetable protein 0.01g, Citrus junos fruit extract 0.004g, phytic acid 0.0015g, Flos Caryophylli extract
Thing 0.001g, NAP 0.0001g, 1,2-propylene glycol 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract
0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract
0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2g, salicylic acid 1g, PCA zinc
0.4g, zinc gluconate 0.1g, nicotiamide 0.05g, mandarin orange peel extract 0.001g, Cortex Phellodendri extract
Thing 0.001g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 50g, 1,3 butylene glycol 4g, two (lauramide glutamine) L-Lysine sodium salt, hydrogenation
Lecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, and suction is true
In empty mulser；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；
Add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinol
Cetylate, beta glucan, Citrus junos fruit extract, water 9g, 1,3 butylene glycol 4g, Cynara scolymus L (Cyhara cardunculus.) leaf extract,
Hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, inositol six phosphorus
Acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 lauric acid
Ester, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum
Powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1,3-propylene glycol, nicotinoyl
Amine, continues to stir, is cooled to room temperature；Fill, to obtain final product.
Test 2 groups: 1,3 butylene glycol 9g, cetearyl alcohol 6g, polydimethylsiloxane 4g, different n-nonanoic acid are different
Nonyl ester 3g, PEG-45 stearate 1.5g, sucrose stearate 1.5g, glyceryl stearate 0.7g, β-
Glucosan 0.5g, two (lauramide glutamine) L-Lysine sodium salt 0.5g, sodium hydroxide 0.45g, arginine
0.4g, carbomer 0.4g, white willow peel extract 0.2g, hydrolecithin 0.2g, resveratrol 0.1g, silver
Fungus polysaccharides 0.1g, glycerol caprylate 0.08g, Herba Artemisiae Scopariae flower extract 0.075g, xanthan gum 0.05g, poly-sweet
Oil-10 laurate 0.03g, pentetic acid five sodium 0.015g, sodium chondroitin sulfate 0.015g, adenosine triphosphate
0.015g, hydrolyzed vegetable protein 0.015g, Citrus junos fruit extract 0.005g, phytic acid 0.0017g, fourth
Fragrant flower extract 0.001g, NAP 0.0001g, 1,2-propylene glycol 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf carry
Take thing 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract
0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA
Zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.1g, mandarin orange peel extract 0.002g, Cortex Phellodendri carry
Take thing 0.002g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 55g, 1,3 butylene glycol 4.5g, two (lauramide glutamine) L-Lysine sodium salt, hydrogenation
Lecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, and suction is true
In empty mulser；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；
Add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinol
Cetylate, beta glucan, Citrus junos fruit extract, water 11g, 1,3 butylene glycol 4.5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract,
Hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, inositol six phosphorus
Acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 lauric acid
Ester, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum
Powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1,3-propylene glycol, nicotinoyl
Amine, continues to stir, is cooled to room temperature；Fill, to obtain final product.
Test 3 groups: 1,3 butylene glycol 10g, cetearyl alcohol 7g, polydimethylsiloxane 5g, different n-nonanoic acid are different
Nonyl ester 4g, PEG-45 stearate 2g, sucrose stearate 2g, glyceryl stearate 0.8g, β-Portugal gather
Sugar 0.6g, two (lauramide glutamine) L-Lysine sodium salt 0.6g, sodium hydroxide 0.5g, arginine 0.5g,
Carbomer 0.5g, white willow peel extract 0.3g, hydrolecithin 0.3g, resveratrol 0.15g, Tremella are many
Sugar 0.15g, glycerol caprylate 0.09g, Herba Artemisiae Scopariae flower extract 0.08g, xanthan gum 0.06g, Natrulon H-10
Laurate 0.04g, pentetic acid five sodium 0.02g, sodium chondroitin sulfate 0.02g, adenosine triphosphate 0.02g,
Hydrolyzed vegetable protein 0.02g, Citrus junos fruit extract 0.006g, phytic acid 0.0020g, Flos Caryophylli extract
Thing 0.001g, NAP 0.0001g, 1,2-propylene glycol 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract
0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract
0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 3g, salicylic acid 2g, PCA zinc
0.6g, zinc gluconate 0.3g, nicotiamide 0.15g, mandarin orange peel extract 0.003g, Cortex Phellodendri extract
Thing 0.003g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 69g, 1,3 butylene glycol 5g, two (lauramide glutamine) L-Lysine sodium salt, hydrogenation
Lecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, and suction is true
In empty mulser；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；
Add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinol
Cetylate, beta glucan, Citrus junos fruit extract, water 11g, 1,3 butylene glycol 5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract,
Hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, inositol six phosphorus
Acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 lauric acid
Ester, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum
Powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1,3-propylene glycol, nicotinoyl
Amine, continues to stir, is cooled to room temperature；Fill, to obtain final product.
Experimental animal: Adult New Zealand large ear rabbit, weight 2.0～3.0kg.
Test method: 2cm × 2cm scope at year New Zealand's large ear rabbit auris dextra inboard ear tube opening, often
It is coated with coal tar diluent (the 2% concentration liquor carbonis detergens that 95% ethanol is made into) 0.25mL once, and left ear is not
Doing any process as a comparison, after perusal modeling, the situation of rabbit ear skin lesion and follicular orifice are with or without horn plug etc.,
Even it is coated with 14d.Take 2 Adult New Zealand large ear rabbits at random, put to death with air tap inserting method, take off ears conduit
The full thickness skin of opening part, 10% formalin solution is fixed, and embeds with hard wax after dehydration, then cuts into slices also
Dry.Routine pathology observation, checking modeling success is carried out after HE dyeing.
Curative effect naked eyes criterion: normal (0): normal structure, without acne.Slightly (I grade): acne are
Main skin lesion, can have a small amount of pimple and pustule.Total focus number is less than 30.Moderate (II～III grade): wherein
II grade has acne, with pimple and the pustule of moderate.Total focus number is between 31～50；III grade at powder
A large amount of pimple and pustule is accompanied on the basis of thorn, accidental big inflammatory damage, widely distributed, there is minority tuberosity to be formed.
Total focus number is between 51～100.Severe (IV grade) is in addition to above-mentioned skin lesion, also with the knot of more than 3
Joint or cyst.
Take New Zealand's large ear rabbit after modeling success, randomly select and be randomly divided into 4 groups again: blank group,
Test group, often group 6.Respectively after above-mentioned criterion classification, test group gives essence cream twice every day,
1mL, is coated with deionized water, every day 1 time, each 1mL outside blank group every time.Perusal after 14d
The recovery situation of rabbit ear skin lesion.
Result of the test: be shown in Table 2.
Perusal statistics before and after table 2 rabbit ear coating
Conclusion (of pressure testing): above-mentioned test shows, essence cream of the present invention has good therapeutical effect to rabbit ear acne,
Absolutely proving, essence cream of the present invention has good anti-acne effect.
Three, stability test
Test 1 group: 1,3 butylene glycol 9g, cetearyl alcohol 6g, polydimethylsiloxane 4g, different n-nonanoic acid are different
Nonyl ester 3g, PEG-45 stearate 1.5g, sucrose stearate 1.5g, glyceryl stearate 0.7g, β-
Glucosan 0.5g, two (lauramide glutamine) L-Lysine sodium salt 0.5g, sodium hydroxide 0.45g, arginine
0.4g, carbomer 0.4g, white willow peel extract 0.2g, hydrolecithin 0.2g, resveratrol 0.1g, silver
Fungus polysaccharides 0.1g, glycerol caprylate 0.08g, Herba Artemisiae Scopariae flower extract 0.075g, xanthan gum 0.05g, poly-sweet
Oil-10 laurate 0.03g, pentetic acid five sodium 0.015g, sodium chondroitin sulfate 0.015g, adenosine triphosphate
0.015g, hydrolyzed vegetable protein 0.015g, Citrus junos fruit extract 0.005g, phytic acid 0.0017g, fourth
Fragrant flower extract 0.001g, NAP 0.0001g, 1,2-propylene glycol 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf carry
Take thing 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract
0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA
Zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.1g, mandarin orange peel extract 0.002g, Cortex Phellodendri carry
Take thing 0.002g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 55g, 1,3 butylene glycol 4.5g, two (lauramide glutamine) L-Lysine sodium salt, hydrogenation
Lecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, and suction is true
In empty mulser；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；
Add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinol
Cetylate, beta glucan, Citrus junos fruit extract, water 11g, 1,3 butylene glycol 4.5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract,
Hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, inositol six phosphorus
Acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 lauric acid
Ester, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum
Powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis, flower extract, 1,3-propylene glycol, cigarette
Amide, continues to stir, is cooled to room temperature；Fill, to obtain final product.
Test 2 groups: 1,3 butylene glycol 9g, cetearyl alcohol 6g, polydimethylsiloxane 4g, different n-nonanoic acid are different
Nonyl ester 3g, PEG-45 stearate 1.5g, sucrose stearate 1.5g, glyceryl stearate 0.7g, β-
Glucosan 0.5g, two (lauramide glutamine) L-Lysine sodium salt 0.5g, carbomer 0.4g, Salix alba bark
Extract 0.2g, hydrolecithin 0.2g, resveratrol 0.1g, tremella polysaccharide 0.1g, glycerol caprylate 0.08g,
Herba Artemisiae Scopariae flower extract 0.075g, xanthan gum 0.05g, Natrulon H-10 laurate 0.03g, pentetic acid five sodium
0.015g, sodium chondroitin sulfate 0.015g, adenosine triphosphate 0.015g, hydrolyzed vegetable protein 0.015g, fragrant citrus
Berry extract 0.005g, phytic acid 0.0017g, Flos Caryophylli extract 0.001g, ascorbic acid phosphoric acid esters
Sodium 0.0001g, 1,2-propylene glycol 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc.
Berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder 0.00000002g, starch
Ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.1g,
Mandarin orange peel extract 0.002g, Cortex Phellodendri extract 0.002g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 55g, 1,3 butylene glycol 4.5g, two (lauramide glutamine) L-Lysine sodium salt, hydrogenation
Lecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, and suction is true
In empty mulser；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；
Add starch ocentyl succinic aluminum, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan,
Citrus junos fruit extract, water 11g, 1,3 butylene glycol 4.5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, triphosphoric acid
Adenosine, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli carry
Take thing, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract,
Zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP,
Prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1,3-PD, nicotiamide, continue to stir, cooling
To room temperature；Fill, to obtain final product.
Test method: take essence cream, is placed in 40 DEG C and deposits 24h, deposit 24h in room temperature, then at-5 DEG C
Depositing 24h, circulation 3 times, have seen whether whether layering, oil slick, color and luster change successively.
Conclusion (of pressure testing): be shown in Table 4.
Table 4 stability test result
| Group | Whether it is layered | Whether oil slick | Whether color and luster changes |
| Test 1 group | No | No | No |
| Test 2 groups | No | Have | Have |
Conclusion (of pressure testing): after being added without sodium hydroxide and arginine in essence cream, essence cream is through cold cycling
After, produce oil slick phenomenon and color and luster changes, and test 1 group and do not produce such phenomenon, fully
Illustrate that essence cream prescription stability of the present invention is preferable.
Preparation embodiment
Embodiment 1
Essence cream prescription is: 1,3 butylene glycol 8g, cetearyl alcohol 5g, polydimethylsiloxane 3g, different nonyl
Acid different nonyl ester 2g, PEG-45 stearate 1g, sucrose stearate 1g, glyceryl stearate 0.6g, β-
Glucosan 0.4g, two (lauramide glutamine) L-Lysine sodium salt 0.4g, sodium hydroxide 0.4g, arginine 0.3g,
Carbomer 0.3g, white willow peel extract 0.1g, hydrolecithin 0.1g, resveratrol 0.05g, tremella polysaccharide
0.05g, glycerol caprylate 0.07g, Herba Artemisiae Scopariae flower extract 0.07g, xanthan gum 0.04g, Natrulon H-10 Laurel
Acid esters 0.02g, pentetic acid five sodium 0.01g, sodium chondroitin sulfate 0.01g, adenosine triphosphate 0.01g, hydrolysis are planted
Thing albumen 0.01g, Citrus junos fruit extract 0.004g, phytic acid 0.0015g, Flos Caryophylli extract 0.001g,
NAP 0.0001g, 1,2-propylene glycol 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide
0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder
0.00000002g, starch ocentyl succinic aluminum 2g, salicylic acid 1g, PCA zinc 0.4g, zinc gluconate 0.1g,
Nicotiamide 0.05g, mandarin orange peel extract 0.001g, Cortex Phellodendri extract 0.001g, retinyl palmitate
0.001g。
The preparation method of essence cream is:
(1) water intaking 50g, 1,3 butylene glycol 4g, two (lauramide glutamine) L-Lysine sodium salt, hydrogenation
Lecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, and suction is true
In empty mulser；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；
Add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinol
Cetylate, beta glucan, Citrus junos fruit extract, water 9g, 1,3 butylene glycol 4g, Cynara scolymus L (Cyhara cardunculus.) leaf extract,
Hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, inositol six phosphorus
Acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 lauric acid
Ester, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum
Powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1,3-propylene glycol, nicotinoyl
Amine, continues to stir, is cooled to room temperature；Fill, to obtain final product.
Embodiment 2
Essence cream prescription is: 1,3 butylene glycol 9g, cetearyl alcohol 6g, polydimethylsiloxane 4g, different nonyl
Acid different nonyl ester 3g, PEG-45 stearate 1.5g, sucrose stearate 1.5g, glyceryl stearate 0.7g,
Beta glucan 0.5g, two (lauramide glutamine) L-Lysine sodium salt 0.5g, sodium hydroxide 0.45g, essence ammonia
Acid 0.4g, carbomer 0.4g, white willow peel extract 0.2g, hydrolecithin 0.2g, resveratrol 0.1g,
Tremella polysaccharide 0.1g, glycerol caprylate 0.08g, Herba Artemisiae Scopariae flower extract 0.075g, xanthan gum 0.05g, poly-
Glycerol-10 laurate 0.03g, pentetic acid five sodium 0.015g, sodium chondroitin sulfate 0.015g, Adenosine triphosphate
Glycosides 0.015g, hydrolyzed vegetable protein 0.015g, Citrus junos fruit extract 0.005g, phytic acid 0.0017g,
Flos Caryophylli extract 0.001g, NAP 0.0001g, 1,2-propylene glycol 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf
Extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extracts
Thing 0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA
Zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.1g, mandarin orange peel extract 0.002g, Cortex Phellodendri carry
Take thing 0.002g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 55g, 1,3 butylene glycol 4.5g, two (lauramide glutamine) L-Lysine sodium salt, hydrogenation
Lecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, and suction is true
In empty mulser；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；
Add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinol
Cetylate, beta glucan, Citrus junos fruit extract, water 11g, 1,3 butylene glycol 4.5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract,
Hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, inositol six phosphorus
Acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 lauric acid
Ester, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum
Powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1,3-propylene glycol, nicotinoyl
Amine, continues to stir, is cooled to room temperature；Fill, to obtain final product.
Embodiment 3
Essence cream prescription is: 1,3 butylene glycol 10g, cetearyl alcohol 7g, polydimethylsiloxane 5g, different nonyl
Acid different nonyl ester 4g, PEG-45 stearate 2g, sucrose stearate 2g, glyceryl stearate 0.8g, β
-glucosan 0.6g, two (lauramide glutamine) L-Lysine sodium salt 0.6g, sodium hydroxide 0.5g, arginine
0.5g, carbomer 0.5g, white willow peel extract 0.3g, hydrolecithin 0.3g, resveratrol 0.15g,
Tremella polysaccharide 0.15g, glycerol caprylate 0.09g, Herba Artemisiae Scopariae flower extract 0.08g, xanthan gum 0.06g, poly-
Glycerol-10 laurate 0.04g, pentetic acid five sodium 0.02g, sodium chondroitin sulfate 0.02g, adenosine triphosphate
0.02g, hydrolyzed vegetable protein 0.02g, Citrus junos fruit extract 0.006g, phytic acid 0.0020g, Flos Caryophylli
Flower extract 0.001g, NAP 0.0001g, 1,2-propylene glycol 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract
Thing 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract
0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 3g, salicylic acid 2g, PCA zinc
0.6g, zinc gluconate 0.3g, nicotiamide 0.15g, mandarin orange peel extract 0.003g, Cortex Phellodendri extract
Thing 0.003g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 69g, 1,3 butylene glycol 5g, two (lauramide glutamine) L-Lysine sodium salt, hydrogenation
Lecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, and suction is true
In empty mulser；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；Add
Sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinol Petiolus Trachycarpi
Acid esters, beta glucan, Citrus junos fruit extract, water 11g, 1,3 butylene glycol 5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolysis
Vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid,
Silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate,
White willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder,
NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis, flower extract, 1,3-PD, nicotiamide,
Continue to stir, be cooled to room temperature；Fill, to obtain final product.
Preparation embodiment includes but not limited to above-mentioned.
Claims (2)
1. an essence cream, it is characterised in that prepare essence cream raw material and include: 1,3 butylene glycol 8-10 weight portion,
Cetearyl alcohol 5-7 weight portion, polydimethylsiloxane 3-5 weight portion, isononyl isononanoate 2-4 weight portion,
PEG-45 stearate 1-2 weight portion, sucrose stearate 1-2 weight portion, glyceryl stearate 0.6-0.8
Weight portion, beta glucan 0.4-0.6 weight portion, two (lauramide glutamine) L-Lysine sodium salt 0.4-0.6
Weight portion, sodium hydroxide 0.4-0.5 weight portion, arginine 0.3-0.5 weight portion, carbomer 0.3-0.5 weight
Part, white willow peel extract 0.1-0.3 weight portion, hydrolecithin 0.1-0.3 weight portion, resveratrol
0.05-0.15 weight portion, tremella polysaccharide 0.05-0.15 weight portion, glycerol caprylate 0.07-0.09 weight portion, mattress
Herba Artemisiae Scopariae flower extract 0.07-0.08 weight portion, xanthan gum 0.04-0.06 weight portion, Natrulon H-10 laurate
0.02-0.04 weight portion, pentetic acid five sodium 0.01-0.02 weight portion, sodium chondroitin sulfate 0.01-0.02 weight portion,
Adenosine triphosphate 0.01-0.02 weight portion, hydrolyzed vegetable protein 0.01-0.02 weight portion, Citrus junos fruit extract
0.004-0.006 weight portion, phytic acid 0.0015-0.0020 weight portion, Flos Caryophylli extract 0.001 weight
Amount part, NAP 0.0001 weight portion, 1,2-propylene glycol 0.0005 weight portion, Cynara scolymus L (Cyhara cardunculus.) leaf carry
Take thing 0.0004 weight portion, silver oxide 0.000162 weight portion, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001 weight portion, white
Flower Chamomile flower extract 0.0000075 weight portion, platinum powder 0.00000002 weight portion, starch octenyl amber
Amber acid aluminum 2-3 weight portion, salicylic acid 1-2 weight portion, zinc pyrrolidone carboxylate salt 0.4-0.6 weight portion, Portugal
Grape saccharic acid zinc 0.1-0.3 weight portion, nicotiamide 0.05-0.15 weight portion, mandarin orange peel extract 0.001-0.003
Weight portion, Cortex Phellodendri extract 0.001-0.003 weight portion, retinyl palmitate 0.001 weight portion.
A kind of essence cream, it is characterised in that the preparation method of essence cream is:
(1) water intaking, 1,3 butylene glycol, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin,
Xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, suction vacuum emulsifying machine
In；
(2) cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 are taken hard
Fat acid ester, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, and stirring is all
Even, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C；
Add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinol
Cetylate, beta glucan, Citrus junos fruit extract, water, 1,3 butylene glycol, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolysis are planted
Thing albumen, adenosine triphosphate, sodium chondroitin sulfate, zinc pyrrolidone carboxylate salt, pentetic acid five sodium, inositol
Six phosphoric acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, the Natrulon H-10 moon
Cinnamic acid ester, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, mandarin orange peel extract, platinum
Powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1,3-propylene glycol, nicotinoyl
Amine, continues to stir, is cooled to room temperature；Fill, to obtain final product.
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| CN113842344A (en) * | 2021-10-14 | 2021-12-28 | 安徽中美生谷生物科技有限公司 | Skin care product composition with acne removing effect and preparation method thereof |
| WO2023131855A1 (en) * | 2022-01-05 | 2023-07-13 | SCG Chemicals Public Company Limited | Antimicrobial composition |
| CN115607465A (en) * | 2022-11-01 | 2023-01-17 | 周嘉奇 | Oil-control moisturizing toner and preparation method thereof |
| CN115844781A (en) * | 2022-12-13 | 2023-03-28 | 上海臻臣化妆品有限公司 | Acne removing composition, acne removing liquid, acne removing emulsion, preparation method of acne removing emulsion and cosmetics |
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| CN100366266C (en) * | 2006-03-21 | 2008-02-06 | 孟祥伟 | Medicine for treating Acne and its preparing method |
| KR20100095447A (en) * | 2007-12-27 | 2010-08-30 | 카오카부시키가이샤 | External skin preparation for pimpled skin |
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Address after: Panyu District Hualong Town Guangzhou city Guangdong province 511434 Liu Wai Street No. 13 (No. 1 building) Patentee after: Hua An Tang biotech Group Co., Ltd. Address before: Panyu District Hualong Town Guangzhou city Guangdong province 511434 Liu Wai Street No. 13 (No. 1 building) Patentee before: City flower An Tang bio tech ltd, Guangzhou |