CN106620089A - Traditional Chinese medicine composition for preventing and treating baldness and scalp itching - Google Patents
Traditional Chinese medicine composition for preventing and treating baldness and scalp itching Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention relates to a traditional Chinese medicine composition for preventing and treating baldness and scalp itching. The traditional Chinese medicine composition is prepared from an effective component and medically acceptable auxiliary materials, and is characterized in that the effective component is prepared from 20 to 80 weight percent of a sophora flavescens water extract extracted from sophora flavescens and 20 to 80 weight percent of a rhizoma acori graminei volatile oil extracted from rhizoma acori graminei. The traditional Chinese medicine composition has little drug flavor, achieves a special medicinal effect with simple medicines, is outstanding in treating effect, and does not have the side effect of reducing dermis thickness and the number of hair follicle.
Description
Invention field
The present invention relates to medicinal preparation, and in particular to containing the pharmaceutical preparation for not determining structure from plant, the medicine
Thing preparation is applied to preventing and treating alopecia and itching of the scalp.
Technical background
The cause of disease of alopecia is complicated, with sex pheromone infection, endocrine disturbance, the nutrition such as heredity, immunity, bacterium and fungi
The factors such as bad, vascular dysfunction, stress are relevant.Itching of the scalp is the common complication of alopecia.This disease has a strong impact on
The quality of life of patient, and the course of disease is touching, recurrent exerbation.The not yet specific medicine appearance of disease that effects a permanent cure clinically is prevented at present, it is existing
For this disease of therapeutic treatment, its curative effect is dissatisfied, and side effect is larger.Therefore a kind of good effect, pair are sought in terms of traditional Chinese medicine
The little medical treatment alopecia of effect and itching of the scalp are significant.
The prescription of traditional Chinese medicine prevention alopecia and itching of the scalp is numerous, wherein representational have：Qu Shi is with sensible stopping of dehumidifying
De- method, application is by the hair growths such as rhizoma atractylodis, the bark of official magnolia, dried orange peel, kuh-seng, rhizoma alismatis, oriental wormwood and raw hawthorn disease, and curative effect is preferable.Young should
With hair growth capsules (red sage root, the dried rhizome of rehmannia, Eclipta prostrata, the vine of multiflower knotweed, radix bupleuri, the root of Dahurain angelica, grass-leaved sweetflag, Tabasheer, rascal, the coptis, rhizoma Gastrodiae, Cape jasmine
Sub- benevolence, the root of herbaceous peony, tribulus terrestris, roud cardamon seed, sealwort, Poria cocos, licorice), hair growth disease 96, total effective rate is 95.8%.But
It is that existing prescription effective prescription is big, and flavour of a drug are on the high side, it is difficult to be prepared into into clinical patent medicine.
The patent application of Publication No. CN103041071A is disclosed a kind of treats alopecia areata, alopecia, skin exfoliation itching
Traditional Chinese medicine liniment, the medicine by：The Chinese medicines such as big cape jasmine, frutus cnidii, grass-leaved sweetflag, Chen Ai, Chinese prickly ash, kuh-seng, alcohol are made.The patent application
The flavour of a drug of described medicine are still on the high side, and alcohol has obvious irritation side effect to skin in side, can dissolve skin thin
The EPL of after birth, destroys the integrality of cell, and Long-Time Service can cause to damage to skin and hair follicle cell, cause alopecia；
Also allergic reaction, such as atrophoderma, crinosity, skin capillary vascular expansion side effect simultaneously.
The content of the invention
Problem to be solved by this invention is to provide a kind of preventing and treating alopecia, the Chinese medicine composition of itching of the scalp, the medicine group
Not only flavour of a drug are few, steady quality, determined curative effect for conjunction, and the side effect without reduction dermis thickness and hair follicle number.
Technical proposal that the invention solves the above-mentioned problems is as described below：
A kind of preventing and treating alopecia, the Chinese medicine composition of itching of the scalp, the pharmaceutical composition can connect by active ingredient and medically
The auxiliary material composition received, it is characterised in that the kuh-seng that described active ingredient is extracted by percentage by weight for the kuh-seng of 20%-80%
The Essential Oil of Acorus tatarinowii composition that the grass-leaved sweetflag of water extract and 20%-80% is extracted.
Aforementioned pharmaceutical compositions can be external preparation, such as：Cream, paint, liniment, shampoo or spray.
Above-mentioned external preparation is obtained by following methods：
(1) take kuh-seng extracting in water 2-3 time, 8-10 times of first time measures water, second 6-8 times measure water, 6 times of amounts of third time
Water, each 1-3h, merging filtrate stands overnight, and takes supernatant liquid filtering and is concentrated into medicinal extract, dry, pulverize and obtains final product kuh-seng water extraction
Take thing；
(2) grass-leaved sweetflag is taken, Essential Oil of Acorus tatarinowii is extracted using steam distillation or carbon dioxide supercritical extraction method；
(3) kuh-seng water extract is well mixed with Essential Oil of Acorus tatarinowii, adds the auxiliary material needed for various formulations by normal
Rule method makes described cream, paint, liniment, shampoo or spray.
Chinese medicine composition of the present invention has advantages below compared with prior art：
Chinese medicine composition of the present invention is only made up of kuh-seng and grass-leaved sweetflag, and flavour of a drug are few, and medicine letter power is specially, evident in efficacy,
Have no side effect, and be conducive to quality control.
The present invention is more fully understood for the ease of the public, is come with zoopery below by the clinic for investigating medicine of the present invention
Further illustrate beneficial effects of the present invention.
First, clinical observation
Case is originated：67 alopecia patients (wherein having 45 merging itching of the scalps) all are from Traditional Chinese Medicine University Of Guangzhou
The outpatient service of the first affiliated hospital and inpatient.Age does not limit, and after patient's signature Informed Consent Form, is tested.
Diagnostic criteria：All cases all in accordance with《Traditional Chinese medical science skin cypridology》Diagnostic criteria, be diagnosed as alopecia.
Inclusive criteria：Meet diagnostic criteria；Test must disable the medicine person relevant with the state of an illness is improved for first 2 weeks；Do not have in the recent period
There are the other diseases related to alopecia；
Exclusion standard：The person that do not meet inclusive criteria；The course of disease more than more than 10 years, the atrophied patient of hair follicle；Have serious complete
Body disease, chronic wasting disease person；
Treatment method：Treatment group 1-3 is respectively adopted the preparation of following embodiments two, three, five and is treated, daily external application 2
It is secondary, each 5-10ml.4 weeks is a course for the treatment of, altogether using 2 courses for the treatment of.
Criterion of therapeutical effect：According to《New Chinese medicine guideline of clinical investigations》The hair growth criterion of therapeutical effect of formulation, recovery from illness：Hair
Send out stopping to come off, new sending out all grows, and its distribution density, thickness, color and luster are identical with Jian Fa areas, sebum secretion recovers normal；It is aobvious
Effect：Hair stops coming off, and new to send out regeneration up to more than 70%, the close Jian Fa areas of its density, thickness and color and luster, sebum secretion is obvious
Reduce；Effectively：Hair stops coming off, new to send out regeneration up to more than 30%, including fine hair on birds or animals hair and white hair grow；It is invalid：Hair regeneration is not
Foot continues to de- originator.The criterion of therapeutical effect for the treatment of pruitus, recovery from illness：Without itch；It is effective：Itch is substantially reduced, and is taken a turn for the better
More than 50%；Effectively：Itch is reduced, improvement less than 50%；It is invalid：Itch is not reduced.
Efficacy result is shown in Table 1 after each treatment group's treatment.
Curative effect after the treatment of each treatment group of table 1
Statistical result showed, each treatment group's curative effect is made with the patent application methods described of Publication No. CN103041071A
Liniment compare, alopecia and itching of the scalp are without significant difference, P>0.05.
2nd, animal experiment
Test medicine：
Blank group：Physiological saline.
Experimental group 1：The drug regimen of following embodiments one.
Experimental group 2：The drug regimen of following embodiments three.
Experimental group 3：The drug regimen of following embodiments five.
Control group 1：The kuh-seng water extract of embodiment 1.
Control group 2：The Essential Oil of Acorus tatarinowii of embodiment 1.
Control group 3：The liniment as made by the methods described of embodiment 2 in the patent application of Publication No. CN103041071A.
Control group 4：Remove the alcohol in raw material described in embodiment 2 in the patent application of Publication No. CN103041071A,
Liniment is made by its same method.
Dosage：
Blank group gives the dosage of physiological saline, experimental group 1-3 and control group 1-4 and is 5g/kg, 2 times/day.
Medication is topical administration.
(1) effect experimental of anti-inflammatory
1st, mice ear experiment
SPF level KM mouse, 18-22g, male and female half and half.Experimental group 1-3, control group 1-3 and blank group are randomly divided into, totally 7
Group, 10 per group.Scorching front mouse back is caused to lose hair or feathers (about 3.0cm × 3.0cm), back coating 5g/kg, 2 times/day (about 2.5cm ×
2.5cm) topical administration 7d, after last dose 0.5h, per mouse, left ear two sides applies 100% dimethylbenzene 0.02ml cause inflammation, and auris dextra is opposed
According to.Cause to put to death animal after inflammation 2h, along auricle baseline two ears are cut, lay the same position disk of ears with diameter 9mm card punch, electricity
Sub- assay balance is weighed, and calculates swelling：Swelling=left auricle weight-auris dextra piece weight；Swelling inhibiting rate %=(blank group swelling
Degree-administration group swelling)/blank group swelling × 100%.
Swelling and swelling inhibiting rate the results are shown in Table 2 after each group treatment.
The impact of ear swelling degree caused by each group paraxylene of table 2
Statistical result showed, compares with blank group, * P<0.05；Compare with control group 1, #P<0.05；Compare with control group 2
Compared with ， ＆P<0.05；Compare with control group 3, P>0.05.
2nd, mouse capillary permeability test
SPF level KM mouse, male and female half and half, body weight 18-22g.Random packet：It is randomly divided into experimental group 1-3, control group 1-
3 and blank group, totally 7 groups, 10 per group.Mouse back loses hair or feathers (about 3.0cm × 3.0cm), back coating 5g/kg, and 2 times/day (about
2.5cm × 2.5cm) administration 7d, after last medicine after 0.5h, her Wen is blue for mouse tail vein injection 0.5% (physiological saline is matched somebody with somebody)
0.1ml/10g body weight.Then, at once the glacial acetic acid solution 0.2ml/ of lumbar injection 0.6% is only.Sacrificed by decapitation animal after 20min, cuts
Skin of abdomen muscle is opened, with 6ml physiological saline fraction time washing abdominal cavity, suction pipe suctions out cleaning solution, merges cleaning solution and adds physiology
Salt solution to 10ml is centrifuged 3000 revs/min, and 30min, supernatant surveys OD values in 590nm.
Mouse capillary permeability the results are shown in Table 3 after each group treatment.
The each group of table 3 affects on the experiment of mouse capillary permeability
Statistical result showed, compares with blank group, * P<0.05；Compare with control group 1, #P<0.05；Compare with control group 2
Compared with ， ＆P<0.05；Compare with control group 3 ,@P<0.05.
(2) antibacterial experimental result
Extracorporeal bacteria inhibitor test:
Under aseptic technique, the ring of each bacterial strain one is taken respectively with different vaccination ring, be seeded in blood respectively with method of scoring and put down
In plate, chocolate flat board and sabouraud culture medium, bacterium is put in 37 DEG C of constant incubators and cultivates 24 hours, is taken out after 24 hours and is put into
Save backup in 4 DEG C of refrigerators；Fungi is incubated 2 weeks on sabouraud culture medium inclined-plane, with the appropriate bacterium colony (about 1 × 1mm) of inoculation hook picking
In being put into sterilization mortar.When using, each bacterial classification prepares bacteria suspension with normal saline dilution respectively, is adjusted with Hematometer tally method
The ultimate density of each bacteria suspension is 5 × 105CFU/ml。
Using Tubes serial dilution method, 7, the test tube (medicine of the 1st cuvette cartridge centrifugation equipped with 1ml nutrient broths is taken respectively
Thing supernatant 1ml), it is arranged on rack for test tube, number, meat soup 1ml is added in the 1st test tube, shake up, draw 1ml and add the 2nd pipe
In, shake up, the 7th test tube is diluted to method, 1ml is discarded, make the 1st to the 7th test tube pastille supernatant concentration be respectively 25%,
12.5%th, 6.25%, 3.125%, 1.56%, 0.78%, 0.39%.Another standby 1 test tube is as blank tube.
The each corresponding bacteria suspensions of 1ml are inoculated with each test tube with pipettor, be respectively staphylococcus aureus, Pseudomonas aeruginosa,
Escherichia coli, micrococcus scarlatinae, corynebacteria, gypsum shape sporidiole bacteria, epidermis floccus mentagrophyte, trichophyton tonsurans, are arranged in addition
Negative control (nutrient broth pipe) and positive control (bacterial classification control tube), staphylococcus aureus, 37 DEG C of incubation 4h of Escherichia coli
Observation result, Pseudomonas aeruginosa, 37 DEG C of incubation 18h observation results of micrococcus scarlatinae and corynebacteria, gypsum shape sporidiole bacteria, table
Skin floccus mentagrophyte, trichophyton tonsurans incubation 12d, daily observation 1 time.7d observations result, has no the test tube of bacterial growth after inoculation
Interior minimum drug concentration is MIC.
Each group antibacterial experiment in vitro the results are shown in Table 4.
The each group antibacterial experiment in vitro result of table 4
(3) the lipometabolic experimental result of skin
SPF level KM mouse, male and female half and half, body weight 18-22g.The propionic acid testis of hypodermic injection 0.01mg/10gd dosage after neck
Ball ketone, one time a day, continuously injects 30d.Random packet：Experimental group 1-3, control group 1-3 and blank group are randomly divided into, totally 7
Group, 10 per group.Mouse back loses hair or feathers (about 3.0cm × 3.0cm), back coating 5g/kg, 2 times/day (about 2.5cm × 2.5cm)
Administration 7d.
Sebum excretion rate：Determine glass dish alcohol degreaser drying and weigh (W1), mouse web portion observation area skin wine
Essence sterilization simultaneously stops administration, and fixed mouse is put to death after 2h on plank, and with petroleum ether mouse web portion observation area skin zone is fully eluted
Grease, collects washing lotion in glass dish, weighs again after volatilizing again (W2).And calculated value.Sebum excretion rate=(W2-W1)/
Area/time.
The each group of table 6 affects on the experiment of mouse sebum excretion rate
Statistical result showed, there was no significant difference between each group, P>0.05.
(4) to the impact of dextran induced mice skin skin itch model
SPF level KM mouse, male and female half and half, body weight 18-22g.Random packet：It is randomly divided into experimental group 1-3, control group 1-
3 and blank group, totally 7 groups, 10 per group.Mouse back loses hair or feathers (about 3.0cm × 3.0cm), back coating 5g/kg, and 2 times/day (about
2.5cm × 2.5cm) administration 7d.After last dose 30min, each group mouse tail vein injection dextran (mw=40000)
1.25mg/kg (0.025%, 0.05ml/10g) causes paroxysmal pruitus animal model.With mouse fore paw grappling fixture portion, rear solid end
Trunk is scratched, mouth stings each position of whole body as itch indication.The number of times of the mouse itch paroxysmal outbreak in record 30min and outbreak
Duration.
The each group of table 7 affects on the experiment of mouse skin skin itch
Statistical result showed, compares with blank group, * P<0.05；Compare with control group 1, #P<0.05；Compare with control group 2
Compared with ， ＆P<0.05；Compare with control group 3 ,@P<0.05.
(5) to the impact of mice skin tissue
SPF level KM mouse, male and female half and half, body weight 18-22g.Random packet：It is randomly divided into experimental group 1-3, control group 3-
4 and blank group, totally 6 groups, 10 per group.Mouse back loses hair or feathers (about 3.0cm × 3.0cm), back coating 5g/kg, and 2 times/day (about
2.5cm × 2.5cm) administration 30d.Neck is taken off after last dose 30min and puts to death mouse, cut about 1.0x1.0cm hair removal section skin groups
Knit block, 10% formalin fix.Routine paraffin wax embedded section, the eosin stains of haematoxylin one, per continuous 2, light of section
Sem observation.Observation index is as follows：(l) dermis thickness.(basilar memebrane is to skin to measure per dermis thickness cut into slices with micro- mircrometer gauge
The distance of undertissue), per is surveyed at three, and it is this dermis of skin thickness to take its average.Obtain each group mouse dermis thickness equal
Value.(2) hair follicle is counted.Per the hair follicle number of 3 high power fields (x400) of number of cases, it is the hair follicle number to take its average, obtains each group
The average of mouse hair follicles number.
Experiment of each group of table 8 on mice skin tissue affects
Statistical result showed, compares with blank group, * P<0.05；Compare with control group 3 ,@P<0.05.
Statistical procedures
Total data carries out statistical analysis, measurement data mean ± standard deviation (x using the statistics softwares of SPSS 19.0
± s) represent.
Above-mentioned experiment shows that Chinese traditional medicine composition of the present invention has the degree for suppressing mice ear；Mouse blood capillary can be reduced
Pipe permeability；Can be to the bacteriums such as staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, micrococcus scarlatinae, corynebacteria and stone
The fungies such as paste sporidiole bacteria, epidermis floccus mentagrophyte, trichophyton tonsurans have inhibitory action；Mouse sebum excretion rate can be reduced；Can subtract
The number of times of when young mouse itch paroxysmal outbreak.Show Chinese traditional medicine composition of the present invention have anti-inflammatory, it is antibacterial, improve sebum excretion rate, only
The effect itched.In addition, Chinese traditional medicine composition of the present invention is compared with blank group, dermis thickness and hair follicle number do not have significant difference, with public affairs
The number of opening is compared for the liniment of the patent application embodiment 2 of CN103041071A, and dermis thickness and hair follicle number have significant difference,
Show the patent application embodiment 2 of Publication No. CN103041071A liniment reduce dermis thickness and hair follicle number side effect it is bright
It is aobvious.
Specific embodiment
Hereinafter the total amount of five embodiment preparation Chinese traditional medicine compositions is 200g.
Embodiment one (cream)
1st, prescription：100 grams of kuh-seng, 100 grams of grass-leaved sweetflag.
2nd, preparation method：Kuh-seng extracting in water 2 times is taken, for the first time 8 times of amount water, second 6 times of amount water, each 2h merges
Filtrate, stands overnight, and takes supernatant liquid filtering and is concentrated into medicinal extract, dry, pulverize and obtains final product kuh-seng water extract；Grass-leaved sweetflag is taken with often
The extraction by steam distillation volatile oil of rule；Kuh-seng water extract is well mixed with Essential Oil of Acorus tatarinowii, stearic acid is added
60g, triethanolamine 7.5ml, glycerin monostearate 20g, glycerine 50g, castor oil 110g, ethyl-para-hydroxybenzoate 0.5g and
Distilled water, is uniformly mixed, and cream is obtained.
Embodiment two (spray)
1st, prescription：40 grams of kuh-seng, 160 grams of grass-leaved sweetflag.
2nd, preparation method：Kuh-seng extracting in water 3 times is taken, for the first time 8 times of amount water, second 8 times of amount water, 6 times of amounts of third time
Water, each 2h, merging filtrate stands overnight, and takes supernatant liquid filtering and is concentrated into medicinal extract, dry, pulverize and obtains final product the extraction of kuh-seng water
Thing；Take the conventional co_2 supercritical fluid extraction method of grass-leaved sweetflag and extract volatile oil；By kuh-seng water extract and grass-leaved sweetflag
Volatile oil is well mixed, and heating for dissolving adds sodium chloride 7g, sodium hydrogensulfite 0.2g, glucose in propane diols 100ml, after cooling
2g, benzalkonium chloride 2.5g, after being well mixed, are settled to 1000ml, after sterilization with the tartaric acid of ph5.5 and its cushioning liquid of salt
Per bottle of dicholorodifluoromethane about 6g is pressed into pressure filling, spray is obtained.
Embodiment three (shampoo)
1st, prescription：80 grams of kuh-seng, 120 grams of grass-leaved sweetflag.
2nd, preparation method：Kuh-seng extracting in water 2 times is taken, for the first time 8 times of amount water, second 8 times of amount water, each 3h merges
Filtrate, stands overnight, and takes supernatant liquid filtering and is concentrated into medicinal extract, dry, pulverize and obtains final product kuh-seng water extract；Grass-leaved sweetflag is taken with often
The extraction by steam distillation volatile oil of rule；Kuh-seng water extract is well mixed with Essential Oil of Acorus tatarinowii, addition boric acid 10g,
Cobastab15, AESA 80g, LSA 60g, CAB-35 65g, 6501 35g, laurate sodium glutamate 30g, EDTA-2NA
1g, amino acid foaming agent 50g, glycerine 30g, propane diols 10g, sodium citrate 6g, Sodium Benzoate 2g, nipalgin ester 1.2g and steaming
Distilled water is settled to 1000ml, stirs, and shampoo is obtained.
Example IV (paint)
1st, prescription：120 grams of kuh-seng, 80 grams of grass-leaved sweetflag.
2nd, preparation method：Kuh-seng extracting in water 3 times is taken, for the first time 8 times of amount water, second 6 times of amount water, 6 times of amounts of third time
Water, each 2h, merging filtrate stands overnight, and takes supernatant liquid filtering and is concentrated into medicinal extract, dry, pulverize and obtains final product the extraction of kuh-seng water
Thing；Take the conventional extraction by steam distillation volatile oil of grass-leaved sweetflag；Kuh-seng water extract is mixed with Essential Oil of Acorus tatarinowii
It is even, add distilled water to be settled to 1000ml, it is uniformly mixed, paint is obtained.
Embodiment five (liniment)
1st, prescription：160 grams of kuh-seng, 40 grams of grass-leaved sweetflag.
2nd, preparation method：Kuh-seng extracting in water 2 times is taken, for the first time 10 times of amount water, second 6 times of amount water, each 3h merges
Filtrate, stands overnight, and takes supernatant liquid filtering and is concentrated into medicinal extract, dry, pulverize and obtains final product kuh-seng water extract；Grass-leaved sweetflag is taken with often
The co_2 supercritical fluid extraction method of rule extracts volatile oil；Kuh-seng water extract is well mixed with Essential Oil of Acorus tatarinowii,
Add dimethyl sulfoxide (DMSO) 100ml, propane diols 100ml and distilled water to be settled to 1000ml, stir, liniment is obtained.
Claims (3)
1. a kind of preventing and treating alopecia, the Chinese medicine composition of itching of the scalp, the pharmaceutical composition is by active ingredient and medically acceptable
Auxiliary material composition, it is characterised in that described active ingredient by percentage by weight for 20%-80% kuh-seng extract kuh-seng water
The Essential Oil of Acorus tatarinowii composition that the grass-leaved sweetflag of extract and 20%-80% is extracted.
2. it is according to claim 1 it is a kind of preventing and treating alopecia, the Chinese medicine composition of itching of the scalp, it is characterised in that it is described
Pharmaceutical composition is cream, paint, liniment, shampoo or spray.
3. it is according to claim 2 it is a kind of preventing and treating alopecia, the Chinese medicine composition of itching of the scalp, it is characterised in that it is described
Pharmaceutical composition is obtained by following methods：
(1) take kuh-seng extracting in water 2-3 time, 8-10 times of first time measures water, second 6-8 times measure water, 6 times of amount water of third time, often
Secondary 1-3h, merging filtrate stands overnight, and takes supernatant liquid filtering and is concentrated into medicinal extract, dry, pulverize and obtains final product kuh-seng water extract；
(2) grass-leaved sweetflag is taken, Essential Oil of Acorus tatarinowii is extracted using steam distillation or carbon dioxide supercritical extraction method；
(3) kuh-seng water extract is well mixed with Essential Oil of Acorus tatarinowii, the auxiliary material added needed for various formulations is routinely square
Method makes described cream, paint, liniment, shampoo or spray.
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| CN201710022660.3A CN106620089A (en) | 2017-01-12 | 2017-01-12 | Traditional Chinese medicine composition for preventing and treating baldness and scalp itching |
| CN201710504122.8A CN107308288B (en) | 2017-01-12 | 2017-06-28 | A Chinese medicinal shampoo for preventing and treating alopecia and scalp pruritus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107308288A (en) * | 2017-01-12 | 2017-11-03 | 高康日化集团有限公司 | A kind of preventing and treating alopecia, the Chinese medicine shampoo of itching of the scalp |
| CN107569665A (en) * | 2017-09-13 | 2018-01-12 | 高康日化集团有限公司 | A kind of shampoo for preventing and treating alopecia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112089773A (en) * | 2020-10-14 | 2020-12-18 | 常州市荟民生物科技有限公司 | Spray for stopping alopecia and promoting hair growth |
| CN112691151A (en) * | 2021-01-27 | 2021-04-23 | 前海国深生物工程(深圳)有限公司 | Anti-hair loss and hair growth promoting traditional Chinese medicine composition |
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| KR20070032459A (en) * | 2005-09-16 | 2007-03-22 | 정용문 | The Composition of Cosmetics making use of Chinese Medicinal HerbsLicorice, Poria cocas wolf, Acorus gramineus, Sophora flavescens and Self Heating System |
| CN103041071A (en) * | 2011-10-13 | 2013-04-17 | 杨柳 | Chinese medicinal liniment for treating alopecia areata, alopecia and skin exfoliation itching |
| CN106620089A (en) * | 2017-01-12 | 2017-05-10 | 高康日化集团有限公司 | Traditional Chinese medicine composition for preventing and treating baldness and scalp itching |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308288A (en) * | 2017-01-12 | 2017-11-03 | 高康日化集团有限公司 | A kind of preventing and treating alopecia, the Chinese medicine shampoo of itching of the scalp |
| CN107308288B (en) * | 2017-01-12 | 2020-05-08 | 高康日化集团有限公司 | A Chinese medicinal shampoo for preventing and treating alopecia and scalp pruritus |
| CN107569665A (en) * | 2017-09-13 | 2018-01-12 | 高康日化集团有限公司 | A kind of shampoo for preventing and treating alopecia |
| CN107569665B (en) * | 2017-09-13 | 2020-12-22 | 高康日化集团有限公司 | Shampoo for preventing and treating alopecia |
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| CN107308288A (en) | 2017-11-03 |
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Application publication date: 20170510 |