CN105250189A - Acne treatment essence cream and preparing method thereof - Google Patents
Acne treatment essence cream and preparing method thereof Download PDFInfo
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- CN105250189A CN105250189A CN201510828759.3A CN201510828759A CN105250189A CN 105250189 A CN105250189 A CN 105250189A CN 201510828759 A CN201510828759 A CN 201510828759A CN 105250189 A CN105250189 A CN 105250189A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to acne treatment essence cream and a preparing method thereof. The essence cream contains aluminum starch octenylsuccinate, salicylic acid, PCA zinc, zinc gluconate, nicotinamide, tangerine orange pericarp extract, amur corktree bark extract and retinyl palmitate. The acne treatment constituents in the essence cream are obtained through screening. The new acne treatment constituents in the essence cream can effectively restrain propionibacterium acnes. Experimental studies prove that a good acne treatment effect can be realized by adding the acne treatment constituents to the essence cream. Stability studies show that the essence cream has higher stability.
Description
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of anti-acne maintenance essence cream and preparation method thereof.
Background technology
Acne is that a kind of pilosebaceous chronic inflammatory skin is sick, and be mainly in face, chest and back, more common at adolescence, main morbidity form is comedo, acne.Acne has various skin damage form, and comprise acne, pimple, pustule, tuberosity etc., therefore, acne is all commonly encountered diseases and the frequently-occurring disease of department of dermatologry all the time.The cause of disease of acne is comparatively complicated, and the factors such as modern medicine thinks that the pathogenesis of acne is main and hypersteatosis, pilosebaceous duct block, bacteriological infection and inflammatory reaction are closely related.After adolescing, in human body, the content of androgen particularly testosterone raises rapidly, promotes that sebaceous gland is grown and produces a large amount of sebum.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia simultaneously, forms horn plug and micropowder thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase decomposition sebum that propionibacterium acnes produces generates free fatty, chemotactic inflammatory cell and medium simultaneously, final induction also exacerbate inflammation reaction.It is long that acne has the course of disease, and the feature of easily recurrence, long-standing problem vast teenager.
At present, the method for Acne treatment has a lot, is main, also comprises minority external used medicine mainly with oral drugs.Oral mode mainly utilizes systemic blood circulation to carry out Formulations for systemic administration, to reach effect of Acne treatment, the general course for the treatment of longer, poor effect.External mode is many by smearing external used medicine at disease sites or cosmetics carry out Acne treatment, medicine can be directly acted on human body face by cosmetic applying, make medicine fully and facial contact and infiltrate skin fast, the time of contact of effective prolong drug and skin, improve skin to the degree of absorption of medicine, significantly shorten treatment cycle.
But, mostly containing the chemical composition such as hydrargyrum, fruit acid in the cosmetics of Acne treatment in the market, easily cause the untoward reaction such as skin allergy, injured cutaneous tissue structure, therapeutic effect is unsatisfactory, although Chinese herbal medicine cosmetic few in number is nontoxic non-stimulated, but often therapeutic effect is single, only there is sterilization, biocidal efficacies, cannot in time detumescence and apocenosis and repair impression, therapeutic effect is not good.Therefore, study new can the cosmetics of Acne treatment, significant for patients with acne.
Summary of the invention
For these reasons, applicant is through years of researches, obtain a kind of essence cream (namely there is the essence cream of Acne treatment effect) with anti-acne effect newly, containing anti-acne composition in this essence cream, anti-acne composition comprises: ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract, Cortex Phellodendri extract, retinyl palmitate.Anti-acne composition of the present invention is obtained by screening, and the new anti-acne composition of the present invention effectively can suppress propionibacterium acnes, and add in essence cream by anti-acne composition, experimental study shows, has good therapeutical effect for acne.Stability study shows, essence cream of the present invention has better stability.
The present invention is achieved through the following technical solutions.
A kind of essence cream, described essence cream comprises anti-acne composition, and described anti-acne composition consists of: starch ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract, Cortex Phellodendri extract, retinyl palmitate.
Preferred anti-acne composition consists of: starch ocentyl succinic aluminum 2-3 weight portion, salicylic acid 1-2 weight portion, PCA zinc 0.4-0.6 weight portion, zinc gluconate 0.1-0.3 weight portion, nicotiamide 0.05-0.15 weight portion, mandarin orange peel extract 0.001-0.003 weight portion, Cortex Phellodendri extract 0.001-0.003 weight portion, retinyl palmitate 0.001 weight portion.
Described essence cream raw material of preparing comprises: 1, 3-butanediol, cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, PEG-45 stearate, sucrose stearate, glyceryl stearate, beta glucan, two (lauramide glutamine) L-Lysine sodium salt, sodium hydroxide, arginine, carbomer, white willow peel extract, hydrolecithin, resveratrol, tremella polysaccharide, glycerol caprylate, Herba Artemisiae Scopariae flower extract, xanthan gum, Natrulon H-10 laurate, pentetic acid five sodium, sodium chondroitin sulfate, adenosine triphosphate, hydrolyzed vegetable protein, Citrus junos fruit extract, phytic acid, Flos Caryophylli extract, NAP, 1, 2-propylene glycol, Cynara scolymus L (Cyhara cardunculus.) leaf extract, silver oxide, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, platinum powder, starch ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract, Cortex Phellodendri extract, retinyl palmitate.
Described essence cream raw material of preparing comprises: 1,3 butylene glycol 8-10 weight portion, cetearyl alcohol 5-7 weight portion, polydimethylsiloxane 3-5 weight portion, isononyl isononanoate 2-4 weight portion, PEG-45 stearate 1-2 weight portion, sucrose stearate 1-2 weight portion, glyceryl stearate 0.6-0.8 weight portion, beta glucan 0.4-0.6 weight portion, two (lauramide glutamine) L-Lysine sodium salt 0.4-0.6 weight portion, sodium hydroxide 0.4-0.5 weight portion, arginine 0.3-0.5 weight portion, carbomer 0.3-0.5 weight portion, white willow peel extract 0.1-0.3 weight portion, hydrolecithin 0.1-0.3 weight portion, resveratrol 0.05-0.15 weight portion, tremella polysaccharide 0.05-0.15 weight portion, glycerol caprylate 0.07-0.09 weight portion, Herba Artemisiae Scopariae flower extract 0.07-0.08 weight portion, xanthan gum 0.04-0.06 weight portion, Natrulon H-10 laurate 0.02-0.04 weight portion, pentetic acid five sodium 0.01-0.02 weight portion, sodium chondroitin sulfate 0.01-0.02 weight portion, adenosine triphosphate 0.01-0.02 weight portion, hydrolyzed vegetable protein 0.01-0.02 weight portion, Citrus junos fruit extract 0.004-0.006 weight portion, phytic acid 0.0015-0.0020 weight portion, Flos Caryophylli extract 0.001 weight portion, NAP 0.0001 weight portion, 1,2-PD 0.0005 weight portion, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004 weight portion, silver oxide 0.000162 weight portion, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001 weight portion, Anthemis nobilis flower extract 0.0000075 weight portion, platinum powder 0.00000002 weight portion, starch ocentyl succinic aluminum 2-3 weight portion, salicylic acid 1-2 weight portion, PCA zinc 0.4-0.6 weight portion, zinc gluconate 0.1-0.3 weight portion, nicotiamide 0.05-0.15 weight portion, mandarin orange peel extract 0.001-0.003 weight portion, Cortex Phellodendri extract 0.001-0.003 weight portion, retinyl palmitate 0.001 weight portion.
The preparation method of described essence cream is:
(1) water intaking, 1,3 butylene glycol, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water, 1, 3-butanediol, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
The application of compositions in acne-eliminating cosmetic of described starch ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract, Cortex Phellodendri extract and retinyl palmitate.
Following is purchase producer and the lot number of part material of the present invention:
Detailed description of the invention
Below in conjunction with example, the present invention is elaborated.Following examples do not limit protection scope of the present invention.
Following test, be on the basis of repeatedly creative test, for the claimed content of the present invention, the concluding of carrying out is tested.
One, screening test: to the inhibitory action of propionibacterium acnes
Test 1 group: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g.
Test 2 groups: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.01g part, mandarin orange peel extract 0.002g.
Test 3 groups: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.01g part, mandarin orange peel extract 0.002g, Cortex Phellodendri extract 0.002g, retinyl palmitate 0.001g.
Test 4 groups: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.01g part, mandarin orange peel extract 0.02g, Cortex Phellodendri extract 0.02g, retinyl palmitate 0.01g.
Test 5 groups: starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.01g part, mandarin orange peel extract 0.2g, Cortex Phellodendri extract 0.2g, retinyl palmitate 0.1g.
Sample preparation: get above-mentioned test group raw material, add 50mL deionized water, then add 50mL1,3-butanediol, mix homogeneously, for subsequent use.
Test method: collection of specimens: choose patients with acne skin lesion (pustule, typical acne), after iodine tincture, alcohol disinfecting, extrudes content with the acne extruder of sterilization, moves into stuart transporting culture medium immediately.
The cultivation of anaerobe, Isolation and Identification: the specimen be inoculated on transporting culture medium is sent into Microbiological Lab immediately, be inoculated in THIO culture medium, uses airbag method, and be placed in 37 DEG C of cultivation 72h in anaerobic jar, make indicator with methylene blue, palladium grain is catalyst.According to colonial morphology, microscopy is gram-positive bacteria, and be bar-shaped or tennis-racket-shaped more, carries out preliminary identification, then the single bacterium colony of picking, and turn 2 pieces of flat boards, one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition; Another block is with 37 DEG C of aerobic cultivations; Observed result after 48h, the flat board seeing Anaerobic culturel occurs form is homogeneous, bacterium colony that canescence, the circle that tiny, diameter is about 1mm projection, edge are slightly neat, without bacterial growth under aerobic cultivation; Bacterium colony is made microscopy, visible chromabacterium biolaceum under mirror, micro-curved in bar-shaped or shaft-like, can the blunt circle in one end, one end attenuates, and painted dark, cell is single, can arrange in pairs or arrange as the shape such as " people ", " V ".Again through oxytolerant test, catalase test, indole test, biochemical serial test for identification be propionibacterium acnes.
Secondary culture P.acne is inoculated in LB fluid medium, opaque is found after 37 DEG C of aerobic cultivation 24h, get bacterium liquid in a ring fluid medium and make microscopy, and observe discovery after coating dull and stereotyped 24h, flat-plate bacterial colony form, Gram's staining and Microscopic observation characteristic of bacteria, catalase test, indole test, oxytolerant are tested, biochemical results is consistent with front.
Anaerobism drug sensitive test: inoculation: a picking 1-2 colony inoculation on LB plating medium, 37 DEG C of aerobic cultivation 24h, by aerobic cultivation 24h purebred P.acne physiological saline solution rinse, flushing liquor puts into sterile test tube; Adopt Maxwell turbidimetry than turbid, opacity tube with front needing jolting 10-12 time, first than turbid to 3*10
8/ mL, then with normal saline dilution to 10
5-10
6/ mL is for subsequent use.LB plating medium is inoculated: the swab stick of sterilizing is dipped bacterium liquid, squeezes and removes unnecessary bacterium liquid, even spread on LB plating medium, and sweep a circle along plate edge ring, build plate, dry 2-3min on tube wall.Aseptic steel bowl (diameter is 6mm) is put down gently on plating medium, fills it up with ready sample liquid, put into 37 DEG C of aerobic cultivation 24h, find that plate is interior without bacterial growth, after continuing 37 DEG C of aerobic cultivation 24h, see have inhibition zone to be formed.
Survey antibacterial circle diameter, 4 groups of antibacterial circle diameter values are averaged by result of determination.Test group antibacterial susceptibility grade classification: it is quick in Gao Min, 10-20mm that inhibition zone diameter is greater than 20mm, being less than 10mm is drug resistance.
Result of the test: in table 1.
The antibacterial Comparative result result of table 1
Conclusion (of pressure testing): above-mentioned result of the test shows, test 1 group, test 2 groups and do not produce fungistatic effect, and after adding micro-mandarin orange peel extract, Cortex Phellodendri extract and retinyl palmitate, in generation quick antibacterial (testing 3 groups), and strengthen mandarin orange peel extract, Cortex Phellodendri extract and retinyl palmitate fungistatic effect do not produce significance change (quick in being still), therefore, our retention test 3 groups is anti-acne component.
Two, demonstration test: to the experimental study of rabbit ear Acne Model therapeutical effect
Test 1 group: 1,3 butylene glycol 8g, cetearyl alcohol 5g, polydimethylsiloxane 3g, isononyl isononanoate 2g, PEG-45 stearate 1g, sucrose stearate 1g, glyceryl stearate 0.6g, beta glucan 0.4g, two (lauramide glutamine) L-Lysine sodium salt 0.4g, sodium hydroxide 0.4g, arginine 0.3g, carbomer 0.3g, white willow peel extract 0.1g, hydrolecithin 0.1g, resveratrol 0.05g, tremella polysaccharide 0.05g, glycerol caprylate 0.07g, Herba Artemisiae Scopariae flower extract 0.07g, xanthan gum 0.04g, Natrulon H-10 laurate 0.02g, pentetic acid five sodium 0.01g, sodium chondroitin sulfate 0.01g, adenosine triphosphate 0.01g, hydrolyzed vegetable protein 0.01g, Citrus junos fruit extract 0.004g, phytic acid 0.0015g, Flos Caryophylli extract 0.001g, NAP 0.0001g, 1,2-PD 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2g, salicylic acid 1g, PCA zinc 0.4g, zinc gluconate 0.1g, nicotiamide 0.05g, mandarin orange peel extract 0.001g, Cortex Phellodendri extract 0.001g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 50g, 1,3 butylene glycol 4g, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water 9g, 1, 3-butanediol 4g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
Test 2 groups: 1,3 butylene glycol 9g, cetearyl alcohol 6g, polydimethylsiloxane 4g, isononyl isononanoate 3g, PEG-45 stearate 1.5g, sucrose stearate 1.5g, glyceryl stearate 0.7g, beta glucan 0.5g, two (lauramide glutamine) L-Lysine sodium salt 0.5g, sodium hydroxide 0.45g, arginine 0.4g, carbomer 0.4g, white willow peel extract 0.2g, hydrolecithin 0.2g, resveratrol 0.1g, tremella polysaccharide 0.1g, glycerol caprylate 0.08g, Herba Artemisiae Scopariae flower extract 0.075g, xanthan gum 0.05g, Natrulon H-10 laurate 0.03g, pentetic acid five sodium 0.015g, sodium chondroitin sulfate 0.015g, adenosine triphosphate 0.015g, hydrolyzed vegetable protein 0.015g, Citrus junos fruit extract 0.005g, phytic acid 0.0017g, Flos Caryophylli extract 0.001g, NAP 0.0001g, 1,2-PD 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.1g, mandarin orange peel extract 0.002g, Cortex Phellodendri extract 0.002g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 55g, 1,3 butylene glycol 4.5g, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water 11g, 1, 3-butanediol 4.5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
Test 3 groups: 1,3 butylene glycol 10g, cetearyl alcohol 7g, polydimethylsiloxane 5g, isononyl isononanoate 4g, PEG-45 stearate 2g, sucrose stearate 2g, glyceryl stearate 0.8g, beta glucan 0.6g, two (lauramide glutamine) L-Lysine sodium salt 0.6g, sodium hydroxide 0.5g, arginine 0.5g, carbomer 0.5g, white willow peel extract 0.3g, hydrolecithin 0.3g, resveratrol 0.15g, tremella polysaccharide 0.15g, glycerol caprylate 0.09g, Herba Artemisiae Scopariae flower extract 0.08g, xanthan gum 0.06g, Natrulon H-10 laurate 0.04g, pentetic acid five sodium 0.02g, sodium chondroitin sulfate 0.02g, adenosine triphosphate 0.02g, hydrolyzed vegetable protein 0.02g, Citrus junos fruit extract 0.006g, phytic acid 0.0020g, Flos Caryophylli extract 0.001g, NAP 0.0001g, 1,2-PD 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 3g, salicylic acid 2g, PCA zinc 0.6g, zinc gluconate 0.3g, nicotiamide 0.15g, mandarin orange peel extract 0.003g, Cortex Phellodendri extract 0.003g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 69g, 1,3 butylene glycol 5g, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water 11g, 1, 3-butanediol 5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
Experimental animal: Adult New Zealand large ear rabbit, weight 2.0 ~ 3.0kg.
Test method: year New Zealand's large ear rabbit auris dextra inboard ear tube opening place 2cm × 2cm scope, 0.25mL to be once coated with coal tar diluent (the 2% concentration liquor carbonis detergens that 95% ethanol is made into) every day, left ear is left intact as a comparison, after perusal modeling, the situation of rabbit ear skin lesion and follicular orifice are with or without horn plug etc., connect and are coated with 14d.Get 2 Adult New Zealand large ear rabbits at random, put to death with air tap inserting method, take off the full thickness skin at ears catheter opening place, 10% formalin solution is fixed, and embeds, then cut into slices and dry after dehydration with hard wax.Routine pathology observation is carried out, checking modeling success after HE dyeing.
Curative effect naked eyes criterion: normal (0): normal structure, without acne.Slightly (I grade): acne are main skin lesion, can have a small amount of pimple and pustule.Total focus number is less than 30.Moderate (II ~ III grade): wherein II grade has acne, with pimple and the pustule of moderate.Total focus number is between 31 ~ 50; A large amount of pimple and pustule is accompanied for III grade, accidental large inflammatory damage on acne basis, widely distributed, there is minority tuberosity to be formed.Total focus number is between 51 ~ 100.Severe (IV grade) except above-mentioned skin lesion, also with tuberosity or the cyst of more than 3.
Get modeling success rear New Zealand large ear rabbit, random selecting is divided into 4 groups more at random: blank group, test group, often organizes 6.Respectively after above-mentioned criterion classification, test group gives essence cream twice every day, each 1mL, and blank group is coated with deionized water outward, every day 1 time, each 1mL.The recovery situation of perusal rabbit ear skin lesion after 14d.
Result of the test: in table 2.
Perusal statistics before and after table 2 rabbit ear coating
Conclusion (of pressure testing): above-mentioned test shows, essence cream of the present invention has good therapeutical effect to rabbit ear acne, absolutely proves, essence cream of the present invention has good anti-acne effect.
Three, stability test
Test 1 group: 1,3 butylene glycol 9g, cetearyl alcohol 6g, polydimethylsiloxane 4g, isononyl isononanoate 3g, PEG-45 stearate 1.5g, sucrose stearate 1.5g, glyceryl stearate 0.7g, beta glucan 0.5g, two (lauramide glutamine) L-Lysine sodium salt 0.5g, sodium hydroxide 0.45g, arginine 0.4g, carbomer 0.4g, white willow peel extract 0.2g, hydrolecithin 0.2g, resveratrol 0.1g, tremella polysaccharide 0.1g, glycerol caprylate 0.08g, Herba Artemisiae Scopariae flower extract 0.075g, xanthan gum 0.05g, Natrulon H-10 laurate 0.03g, pentetic acid five sodium 0.015g, sodium chondroitin sulfate 0.015g, adenosine triphosphate 0.015g, hydrolyzed vegetable protein 0.015g, Citrus junos fruit extract 0.005g, phytic acid 0.0017g, Flos Caryophylli extract 0.001g, NAP 0.0001g, 1,2-PD 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.1g, mandarin orange peel extract 0.002g, Cortex Phellodendri extract 0.002g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 55g, 1,3 butylene glycol 4.5g, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water 11g, 1, 3-butanediol 4.5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis, flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
Test 2 groups: 1,3 butylene glycol 9g, cetearyl alcohol 6g, polydimethylsiloxane 4g, isononyl isononanoate 3g, PEG-45 stearate 1.5g, sucrose stearate 1.5g, glyceryl stearate 0.7g, beta glucan 0.5g, two (lauramide glutamine) L-Lysine sodium salt 0.5g, carbomer 0.4g, white willow peel extract 0.2g, hydrolecithin 0.2g, resveratrol 0.1g, tremella polysaccharide 0.1g, glycerol caprylate 0.08g, Herba Artemisiae Scopariae flower extract 0.075g, xanthan gum 0.05g, Natrulon H-10 laurate 0.03g, pentetic acid five sodium 0.015g, sodium chondroitin sulfate 0.015g, adenosine triphosphate 0.015g, hydrolyzed vegetable protein 0.015g, Citrus junos fruit extract 0.005g, phytic acid 0.0017g, Flos Caryophylli extract 0.001g, NAP 0.0001g, 1,2-PD 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.1g, mandarin orange peel extract 0.002g, Cortex Phellodendri extract 0.002g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 55g, 1,3 butylene glycol 4.5g, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add starch ocentyl succinic aluminum, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water 11g, 1, 3-butanediol 4.5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
Whether whether test method: get essence cream, is placed in 40 DEG C and deposits 24h, deposit 24h, then deposit 24h in-5 DEG C in room temperature, circulates 3 times successively, observe and have layering, oil slick, color and luster to change.
Conclusion (of pressure testing): in table 4.
Table 4 stability test result
| Group | Whether layering | Whether oil slick | Whether color and luster changes |
| Test 1 group | No | No | No |
| Test 2 groups | No | Have | Have |
Conclusion (of pressure testing): after not adding sodium hydroxide and arginine in essence cream, essence cream, after cold cycling, produces oil slick phenomenon and color and luster and changes, and tests 1 group and do not produce such phenomenon, absolutely proves that essence cream prescription stability of the present invention is better.
Preparation embodiment
Embodiment 1
Essence cream prescription is: 1,3 butylene glycol 8g, cetearyl alcohol 5g, polydimethylsiloxane 3g, isononyl isononanoate 2g, PEG-45 stearate 1g, sucrose stearate 1g, glyceryl stearate 0.6g, beta glucan 0.4g, two (lauramide glutamine) L-Lysine sodium salt 0.4g, sodium hydroxide 0.4g, arginine 0.3g, carbomer 0.3g, white willow peel extract 0.1g, hydrolecithin 0.1g, resveratrol 0.05g, tremella polysaccharide 0.05g, glycerol caprylate 0.07g, Herba Artemisiae Scopariae flower extract 0.07g, xanthan gum 0.04g, Natrulon H-10 laurate 0.02g, pentetic acid five sodium 0.01g, sodium chondroitin sulfate 0.01g, adenosine triphosphate 0.01g, hydrolyzed vegetable protein 0.01g, Citrus junos fruit extract 0.004g, phytic acid 0.0015g, Flos Caryophylli extract 0.001g, NAP 0.0001g, 1,2-PD 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2g, salicylic acid 1g, PCA zinc 0.4g, zinc gluconate 0.1g, nicotiamide 0.05g, mandarin orange peel extract 0.001g, Cortex Phellodendri extract 0.001g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 50g, 1,3 butylene glycol 4g, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water 9g, 1, 3-butanediol 4g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
Embodiment 2
Essence cream prescription is: 1,3 butylene glycol 9g, cetearyl alcohol 6g, polydimethylsiloxane 4g, isononyl isononanoate 3g, PEG-45 stearate 1.5g, sucrose stearate 1.5g, glyceryl stearate 0.7g, beta glucan 0.5g, two (lauramide glutamine) L-Lysine sodium salt 0.5g, sodium hydroxide 0.45g, arginine 0.4g, carbomer 0.4g, white willow peel extract 0.2g, hydrolecithin 0.2g, resveratrol 0.1g, tremella polysaccharide 0.1g, glycerol caprylate 0.08g, Herba Artemisiae Scopariae flower extract 0.075g, xanthan gum 0.05g, Natrulon H-10 laurate 0.03g, pentetic acid five sodium 0.015g, sodium chondroitin sulfate 0.015g, adenosine triphosphate 0.015g, hydrolyzed vegetable protein 0.015g, Citrus junos fruit extract 0.005g, phytic acid 0.0017g, Flos Caryophylli extract 0.001g, NAP 0.0001g, 1,2-PD 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 2.5g, salicylic acid 1.5g, PCA zinc 0.5g, zinc gluconate 0.2g, nicotiamide 0.1g, mandarin orange peel extract 0.002g, Cortex Phellodendri extract 0.002g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 55g, 1,3 butylene glycol 4.5g, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water 11g, 1, 3-butanediol 4.5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
Embodiment 3
Essence cream prescription is: 1,3 butylene glycol 10g, cetearyl alcohol 7g, polydimethylsiloxane 5g, isononyl isononanoate 4g, PEG-45 stearate 2g, sucrose stearate 2g, glyceryl stearate 0.8g, beta glucan 0.6g, two (lauramide glutamine) L-Lysine sodium salt 0.6g, sodium hydroxide 0.5g, arginine 0.5g, carbomer 0.5g, white willow peel extract 0.3g, hydrolecithin 0.3g, resveratrol 0.15g, tremella polysaccharide 0.15g, glycerol caprylate 0.09g, Herba Artemisiae Scopariae flower extract 0.08g, xanthan gum 0.06g, Natrulon H-10 laurate 0.04g, pentetic acid five sodium 0.02g, sodium chondroitin sulfate 0.02g, adenosine triphosphate 0.02g, hydrolyzed vegetable protein 0.02g, Citrus junos fruit extract 0.006g, phytic acid 0.0020g, Flos Caryophylli extract 0.001g, NAP 0.0001g, 1,2-PD 0.0005g, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004g, silver oxide 0.000162g, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001g, Anthemis nobilis flower extract 0.0000075g, platinum powder 0.00000002g, starch ocentyl succinic aluminum 3g, salicylic acid 2g, PCA zinc 0.6g, zinc gluconate 0.3g, nicotiamide 0.15g, mandarin orange peel extract 0.003g, Cortex Phellodendri extract 0.003g, retinyl palmitate 0.001g.
The preparation method of essence cream is:
(1) water intaking 69g, 1,3 butylene glycol 5g, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water 11g, 1, 3-butanediol 5g, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis, flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
Preparation embodiment includes but not limited to above-mentioned.
Claims (6)
1. an essence cream, is characterized in that essence cream comprises starch ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract, Cortex Phellodendri extract, retinyl palmitate.
2. a kind of essence cream according to claim 1, wherein starch ocentyl succinic aluminum 2-3 weight portion, salicylic acid 1-2 weight portion, PCA zinc 0.4-0.6 weight portion, zinc gluconate 0.1-0.3 weight portion, nicotiamide 0.05-0.15 weight portion, mandarin orange peel extract 0.001-0.003 weight portion, Cortex Phellodendri extract 0.001-0.003 weight portion, retinyl palmitate 0.001 weight portion.
3. a kind of essence cream according to claim 1 and 2, wherein prepares essence cream raw material and comprises: 1,3 butylene glycol, cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, PEG-45 stearate, sucrose stearate, glyceryl stearate, beta glucan, two (lauramide glutamine) L-Lysine sodium salt, sodium hydroxide, arginine, carbomer, white willow peel extract, hydrolecithin, resveratrol, tremella polysaccharide, glycerol caprylate, Herba Artemisiae Scopariae flower extract, xanthan gum, Natrulon H-10 laurate, pentetic acid five sodium, sodium chondroitin sulfate, adenosine triphosphate, hydrolyzed vegetable protein, Citrus junos fruit extract, phytic acid, Flos Caryophylli extract, NAP, 1,2-PD, Cynara scolymus L (Cyhara cardunculus.) leaf extract, silver oxide, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, platinum powder, starch ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract, Cortex Phellodendri extract, retinyl palmitate.
4. a kind of essence cream according to claim 1 and 2, wherein prepares essence cream raw material and comprises: 1,3 butylene glycol 8-10 weight portion, cetearyl alcohol 5-7 weight portion, polydimethylsiloxane 3-5 weight portion, isononyl isononanoate 2-4 weight portion, PEG-45 stearate 1-2 weight portion, sucrose stearate 1-2 weight portion, glyceryl stearate 0.6-0.8 weight portion, beta glucan 0.4-0.6 weight portion, two (lauramide glutamine) L-Lysine sodium salt 0.4-0.6 weight portion, sodium hydroxide 0.4-0.5 weight portion, arginine 0.3-0.5 weight portion, carbomer 0.3-0.5 weight portion, white willow peel extract 0.1-0.3 weight portion, hydrolecithin 0.1-0.3 weight portion, resveratrol 0.05-0.15 weight portion, tremella polysaccharide 0.05-0.15 weight portion, glycerol caprylate 0.07-0.09 weight portion, Herba Artemisiae Scopariae flower extract 0.07-0.08 weight portion, xanthan gum 0.04-0.06 weight portion, Natrulon H-10 laurate 0.02-0.04 weight portion, pentetic acid five sodium 0.01-0.02 weight portion, sodium chondroitin sulfate 0.01-0.02 weight portion, adenosine triphosphate 0.01-0.02 weight portion, hydrolyzed vegetable protein 0.01-0.02 weight portion, Citrus junos fruit extract 0.004-0.006 weight portion, phytic acid 0.0015-0.0020 weight portion, Flos Caryophylli extract 0.001 weight portion, NAP 0.0001 weight portion, 1,2-PD 0.0005 weight portion, Cynara scolymus L (Cyhara cardunculus.) leaf extract 0.0004 weight portion, silver oxide 0.000162 weight portion, prunus mume (sieb.) sieb.et zucc. berry extract 0.00001 weight portion, Anthemis nobilis flower extract 0.0000075 weight portion, platinum powder 0.00000002 weight portion, starch ocentyl succinic aluminum 2-3 weight portion, salicylic acid 1-2 weight portion, PCA zinc 0.4-0.6 weight portion, zinc gluconate 0.1-0.3 weight portion, nicotiamide 0.05-0.15 weight portion, mandarin orange peel extract 0.001-0.003 weight portion, Cortex Phellodendri extract 0.001-0.003 weight portion, retinyl palmitate 0.001 weight portion.
5. a kind of essence cream according to claim 4, is characterized in that the preparation method of essence cream is:
(1) water intaking, 1,3 butylene glycol, two (lauramide glutamine) L-Lysine sodium salt, hydrolecithin, xanthan gum, carbomer, add aqueous phase pot, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) get cetearyl alcohol, polydimethylsiloxane, isononyl isononanoate, salicylic acid, PEG-45 stearate, sucrose stearate, glyceryl stearate, add oil phase pot, be heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(3) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add sodium hydroxide, starch ocentyl succinic aluminum, arginine, resveratrol, tremella polysaccharide, retinyl palmitate, beta glucan, Citrus junos fruit extract, water, 1, 3-butanediol, Cynara scolymus L (Cyhara cardunculus.) leaf extract, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, PCA zinc, pentetic acid five sodium, phytic acid, silver oxide, Flos Caryophylli extract, Herba Artemisiae Scopariae flower extract, glycerol caprylate, Natrulon H-10 laurate, white willow peel extract, zinc gluconate, Cortex Phellodendri extract, satsuma orange peel extract, platinum powder, NAP, prunus mume (sieb.) sieb.et zucc. berry extract, Anthemis nobilis flower extract, 1, ammediol, nicotiamide, continue to stir, be cooled to room temperature, fill, to obtain final product.
6. a kind of essence cream according to claim 1 and 2, is characterized in that the application of compositions in acne-eliminating cosmetic of described starch ocentyl succinic aluminum, salicylic acid, PCA zinc, zinc gluconate, nicotiamide, mandarin orange peel extract, Cortex Phellodendri extract and retinyl palmitate.
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| CN1857376A (en) * | 2006-03-21 | 2006-11-08 | 孟祥伟 | Medicine for treating Acne and its preparing method |
| CN101909586A (en) * | 2007-12-27 | 2010-12-08 | 花王株式会社 | External skin preparation for pimpled skin |
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Address after: Panyu District Hualong Town Guangzhou city Guangdong province 511434 Liu Wai Street No. 13 (No. 1 building) Patentee after: Hua An Tang biotech Group Co., Ltd. Address before: Panyu District Hualong Town Guangzhou city Guangdong province 511434 Liu Wai Street No. 13 (No. 1 building) Patentee before: City flower An Tang bio tech ltd, Guangzhou |