CN115844781A - Acne removing composition, acne removing liquid, acne removing emulsion, preparation method of acne removing emulsion and cosmetics - Google Patents
Acne removing composition, acne removing liquid, acne removing emulsion, preparation method of acne removing emulsion and cosmetics Download PDFInfo
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Abstract
The application discloses an acne-removing composition, acne-removing liquid, acne-removing emulsion, a preparation method thereof and cosmetics. The acne-removing composition comprises the following components in parts by weight: 1 part of Chinese kiwi fruit seed extract; 0.22-50 parts of honeysuckle flower extract; 0.02-50 parts of magnolia bark extract; asiaticoside, centella asiatica extract or their combination, 0.02-50 parts; 0.02-100 parts of arnica extract; 0.02-100 parts of citrus unshiu peel extract; and lactobacillus fermentation lysate, 0.02-100 parts. The acne-removing composition disclosed by the application eliminates or weakens the problem of acnes in 5 aspects of inhibiting 5 alpha-reductase, inhibiting inflammation, repairing acne damage, weakening or eliminating acnes and opening pores, simultaneously prevents acnes from being generated, has a more comprehensive mechanism and is milder, relieves or eliminates the acnes, and effectively ensures the health of skin.
Description
Technical Field
The application belongs to the technical field of daily cosmetics, and particularly relates to an acne removing composition, acne removing lotion, acne removing emulsion, a preparation method of the acne removing composition and cosmetics.
Background
The skin is easily affected by external factors such as light, heat, air pollution, climate, bacterial infection and the like or internal factors such as endocrine disturbance and the like of a human body, so that inflammation and allergic symptoms are caused, and great troubles are brought to the life of people. In addition, inflammation, allergy, endocrine disorder, and the like may cause acne, and the like, causing skin problems.
The existing acne-removing products mostly adopt salicylic acid, mandelic acid and other acid components, or the addition ratio is higher, so that the skin is usually irritated and the skin is greatly damaged.
Disclosure of Invention
In view of the above, the application provides an acne-removing composition, a preparation method thereof and a cosmetic, and aims to solve the problem of acne growth on skin.
On one hand, the embodiment of the application provides an acne-removing composition which comprises the following components in parts by weight:
1 part of Chinese kiwi fruit seed extract;
0.22-50 parts of honeysuckle flower extract;
0.02-50 parts of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.02-50 parts;
0.02-100 parts of arnica extract;
0.02-100 parts of citrus unshiu peel extract; and
0.02-100 parts of lactobacillus fermentation lysate.
According to an embodiment of one aspect of the application, the acne-removing composition comprises the following components in parts by weight:
1 part of Chinese kiwi fruit seed extract;
2-20 parts of honeysuckle flower extract;
2-20 parts of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 2-20 parts;
2-50 parts of arnica extract;
2-50 parts of citrus unshiu peel extract; and
lactobacillus fermentation lysate, 2-50 parts.
According to an embodiment of one aspect of the application, the acne-removing composition comprises the following components in parts by weight:
1 part of Chinese kiwi fruit seed extract;
2-10 parts of honeysuckle flower extract;
2-10 parts of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 2-10 parts;
5-20 parts of arnica extract;
5-20 parts of citrus unshiu peel extract; and
lactobacillus fermentation lysate, 5-20 parts.
In a second aspect, the embodiment of the application provides an acne removing liquid, which comprises the following components in percentage by mass:
0.1 to 5 percent of Chinese kiwi fruit seed extract;
honeysuckle flower extract, 0.11% -5%;
0.1 to 5 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.1% -5%;
0.1 to 10 percent of arnica extract
0.1 to 10 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.1% -10%;
0-3% of preservative;
0-3% of humectant;
53 to 94.9 percent of water.
According to an aspect of the application, the acne removing liquid comprises the following components in percentage by mass:
0.5 to 4 percent of Chinese kiwi fruit seed extract;
0.5-4% of honeysuckle flower extract;
0.5 to 4 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.5% -4%;
0.5 to 8 percent of arnica extract
0.5 to 8 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.5% -8%;
0.2 to 1 percent of preservative;
0.2 to 1 percent of humectant;
53 to 94.9 percent of water.
In a third aspect, the embodiment of the application provides an acne-removing emulsion, which comprises the following components in parts by mass:
0.1 to 5 percent of Chinese kiwi fruit seed extract;
honeysuckle flower extract, 0.11% -5%;
0.1 to 5 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.1% -5%;
0.1 to 10 percent of arnica extract
0.1 to 10 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.1% -10%;
0-1% of preservative;
0-1% of humectant;
a thickening agent, and a water-soluble polymer, 0.1 to 3 percent
0.01-1% of metal chelating agent
38% -89.9% of water phase component;
3 to 10 percent of oil phase component
2-5% of oil-in-water type emulsifier.
According to an embodiment of one aspect of the application, the acne-removing lotion comprises the following components in parts by mass:
0.5 to 4 percent of Chinese kiwi fruit seed extract;
0.5-4% of honeysuckle flower extract;
0.5 to 4 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.5% -4%;
0.5 to 8 percent of arnica extract
0.5 to 8 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.5% -8%;
0-1% of preservative;
0-1% of humectant;
0.1 to 3 percent of thickening agent
0.01-1% of metal chelating agent
38% -89.9% of water phase component;
3 to 10 percent of oil phase component
2-5% of oil-in-water type emulsifier.
According to an embodiment of one aspect of the application, the acne-removing emulsion satisfies at least one of the following conditions:
the preservative is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, p-anisic acid, caprylyl glycol, ethylhexyl glycerol, benzoic acid, sodium benzoate, caprylyl hydroxamic acid, or combinations thereof;
the humectant is selected from glycerin, butylene glycol, 1, 3-propylene glycol, 1, 2-pentanediol, caprylyl glycol, and sodium hyaluronate, or a combination thereof;
the thickening agent is selected from carbomer, acrylic acid cross-linked polymer with C10-C30 alkanol acrylate, xanthan gum or combination thereof;
the metal chelating agent is selected from disodium ethylene diamine tetraacetate, ethylene diamine tetraacetic acid or a combination thereof;
the water phase component is selected from deionized water, plant flower water or their combination;
the oil phase component is selected from coconut oil alcohol-caprylate/caprate, isononyl isononanoate cyclopentadimethylsiloxane, polydimethylsiloxane, polymethylphenylsiloxane, cyclomethicone, or combinations thereof;
the oil-in-water emulsifier is selected from lecithin, polyacrylamide, C13-14 isoparaffin, laureth-7, cetearyl alcohol or their combination.
In a fourth aspect, the embodiment of the application provides a preparation method of the acne-removing lotion, which comprises the step of mixing the components of the acne-removing lotion of the third aspect.
In a fifth aspect, the present embodiments provide a cosmetic or pharmaceutical composition comprising a composition of the first aspect and a cosmetically or pharmaceutically acceptable excipient.
Compared with the prior art, the application has at least the following beneficial effects:
the acne-removing composition comprises an actinidia chinensis seed extract, a honeysuckle flower extract, a magnolia bark extract, asiaticoside, an asiatic centella extract or a combination of the actinidia chinensis seed extract and the honeysuckle flower extract, a arnica montana flower extract, a wenzhou mandarin orange peel extract and a lactobacillus fermentation lysate, and has combined action and synergistic effect within the weight ratio range, and compared with the conventional combination of any one or more plant extracts, the acne-removing composition has a better acne-removing effect; the acne-removing composition disclosed by the application eliminates or weakens the problem of acnes in 5 aspects of inhibiting 5 alpha-reductase, inhibiting inflammation, repairing acne damage, weakening or eliminating acnes and opening pores, and simultaneously prevents acnes from being generated, has a more comprehensive mechanism and a milder and multiple effects, relieves or eliminates the acnes, and effectively ensures the health of skin.
Drawings
Fig. 1 shows a microscopic effect plot of 0, 1,3, 7, 21, 28 days using the acne treatment lotion product of example 1;
fig. 2 shows a 0, 1,3, 7, 21, 28 day topical plot using the example 1 acne treatment lotion product.
Detailed Description
In order to make the application purpose, technical solution and beneficial technical effects of the present application clearer, the present application is further described in detail with reference to the following embodiments. It should be understood that the embodiments described in this specification are only for the purpose of explaining the present application and are not intended to limit the present application.
For the sake of brevity, only some numerical ranges are explicitly disclosed herein. However, any lower limit may be combined with any upper limit to form ranges not explicitly recited; and any lower limit may be combined with any other lower limit to form a range not explicitly recited, and similarly any upper limit may be combined with any other upper limit to form a range not explicitly recited. Also, although not explicitly recited, each point or individual value between endpoints of a range is encompassed within the range. Thus, each point or individual value may, as its lower or upper limit, be combined with any other point or individual value or with other lower or upper limits to form ranges not explicitly recited.
In the description of the present application, it is to be noted that, unless otherwise specified, "above" and "below" are inclusive of the present number, and "plural" of "one or more" means two or more.
The above summary of the present application is not intended to describe each disclosed embodiment or every implementation of the present application. The following description more particularly exemplifies illustrative embodiments. At various points throughout this application, guidance is provided through lists of examples, which examples can be used in various combinations. In each instance, the list is provided only as a representative group and should not be construed as exhaustive.
Acne is usually found on the surface of the skin of a patient, and is caused by endocrine abnormality of the body, so that the hair follicle is blocked by the excessive secretion of grease from the sebaceous gland on the surface of the skin, or the hair follicle on the surface of the skin is infected by bacteria or viruses. Patients can often select topical, oral, or physical therapy for conditioning.
Common causes of acne include:
1. genetic factors: the oil secretion on the surface of the skin of some patients is excessive due to the influence of genetic factors, so that acne is easy to generate;
2. abnormal secretion of sex hormones: such as increased androgen secretion, may cause increased oil secretion on the skin surface of a patient, leading to pore blockage, and thus causing acne;
3. infection of hair follicles: if the hair follicles on the skin surface of a patient are infected by bacteria or viruses, the skin surface can cause the blockage of pores of the patient, so that acne is generated;
4. stimulation by drugs: if a patient takes glucocorticoid, iodide and other medicines for a long time, endocrine of the patient is possibly abnormal, so that acne is caused;
5. other factors: the symptoms of acne may be caused by bad living habits such as staying up all night, being fond of spicy food, using cosmetics with poor quality and the like.
The common acne-removing nursing products in the market mostly adopt salicylic acid, mandelic acid and other acid components, or are added into the nursing products in a high proportion to open and block pores. However, the method has strong irritation and single target point, and can not effectively remove the pox from various aspects.
The inventor researches and discovers that the Chinese gooseberry seed extract, the honeysuckle flower extract, the bark extract of the magnolia officinalis, the asiaticoside, the asiatic centella extract or the combination thereof, the arnica extract, the wenzhou mandarin orange peel extract and the lactobacillus fermentation lysate are adopted to realize the combined action and the synergistic effect in the weight ratio; on one hand, the composition can comprehensively regulate and control sex hormone secretion, regulate grease secretion and reduce or avoid pore blockage; on the other hand, the acne treatment solution can open pores or hair follicles, inhibit virus and bacteria interference and inhibit inflammation, and in addition, the specific plant extract combination is mild and non-irritant, so that the acne problem can be solved from multiple aspects.
Acne removing composition
The embodiment of the application provides an acne-removing composition which comprises the following components in parts by weight:
1 part of Chinese kiwi fruit seed extract;
0.22-50 parts of honeysuckle flower extract;
0.02-50 parts of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.02-50 parts;
0.02-100 parts of arnica extract;
0.02-100 parts of citrus unshiu peel extract; and
0.02-100 parts of lactobacillus fermentation lysate.
According to the embodiment of the application, the Chinese kiwifruit seed extract has a large amount of fruit acid, can open pores when being used for the acne removing composition, is beneficial to other components to realize the effects of repairing and treating, and also has a good contraction effect, so that excessive cuticle is effectively removed, black spots are effectively lightened, and pockmarks are removed; can promote the biosynthesis of cholesterol, promote the proliferation of epidermal cells, eliminate free radicals, effectively remove acne marks under the combined action of other components, and has the moisture retention function and obvious effect on improving dry and oily skin tissues.
According to the embodiment of the application, the honeysuckle flower extract contains caffeic acid and luteolin, and the caffeic acid has the effects of resisting bacteria, reducing fat, beautifying skin and preventing skin aging; luteolin has antibacterial and antiinflammatory effects, has strong skin penetration force, can reach deep skin, and can open pores to make other active components deep to achieve repairing and placing effects; can also inhibit the activity of hyaluronidase, prolong the activity of the product when used together with hyaluronidase, eliminate free radicals, and absorb ultraviolet rays, so as to inhibit and eliminate skin color spots; the honeysuckle flower extract is used for the acne-removing composition, and has the effects of resisting oxidation, whitening skin, removing freckles, removing acne marks and resisting inflammation under the combined action of other components.
According to the embodiment of the application, the main effective component magnolol of the cortex magnoliae officinalis extract has obvious antifungal effect and antibacterial effect, can be used as an antibacterial agent, and can be used for treating acne; the Magnolia officinalis extract has antioxidant effect, and can eliminate free radicals, and has antibacterial, antioxidant and antiinflammatory effects; the cortex magnoliae officinalis extract is used for the acne-removing composition and has anti-inflammatory and antibacterial effects.
According to the embodiment of the application, the asiaticoside, the centella asiatica extract or the combination thereof is used for the acne removing composition, can stimulate the production of type I and type III collagen and recombine dermis of extracellular matrix, can improve sensitive skin, is used for skin repair, promotes wound healing, repairs acne injuries and scar repair, and also has good anti-wrinkle performance.
According to the embodiment of the application, the arnica extract has the effects of anti-inflammation and antioxidation; promoting activity of tissue protease and proliferation of fibroblasts, regenerating collagen, elastin and hyaluronic acid which can maintain skin elasticity, repairing acne injury, enhancing cell metabolism, combining with its oxidation resistance, and activating skin and resisting aging; inhibition of luciferase activity indicates an anti-inflammatory effect; the conventional cosmetics containing the arnica extract cannot be used for the damaged skin, and should be stopped immediately if skin allergy occurs, but the arnica extract can be used together with other components when damaged pockmarks and pox loss occur on the skin, and can achieve the aim of repairing.
According to the embodiment of the application, the wenzhou mandarin orange peel extract used in the acne-removing composition has the effects of promoting the generation of ceramide, so that the acne-removing composition has the effects of activating skin, promoting the proliferation capacity of cells, and well resisting aging and removing pockmarks; has promoting effect on luciferase activity and anti-inflammatory effect.
According to the embodiment of the application, the lactobacillus fermentation lysate comprises a complex consisting of lactobacillus metabolites, cytoplasmic fragments, cell wall components and polysaccharides, peptidoglycan, teichoic acid, protein, phospholipid, sterol, fatty acid, various enzymes, peptide and amino acid, nucleotide, extracellular polysaccharide and the like, and the acne-removing composition used in the application has the effects of inhibiting and promoting the repair of skin barrier, moisturizing, repairing, inhibiting inflammation and increasing the speed of cell metabolism.
The acne-removing composition disclosed by the application eliminates or weakens the problem of acnes from 5 aspects of inhibiting 5 alpha-reductase, inhibiting inflammation, repairing acne injury, weakening or eliminating acne marks and opening pores, simultaneously prevents acne marks from being generated, promotes cutin to be renewed, has a more comprehensive mechanism, is warmer and non-irritant, relieves or eliminates the generation of acnes, and effectively guarantees the health of skin.
In some embodiments, the acne-removing composition comprises the following components in parts by weight:
1 part of Chinese kiwi fruit seed extract;
2-20 parts of honeysuckle flower extract;
2-20 parts of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 2-20 parts;
2-50 parts of arnica extract;
2-50 parts of citrus unshiu peel extract; and
lactobacillus fermentation lysate, 2-50 parts.
In some embodiments, the acne-removing composition comprises the following components in parts by weight:
1 part of Chinese gooseberry seed extract;
2-10 parts of honeysuckle flower extract;
2-10 parts of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 2-10 parts;
5-20 parts of arnica extract;
5-20 parts of citrus unshiu peel extract; and
lactobacillus fermentation lysate, 5-20 parts.
According to the embodiment of the application, the acne-removing composition with the weight parts has the combined action and the synergistic effect, all the components are matched with each other, and the acne-removing composition further eliminates or weakens the acne problem in the aspects of inhibiting 5 alpha-reductase, inhibiting inflammation, repairing acne injury, weakening or eliminating acne marks and opening pores by 5 aspects, simultaneously prevents the acne from generating, repairs skin barriers, effectively ensures the health of the skin, has mild effect and realizes mild acne removal.
According to the embodiment of the application, the acne-removing compositions in parts by weight have combined action, and can effectively inhibit propionibacterium acnes of the acne muscle and repair acne breeding on oily skin by inhibiting 5 alpha-reductase and grease secretion.
Acne removing liquid
In a second aspect, the embodiment of the application provides an acne removing liquid, which comprises the following components in percentage by mass:
0.1 to 5 percent of Chinese kiwi fruit seed extract;
honeysuckle flower extract, 0.11% -5%;
0.1 to 5 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.1% -5%;
0.1 to 10 percent of arnica extract
0.1 to 10 percent of citrus unshiu peel extract;
lactobacillus fermentation lysate, 0.1% -10%;
0-3% of preservative;
0-3% of humectant;
53 to 94.9 percent of water.
According to the embodiment of the application, the acne removing liquid contains Chinese gooseberry seed extract, honeysuckle flower extract, magnolia bark extract, asiaticoside, asiatic centella extract or a combination thereof, arnica extract, citrus unshiu peel extract and lactobacillus fermentation lysate, and the aim of mild acne removing is fulfilled through synergistic effect, and in addition, water is added into the acne removing liquid, so that the acne removing liquid is fresh and cool in texture, the kinematic viscosity is 2000-25000cst, the application range of 5000-2000cst can be selected, and the acne removing liquid can be used for particularly sensitive skin.
The viscosity detection method comprises the following steps: the assay was performed using a German IKAROTAVISC hi-vi II HELIComplete rotary viscometer.
The acne removing liquid of the application has the following effects in 5 aspects:
(1) Can effectively reduce interleukin-1 alpha, resist elastase activity and resist free radical activity;
(2) Controlling excessive keratinization, promoting cutin renewal, reducing expression of filaggrin, and maintaining skin barrier function;
can effectively control excessive keratinization, and the protein expression level of a keratinocyte proliferation marker is measured through filaggrin, so that the blockage of pores is reduced, and the generation of acnes is reduced.
(3) Inhibiting 5 alpha-reductase activity and inhibiting excessive secretion of grease of sebaceous glands;
(4) Repairing pox lesions and (5) removing pockmarks.
In some embodiments, the acne treatment lotion comprises the following components in percentage by mass:
0.5 to 4 percent of Chinese kiwi fruit seed extract;
0.5-4% of honeysuckle flower extract;
0.5 to 4 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.5% -4%;
0.5 to 8 percent of arnica extract
0.5 to 8 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.5% -8%;
0.2 to 1 percent of preservative;
0.2 to 1 percent of humectant;
53 to 94.9 percent of water.
In some embodiments, the preservative is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, p-anisic acid, caprylyl glycol, ethylhexyl glycerin, benzoic acid, sodium benzoate, caprylyl hydroxamic acid, or combinations thereof; the above-mentioned preservatives are well compatible with other substances, and by adding the above-mentioned preservatives, can prolong the service life of the acne-removing lotion and prolong the shelf life.
In some embodiments, the humectant is selected from glycerin, butylene glycol, 1, 3-propanediol, 1, 2-pentanediol, caprylyl glycol, and sodium hyaluronate, or a combination thereof; the humectant can further improve the moisture retention of the deep layer of the skin and realize long-acting moisture retention. According to the embodiment of the application, the components with the mass fractions can further improve the acne removing effect of the acne removing liquid.
Acne removing lotion
In a third aspect, the embodiment of the application provides an acne-removing lotion, which comprises the following components in parts by mass:
0.1 to 5 percent of Chinese kiwi fruit seed extract;
honeysuckle flower extract, 0.11% -5%;
0.1 to 5 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.1% -5%;
0.1 to 10 percent of arnica extract
0.1 to 10 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.1% -10%;
0-1% of preservative;
0-1% of humectant;
0.1 to 3 percent of thickening agent
0.01-1% of metal chelating agent
38% -89.9% of water phase component;
3 to 10 percent of oil phase component
2-5% of oil-in-water type emulsifier.
According to the embodiment of the application, the acne removing emulsion comprises Chinese gooseberry seed extract, honeysuckle flower extract, magnolia bark extract, asiaticoside, asiatic centella extract or a combination thereof, arnica extract, citrus unshiu peel extract and lactobacillus fermentation lysate which act together and synergically to achieve the purpose of mild acne removing, and in addition, an aqueous phase component, an oil phase component and an oil-in-water type emulsifier are added into the acne removing emulsion, so that the acne removing emulsion is an oil-in-water type emulsion, is fresh in texture, has the kinematic viscosity of 2500-7000cst (optionally 2500-5000 cst), is wide in application range, and can be used for particularly sensitive skin.
In some embodiments, the acne-removing lotion comprises the following components in parts by mass:
0.5 to 4 percent of Chinese kiwi fruit seed extract;
0.5 to 4 percent of honeysuckle flower extract;
0.5 to 4 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.5% -4%;
0.5 to 8 percent of arnica extract
0.5 to 8 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.5% -8%;
0-1% of preservative;
0-1% of humectant;
0.1 to 3 percent of thickening agent
A metal-chelating agent which is a metal-chelating agent, 0.01 to 1 percent
38% -89.9% of water phase component;
3 to 10 percent of oil phase component
2-5% of oil-in-water type emulsifier.
In some embodiments, the acne-removing emulsion satisfies at least one of the following conditions:
the antiseptic is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, p-anisic acid, caprylyl glycol, ethylhexylglycerin, benzoic acid, sodium benzoate, caprylyl hydroxamic acid, or a combination thereof; the preservative can be well compatible with other substances, and the shelf life of the acne removing lotion can be prolonged by adding the preservative.
The humectant is selected from glycerin, butylene glycol, 1, 3-propylene glycol, 1, 2-pentanediol, caprylyl glycol, and sodium hyaluronate, or a combination thereof; the humectant can further improve the moisture retention of deep skin and realize long-acting moisture retention.
The thickening agent is selected from carbomer, acrylic acid cross-linked polymer with C10-C30 alkanol acrylate, xanthan gum or combination thereof; the thickening agent has important effects on thickening, stability and rheological property of the acne-removing lotion; by using the thickener in the above weight ratio, it is possible to give a good consistency, and excellent spreadability and spreadability. By adding the thickener, the viscosity of the oil-in-water emulsion can be adjusted, and the skin-sticking property and the use feeling can be enhanced.
The metal chelating agent is selected from disodium ethylenediamine tetraacetic acid, ethylenediamine tetraacetic acid or a combination thereof; according to the embodiment of the application, the oil phase component can comprise a synthetic compound, the synthetic compound generally contains trace metal elements, and the addition of the metal chelating agent is beneficial to reducing or avoiding the irritation of metal to the skin.
The water phase component is selected from deionized water, plant flower water or their combination; deionized water contains no impurities and is a universal solvent; the plant flower water can be at least one of Lavender flower water, flos Rosae Rugosae water, bitter orange flower water, herba Verbenae flower water, and vegetarian flower water. Is a 100% saturated distillate stock separated during the extraction of essential oils, which is a by-product of essential oils, containing about 0.3-0.5% of essential oil components, in addition to water soluble substances of the whole plant. The lavender flower water is a distillate of lavender flower water, is colorless and transparent clear liquid, is a 100% saturated hydrolat separated from fresh lavender petals in the process of extracting lavender oil, and contains water-soluble components such as tannin, protein, plant sugar, etc.
The oil phase component is selected from coconut oil alcohol-caprylate/caprate, isononyl isononanoate cyclopentadimethylsiloxane, polydimethylsiloxane, polymethylphenylsiloxane, cyclomethicone, or combinations thereof;
according to the present application, the kind of the oil phase component is not particularly limited, and some vegetable oils and fats may be selected according to the requirement, and in some embodiments, the oil phase component includes isononyl cyclopentadimethylsiloxane or polydimethylsiloxane, or a mixture of both, and may further include a mixture of isononyl cyclopentadimethylsiloxane and dimethiconol, wherein the mixture of isononyl cyclopentadimethylsiloxane and dimethiconol is configured as follows: isononyl isononanoate cyclopentadecanol and dimethiconol were formulated at a ratio of 3. The oil phase component has good permeability to skin, has good effect on increasing the softness of the skin, is fresh and smooth when being smeared on the skin, can further improve the moistening property, the fluidity, the repairability and the ductility of the acne-removing lotion by being matched with other components, and ensures the moisturizing effect of the acne-removing lotion.
The oil-in-water emulsifier is selected from lecithin, PEG/PPG-14/7 dimethyl ether, PEG/PPG-17/6 copolymer, C13-14 isoparaffin, laureth-7, cetearyl alcohol or their combination. The emulsifier can provide excellent emulsification effect, can mix the oily component and the aqueous component together to form emulsion, enables the components in the acne-removing emulsion to have good dispersity and stability, is fresh and comfortable to use without greasy feeling, and enables the acne-removing emulsion to have good consistency, excellent spreadability and excellent ductility.
Preparation method of acne-removing lotion
In a fourth aspect, the embodiments of the present application provide a method for preparing an acne-removing lotion, comprising mixing the components of the acne-removing lotion of the third aspect.
In some embodiments, the components of the acne-removing lotion are mixed under heating to 40-80 ℃.
In some embodiments, the mixing comprises: preparing water phase solution, preparing oil phase solution, mixing the water phase solution and the oil phase solution, and stirring to uniformly mix the substances.
In some embodiments, after mixing, the components are homogenized and emulsified before adding the actinidia chinensis seed extract, the honeysuckle extract, the magnolia bark extract, asiaticoside, centella asiatica extract or combinations thereof, arnica extract, satsuma mandarin peel extract and the lactic acid bacteria fermentation lysate to obtain the acne removing emulsion.
In some embodiments, the components are homogenized and emulsified at 50-60 ℃ to reduce the temperature to obtain the acne-removing lotion.
Cosmetic or pharmaceutical composition
In a fifth aspect, embodiments herein provide a cosmetic or pharmaceutical composition comprising a composition of the first aspect and a cosmetically or pharmaceutically acceptable excipient.
The cosmetic or pharmaceutical composition of the present application may be added with various desired cosmetic or pharmaceutically acceptable excipients according to various formulation forms of the composition. For example, when the composition of the present application is prepared as a liquid, the excipient may be selected from water, physiological saline, and the like; when the composition of the present invention is prepared into a gel, the excipient may be selected from cellulose derivatives, starch, gelatin, agar, polysaccharides, and the like; when the composition of the present application is prepared as a cream, the excipient may be selected from glycerin, vaseline, paraffin, etc.; when the composition of the present application is prepared as a foam, the excipient may be selected from hydroxypropyl methylcellulose, sodium lauryl sulfate polyethylene glycol, sodium fatty alcohol-polyoxyethylene ether sulfonate, and the like; when the compositions of the present application are prepared as a patch, the excipient may be selected from cellulose derivatives, starch, gelatin, agar, polysaccharides, and the like.
Examples
The present disclosure is more particularly described in the following examples that are intended as illustrative only, since various modifications and changes within the scope of the present disclosure will be apparent to those skilled in the art. Unless otherwise indicated, all parts, percentages, and ratios reported in the following examples are on a weight basis, and all reagents used in the examples are commercially available or synthesized according to conventional methods and can be used directly without further treatment, and the equipment used in the examples is commercially available.
The sources of the components in the examples of the application are as follows: the other raw materials may be any commercially available cosmetic raw materials.
Examples 1 to 3
The embodiment of the application provides acne removing liquid which comprises the following components in percentage by mass:
0.1% -5% of Chinese gooseberry seed extract;
0.11 to 5 percent of honeysuckle flower extract;
0.1 to 5 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.1% -5%;
0.1 to 10 percent of arnica extract
0.1 to 10 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.1% -10%;
0-3% of preservative;
0-3% of humectant;
53 to 94.9 percent of water.
The components and amounts of examples 1-3 are shown in Table 1.
Examples 4 to 7
The embodiment of the application provides acne-removing emulsion which comprises the following components in parts by mass:
0.1 to 5 percent of Chinese kiwi fruit seed extract;
honeysuckle flower extract, 0.11% -5%;
0.1 to 5 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.1% -5%;
0.1 to 10 percent of arnica extract
0.1 to 10 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.1% -10%;
0-1% of preservative;
0-1% of humectant;
0.1 to 3 percent of thickening agent
0.01-1% of metal chelating agent
38% -89.9% of water phase component;
3 to 10 percent of oil phase component
2-5% of oil-in-water type emulsifier.
The components and amounts of examples 4-7 are shown in Table 1.
TABLE 1
Comparative examples 1 to 7
The comparative examples of the present application differ from example 4 in that: the components and their contents are different. See table 2.
Test section
1) Oil evaluation test:
1. test objects: each group selects 5 forehead grease with the grease content of more than 100 mu g/cm 2 The test subjects are taken as experimental subjects, the detection results are averaged, and the effect of the oil control effect of the acne removing composition is evaluated.
2. Detection indexes are as follows:
oil content (. Mu.g/cm) 2 ) Use of a Sebumeter-SM-815 from CK, germany
3. Experimental methods
3.1 test screening: the grease content of the forehead of the subject is tested by a Sebumeter probe, and the grease content of the forehead is more than 100 mu g/cm 2 The groups are entered.
3.2 base value test: the testee cleans the face by using an amino acid cleansing face uniformly provided by a laboratory, and after waiting for 30min in the laboratory environment, the left and right faces of the testee are shot by an Antera 3D image acquisition device, and the grease content at the forehead of the testee is tested.
3.3 Return visit test: the subjects used the products of examples and comparative examples all face in the morning and evening each day, 12 days later, returned to the laboratory, subjects again cleaned their faces using the amino acid cleansing surface uniformly provided by the laboratory, and after waiting 30min in the laboratory environment, the subjects' left and right faces were photographed by the laboratory staff using an ant 3D image capturing device. And the oil content at the forehead was measured with a German CK oil tester, the results are shown in Table 3.
TABLE 3
The experimental results are as follows: after using the sample of example 1 and the blank, the forehead of the test tube was examined for oil secretionAfter 8h, the temperature is reduced by 105 mu g/cm 2 After comparing the sample of example 2 with the blank, the person detected a decrease of 102. Mu.g/cm in the fat secreted by his forehead after 8h 2 After comparing the sample of example 3 with the blank, the person tested that the fat secreted from the forehead had decreased by 107. Mu.g/cm after 8 hours 2 After comparing the sample of example 4 with the blank, the person detected a drop of 105. Mu.g/cm in the fat secreted by his forehead after 8h 2 After comparing the sample of example 5 with the blank, the person tested that the fat secreted from the forehead decreased by 106. Mu.g/cm after 8h 2 The reduction of secretion is more and the oil control effect is better. After comparing the sample of the comparative example with the blank, the person detected that the fat secreted by the forehead declined by 40-70 mug/cm after 8h 2 The oil control effect of the left and right embodiment groups is better.
In summary, the composition containing acne is safe and low in irritation, and can effectively inhibit the secretion of grease on the facial skin, improve the greasy phenomenon of the skin and greatly improve the comfort of people after being frequently used.
2) Evaluation of acne removal efficacy
Screening subjects with obvious acne skin to carry out human body trial evaluation experiments, selecting 18 volunteers with 18-30 years old according with requirements as test subjects, dividing 1 group of the test subjects for every 3 persons, carrying out oil control and acne treatment efficacy evaluation by using the acne treatment products of the embodiment and the comparative example, and taking a mean value of the evaluation results.
The test method comprises the following steps:
after a subject cleans the face with the amino acid facial cleanser in the morning and at night, the test samples of the examples and the comparative examples are tried, the face is uniformly smeared, the mixture stays for 15-20min, and the mixture is cleaned with clear water.
The oil control and acne removal effects of the test samples are evaluated by intensively testing the secretion of facial oil and observing the recovery condition of the acne skin for corresponding scoring, the trial evaluation period is 28 days, and the skin continuous improvement condition is observed.
And (3) testing results:
the subjects used the acne-removing composition for skin improvement evaluation, and the skin reactions of the subjects were recorded according to the test evaluation criteria:
the test subjects used the test samples for 1 day, 2 days, 7 days, 14 days, 21 days, and 28 days, respectively, and the evaluation scores were as follows.
TABLE 4
The table shows that the acne removing product of the embodiment can obviously and efficiently improve the fever, pruritus and redness of acne skin; the acne cream can better inhibit and improve blackheads, white heads, edema and pustules appearing on acne skin; aiming at acne mark skin, the example sample shows better comprehensive improvement than a reference sample, and the acne removing product has better effect on repairing the acne mark skin.
3) Vaccinia was measured on vaccinia muscle patients using the american VISIA instrument and 30 values were taken for each group of data and compared. The following results were obtained.
As can be seen from the above table, a ×, which represents the average value of the plane size of the pox, decreases with the time of use, and decreases in volume, area and height of the pox. Compared with the effect of day 1 and day 0, some values of day 1 are greater than day 0 because the acne grows up, and the acne removing product of the embodiment just used can only inhibit the acne from growing up rapidly on the basis of the original growth and cannot be repaired to become small immediately. The acne removing product of the embodiment can achieve the effect of removing acnes. The microscopic effect patterns of the products of the acne removing lotion of example 1 in 0, 1,3, 7, 21 and 28 days are shown in figure 1, and the partial patterns of the products of the acne removing lotion of example 1 in 0, 1,3, 7, 21 and 28 days are sequentially shown in figure 2. It is demonstrated that the acne removing lotion of example 1 has good acne removing effect.
While the invention has been described with reference to specific embodiments, the scope of the invention is not limited thereto, and those skilled in the art can easily conceive various equivalent modifications or substitutions within the technical scope of the invention. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (10)
1. The acne-removing composition comprises the following components in parts by weight:
1 part of Chinese kiwi fruit seed extract;
0.22-50 parts of honeysuckle flower extract;
0.02-50 parts of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.02-50 parts;
0.02-100 parts of arnica extract;
0.02-100 parts of citrus unshiu peel extract; and
0.02-100 parts of lactobacillus fermentation lysate.
2. The acne treatment composition according to claim 1, wherein the acne treatment composition comprises the following components in parts by weight:
1 part of Chinese kiwi fruit seed extract;
2-20 parts of honeysuckle flower extract;
2-20 parts of magnolia bark extract;
asiaticoside, centella asiatica extract or a combination thereof, 2-20 parts;
2-50 parts of arnica extract;
2-50 parts of citrus unshiu peel extract; and
lactobacillus fermentation lysate, 2-50 parts.
3. The acne treatment composition according to claim 2, wherein the acne treatment composition comprises the following components in parts by weight:
1 part of Chinese kiwi fruit seed extract;
2-10 parts of honeysuckle flower extract;
2-10 parts of magnolia bark extract;
asiaticoside, centella asiatica extract or a combination thereof, 2-10 parts;
5-20 parts of arnica extract;
5-20 parts of citrus unshiu peel extract; and
lactobacillus fermentation lysate, 5-20 parts.
4. The acne removing liquid comprises the following components in percentage by mass:
0.1 to 5 percent of Chinese kiwi fruit seed extract;
0.11 to 5 percent of honeysuckle flower extract;
0.1 to 5 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.1% -5%;
0.1 to 10 percent of arnica extract
0.1 to 10 percent of citrus unshiu peel extract;
lactobacillus fermentation lysate, 0.1% -10%;
0-3% of preservative;
0-3% of humectant;
53 to 94.9 percent of water.
5. The acne removing liquid according to claim 4, comprising the following components in percentage by mass:
0.5% -4% of Chinese gooseberry seed extract;
0.5-4% of honeysuckle flower extract;
0.5 to 4 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.5% -4%;
0.5 to 8 percent of arnica extract
0.5 to 8 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.5% -8%;
0.2 to 1 percent of preservative;
0.2 to 1 percent of humectant;
53 to 94.9 percent of water.
6. An acne-removing emulsion comprises the following components in parts by mass:
0.1% -5% of Chinese gooseberry seed extract;
honeysuckle flower extract, 0.11% -5%;
0.1 to 5 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.1% -5%;
0.1 to 10 percent of arnica extract
0.1 to 10 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.1% -10%;
0-1% of preservative;
0-1% of humectant;
0.1 to 3 percent of thickening agent
0.01-1% of metal chelating agent
38% -89.9% of water phase component;
3 to 10 percent of oil phase component
2-5% of oil-in-water type emulsifier.
7. The anti-acne lotion according to claim 6, characterized in that it comprises the following components in parts by mass:
0.5 to 4 percent of Chinese kiwi fruit seed extract;
0.5-4% of honeysuckle flower extract;
0.5 to 4 percent of magnolia bark extract;
asiaticoside, centella asiatica extract or their combination, 0.5% -4%;
0.5 to 8 percent of arnica extract
0.5 to 8 percent of wenzhou mandarin orange peel extract;
lactobacillus fermentation lysate, 0.5% -8%;
0-1% of preservative;
0-1% of humectant;
0.1 to 3 percent of thickening agent
0.01-1% of metal chelating agent
38% -89.9% of water phase component;
3 to 10 percent of oil phase component
2-5% of oil-in-water type emulsifier.
8. The acne removing emulsion according to claim 6 or 7, wherein the emulsion satisfies at least one of the following conditions:
the preservative is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, p-anisic acid, caprylyl glycol, ethylhexylglycerin, benzoic acid, sodium benzoate, caprylyl hydroxamic acid, or a combination thereof;
the humectant is selected from glycerin, butylene glycol, 1, 3-propylene glycol, 1, 2-pentanediol, caprylyl glycol, and sodium hyaluronate, or a combination thereof;
the thickening agent is selected from carbomer, acrylic acid cross-linked polymer with C10-C30 alkanol acrylate, xanthan gum or combination thereof;
the metal chelating agent is selected from disodium ethylene diamine tetraacetate, ethylene diamine tetraacetic acid or a combination thereof;
the water phase component is selected from deionized water, plant flower water or the combination thereof;
the oil phase component is selected from coconut oil alcohol-caprylate/caprate, isononyl isononanoate cyclopentademethicone, dimethicone, polymethylphenylsiloxane, cyclomethicone, or combinations thereof;
the oil-in-water emulsifier is selected from lecithin, polyacrylamide, C13-14 isoparaffin, laureth-7, cetearyl alcohol or combination thereof.
9. A method of preparing an anti-acne lotion comprising mixing the components of any one of claims 6-8.
10. A cosmetic or pharmaceutical composition comprising a composition according to any one of claims 1 to 3 and a cosmetically or pharmaceutically acceptable excipient.
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