CN105243295B - 与癌症相关的遗传或分子畸变的检测 - Google Patents

与癌症相关的遗传或分子畸变的检测 Download PDF

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CN105243295B
CN105243295B CN201510615900.1A CN201510615900A CN105243295B CN 105243295 B CN105243295 B CN 105243295B CN 201510615900 A CN201510615900 A CN 201510615900A CN 105243295 B CN105243295 B CN 105243295B
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chromosomal
nucleic acid
regions
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acid molecules
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CN105243295A (zh
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卢煜明
陈君赐
赵慧君
江培勇
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Chinese University of Hong Kong CUHK
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • C12Q2600/172—Haplotypes

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CN201510615900.1A 2010-11-30 2011-11-30 与癌症相关的遗传或分子畸变的检测 Active CN105243295B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US41839110P 2010-11-30 2010-11-30
US61/418,391 2010-11-30
US201161529877P 2011-08-31 2011-08-31
US61/529,877 2011-08-31
CN201180066175.7A CN103403182B (zh) 2010-11-30 2011-11-30 与癌症相关的遗传或分子畸变的检测
PCT/AU2011/001562 WO2012071621A1 (en) 2010-11-30 2011-11-30 Detection of genetic or molecular aberrations associated with cancer

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CN105243295A CN105243295A (zh) 2016-01-13
CN105243295B true CN105243295B (zh) 2018-08-17

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CN202210291074.XA Pending CN114678128A (zh) 2010-11-30 2011-11-30 与癌症相关的遗传或分子畸变的检测
CN201510615900.1A Active CN105243295B (zh) 2010-11-30 2011-11-30 与癌症相关的遗传或分子畸变的检测
CN201810817319.1A Active CN108899091B (zh) 2010-11-30 2011-11-30 与癌症相关的遗传或分子畸变的检测
CN201180066175.7A Active CN103403182B (zh) 2010-11-30 2011-11-30 与癌症相关的遗传或分子畸变的检测

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CN201180066175.7A Active CN103403182B (zh) 2010-11-30 2011-11-30 与癌症相关的遗传或分子畸变的检测

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US (4) US8741811B2 (enExample)
EP (4) EP4269623A3 (enExample)
JP (5) JP6196157B2 (enExample)
KR (6) KR102185244B1 (enExample)
CN (4) CN114678128A (enExample)
AU (1) AU2011335891B2 (enExample)
BR (1) BR112013013421A2 (enExample)
CA (1) CA2817370C (enExample)
DK (2) DK2646579T3 (enExample)
EA (1) EA038374B1 (enExample)
IL (3) IL226272A (enExample)
MX (3) MX349568B (enExample)
MY (1) MY169852A (enExample)
NZ (1) NZ611599A (enExample)
SG (3) SG10201509766YA (enExample)
TW (5) TW202242133A (enExample)
WO (1) WO2012071621A1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11168356B2 (en) 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
CN106886688B (zh) 2007-07-23 2020-07-10 香港中文大学 用于分析癌症相关的遗传变异的系统
CA3116156C (en) 2008-08-04 2023-08-08 Natera, Inc. Methods for allele calling and ploidy calling
WO2011041485A1 (en) 2009-09-30 2011-04-07 Gene Security Network, Inc. Methods for non-invasive prenatal ploidy calling
EP3006573B1 (en) 2010-01-19 2018-03-07 Verinata Health, Inc Methods for determining fraction of fetal nucleic acids in maternal samples
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US10662474B2 (en) 2010-01-19 2020-05-26 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US8700341B2 (en) 2010-01-19 2014-04-15 Verinata Health, Inc. Partition defined detection methods
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2854057B1 (en) 2010-05-18 2018-03-07 Natera, Inc. Methods for non-invasive pre-natal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
EP4269623A3 (en) 2010-11-30 2024-03-06 The Chinese University Of Hong Kong Analysis of a biological sample of an organism for chromosomal deletions or amplifications associated with cancer
CA2821906C (en) 2010-12-22 2020-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
JP2014506465A (ja) * 2011-02-09 2014-03-17 バイオ−ラド ラボラトリーズ，インコーポレイティド 核酸の分析
DK2697392T3 (en) 2011-04-12 2016-03-29 Verinata Health Inc SOLUTION OF GENOME FRACTIONS USING Polymorphism COUNTS
WO2014014498A1 (en) * 2012-07-20 2014-01-23 Verinata Health, Inc. Detecting and classifying copy number variation in a fetal genome
CN110016499B (zh) 2011-04-15 2023-11-14 约翰·霍普金斯大学 安全测序系统
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
EP3401399B1 (en) 2012-03-02 2020-04-22 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9892230B2 (en) * 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US9862995B2 (en) 2012-03-13 2018-01-09 Abhijit Ajit Patel Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
US11261494B2 (en) * 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
ES2769241T5 (es) 2012-09-04 2023-05-30 Guardant Health Inc Sistemas y métodos para detectar variación en el número de copias
WO2014043763A1 (en) 2012-09-20 2014-03-27 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
PL2912468T3 (pl) 2012-10-29 2019-04-30 Univ Johns Hopkins Test papanicolaou pod kątem raka jajnika i endometrium
SG10202009015SA (en) 2012-12-10 2020-10-29 Resolution Bioscience Inc Methods for targeted genomic analysis
US10643738B2 (en) * 2013-01-10 2020-05-05 The Chinese University Of Hong Kong Noninvasive prenatal molecular karyotyping from maternal plasma
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
CN105518151B (zh) * 2013-03-15 2021-05-25 莱兰斯坦福初级大学评议会 循环核酸肿瘤标志物的鉴别和用途
WO2014190286A2 (en) 2013-05-24 2014-11-27 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3024948B1 (en) 2013-07-25 2020-01-15 Bio-rad Laboratories, Inc. Genetic assays for detecting viral recombination rate
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10851414B2 (en) * 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
KR102373647B1 (ko) * 2013-10-21 2022-03-11 베리나타 헬스, 인코포레이티드 사본수 변동을 결정함에 있어서 검출의 감수성을 향상시키기 위한 방법
CN111534580B (zh) 2013-12-28 2024-06-04 夸登特健康公司 用于检测遗传变异的方法和系统
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
AU2015249846B2 (en) 2014-04-21 2021-07-22 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
WO2015164432A1 (en) * 2014-04-21 2015-10-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US10318704B2 (en) 2014-05-30 2019-06-11 Verinata Health, Inc. Detecting fetal sub-chromosomal aneuploidies
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
TWI727156B (zh) 2014-07-18 2021-05-11 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
WO2016015058A2 (en) 2014-07-25 2016-01-28 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
ES3047391T3 (en) * 2014-07-30 2025-12-03 Sequenom Inc Methods and processes for non-invasive assessment of genetic variations
US20160048608A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
EP3567120B1 (en) 2014-12-12 2020-08-19 Verinata Health, Inc. Using cell-free dna fragment size to determine copy number variations
US11242559B2 (en) 2015-01-13 2022-02-08 The Chinese University Of Hong Kong Method of nuclear DNA and mitochondrial DNA analysis
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US10319463B2 (en) * 2015-01-23 2019-06-11 The Chinese University Of Hong Kong Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations
SG11201706529TA (en) 2015-02-10 2017-09-28 Univ Hong Kong Chinese Detecting mutations for cancer screening and fetal analysis
US10424396B2 (en) * 2015-03-27 2019-09-24 Sentieon Inc. Computation pipeline of location-dependent variant calls
TW201643760A (zh) * 2015-04-10 2016-12-16 Social Welfare Organization Saiseikai Imp Gift Foundation Inc Saiseikai Suita Hospital 判別肝疾病之疾病狀態之方法
EP3294906B1 (en) 2015-05-11 2024-07-10 Natera, Inc. Methods for determining ploidy
EP3325663B1 (en) 2015-07-20 2020-08-19 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
DK3325664T3 (da) 2015-07-23 2022-03-07 Univ Hong Kong Chinese Analyse af fragmenteringsmønstre for cellefrit DNA
JP6675164B2 (ja) * 2015-07-28 2020-04-01 株式会社理研ジェネシス 変異判定方法、変異判定プログラムおよび記録媒体
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
TWI793586B (zh) 2015-08-12 2023-02-21 香港中文大學 血漿dna之單分子定序
CA3004435A1 (en) 2015-11-11 2017-05-18 Resolution Bioscience, Inc. High efficiency construction of dna libraries
CA3008651A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
CN109154599A (zh) 2016-03-24 2019-01-04 生物动力学公司 一次性射流卡盘及组件
WO2017181202A2 (en) 2016-04-15 2017-10-19 Natera, Inc. Methods for lung cancer detection
IL262953B2 (en) 2016-05-30 2023-11-01 Univ Hong Kong Chinese Detection of hematological disorders using cell-free DNA in blood
EP3491560A1 (en) 2016-07-27 2019-06-05 Sequenom, Inc. Genetic copy number alteration classifications
US11319594B2 (en) 2016-08-25 2022-05-03 Resolution Bioscience, Inc. Methods for the detection of genomic copy changes in DNA samples
EP3518974A4 (en) * 2016-09-29 2020-05-27 Myriad Women's Health, Inc. NON-INVASIVE PRENATAL SCREENING USING DYNAMIC ITERATIVE DEEP OPTIMIZATION
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
TWI797095B (zh) 2016-10-24 2023-04-01 美商格瑞爾有限責任公司 腫瘤檢測之方法及系統
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US11435339B2 (en) * 2016-11-30 2022-09-06 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CA3207879A1 (en) 2017-01-24 2018-08-02 Sequenom, Inc. Methods and processes for assessment of genetic variations
ES2990117T3 (es) 2017-01-25 2024-11-28 Univ Hong Kong Chinese Aplicaciones de diagnóstico que utilizan fragmentos de ácido nucleico
EP3585889A1 (en) 2017-02-21 2020-01-01 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
EP3998350B1 (en) 2017-03-17 2025-05-07 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
US11342047B2 (en) 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
EP3622084A4 (en) 2017-05-08 2021-02-17 Biological Dynamics, Inc. PROCESSES AND SYSTEMS FOR PROCESSING INFORMATION ON ANALYTES
KR102145417B1 (ko) * 2017-05-24 2020-08-19 지니너스 주식회사 무세포 핵산으로부터 수득된 서열 분석 데이터에 대한 배경 대립인자의 빈도 분포를 생성하는 방법 및 이를 이용하여 무세포 핵산으로부터 변이를 검출하는 방법
JP2020523009A (ja) * 2017-06-08 2020-08-06 ナントミクス，エルエルシー ファーマコゲノミクススクリーニングへの統合パノミックアプローチ
ES2959360T3 (es) 2017-07-26 2024-02-23 Univ Hong Kong Chinese Mejora del cribado del cáncer mediante ácidos nucleicos víricos acelulares
BR112020002555A2 (pt) 2017-08-07 2020-08-11 The Johns Hopkins University métodos e materiais para avaliar e tratar câncer
CN110021355B (zh) * 2017-09-22 2021-05-04 深圳华大生命科学研究院 二倍体基因组测序片段的单倍体分型和变异检测方法和装置
TWI669618B (zh) * 2017-11-24 2019-08-21 南韓商韓國美迪基因科技有限公司 預測疾病的方法及裝置以及計算每種疾病發生風險的加權分數的方法
WO2019118926A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
JP2021509265A (ja) 2017-12-19 2021-03-25 バイオロジカル ダイナミクス，インク． 生体サンプルからの複数の分析物の検出のための方法およびデバイス
US20210214798A1 (en) * 2017-12-19 2021-07-15 Biological Dynamics, Inc. Methods and devices for detecting and quantifying cell-free dna fragments
WO2019161244A1 (en) 2018-02-15 2019-08-22 Natera, Inc. Methods for isolating nucleic acids with size selection
CA3092998A1 (en) 2018-03-13 2019-09-19 Grail, Inc. Anomalous fragment detection and classification
WO2019178496A1 (en) 2018-03-15 2019-09-19 Grail, Inc. Tissue-specific methylation marker
US12154661B2 (en) 2018-03-22 2024-11-26 The Regents Of The University Of Michigan Method and apparatus for analysis of chromatin interaction data
JP2021520218A (ja) 2018-04-02 2021-08-19 バイオロジカル ダイナミクス，インク． 誘電体材料
EP3776555A2 (en) 2018-04-13 2021-02-17 Grail, Inc. Multi-assay prediction model for cancer detection
CA3090426A1 (en) 2018-04-14 2019-10-17 Natera, Inc. Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna
US20190341127A1 (en) 2018-05-03 2019-11-07 The Chinese University Of Hong Kong Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures
TW202410055A (zh) 2018-06-01 2024-03-01 美商格瑞爾有限責任公司 用於資料分類之卷積神經網路系統及方法
TW202013385A (zh) 2018-06-07 2020-04-01 美商河谷控股Ｉｐ有限責任公司 基於差異的基因組之辨識分數
WO2019237230A1 (zh) * 2018-06-11 2019-12-19 深圳华大生命科学研究院 确定待测样本类型的方法及系统
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CA3107948A1 (en) * 2018-10-08 2020-04-16 Freenome Holdings, Inc. Transcription factor profiling
US11581062B2 (en) 2018-12-10 2023-02-14 Grail, Llc Systems and methods for classifying patients with respect to multiple cancer classes
AU2019410635A1 (en) 2018-12-19 2021-06-17 Grail, Inc. Cell-free DNA end characteristics
WO2020132572A1 (en) 2018-12-21 2020-06-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free-dna samples
WO2020127629A1 (en) * 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Identification of global sequence features in whole genome sequence data from circulating nucelic acid
EP3938534A4 (en) 2019-03-13 2023-03-29 Grail, LLC SYSTEMS AND METHODS FOR ENCOURAGEMENT OF CANCER DERIVATIVE FRAGMENTS BY FRAGMENT SIZE
AU2020246747A1 (en) 2019-03-25 2021-08-26 Grail, Inc. Determining linear and circular forms of circulating nucleic acids
JP2022527316A (ja) * 2019-04-02 2022-06-01 グレイル， インコーポレイテッド ウィルスに関連した癌のリスクの層別化
US12497662B2 (en) 2019-04-16 2025-12-16 Grail, Inc. Systems and methods for tumor fraction estimation from small variants
WO2020229152A1 (en) * 2019-05-10 2020-11-19 Bayer Consumer Care Ag Identification of candidate signs indicative of an ntrk oncogenic fusion
EP3980559A1 (en) 2019-06-06 2022-04-13 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
CN110825819A (zh) * 2019-09-24 2020-02-21 昆明理工大学 一种处理有缺失值和不平衡非小细胞肺癌数据的二分类方法
AU2020391488A1 (en) 2019-11-27 2022-06-09 GRAIL, Inc Systems and methods for evaluating longitudinal biological feature data
CA3170345A1 (en) 2020-02-14 2021-08-19 The Johns Hopkins University Methods and materials for assessing nucleic acids
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
CN114093417B (zh) * 2021-11-23 2022-10-04 深圳吉因加信息科技有限公司 一种鉴定染色体臂杂合性缺失的方法和装置
CN115220623B (zh) * 2021-12-17 2023-12-05 深圳市瑞图生物技术有限公司 染色体图像分析方法、设备及存储介质
EP4530356A3 (en) 2022-02-07 2025-07-09 Centre for Novostics Fragmentation for measuring methylation and disease
CN114525341A (zh) * 2022-02-24 2022-05-24 苏州宏元生物科技有限公司 一种同时检测肺癌和肺部感染的试剂盒
EP4547869A1 (en) 2022-06-29 2025-05-07 Raman Govindarajan Method for detecting cancer susceptibility, early detection and predicting cancer behaviour
CN114898802B (zh) * 2022-07-14 2022-09-30 臻和(北京)生物科技有限公司 基于血浆游离dna甲基化测序数据的末端序列频率分布特征确定方法、评价方法及装置
EP4634407A1 (en) * 2022-12-12 2025-10-22 Flagship Pioneering Innovations VI, LLC Phased sequencing information from circulating tumor dna
WO2024203348A1 (ja) * 2023-03-31 2024-10-03 ソニーグループ株式会社 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08503367A (ja) * 1992-11-13 1996-04-16 カリフォルニア インスティテュート オブ バイオロジカル リサーチ 遺伝子の挿入及び欠失の検出による新生物の同定
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
EP0956365A4 (en) * 1996-08-28 2004-08-25 Univ Johns Hopkins Med METHOD FOR DETECTING CELL PROLIFERATIVE DEREGULATIONS
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
US20030219802A1 (en) * 2002-03-08 2003-11-27 The Regents Of The University Of Michigan Diagnosis and treatment of osteosarcoma
AU2003291481A1 (en) * 2002-11-11 2004-06-03 Affymetrix, Inc. Methods for identifying dna copy number changes
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
EP1678329A4 (en) 2003-10-30 2008-07-02 Tufts New England Medical Ct PRENATAL DIAGNOSIS USING CELL-FREE FEDERAL DNA IN FRUIT WATER
EP1531183A1 (en) * 2003-11-14 2005-05-18 bioMérieux BV Method for amplification of RNA sequences
JP2006094760A (ja) * 2004-09-29 2006-04-13 Canon Inc 細胞のスクリーニング方法および口腔癌細胞検出方法
ES2313143T3 (es) 2005-04-06 2009-03-01 Maurice Stroun Metodo para el diagnostico de cancer mediante la deteccion de adn y arn circulantes.
US20070207481A1 (en) * 2005-12-14 2007-09-06 Michael Wigler Use of roma for characterizing genomic rearrangements
US8554488B2 (en) * 2005-12-14 2013-10-08 Cold Spring Harbor Laboratory Determining a probabilistic diagnosis of autism by analysis of genomic copy number variations
FI20061136A0 (fi) * 2006-12-19 2006-12-19 Sakari Knuutila Seulontamenetelmä
CN100533120C (zh) * 2007-03-24 2009-08-26 辽宁师范大学 多色荧光复合扩增11个肺癌易感性相关snp位点试剂盒
WO2008156827A2 (en) * 2007-06-20 2008-12-24 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular grading methods for ductal carcinoma in situ
CN106886688B (zh) * 2007-07-23 2020-07-10 香港中文大学 用于分析癌症相关的遗传变异的系统
US12180549B2 (en) * 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
US8093063B2 (en) 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
US20100041048A1 (en) * 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
EP2719774B8 (en) * 2008-11-07 2020-04-22 Adaptive Biotechnologies Corporation Methods of monitoring conditions by sequence analysis
US20100136560A1 (en) 2008-12-02 2010-06-03 The Johns Hopkins University Integrated Analyses of Breast and Colorectal Cancers
WO2010070366A1 (en) * 2008-12-15 2010-06-24 Debreceni Egyetem Cytometric method for the comparative analysis of the length of pcr products and uses of this method
JP2012513217A (ja) * 2008-12-22 2012-06-14 セルラ・インコーポレイテッド 対立遺伝子、ゲノムおよびトランスクリプトームを検出する方法および遺伝子型決定パネル
WO2011057094A1 (en) 2009-11-05 2011-05-12 The Chinese University Of Hong Kong Fetal genomic analysis from a maternal biological sample
AU2010317019B2 (en) 2009-11-06 2014-10-30 The Chinese University Of Hong Kong Size-based genomic analysis
EP3006573B1 (en) * 2010-01-19 2018-03-07 Verinata Health, Inc Methods for determining fraction of fetal nucleic acids in maternal samples
US10662474B2 (en) 2010-01-19 2020-05-26 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
US20130210645A1 (en) 2010-02-18 2013-08-15 The Johns Hopkins University Personalized tumor biomarkers
ES2703769T3 (es) * 2010-04-16 2019-03-12 Chronix Biomedical Biomarcadores de ácidos nucleicos en circulación asociados al cáncer de mama
CN106951732B (zh) * 2010-05-25 2020-03-10 加利福尼亚大学董事会 基于计算机的基因组序列分析系统
US20120034603A1 (en) * 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
EP4269623A3 (en) 2010-11-30 2024-03-06 The Chinese University Of Hong Kong Analysis of a biological sample of an organism for chromosomal deletions or amplifications associated with cancer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11168356B2 (en) 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection

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