EA201300649A1 - Выявление генетических или молекулярных аббераций, ассоциированных с раком - Google Patents

Выявление генетических или молекулярных аббераций, ассоциированных с раком

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EA201300649A1
EA201300649A1 EA201300649A EA201300649A EA201300649A1 EA 201300649 A1 EA201300649 A1 EA 201300649A1 EA 201300649 A EA201300649 A EA 201300649A EA 201300649 A EA201300649 A EA 201300649A EA 201300649 A1 EA201300649 A1 EA 201300649A1
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patient
imbalance
cancer
well
detect
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EA201300649A
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English (en)
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EA038374B1 (ru
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Юйк Мин Дэннис Ло
Квань Чэ Чань
Вай Квунь Росса Чиу
Пэйюн Цзян
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Те Чайниз Юниверсити Ов Гонконг
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Application filed by Те Чайниз Юниверсити Ов Гонконг filed Critical Те Чайниз Юниверсити Ов Гонконг
Publication of EA201300649A1 publication Critical patent/EA201300649A1/ru
Publication of EA038374B1 publication Critical patent/EA038374B1/ru

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
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    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
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    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
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    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

Предложены системы, устройства и способы для выявления генетических или молекулярных аберраций в биологическом образце, отобранном из организма. Биологические образцы, включающие бесклеточные фрагменты ДНК, анализируют с целью выявления дисбаланса между областями хромосом, например, вследствие делеций и/или амплификации в опухоли. Используют множество локусов каждой области хромосомы. Затем такие варианты выявленного дисбаланса можно применять для диагностики (скрининга) пациента для выявления рака, а также для составления прогноза состояния пациента с раком или для выявления или отслеживания прогрессирования предракового состояния у пациента. Можно применять степень дисбаланса, а также количество областей, проявляющих указанный дисбаланс. Систематический анализ неперекрывающихся сегментов генома может быть основным средством скрининга образца. Кроме того, состояние пациента можно исследовать во времени, чтобы отслеживать степень тяжести заболевания для каждой из одной или более областей хромосом и количество областей хромосом, что создает возможность для скрининга и прогнозирования, а также отслеживания прогресса (например, после лечения).
EA201300649A 2010-11-30 2011-11-30 Способ анализа биологического образца организма для выявления хромосомных делеций или амплификаций, ассоциированных с раком EA038374B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41839110P 2010-11-30 2010-11-30
US201161529877P 2011-08-31 2011-08-31
PCT/AU2011/001562 WO2012071621A1 (en) 2010-11-30 2011-11-30 Detection of genetic or molecular aberrations associated with cancer

Publications (2)

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EA201300649A1 true EA201300649A1 (ru) 2013-10-30
EA038374B1 EA038374B1 (ru) 2021-08-17

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EA201300649A EA038374B1 (ru) 2010-11-30 2011-11-30 Способ анализа биологического образца организма для выявления хромосомных делеций или амплификаций, ассоциированных с раком

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US (3) US8741811B2 (ru)
EP (4) EP2646579B1 (ru)
JP (5) JP6196157B2 (ru)
KR (6) KR102185244B1 (ru)
CN (4) CN114678128A (ru)
AU (1) AU2011335891B2 (ru)
BR (1) BR112013013421A2 (ru)
CA (1) CA2817370C (ru)
DK (2) DK3243910T3 (ru)
EA (1) EA038374B1 (ru)
HK (2) HK1190437A1 (ru)
IL (3) IL226272A (ru)
MX (3) MX370249B (ru)
MY (1) MY169852A (ru)
NZ (1) NZ611599A (ru)
SG (3) SG10201509766YA (ru)
TW (5) TWI786520B (ru)
WO (1) WO2012071621A1 (ru)
ZA (1) ZA201304625B (ru)

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