CN105209043B - 噻唑并嘧啶酮用于治疗炎症性肠病的应用 - Google Patents

噻唑并嘧啶酮用于治疗炎症性肠病的应用 Download PDF

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Publication number
CN105209043B
CN105209043B CN201480028313.6A CN201480028313A CN105209043B CN 105209043 B CN105209043 B CN 105209043B CN 201480028313 A CN201480028313 A CN 201480028313A CN 105209043 B CN105209043 B CN 105209043B
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China
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compound
present
pharmaceutical composition
composition
dose
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Expired - Fee Related
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CN201480028313.6A
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English (en)
Chinese (zh)
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CN105209043A (zh
Inventor
海坦亚·杜特
维贾伊·乔泰瓦利
拉姆·古普塔
希塔尔库马尔·桑巴德
沙伊莱什·德什潘德
吉格内什·科特查
拉梅什·古普塔
桑贾伊·斯里瓦斯塔瓦
拉克西米坎特·奇帕
贾亚·亚伯拉罕
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Torrent Pharmaceuticals Ltd
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Torrent Pharmaceuticals Ltd
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
CN201480028313.6A 2013-05-14 2014-05-12 噻唑并嘧啶酮用于治疗炎症性肠病的应用 Expired - Fee Related CN105209043B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN1718/MUM/2013 2013-05-14
IN1718MU2013 2013-05-14
IN2309MU2013 2013-07-09
IN2309/MUM/2013 2013-07-09
PCT/IB2014/000707 WO2014184631A1 (en) 2013-05-14 2014-05-12 Use of a thiazolo pyrimidinone for the treatment of inflammatory bowel disease

Publications (2)

Publication Number Publication Date
CN105209043A CN105209043A (zh) 2015-12-30
CN105209043B true CN105209043B (zh) 2019-07-02

Family

ID=50896342

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480028313.6A Expired - Fee Related CN105209043B (zh) 2013-05-14 2014-05-12 噻唑并嘧啶酮用于治疗炎症性肠病的应用

Country Status (28)

Country Link
US (2) US9610247B2 (OSRAM)
EP (1) EP2996693B1 (OSRAM)
JP (1) JP6407974B2 (OSRAM)
KR (1) KR102239649B1 (OSRAM)
CN (1) CN105209043B (OSRAM)
AU (1) AU2014266968B2 (OSRAM)
BR (1) BR112015028581B1 (OSRAM)
CA (1) CA2912011C (OSRAM)
CY (1) CY1121280T1 (OSRAM)
DK (1) DK2996693T3 (OSRAM)
EA (1) EA030590B1 (OSRAM)
ES (1) ES2712705T3 (OSRAM)
HR (1) HRP20190315T1 (OSRAM)
HU (1) HUE042691T2 (OSRAM)
IL (1) IL242490B (OSRAM)
LT (1) LT2996693T (OSRAM)
MX (1) MX358198B (OSRAM)
MY (1) MY179215A (OSRAM)
PH (1) PH12015502560B1 (OSRAM)
PL (1) PL2996693T3 (OSRAM)
PT (1) PT2996693T (OSRAM)
RS (1) RS58423B1 (OSRAM)
SG (1) SG11201509275PA (OSRAM)
SI (1) SI2996693T1 (OSRAM)
SM (1) SMT201900111T1 (OSRAM)
TW (1) TWI661828B (OSRAM)
UA (1) UA117244C2 (OSRAM)
WO (1) WO2014184631A1 (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI781922B (zh) * 2016-03-14 2022-11-01 日商參天製藥股份有限公司 由葡甲胺或其鹽構成之防腐劑

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110065771A1 (en) * 2007-06-27 2011-03-17 Colgan Sean P Inflammatory bowel disease therapies
US20110130414A1 (en) * 2009-11-27 2011-06-02 Torrent Pharmaceuticals Limited Novel fused thiazolo and oxazolo pyrimidinones
CN102549000A (zh) * 2009-10-13 2012-07-04 托伦特药物有限公司 稠合噻唑并和噁唑并嘧啶酮

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110065771A1 (en) * 2007-06-27 2011-03-17 Colgan Sean P Inflammatory bowel disease therapies
CN102549000A (zh) * 2009-10-13 2012-07-04 托伦特药物有限公司 稠合噻唑并和噁唑并嘧啶酮
US20110130414A1 (en) * 2009-11-27 2011-06-02 Torrent Pharmaceuticals Limited Novel fused thiazolo and oxazolo pyrimidinones

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Jörn Karhausen 等.Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.《The Journal of Clinical Investigation》.2004,第1098-1106页. *
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition;Andreas Robinson 等;《Gastroenterology》;20071228;第145-155页 *
Treatment with a Novel Hypoxia-Inducible Factor Hydroxylase Inhibitor (TRC160334) Ameliorates Ischemic Acute Kidney Injury;Prashant Jamadarkhana 等;《American journal of nephrology》;20120828;第208-218页 *

Also Published As

Publication number Publication date
HRP20190315T1 (hr) 2019-04-05
PL2996693T3 (pl) 2019-05-31
CA2912011A1 (en) 2014-11-20
SG11201509275PA (en) 2015-12-30
AU2014266968A1 (en) 2015-12-03
US20160120801A1 (en) 2016-05-05
SI2996693T1 (sl) 2019-04-30
ES2712705T3 (es) 2019-05-14
PH12015502560A1 (en) 2016-02-22
EP2996693B1 (en) 2018-12-12
IL242490B (en) 2018-11-29
US20170157129A1 (en) 2017-06-08
EA030590B1 (ru) 2018-08-31
AU2014266968B2 (en) 2019-09-19
EA201592159A1 (ru) 2016-04-29
US10471005B2 (en) 2019-11-12
CN105209043A (zh) 2015-12-30
US9610247B2 (en) 2017-04-04
UA117244C2 (uk) 2018-07-10
TW201513866A (zh) 2015-04-16
BR112015028581B1 (pt) 2022-05-03
KR102239649B1 (ko) 2021-04-12
KR20160008571A (ko) 2016-01-22
SMT201900111T1 (it) 2019-02-28
TWI661828B (zh) 2019-06-11
MY179215A (en) 2020-11-02
BR112015028581A2 (pt) 2017-07-25
MX2015015682A (es) 2016-07-20
PH12015502560B1 (en) 2016-02-22
PT2996693T (pt) 2019-02-27
HUE042691T2 (hu) 2019-07-29
DK2996693T3 (en) 2019-03-18
NZ714098A (en) 2020-12-18
JP6407974B2 (ja) 2018-10-17
LT2996693T (lt) 2019-03-12
CY1121280T1 (el) 2020-05-29
EP2996693A1 (en) 2016-03-23
WO2014184631A1 (en) 2014-11-20
MX358198B (es) 2018-08-08
CA2912011C (en) 2021-10-26
JP2016518440A (ja) 2016-06-23
RS58423B1 (sr) 2019-04-30

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Granted publication date: 20190702