CN105193893A - Carthamus tinctorius L. extract, cosmetic adopting same as active ingredient and application - Google Patents
Carthamus tinctorius L. extract, cosmetic adopting same as active ingredient and application Download PDFInfo
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- CN105193893A CN105193893A CN201510725024.8A CN201510725024A CN105193893A CN 105193893 A CN105193893 A CN 105193893A CN 201510725024 A CN201510725024 A CN 201510725024A CN 105193893 A CN105193893 A CN 105193893A
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Abstract
The invention discloses Carthamus tinctorius L. plant extract, a cosmetic additive adopting the same for realizing skin whitening, moisturizing and antioxidant activity and a combined application of the Carthamus tinctorius L. extract in cosmetics. The Carthamus tinctorius L. extract is ethanol extract of Carthamus tinctorius L. bee pollen or Carthamus tinctorius L. inflorescence or Carthamus tinctorius L. seed oil extract. The extract has good DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical cleaning capacity and is a good natural antioxidant. The Carthamus tinctorius L. extract has excellent skin cosmetic application potential in aspects of wrinkle resisting, whitening, sunscreen and the like in terms of skin care of a human body. With the effective utilization of Carthamus tinctorius L. which is the traditional medicinal plant in China, the Carthamus tinctorius L. extract with very high skin cosmetic activity is obtained, and the extract can be used for preparing a good tyrosinase activity inhibitor and a collagen secretion promoting active agent and is a good raw material for herbal cosmetics.
Description
Technical field
The invention belongs to cosmetics and medical art, be specifically related to extract natural active matter from a kind of Chinese tradition medicinal plants Flos Carthami--Flos Carthami extract, the cosmetics being active component with it or medicine, and the application of Flos Carthami extract in the various skin cosmetics such as preparation moisturizing, skin care, crease-resistant, sun-proof, whitening, also have in preparation treatment or prevent in dermopathic medicine application
Technical background
Flos Carthami (CarthamustinctoriusL.), having another name called red Cymbidium ensifolium (L.) Sw., thorn Flos Carthami, is Compositae Flos Carthami platymiscium, and dry tubular flower is orange red, has special fragrance, mildly bitter flavor.Flos Carthami is mainly distributed in the area of warmer climate drying, in China, is common in the ground such as Henan, Hunan, Sichuan, Xinjiang and Tibet.
The Land use systems of Flos Carthami is common is medicinal and dyeing.Flos Carthami has blood circulation promoting and blood stasis dispelling, and wet dissipation removes swollen grade for medicinal function, records " Flos Carthami: invigorate blood circulation, moisturizes, pain relieving, loose swollen, stimulates the menstrual flow " in " detailed outline ".In addition, since ancient times, Flos Carthami is just used for medicated clothing dyeing or makees kermes using as the good orchil of one.Although the use of the mankind to Flos Carthami is with a long history, the report that yet there are no Flos Carthami extract and used as a kind of raw material of skin care articles.
Summary of the invention
The object of the invention is to provide Flos Carthami extract, the cosmetics being active component with it, their preparation method, and is preparing the application in cosmetics.The present invention specify that Flos Carthami extract has good skin effect and safety, becomes good natural skin care cosmetic raw materials.
In order to realize above-mentioned purpose of the present invention, the invention provides following technical scheme:
Flos Carthami extract, is prepared by following method and obtains: getting safflower bee pollen or Flos Carthami inflorescence, pulverize, with the 85%-95% ethanol merceration 18-28h of the 15-30 times amount of safflower bee pollen or Flos Carthami inflorescence, collect filtrate, repeat 2-5 time, filtrate decompression is distilled, concentrated filtrate, cold drying, obtain crude extract, crude extract is decoloured through macroporous resin adsorption, after 85%-95% ethanol elution, concentrated evaporate to dryness, frozen drying, obtains safflower bee pollen extract or Flos Carthami inflorescence extract.Or it is some to get Semen Flos Carthami, carry out screening and removing impurities, carry out after the cold refining of hydraulic cold and physical squeezing become crude oil, with pure washing, precipitation, filtration, dehydration, filtering safflower oil is Flos Carthami extract under the condition of pressure 350Pma-450Pma and temperature 25 DEG C-35 DEG C.
The present invention provides the preparation method of above-mentioned Flos Carthami extract simultaneously, comprises the steps: to get safflower bee pollen or Flos Carthami inflorescence, pulverize, with 85%-95% ethanol 15-30 times amount merceration 18-28h, collect filtrate, repeat 2-5 time, filtrate decompression is distilled, concentrated filtrate, cold drying, obtain crude extract, crude extract is decoloured through macroporous resin adsorption, after 85%-95% ethanol elution, concentrated evaporate to dryness, frozen drying, obtains safflower bee pollen extract or Flos Carthami inflorescence extract; Or get Semen Flos Carthami, carry out screening and removing impurities, carry out after the cold refining of hydraulic cold and physical squeezing become crude oil, with pure washing, precipitation, filtration, dehydration, filtering safflower oil is Flos Carthami extract under the condition of pressure 350Pma-450Pma and temperature 25 DEG C-35 DEG C.
Present invention also offers a kind of cosmetics, be made up of above-mentioned Flos Carthami extract and cosmetics common carrier, described carrier is selected from one or more Aquo Systems, glycerol, C1-4 alcohol, fatty alcohol, polyhydric alcohol, aliphatic ether, fatty ester, ethylene glycol, propylene glycol, vegetable oil, mineral oil, liposome, laminar lipid materials, silicone oil, water, or their combination.
And described Flos Carthami extract is preparing the application in cosmetics.
Described Flos Carthami extract is in preparation moisturizing or skin care is crease-resistant or sun-proof or application in skin-lightening cosmetic.
Described Flos Carthami extract is preparing the application in anesthetis, antifungal, antiinflammatory, antioxidant, antiseptic, chelating agen, coloring agent, depigmenting agent, softening agent, emulsifying agent, agents for defoliating, film former, aromatic, wetting agent, anthelmintic, lubricant, humidizer, medicament, light stabilizer, antiseptic, Derma-Guard, skin penetration enhancer, sunscreen, stabilizing agent, surfactant, thickening agent, viscosity modifier, vitamin.
Described Flos Carthami extract is preparing the application in anesthetis, antifungal, antiinflammatory, antioxidant, antiseptic, chelating agen, coloring agent, depigmenting agent, softening agent, emulsifying agent, agents for defoliating, film former, aromatic, wetting agent, anthelmintic, lubricant, humidizer, medicament, light stabilizer, antiseptic, Derma-Guard, skin penetration enhancer, sunscreen, stabilizing agent, surfactant, thickening agent, viscosity modifier, vitamin.
Described Flos Carthami extract is preparing the application in tyrosinase activity inhibitor and short collagen secretion activator.
Present invention also offers a kind of prevention or treat dermopathic pharmaceutical composition, be made up of described Flos Carthami extract and medicine common carrier, described carrier is selected from one or more Aquo Systems, glycerol, C1-4 alcohol, fatty alcohol, polyhydric alcohol, aliphatic ether, fatty ester, ethylene glycol, propylene glycol, vegetable oil, mineral oil, liposome, laminar lipid materials, silicone oil, water, or their combination.
The application that Flos Carthami extract of the present invention prevents in preparation or treats in dermopathic medicine.
Compared with prior art, the present invention possesses following excellent benefit: the present invention obtains Objective extraction thing by carrying out concentration extraction to safflower plant, cytotoxicity experiment and cosmetics for skin activity experiment have been carried out to Objective extraction thing, demonstrate the safety of Objective extraction thing, specify that the cosmetic active that Objective extraction thing is excellent and pharmaceutically active.What invention increases Flos Carthami utilizes function and added value, has expanded again the source of natural skin care product plant material.The present invention extracts the activity extract in safflower pollen, Flos Carthami inflorescence and safflower oil by experiment, and carried out cytotoxicity and cosmetics for skin activity experiment, specify that Flos Carthami extract not only has good safety and also shows good tyrosinase activity inhibition and stronger short collagen secretion activity, make it to become good natural skin care product material of vegetable origin, widen the utilization ways of Flos Carthami, the utilization of resources improving Flos Carthami has been worth and is significant.
Accompanying drawing illustrates:
Fig. 1: Flos Carthami inflorescence extract is to the inhibitory action of tryrosinase;
Fig. 2: safflower bee pollen extract is to the inhibitory action of tryrosinase;
Fig. 3: safflower oil is to the facilitation of HDFa collagen secretion;
Fig. 4: preparation technology's flow chart of Flos Carthami extract.
Detailed description of the invention:
Below in conjunction with accompanying drawing, with embodiments of the invention, the present invention is more described in detail, but do not limit the scope of the invention.
Embodiment 1:
The preparation of Flos Carthami extract:
Take Flos Carthami (CarthamustinctoriusL.) sample (safflower bee pollen or Flos Carthami inflorescence) 60g, by sample grind into fine powder, with 85% ethanol 25 times amount (1807-1808mL) merceration 24h, then collect filtrate with buchner funnel, repeat 3 times.Filtrate is used Rotary Evaporators distilling under reduced pressure, concentrated filtrate, concentrated filtrate cold drying, obtains crude extract.By crude extract through macroporous resin (D101) adsorption bleaching, after 95% ethanol elution, eluent is concentrated evaporate to dryness, frozen drying, obtain Flos Carthami inflorescence extract 18.6g, extraction ratio is 31%; Safflower bee pollen extract 34.6g, extraction ratio is 57.6%;
Or, take Flos Carthami (CarthamustinctoriusL.) sample (safflower bee pollen or Flos Carthami inflorescence) 60g, by sample grind into fine powder, with 95% ethanol 20 times amount merceration 20h, then collect filtrate with buchner funnel, repeat 4 times.Filtrate is used Rotary Evaporators distilling under reduced pressure, concentrated filtrate, concentrated filtrate cold drying, obtains crude extract.By crude extract through macroporous resin (D101) adsorption bleaching, after 90% ethanol elution, eluent is concentrated evaporate to dryness, frozen drying, obtain Flos Carthami inflorescence extract 19.2g, extraction ratio is 32%; Safflower bee pollen extract 35.8g, extraction ratio is 59.7%.
Or get Semen Flos Carthami 1000g, carry out screening and removing impurities, carry out after the cold refining of hydraulic cold and physical squeezing become crude oil under the condition of pressure 350Pma and temperature 30 DEG C, with pure washing, precipitation, filtration, dehydration, filter to obtain safflower oil and Flos Carthami extract 123.6g, extraction ratio is 12.4%.
Or get Semen Flos Carthami 1000g, carry out screening and removing impurities, carry out after the cold refining of hydraulic cold and physical squeezing become crude oil under the condition of pressure 450Pma and temperature 25 DEG C, with pure washing, precipitation, filtration, dehydration, filter to obtain safflower oil and Flos Carthami extract 144g, extraction ratio is 14.4%.
Embodiment 2:
The cytotoxicity experiment of Flos Carthami extract: by MTS colorimetry, determines the CC of sample
50(50%cytotoxicconcentration), namely to 50% cell produce toxicity time drug level, thus determine the secure sample concentration of following activity experiment.
Experimental technique: on 96 porocyte culture plates, mixes B16 cell with the drug solution to be measured of variable concentrations, sets 3 repeating holes, arranges the blank of not drug containing, 37 DEG C, 5%CO simultaneously
2cultivate 24h, adopt MTS colorimetric determination cytotoxicity, microplate reader measures OD value, measures wavelength 490nm.Calculate CC
50value.
Cell survival rate (%)=experimental port OD
490nm/ blank well OD
490nm× 100%
Experimental result: the cell survival rate of Flos Carthami inflorescence extract is 118.877%, safflower bee pollen extract cell survival rate be 111.418% and safflower oil extract cell survival rate be 111.694%, can obviously find out that Flos Carthami extract does not have toxic action to cell, have promoting growth of cell ability on the contrary, the safety as the natural material of cosmetics for skin is guaranteed.
Embodiment 3:
Tryrosinase Inhibition test: medicine to be measured is mixed with L-Dopa (final concentration 1.25mM), add tryrosinase (final concentration 25U/mL) and start reaction, set 3 repeating holes, blank and the KojicAcid positive control of not drug containing are set simultaneously, room temperature, 5min, microplate reader measures OD value, and determined wavelength is 490nm.Calculate inhibitory activity against tyrosinase.
Inhibitory activity against tyrosinase (%)=(1 – (sample OD
490nm-sample Background control OD
490nm)/experiment contrast hole OD
490nm) × 100%
Experimental result: Flos Carthami inflorescence extract and safflower bee pollen extract have good inhibition (see Fig. 2,3) to tryrosinase, get suppression ratio be 50% extract concentrations compare.Wherein safflower pollen extract is IC
50=89.231 μ g/mL, Flos Carthami inflorescence extract are IC
50=113.176 μ g/mL, the active application potential of the cosmetics for skin of the tool whitening of safflower bee pollen Flos Carthami inflorescence extract or de-black pigment (speckle) is described, but the tyrosinase inhibitory activity effect of safflower bee pollen are more slightly better than Flos Carthami inflorescence.
Embodiment 4:
Short HDFa collagen secretion experiment: on 12 porocyte culture plates, mixed by HDFa cell with the drug solution to be measured of variable concentrations, the blank arranging not drug containing is shone and TGF-β positive control.37 DEG C, 5%CO
2cultivate 3 days, collect cells and supernatant, be stored in-80 DEG C; Add MTS, adopt the OD value of MTS colorimetric determination 490nm; Detect the secretion of collagen protein by the method provided in collagen E LISA test kit, microplate reader measures OD value, and determined wavelength is 450nm.Calculate collagen secretion increment rate.
Cell survival rate (%)=experimental port OD
490nm/ blank well OD
490nm× 100%
Collagen secretion increment rate (%)=(experimental port OD
450nm/ cell survival rate/blank well OD
450 nm-1) × 100%
Experimental result: with the Dual culture of people fibroblast, safflower oil extract (EC
50=70.408 μ g/mL) present the active and good dose-effect relationship of tool (see Fig. 3) of good short collagen secretion, illustrates that safflower oil extract has and well moisten or moisturizing and improve the cosmetics for skin activity application potential of skin own metabolism function or skin barrier function.
The invention provides the compositions with natural plant composition or natural plant composition mixture, its acceptable carrier pharmaceutically or on cosmetics.These compositionss can suppress the tyrosinase activity of skin, and B16 cell melanin generates inhibit activities, and elastin laminin is active, and TNF-α secretes inhibit activities, and short collagen secretion is active, suppresses the oxidation of skin.These compositionss can be used for microgroove and/wrinkle, skin erythema, dryness, responsive skin, skin pruritus, colour of skin inequality or skin black speck, chafing and the uncomfortable disease of other skin related to this.These compositionss include the extract obtained from Flos Carthami or the active component obtained from this plant.These compositionss can suppress the lipoxidase of skin further, and COX (Cycloxygenase) is active, MMP-1 and MMP-3 is active.In these compositionss, the content of safflower plant extract is the 0.001wt% to 20.0wt% of compositions gross weight.These compositionss can be skin care liquid, protective skin cream or Emulsion etc.The extract of Flos Carthami can be water solubility extract, and this extract can use alcohol (such as methanol, ethanol, propanol, butanols etc.) to extract.
Compositions containing Flos Carthami extract in the present invention can be used for topical skin care or hair products.These compositionss can make emulsifying agent (such as oil-in-water, Water-In-Oil, silicon Water-In-Oil, water bag silicone oil, W/O/W, Water-In-Oil bag oil, Water-In-Oil bag silicone oil etc.), cream, skin care liquid, liquid (such as water preparation or water-alcohol solution), anhydrous substrate (such as lip pomade or powder etc.), gel, ointment, milk, ointment, spray, solid formulation, eye cream etc.
Topical skin care compositions in the present invention includes the extract of Flos Carthami or the component obtained from Flos Carthami extract or composition.These compositionss of local application can alleviate the outward appearance (as skin erythema, allergic skin, red swelling of the skin, inflammation etc.) of skin erythema, also can alleviate the pain because erythema causes.Erythema generally can by the electrotherapy of skin sunburn, skin, skin burn, Contact hyper sensitization, systemic anaphylaxis, dermal toxicity, exercise, insect bite, bacteriological infection, viral infection, fungal infection, protozoa infection, massage and blow wind-induced dermatitis etc.These compositionss of local application can be treated dry skin, sensitive skin or skin itching or be reduced the outward appearance of colour of skin inequality.These compositionss of local application can reduce the outward appearance of microgroove or wrinkle.These extracts can be water miscible or non-water-soluble extracts, and their available alcohol (methanol, ethanol, propanol or butanols etc.), glycol, oil, water etc. extract.
Topical skin care compositions in the present invention includes the extract of Flos Carthami or the component obtained from Flos Carthami extract or composition.These compositionss of local application can be treated or prevent dermatosis.Dermatosis comprises dry skin, skin itching, chafing, erythema, skin allergy, pruritus, Aranea blood vessel, passeris montani saturati speckle, senile plaque, senile purpura, seborrheic keratosis, melasma, pimple, microgroove or wrinkle, tuberosity, skin sun-damaged, dermatitis (seborrheic dermatitis, nummular dermatitis, contact dermatitis, atoipc dermatitis, exfoliative dermatitis, Perioral Dermatitis and stasis dermatitis etc.), psoriasis, folliculitis, acne erythematosa, acne, pus born of the same parents are sick, erysipelas, erythrasma, eczema, sunburn, skin burn, open wound, infective factors etc.Dermatosis also can by exposing under ultraviolet light, age, radiation, be chronically exposed to the sun under, environmental pollution, air pollution, wind, hot and cold, chemicals, pathology, smoking or lack nutrition etc. and cause.This method increases the conversion rate of keratodermatitis by local application compositions of the present invention, increase the synthesis of collagen protein in fibroblast, strengthen cellular anti-oxidant defense mechanism (can improve as outer antioxidative strengthens, supplement or prevent cellular antioxidants as Skin Cell---keratinocyte, melanocyte, reduce in Langerhans cell or prevent skin, cell, the catalyzing enzyme of albumen and lipid oxidation damage and the loss of glutathion), melanic generation in check melanin cell, reduce or stop skin oxidative damage (comprising the oxidation of albumen in the quantity and/or skin reducing lipid peroxidation enzyme).
Compositions in the present invention can reduce the quantity of internal oxidation and/or the damage of external oxygen voltinism in cell, increases the synthesis of collagen protein in cell, reduces the generation of the infection cell factor in cell.These cells comprise human epidermic keratinocyte, fibroblasts of adult human dermis, or human melanoma cell, or their combination in any (as Human keratinocytes and the combination of human fibroblasts or the combination of people's keratinocyte and human melanoma cell).
Compositions in the present invention can treat hyperpigmentation, and this method also can comprise determines that a people is excessively calm the need for the treatment of skin pigment.Also can be used for reducing senile plaque, hypopigmentation of skin, the freckle in skin appearance by the compositions used in the present invention, reduce or prevent microgroove or the wrinkle of skin, increase the tightness of skin.
There is containing the compositions of Flos Carthami extract in the present invention the ability of the activity of antioxidation, restraint of tyrosinase, suppression Elastase, suppression TNF-α enzyme, suppression lipoxidase, suppression COX-1 and/or COX-2 enzyme and suppression MMP-1 and/or MMP-2.These compositionss can be used as topical skin composition, comprise acceptable carrier on Dermatology.The dermatosis relevant to the activity of tryrosinase, Elastase, TNF-α enzyme, lipoxidase, COX-1 and/or COX-2 enzyme and MMP-1 and/or MMP-2 in skin oxidative, Skin Cell can be treated or prevent to these compositionss.
Embodiment 5:
Obtain Flos Carthami extract by embodiment 1, add excipient in extract and excipient weight than the ratio of 1:1, pelletizing press sheet.
Embodiment 6:
Obtain Flos Carthami extract by embodiment 1, add excipient in extract and excipient weight than the ratio of 1:2, pelletizing press sheet.
Embodiment 7:
Obtain Flos Carthami extract by embodiment 1, capsule preparations method makes capsule routinely.
Embodiment 8:
First obtain Flos Carthami extract by embodiment 1, then make tablet as follows
Tablet: Flos Carthami extract 100mg
Starch is appropriate
Semen Maydis pulp is appropriate
Magnesium Stearate proper quantity
Embodiment 9:
Capsule: Flos Carthami extract 100mg
Starch is appropriate
Magnesium Stearate proper quantity
Preparation method: mixed with auxiliary agent by Flos Carthami extract, sieves, Homogeneous phase mixing in suitable container, and the mixture obtained is loaded hard gelatin capsule.
Embodiment 10:
Preparation method: at every turn add a kind of composition under stirring in the double distilled water of proper volume, separates until completely dark, and then adds another kind of composition.After adding water to 2ml, this solution is filtered on sterilizing filter, to load in bottle and to separate according to suitable dosage.
Embodiment 11:
Drop pill: Flos Carthami extract 1g
Polyethylene glycol 6000 9g
Method for making: the preparation of Flos Carthami extract 6000 fused solution: take Flos Carthami extract by above-mentioned recipe quantity, add appropriate dehydrated alcohol, after slight fever is dissolved, add (60 DEG C of water bath heat preservations) in the Polyethylene Glycol fused solution of recipe quantity, be uniformly mixed, till ethanol is waved to the greatest extent, be statically placed in 60 DEG C of water-baths and be incubated 30 minutes, treat that bubble eliminates, then the above-mentioned mixing fused solution eliminating bubble is proceeded in surge drum, under the condition of insulation 80-85 DEG C, control to drip speed, instill dropwise in condensed fluid, complete Deng condensation, incline condensed fluid, collect drop pill, drop is clean and remove the condensed fluid on ball with filter paper, place in silica gel drier or natural drying.
Embodiment 12:
Tablet: embodiment 1 gained Flos Carthami extract 10mg, lactose 180mg, starch 55mg, magnesium stearate 5mg;
Preparation method: by Flos Carthami extract, the mixing of newborn sugar and starch, evenly moistening with water, sieves the mixture after moistening drying, after sieve, adds magnesium stearate, and then by mixture tabletting, the heavy 250mg of every sheet, compounds content is 10mg.
Embodiment 13:
Ampulla: embodiment 1 gained Flos Carthami extract 2mg, sodium chloride 10mg;
Preparation method: Flos Carthami extract and sodium chloride are dissolved in appropriate water for injection, filters gained solution, aseptically loads in ampoule bottle.
Embodiment 14:
Capsule: embodiment 1 gained Flos Carthami extract 10mg, lactose 187mg, magnesium stearate 3mg;
Preparation method: mixed with auxiliary agent by Flos Carthami extract, sieves, Homogeneous phase mixing, and the mixture obtained is loaded hard gelatin capsule, and the heavy 200mg of each capsule, active component content is 10mg.
Embodiment 15:
Skin whitener formula (W%) containing Flos Carthami extract:
The method making cosmetics routinely obtains the cosmetics of the above-mentioned formula of the present invention.
Embodiment 16:
Emulsion formulations (W%) containing Flos Carthami extract:
The method making cosmetics routinely obtains the cosmetics of the above-mentioned formula of the present invention.
Embodiment 17:
Formula:
A oil phase w (mass percent)
Cera Flava 2%, stearic acid 5%, octadecanol 3%, lanoline 2%, sorbester p17 3%, POLYSORBATE 80 3%,
Paraffin oil 3%.
B aqueous phase w (mass percent)
Glycerol 5%, Flos Carthami extract 5% of the present invention, triethanolamine 0.3%, distilled water 75%.
C essence is appropriate, propylparaben 0.2%
Method:
Oil phase is placed in thermostat water bath be heated with stirring to 90 DEG C be fused into homogeneous phase completely after, slowly add aqueous phase, continue stir 30min; Add essence, propylparaben during slow cooling to 45 DEG C, continue to stir; When temperature is down to about 35 DEG C, stop stirring, leave standstill, cooling, obtains newborn creamy product.
Claims (9)
1. Flos Carthami extract, is prepared by following method and obtains: getting safflower bee pollen or Flos Carthami inflorescence, pulverize, with 85% ethanol of 3-5 times of volume of safflower bee pollen or Flos Carthami inflorescence, merceration 18-28h, collects filtrate, repeat 2-5 time, filtrate decompression is distilled, concentrated filtrate, cold drying, obtains crude extract, is decoloured by crude extract through macroporous resin adsorption, after 85%-95% ethanol elution, concentrated evaporate to dryness, frozen drying, obtains safflower bee pollen extract or Flos Carthami inflorescence extract; Or get Semen Flos Carthami, carry out screening and removing impurities, carry out after the cold refining of hydraulic cold and physical squeezing become crude oil under the condition of pressure 350Pma-450Pma and temperature 25 DEG C-35 DEG C, with after pure washing, precipitation, filtration, dehydration, filtration safflower oil be Flos Carthami extract.
2. the preparation method of Flos Carthami extract, is characterized in that the method comprises the steps: to get safflower bee pollen or Flos Carthami inflorescence, pulverize, with the 85%-95% ethanol of the 15-30 times amount of safflower bee pollen or Flos Carthami inflorescence, collect filtrate, repeat 2-5 time, filtrate decompression is distilled, concentrated filtrate, cold drying, obtain crude extract, crude extract is decoloured through macroporous resin adsorption, after 85%-95% ethanol elution, concentrated evaporate to dryness, frozen drying, obtains safflower bee pollen extract or Flos Carthami inflorescence extract; Or get Semen Flos Carthami, carry out screening and removing impurities, carry out after the cold refining of hydraulic cold and physical squeezing become crude oil under the condition of pressure 350Pma-450Pma and temperature 25 DEG C-35 DEG C, with after pure washing, precipitation, filtration, dehydration, filtration safflower oil be Flos Carthami extract.
3. cosmetics, be made up of Flos Carthami extract according to claim 1 and cosmetics common carrier, described carrier is selected from one or more Aquo Systems, glycerol, C1-4 alcohol, fatty alcohol, polyhydric alcohol, aliphatic ether, fatty ester, ethylene glycol, propylene glycol, vegetable oil, mineral oil, liposome, laminar lipid materials, silicone oil, water, or their combination.
4. Flos Carthami extract according to claim 1 is preparing the application in cosmetics.
5. Flos Carthami extract according to claim 1 is in preparation moisturizing or skin care is crease-resistant or sun-proof or application in skin-lightening cosmetic.
6. Flos Carthami extract according to claim 1 is preparing the application in anesthetis, antifungal, antiinflammatory, antioxidant, antiseptic, chelating agen, coloring agent, depigmenting agent, softening agent, emulsifying agent, agents for defoliating, film former, aromatic, wetting agent, anthelmintic, lubricant, humidizer, medicament, light stabilizer, antiseptic, Derma-Guard, skin penetration enhancer, sunscreen, stabilizing agent, surfactant, thickening agent, viscosity modifier, vitamin.
7. Flos Carthami extract according to claim 1 is preparing the application in tyrosinase activity inhibitor and short collagen secretion activating agent.
8. prevent or treat dermopathic pharmaceutical composition, be made up of Flos Carthami extract according to claim 1 and medicine common carrier, described carrier is selected from one or more Aquo Systems, glycerol, C1-4 alcohol, fatty alcohol, polyhydric alcohol, aliphatic ether, fatty ester, ethylene glycol, propylene glycol, vegetable oil, mineral oil, liposome, laminar lipid materials, silicone oil, water, or their combination.
9. Flos Carthami extract according to claim 1 is in the application preparing prevention or treat in dermopathic medicine.
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| CN106420564A (en) * | 2016-10-31 | 2017-02-22 | 江苏煌上田投资有限公司 | Cornu cervi pantotrichum external restoration composition |
| CN106821865A (en) * | 2017-03-25 | 2017-06-13 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of anti-apolexis composition and its application |
| CN107982131A (en) * | 2017-12-19 | 2018-05-04 | 广东德新科技孵化器有限公司 | A kind of moisturizing emulsion of crease-resistant water lock and preparation method thereof |
| CN108782735A (en) * | 2018-06-15 | 2018-11-13 | 宁波大学 | A kind of nano liposomes and preparation method thereof fresh-keeping for dry-cured ham |
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