CN105188691A - 用于治疗组织创伤的α-肾上腺素能激动剂 - Google Patents
用于治疗组织创伤的α-肾上腺素能激动剂 Download PDFInfo
- Publication number
- CN105188691A CN105188691A CN201480026013.4A CN201480026013A CN105188691A CN 105188691 A CN105188691 A CN 105188691A CN 201480026013 A CN201480026013 A CN 201480026013A CN 105188691 A CN105188691 A CN 105188691A
- Authority
- CN
- China
- Prior art keywords
- hydrochloride
- methods according
- oxymetazoline
- alpha
- group formed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361819927P | 2013-05-06 | 2013-05-06 | |
US61/819,927 | 2013-05-06 | ||
PCT/US2014/036778 WO2014182610A2 (en) | 2013-05-06 | 2014-05-05 | Alpha adrenergic agonists for the treatment of tissue trauma |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105188691A true CN105188691A (zh) | 2015-12-23 |
Family
ID=50928274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480026013.4A Pending CN105188691A (zh) | 2013-05-06 | 2014-05-05 | 用于治疗组织创伤的α-肾上腺素能激动剂 |
Country Status (14)
Country | Link |
---|---|
US (2) | US20140329874A1 (ja) |
EP (1) | EP2994120B1 (ja) |
JP (1) | JP2016518409A (ja) |
KR (1) | KR20160005351A (ja) |
CN (1) | CN105188691A (ja) |
AU (1) | AU2014262960A1 (ja) |
BR (1) | BR112015027984A2 (ja) |
CA (1) | CA2911472A1 (ja) |
ES (1) | ES2765264T3 (ja) |
HK (1) | HK1222558A1 (ja) |
MX (1) | MX2015015379A (ja) |
RU (1) | RU2015148910A (ja) |
SG (1) | SG11201509173WA (ja) |
WO (1) | WO2014182610A2 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105579042A (zh) * | 2013-07-26 | 2016-05-11 | 格拉德曼研究与发展公司 | 治疗皮肤增厚的方法 |
US11213480B1 (en) | 2015-08-06 | 2022-01-04 | Hikma Pharmaceuticals International Limited | Phenylephrine hydrochloride ready-to-use solution |
WO2017132214A1 (en) * | 2016-01-26 | 2017-08-03 | Scherer Warren J | Compositions and methods for treating rebound erythema associated with topical alpha-adrenergic agonists |
WO2018074879A1 (ko) * | 2016-10-21 | 2018-04-26 | 주식회사 셀버틱스 | 미도드린 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 당뇨병 및/또는 고지혈증의 예방 또는 치료용 약학적 조성물 |
CN113197848B (zh) * | 2021-05-24 | 2023-06-09 | 成都欣捷高新技术开发股份有限公司 | 一种重酒石酸间羟胺药物组合物及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997004764A1 (en) * | 1995-07-28 | 1997-02-13 | Armstrong Kenneth T | Topical phenylephrine preparation |
WO2005115395A2 (en) * | 2004-05-25 | 2005-12-08 | Sansrosa Pharmaceutical Development, Inc. | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
CN101977595A (zh) * | 2007-11-08 | 2011-02-16 | 阿西克斯医疗公司 | 用于治疗以及预防眼睑肿胀的组合物 |
EP2329849A1 (en) * | 2009-11-18 | 2011-06-08 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
WO2013001073A1 (en) * | 2011-06-29 | 2013-01-03 | Galderma Research & Development | A new stable anesthetic composition for reducing skin reactions |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1282855B (de) * | 1966-08-27 | 1968-11-14 | Merck Ag E | Kosmetisches Lichtschutzmittel |
US6009234A (en) * | 1995-04-14 | 1999-12-28 | Kabushiki Kaisha Toshiba | Method of reproducing information |
US7439241B2 (en) | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
US7812049B2 (en) * | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
EP2055719A1 (en) * | 2007-11-05 | 2009-05-06 | Total Petrochemicals Research Feluy | Optimisation of the ethylene polymerisation process |
NZ600125A (en) * | 2009-10-26 | 2014-05-30 | Galderma Pharma Sa | Methods of treating or preventing acute erythema |
AU2011204315A1 (en) * | 2010-01-08 | 2012-08-02 | Recro Pharma, Inc. | Topical transdermal dexmedetomidine compositions and methods of use thereof |
US20120076738A1 (en) * | 2010-09-28 | 2012-03-29 | Michael Graeber | Combination treatment for dermatological conditions |
FR2966365B1 (fr) * | 2010-10-21 | 2012-11-09 | Galderma Sa | Composition de gel topique |
EP2645993B1 (en) * | 2010-12-03 | 2016-11-02 | Allergan, Inc. | Pharmaceutical cream compositions comprising oxymetazoline |
US20120225918A1 (en) * | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
JP2014523908A (ja) * | 2011-07-14 | 2014-09-18 | アラーガン インコーポレイテッド | オキシメタゾリンのゲル組成物および使用方法 |
UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном |
-
2014
- 2014-05-05 BR BR112015027984A patent/BR112015027984A2/pt not_active Application Discontinuation
- 2014-05-05 EP EP14729541.4A patent/EP2994120B1/en active Active
- 2014-05-05 JP JP2016512984A patent/JP2016518409A/ja active Pending
- 2014-05-05 CA CA2911472A patent/CA2911472A1/en not_active Abandoned
- 2014-05-05 AU AU2014262960A patent/AU2014262960A1/en not_active Abandoned
- 2014-05-05 US US14/269,337 patent/US20140329874A1/en not_active Abandoned
- 2014-05-05 ES ES14729541T patent/ES2765264T3/es active Active
- 2014-05-05 CN CN201480026013.4A patent/CN105188691A/zh active Pending
- 2014-05-05 WO PCT/US2014/036778 patent/WO2014182610A2/en active Application Filing
- 2014-05-05 RU RU2015148910A patent/RU2015148910A/ru not_active Application Discontinuation
- 2014-05-05 SG SG11201509173WA patent/SG11201509173WA/en unknown
- 2014-05-05 MX MX2015015379A patent/MX2015015379A/es active IP Right Grant
- 2014-05-05 KR KR1020157034322A patent/KR20160005351A/ko not_active Application Discontinuation
-
2016
- 2016-09-12 HK HK16110767.2A patent/HK1222558A1/zh unknown
-
2019
- 2019-03-21 US US16/361,085 patent/US20200054608A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997004764A1 (en) * | 1995-07-28 | 1997-02-13 | Armstrong Kenneth T | Topical phenylephrine preparation |
WO2005115395A2 (en) * | 2004-05-25 | 2005-12-08 | Sansrosa Pharmaceutical Development, Inc. | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
CN101977595A (zh) * | 2007-11-08 | 2011-02-16 | 阿西克斯医疗公司 | 用于治疗以及预防眼睑肿胀的组合物 |
EP2329849A1 (en) * | 2009-11-18 | 2011-06-08 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
WO2013001073A1 (en) * | 2011-06-29 | 2013-01-03 | Galderma Research & Development | A new stable anesthetic composition for reducing skin reactions |
Also Published As
Publication number | Publication date |
---|---|
BR112015027984A2 (pt) | 2017-09-05 |
SG11201509173WA (en) | 2015-12-30 |
HK1222558A1 (zh) | 2017-07-07 |
KR20160005351A (ko) | 2016-01-14 |
EP2994120B1 (en) | 2019-10-09 |
MX2015015379A (es) | 2016-03-04 |
EP2994120A2 (en) | 2016-03-16 |
AU2014262960A1 (en) | 2015-11-26 |
WO2014182610A3 (en) | 2014-12-31 |
US20140329874A1 (en) | 2014-11-06 |
ES2765264T3 (es) | 2020-06-08 |
JP2016518409A (ja) | 2016-06-23 |
US20200054608A1 (en) | 2020-02-20 |
WO2014182610A2 (en) | 2014-11-13 |
RU2015148910A (ru) | 2017-06-13 |
CA2911472A1 (en) | 2014-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151223 |