CN105170203B - 检测选定体积的材料在样本处理装置中存在的系统和方法 - Google Patents

检测选定体积的材料在样本处理装置中存在的系统和方法 Download PDF

Info

Publication number
CN105170203B
CN105170203B CN201510501889.6A CN201510501889A CN105170203B CN 105170203 B CN105170203 B CN 105170203B CN 201510501889 A CN201510501889 A CN 201510501889A CN 105170203 B CN105170203 B CN 105170203B
Authority
CN
China
Prior art keywords
sample
detection chambers
processing apparatus
sample processing
disk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201510501889.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN105170203A (zh
Inventor
彼得·D·陆德外斯
戴维·A·惠特曼
凯尔·C·阿尔芒特劳特
莫里斯·埃克斯纳
卢西恩·A·E·雅基
米切尔·塔布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Soring Italian Ag
Original Assignee
3M Innovative Properties Co
Focus Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co, Focus Diagnostics Inc filed Critical 3M Innovative Properties Co
Publication of CN105170203A publication Critical patent/CN105170203A/zh
Application granted granted Critical
Publication of CN105170203B publication Critical patent/CN105170203B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L99/00—Subject matter not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0441—Rotary sample carriers, i.e. carousels for samples

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201510501889.6A 2011-05-18 2012-05-18 检测选定体积的材料在样本处理装置中存在的系统和方法 Active CN105170203B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161487618P 2011-05-18 2011-05-18
US61/487,618 2011-05-18
CN201280035189.7A CN103648649A (zh) 2011-05-18 2012-05-18 检测选定体积的材料在样本处理装置中存在的系统和方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280035189.7A Division CN103648649A (zh) 2011-05-18 2012-05-18 检测选定体积的材料在样本处理装置中存在的系统和方法

Publications (2)

Publication Number Publication Date
CN105170203A CN105170203A (zh) 2015-12-23
CN105170203B true CN105170203B (zh) 2017-07-18

Family

ID=46298663

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201510501889.6A Active CN105170203B (zh) 2011-05-18 2012-05-18 检测选定体积的材料在样本处理装置中存在的系统和方法
CN201280035189.7A Pending CN103648649A (zh) 2011-05-18 2012-05-18 检测选定体积的材料在样本处理装置中存在的系统和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280035189.7A Pending CN103648649A (zh) 2011-05-18 2012-05-18 检测选定体积的材料在样本处理装置中存在的系统和方法

Country Status (10)

Country Link
US (2) US9168523B2 (enExample)
EP (1) EP2709762B1 (enExample)
JP (1) JP6235462B2 (enExample)
KR (1) KR101992503B1 (enExample)
CN (2) CN105170203B (enExample)
AU (1) AU2012255151B2 (enExample)
BR (1) BR112013029181B1 (enExample)
ES (1) ES2870874T3 (enExample)
MX (1) MX337943B (enExample)
WO (1) WO2012158997A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3756767B1 (en) 2007-10-02 2024-05-01 Labrador Diagnostics LLC Modular point-of-care devices and uses thereof
CA3097861A1 (en) 2011-01-21 2012-07-26 Labrador Diagnostics Llc Systems and methods for sample use maximization
JP5822534B2 (ja) * 2011-05-13 2015-11-24 株式会社日立ハイテクノロジーズ 自動分析装置
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
BR112014011531B1 (pt) * 2011-11-15 2022-03-03 Société des Produits Nestlé S.A. Suporte e cápsula para o preparo de uma bebida por centrifugação, sistema e método para o preparo de uma bebida por centrifugação
US11008628B1 (en) 2013-02-18 2021-05-18 Labrador Diagnostics Llc Systems and methods for analyte testing and laboratory oversight
US10401373B1 (en) 2013-02-18 2019-09-03 Theranos Ip Company, Llc Systems and methods for analyte testing and laboratory oversight
US8858886B1 (en) 2013-05-08 2014-10-14 Agilent Technologies, Inc. Scanning system with interchangeable optical cartridges for fluorescence measurements
DE102013012609B4 (de) * 2013-07-26 2024-06-27 Carl Zeiss Microscopy Gmbh Optoelektronischer Detektor, insbesondere für hochauflösende Lichtrastermikroskope und Lichtrastermikroskop
KR102176587B1 (ko) * 2013-10-15 2020-11-10 삼성전자주식회사 시료분석장치, 시료분석방법, 및 밸브의 동적 작동 방법
CN105229450B (zh) * 2014-02-20 2019-06-14 罗斯蒙特公司 具有脱泡功能的比色分析仪
US11360107B1 (en) 2014-02-25 2022-06-14 Labrador Diagnostics Llc Systems and methods for sample handling
WO2015128737A2 (en) * 2014-02-25 2015-09-03 C.Y. O'connor Erade Village Foundation Inc. Methods and systems for measuring melting temperatures
CN107148479A (zh) 2014-09-04 2017-09-08 赛拉诺斯股份有限公司 病原体和抗微生物剂抗性检测
WO2016085955A1 (en) * 2014-11-25 2016-06-02 Quest Diagnostics Investments Incorporated Amplification and detection of nucleic acids in a biological sample
EP3239691B1 (en) 2014-12-26 2021-11-17 Sysmex Corporation Cell imaging device, cell imaging method, and sample cell
KR20160081022A (ko) 2014-12-30 2016-07-08 삼성전자주식회사 미세유동장치 및 이에 공급된 시료의 검출방법
US9335248B1 (en) * 2015-03-05 2016-05-10 Lam Research Corporation Systems and methods for quantifying particle performance in a substrate processing system
EP3312586B1 (en) * 2015-06-16 2020-12-16 Tascom Co., Ltd. Biological material measuring instrument
WO2016204533A1 (ko) 2015-06-16 2016-12-22 (주)타스컴 생체 측정기
US10288633B2 (en) 2015-06-26 2019-05-14 Abbott Laboratories Reaction vessel moving member for moving reaction vessels from a processing track to a rotating device in a diagnostic analyzer
SG11201803655SA (en) 2015-11-04 2018-05-30 Nitto Denko Corp Apparatus and system for biofluid sample dispensing and/or assay
US10272510B2 (en) * 2016-01-14 2019-04-30 United Technologies Corporation Electrical discharge machining apparatus
JP6987121B2 (ja) * 2016-07-21 2021-12-22 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. 測光キュベットマッピング
US10324041B2 (en) * 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
US10677741B2 (en) * 2017-07-31 2020-06-09 United States Of America As Represented By The Administrator Of Nasa Laser surface treatment and spectroscopic analysis system
EP3450959A1 (en) 2017-09-05 2019-03-06 Biosurfit, S.A. Detection method
NO346147B1 (en) * 2017-11-09 2022-03-21 Spinchip Diagnostics As Method and apparatus for controlling a focus point of stationary beam focusing on a sample in a rotating cartridge placed in a rotating disc
JP7449876B2 (ja) * 2018-11-16 2024-03-14 イルミナ インコーポレイテッド 流体カートリッジ用積層流体回路
CN110161003B (zh) * 2019-05-17 2022-07-22 深圳市刚竹医疗科技有限公司 光学检测装置及实时荧光定量核酸扩增检测系统
CN114126750A (zh) 2019-05-22 2022-03-01 赛特珍公司 用于快速识别微生物的设备和方法
CN110514591B (zh) * 2019-08-27 2022-01-11 南京林业大学 基于表型信息采集的植物光环境影响实验装置及实验方法
IT201900021264A1 (it) * 2019-11-15 2021-05-15 Macs S R L Dispositivo e metodo di certificazione delle operazioni di una macchina di analisi diagnostica in vitro
US11826707B2 (en) 2020-03-10 2023-11-28 Wellsim Biomedical Technologies, Inc Isolation chip for isolating target particles from liquid sample, and device and method for detecting the target particles
WO2021236683A1 (en) * 2020-05-18 2021-11-25 Truvian Sciences, Inc. Continuous scanning optical assembly and method of use thereof
US11353381B1 (en) * 2020-06-09 2022-06-07 Applied Materials, Inc. Portable disc to measure chemical gas contaminants within semiconductor equipment and clean room
EP3974839B1 (en) * 2020-09-23 2024-03-27 Roche Diagnostics GmbH A method for detecting and reporting an operation error in an in-vitro diagnostic system, a transport device for a laboratory sample distribution system, and a laboratory sample distribution system
KR102514955B1 (ko) * 2021-05-10 2023-03-29 건국대학교 산학협력단 Pcr 검사용 유체제어칩 및 이를 이용한 pcr 검사시스템
CN114965995B (zh) * 2022-05-20 2023-04-11 河南申友医学检验所有限公司 一种免疫层析分析检测系统及方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1346058A (zh) * 2000-09-22 2002-04-24 迪亚西斯公司 用于自动处理液体样本的装置
WO2006085071A2 (en) * 2005-02-08 2006-08-17 Lab901 Limited Analysis instrument for processing a microfluidic device

Family Cites Families (293)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3555284A (en) 1968-12-18 1971-01-12 Norman G Anderson Multistation, single channel analytical photometer and method of use
US3595386A (en) 1969-01-27 1971-07-27 Joseph R Hradel Process for beneficiation of nonmagnetic material
US3713124A (en) 1970-07-13 1973-01-23 Beckman Instruments Inc Temperature telemetering apparatus
US3798459A (en) 1972-10-06 1974-03-19 Atomic Energy Commission Compact dynamic multistation photometer utilizing disposable cuvette rotor
US3856470A (en) 1973-01-10 1974-12-24 Baxter Laboratories Inc Rotor apparatus
US3795451A (en) 1973-04-24 1974-03-05 Atomic Energy Commission Rotor for fast analyzer of rotary cuvette type
US3873217A (en) 1973-07-24 1975-03-25 Atomic Energy Commission Simplified rotor for fast analyzer of rotary cuvette type
US3912799A (en) 1973-10-15 1975-10-14 Dow Chemical Co Centrifugal extrusion employing eddy currents
DE2450482C1 (de) 1974-10-24 1985-10-31 Messerschmitt-Bölkow-Blohm GmbH, 8000 München Beheizbare Zentrifuge
US3964867A (en) 1975-02-25 1976-06-22 Hycel, Inc. Reaction container
US4046511A (en) 1975-06-16 1977-09-06 Union Carbide Corporation Pipettor apparatus
US4053054A (en) 1975-10-07 1977-10-11 Padeg A.G. Package having individual isolated cells
US4030834A (en) 1976-04-08 1977-06-21 The United States Of America As Represented By The United States Energy Research And Development Administration Dynamic multistation photometer
US4123173A (en) 1976-06-09 1978-10-31 Electro-Nucleonics, Inc. Rotatable flexible cuvette arrays
IT1097442B (it) 1977-08-18 1985-08-31 Guigan Jean Dispositivo di condizionamento di un campione di liquido in preparazione della sua analisi
US4252538A (en) 1979-03-02 1981-02-24 Engineering & Research Associates, Inc. Apparatus and method for antibody screening, typing and compatibility testing of red blood cells
JPS5677746A (en) 1979-11-30 1981-06-26 Fuji Photo Film Co Ltd Chemical analyzing device
US4284602A (en) 1979-12-10 1981-08-18 Immutron, Inc. Integrated fluid manipulator
US4256696A (en) 1980-01-21 1981-03-17 Baxter Travenol Laboratories, Inc. Cuvette rotor assembly
US4298570A (en) 1980-04-18 1981-11-03 Beckman Instruments, Inc. Tray section for automated sample handling apparatus
DE3044372A1 (de) 1980-11-25 1982-07-08 Boehringer Mannheim Gmbh, 6800 Mannheim Rotoreinheit mit einsatzelementen fuer einen zentrifugalanalysator
USD271993S (en) 1981-05-22 1983-12-27 Swartz Peter J Cuvette array
US4384193A (en) 1981-06-09 1983-05-17 Immulok, Inc. Incubating device for specimen mounted on glass slides in immunoassays
DE3130245A1 (de) 1981-07-31 1983-02-17 Bodenseewerk Perkin-Elmer & Co GmbH, 7770 Überlingen Probengeber zum aufgeben von proben bei der gaschromatographie
US4396579A (en) 1981-08-06 1983-08-02 Miles Laboratories, Inc. Luminescence detection device
US4390499A (en) 1981-08-13 1983-06-28 International Business Machines Corporation Chemical analysis system including a test package and rotor combination
US5496520A (en) 1982-01-08 1996-03-05 Kelton; Arden A. Rotary fluid manipulator
USD277891S (en) 1982-09-13 1985-03-05 Technicon Instruments Corporation Cuvette tray
US4673657A (en) 1983-08-26 1987-06-16 The Regents Of The University Of California Multiple assay card and system
USD274553S (en) 1983-10-03 1984-07-03 American Hospital Supply Corporation Cuvette rotor
US4580896A (en) 1983-11-07 1986-04-08 Allied Corporation Multicuvette centrifugal analyzer rotor with annular recessed optical window channel
US4554436A (en) 1984-03-15 1985-11-19 Bodenseewerk Perkin-Elmer & Co., Gmbh Electric heater for a rotating sample vessel container in a sampling device for gas chromatography
US4632908A (en) 1984-05-03 1986-12-30 Abbott Laboratories Heating system for rotating members
DE3570843D1 (en) * 1984-05-03 1989-07-13 Abbott Lab Centrifuge
JPS60241884A (ja) 1984-05-15 1985-11-30 Tokyo Daigaku 自動サイクリング反応装置およびこれを用いる自動分析装置
US4580898A (en) 1984-05-31 1986-04-08 Allied Corporation Analytical system
USD288124S (en) 1984-05-31 1987-02-03 Fisher Scientific Company Centrifugal analyzer rotor
US4766078A (en) 1985-03-07 1988-08-23 Henry Gang Automated consecutive reaction analyzer
US4839296A (en) 1985-10-18 1989-06-13 Chem-Elec, Inc. Blood plasma test method
US4695430A (en) 1985-10-31 1987-09-22 Bio/Data Corporation Analytical apparatus
US4814279A (en) 1986-03-17 1989-03-21 Fuji Photo Film Co., Ltd. Incubator for chemical-analytical slide
US4933146A (en) 1986-07-11 1990-06-12 Beckman Instruments, Inc. Temperature control apparatus for automated clinical analyzer
DE3712624A1 (de) 1987-04-14 1988-11-03 Holzer Walter Kleinzentrifuge
US4906432B1 (en) 1987-07-17 1991-06-25 Liquid handling
US4990075A (en) 1988-04-11 1991-02-05 Miles Inc. Reaction vessel for performing sequential analytical assays
USRE35716E (en) 1988-08-02 1998-01-20 Gene Tec Corporation Temperature control apparatus and method
US5281516A (en) 1988-08-02 1994-01-25 Gene Tec Corporation Temperature control apparatus and method
US5160702A (en) 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US6645758B1 (en) 1989-02-03 2003-11-11 Johnson & Johnson Clinical Diagnostics, Inc. Containment cuvette for PCR and method of use
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5182083A (en) 1989-03-13 1993-01-26 Beckman Instruments, Inc. Sample wheel for chemistry analyzers
CA1329698C (en) 1989-06-12 1994-05-24 Mark Joseph Devaney, Jr. Temperature control device
US5089233A (en) 1989-06-12 1992-02-18 Eastman Kodak Company Processing apparatus for a chemical reaction pack
US5149505A (en) 1989-07-18 1992-09-22 Abbott Laboratories Diagnostic testing device
USD329024S (en) 1989-11-14 1992-09-01 Palintest Ltd. Color disc for an analytical instrument
US5089229A (en) 1989-11-22 1992-02-18 Vettest S.A. Chemical analyzer
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
WO1991013350A2 (en) 1990-03-02 1991-09-05 Tekmar Company Analyzer transport device
US5258163A (en) 1990-04-14 1993-11-02 Boehringer Mannheim Gmbh Test carrier for analysis of fluids
US5219526A (en) 1990-04-27 1993-06-15 Pb Diagnostic Systems Inc. Assay cartridge
US5207987A (en) 1990-05-21 1993-05-04 Pb Diagnostic Systems Inc. Temperature controlled chamber for diagnostic analyzer
ES2057904T3 (es) 1990-06-15 1994-10-16 Chiron Corp Conjunto y aparato de ensayo, autonomos y completos en si mismos.
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5264184A (en) 1991-03-19 1993-11-23 Minnesota Mining And Manufacturing Company Device and a method for separating liquid samples
US5278377A (en) 1991-11-27 1994-01-11 Minnesota Mining And Manufacturing Company Electromagnetic radiation susceptor material employing ferromagnetic amorphous alloy particles
FI915731A0 (fi) 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
US5254479A (en) 1991-12-19 1993-10-19 Eastman Kodak Company Methods for preventing air injection into a detection chamber supplied with injected liquid
US5438128A (en) 1992-02-07 1995-08-01 Millipore Corporation Method for rapid purifiction of nucleic acids using layered ion-exchange membranes
US6190617B1 (en) 1992-03-27 2001-02-20 Abbott Laboratories Sample container segment assembly
WO1993019827A1 (en) 1992-04-02 1993-10-14 Abaxis, Inc. Analytical rotor with dye mixing chamber
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5601141A (en) 1992-10-13 1997-02-11 Intelligent Automation Systems, Inc. High throughput thermal cycler
US5288463A (en) 1992-10-23 1994-02-22 Eastman Kodak Company Positive flow control in an unvented container
US5422271A (en) 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
WO1994011489A1 (en) 1992-11-06 1994-05-26 Biolog, Inc. Testing device for liquid and liquid suspended samples
EP0612848A3 (fr) 1993-02-24 1995-05-24 Sandoz Ltd Gène associé à l'hypersensibilité.
WO1994026414A1 (en) 1993-05-17 1994-11-24 Syntex (U.S.A.) Inc. Reaction container for specific binding assays and method for its use
SE501380C2 (sv) 1993-06-15 1995-01-30 Pharmacia Lkb Biotech Sätt att tillverka mikrokanal/mikrokavitetsstrukturer
ATE208658T1 (de) 1993-07-28 2001-11-15 Pe Corp Ny Vorrichtung und verfahren zur nukleinsäurevervielfältigung
US6235531B1 (en) 1993-09-01 2001-05-22 Abaxis, Inc. Modified siphons for improved metering precision
CA2130013C (en) 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
US5439649A (en) 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
US5415839A (en) 1993-10-21 1995-05-16 Abbott Laboratories Apparatus and method for amplifying and detecting target nucleic acids
JP3051626B2 (ja) 1993-12-09 2000-06-12 富士写真フイルム株式会社 インキュベータ
US5411065A (en) 1994-01-10 1995-05-02 Kvm Technologies, Inc. Liquid specimen transfer apparatus and method
EP0739241B1 (en) 1994-01-11 1998-08-12 Abbott Laboratories Apparatus and method for thermal cycling nucleic acid assays
WO1995019781A1 (en) 1994-01-25 1995-07-27 Rodrick, Richard, J. Assays for mycobacterium tuberculosis using monospecific antibodies
US6780818B2 (en) 1994-02-02 2004-08-24 The Regents Of The University Of California Quantitative organic vapor-particle sampler
US5525514A (en) 1994-04-06 1996-06-11 Johnson & Johnson Clinical Diagnostics, Inc. Wash detection method for dried chemistry test elements
AU698953B2 (en) 1994-04-29 1998-11-12 Applied Biosystems, Llc System for real time detection of nucleic acid amplification products
JPH10501340A (ja) 1994-06-06 1998-02-03 アバクシス，インコーポレイテッド 測定精度を改善するための改良サイホン
US5700695A (en) 1994-06-30 1997-12-23 Zia Yassinzadeh Sample collection and manipulation method
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5599501A (en) 1994-11-10 1997-02-04 Ciba Corning Diagnostics Corp. Incubation chamber
EP0791238B1 (en) 1994-11-10 2004-09-22 Orchid BioSciences, Inc. Liquid distribution system
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5578270A (en) 1995-03-24 1996-11-26 Becton Dickinson And Company System for nucleic acid based diagnostic assay
US5886863A (en) 1995-05-09 1999-03-23 Kyocera Corporation Wafer support member
US5604130A (en) 1995-05-31 1997-02-18 Chiron Corporation Releasable multiwell plate cover
CA2219080A1 (en) 1995-06-07 1996-12-27 Ariad Gene Therapeutics, Inc. Rapamycin-based regulation of biological events
WO1996041864A1 (en) 1995-06-13 1996-12-27 The Regents Of The University Of California Diode laser heated micro-reaction chamber with sample detection means
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
DE69634490T2 (de) 1995-12-05 2006-03-02 Tecan Trading Ag Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung
US20010055812A1 (en) 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6709869B2 (en) 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US6068751A (en) 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US5833923A (en) 1995-12-22 1998-11-10 Universal Healthwatch, Inc. Sampling-assay interface system
US5721123A (en) 1996-01-05 1998-02-24 Microfab Technology, Inc. Methods and apparatus for direct heating of biological material
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
FR2744803B1 (fr) 1996-02-12 1998-03-13 Bio Merieux Procede et dispositif de traitement d'une carte d'analyse
US6825047B1 (en) 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
US5837203A (en) 1996-04-09 1998-11-17 Sievers Instruments, Inc. Device to alternately supply a fluid to an analyzer
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
DE19622402C1 (de) 1996-06-04 1997-10-16 Siemens Ag Vorrichtung zum Behandeln wenigstens eines Substrats sowie Verwendung der Vorrichtung
ATE390491T1 (de) 1996-06-04 2008-04-15 Univ Utah Res Found Behälter zum durchführen und beobachten biologischer prozesse
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6143248A (en) 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5804141A (en) 1996-10-15 1998-09-08 Chianese; David Reagent strip slide treating apparatus
US5811296A (en) 1996-12-20 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Blocked compartments in a PCR reaction vessel
WO1998028623A1 (en) 1996-12-20 1998-07-02 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
US6048457A (en) 1997-02-26 2000-04-11 Millipore Corporation Cast membrane structures for sample preparation
US5997818A (en) 1997-02-27 1999-12-07 Minnesota Mining And Manufacturing Company Cassette for tonometric calibration
EE9900377A (et) 1997-02-28 2000-04-17 Burstein Laboratories, Inc. Labor laserkettas
AUPO652997A0 (en) 1997-04-30 1997-05-29 Kindconi Pty Limited Temperature cycling device and method
WO1998050147A1 (en) 1997-05-09 1998-11-12 The Regents Of The University Of California Peltier-assisted microfabricated reaction chambers for thermal cycling
US6063589A (en) 1997-05-23 2000-05-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system
US6632399B1 (en) 1998-05-22 2003-10-14 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays
JP3896447B2 (ja) 1997-06-12 2007-03-22 アークレイ株式会社 臨床検査装置
US6001643A (en) 1997-08-04 1999-12-14 C-Med Inc. Controlled hydrodynamic cell culture environment for three dimensional tissue growth
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
AU9020698A (en) 1997-08-15 1999-03-08 Alexion Pharmaceuticals, Inc. Apparatus for performing assays at reaction sites
JP2001517789A (ja) 1997-09-19 2001-10-09 アクレイラ バイオサイエンシズ，インコーポレイティド 液体移送装置および液体移送方法
JP2001517794A (ja) 1997-09-19 2001-10-09 アクレイラ バイオサイエンシズ，インコーポレイティド キャピラリ電気フロー装置および方法
US6558947B1 (en) 1997-09-26 2003-05-06 Applied Chemical & Engineering Systems, Inc. Thermal cycler
US6013513A (en) 1997-10-30 2000-01-11 Motorola, Inc. Molecular detection apparatus
US5922617A (en) 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
EP1179585B1 (en) 1997-12-24 2008-07-09 Cepheid Device and method for lysis
ID23862A (id) 1998-02-20 2000-05-25 Scil Diagnotics Gmbh Sistem analisis
US6183693B1 (en) 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US7396508B1 (en) 2000-07-12 2008-07-08 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
AU763354B2 (en) 1998-02-27 2003-07-17 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
GB9804483D0 (en) 1998-03-02 1998-04-29 Central Research Lab Ltd Apparatus for and method of controlling the rate of flow of fluid along a pathway
EP1062510A2 (en) 1998-03-10 2000-12-27 Strategic Diagnostics Inc. Integrated assay device and methods of production and use
US6265168B1 (en) 1998-10-06 2001-07-24 Transgenomic, Inc. Apparatus and method for separating and purifying polynucleotides
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
GB9809943D0 (en) 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6093370A (en) 1998-06-11 2000-07-25 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
US6153148A (en) 1998-06-15 2000-11-28 Becton, Dickinson And Company Centrifugal hematology disposable
EP1088229A4 (en) 1998-06-25 2002-05-08 Caliper Techn Corp HIGH THROUGHPUT METHODS, SYSTEMS AND APPARATUS FOR CELL SCREENING TEST
EP1092144A1 (de) 1998-06-29 2001-04-18 Evotec BioSystems AG Verfahren und vorrichtung zur manipulation von partikeln in mikrosystemen
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6240790B1 (en) 1998-11-09 2001-06-05 Agilent Technologies, Inc. Device for high throughout sample processing, analysis and collection, and methods of use thereof
DE19858443A1 (de) 1998-12-17 2000-07-06 Inst Mikrotechnik Mainz Gmbh Verfahren zum Abgeben eines Fluids, fluidisches Bauteil sowie Vorrichtung zur Handhabung solcher Bauteile
GB9828785D0 (en) 1998-12-30 1999-02-17 Amersham Pharm Biotech Ab Sequencing systems
US6391264B2 (en) 1999-02-11 2002-05-21 Careside, Inc. Cartridge-based analytical instrument with rotor balance and cartridge lock/eject system
GB9903474D0 (en) 1999-02-17 1999-04-07 Univ Newcastle Process for the conversion of a fluid phase substrate by dynamic heterogenous contact with an agent
US6632655B1 (en) 1999-02-23 2003-10-14 Caliper Technologies Corp. Manipulation of microparticles in microfluidic systems
US6479300B1 (en) 1999-03-15 2002-11-12 Millipore Corporation Metal loaded ligand bound membranes for metal ion affinity chromatography
US6306273B1 (en) 1999-04-13 2001-10-23 Aclara Biosciences, Inc. Methods and compositions for conducting processes in microfluidic devices
US20040053290A1 (en) 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
AU4713400A (en) 1999-05-14 2000-12-05 Gamera Bioscience Corporation A centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
US7332326B1 (en) 1999-05-14 2008-02-19 Tecan Trading Ag Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
EP1230544B1 (en) 1999-06-18 2004-07-28 Gamera Bioscience Corporation Devices and methods for the performance of miniaturized homogeneous assays
AU5887000A (en) 1999-06-22 2001-01-09 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6664104B2 (en) 1999-06-25 2003-12-16 Cepheid Device incorporating a microfluidic chip for separating analyte from a sample
EP1813683A1 (en) 1999-07-16 2007-08-01 Applera Corporation Method for polymerase chain reaction in a microfluidic device
USD441873S1 (en) 1999-07-21 2001-05-08 Eppendorf Ag Rotor for a centrifuge
US6461287B1 (en) 1999-07-22 2002-10-08 Thermo Savant Inc. Centrifugal vacuum concentrator and modular structured rotor assembly for use therein
WO2001007892A1 (en) 1999-07-27 2001-02-01 Esperion Therapeutics, Inc. Method and device for measurement of cholesterol efflux
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US6414136B1 (en) 1999-10-06 2002-07-02 Prolinx, Inc. Removal of dye-labeled dideoxy terminators from DNA sequencing reactions
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
CA2290731A1 (en) 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6692596B2 (en) 1999-12-23 2004-02-17 3M Innovative Properties Company Micro-titer plate and method of making same
AU3986501A (en) 2000-02-23 2001-09-03 Zyomyx Inc Chips having elevated sample surfaces
US6593143B1 (en) 2000-02-29 2003-07-15 Agilent Technologies, Inc. Centrifuge system with contactless regulation of chemical-sample temperature using eddy currents
EP1134586A1 (en) 2000-03-08 2001-09-19 Tibotec N.V. Method for adding a fluid in a series of wells
US6824738B1 (en) 2000-04-14 2004-11-30 Discovery Partners International, Inc. System and method for treatment of samples on solid supports
US6432365B1 (en) 2000-04-14 2002-08-13 Discovery Partners International, Inc. System and method for dispensing solution to a multi-well container
JP2003533681A (ja) 2000-05-15 2003-11-11 テカン・トレーディング・アクチェンゲゼルシャフト ミクロ流体装置および細胞ベースの分析を実行する方法
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6566637B1 (en) 2000-06-28 2003-05-20 Cem Corporation Microwave assisted content analyzer
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
EP2295141B1 (en) 2000-06-28 2014-10-29 3M Innovative Properties Co. Enhanced sample processing methods
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6648853B1 (en) 2000-10-31 2003-11-18 Agilent Technologies Inc. Septum
US8097471B2 (en) 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
US20020076354A1 (en) 2000-12-01 2002-06-20 Cohen David Samuel Apparatus and methods for separating components of particulate suspension
US6467275B1 (en) 2000-12-07 2002-10-22 International Business Machines Corporation Cold point design for efficient thermoelectric coolers
US6617136B2 (en) 2001-04-24 2003-09-09 3M Innovative Properties Company Biological sample processing methods and compositions that include surfactants
US20030017567A1 (en) 2001-04-24 2003-01-23 3M Innovative Properties Company Biological sample processing methods and compositions that include surfactants
US20030118804A1 (en) 2001-05-02 2003-06-26 3M Innovative Properties Company Sample processing device with resealable process chamber
US6565808B2 (en) 2001-05-18 2003-05-20 Acon Laboratories Line test device and methods of use
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US7192560B2 (en) 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
US7347976B2 (en) 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US6532997B1 (en) 2001-12-28 2003-03-18 3M Innovative Properties Company Sample processing device with integral electrophoresis channels
US6833238B2 (en) 2002-01-04 2004-12-21 Applera Corporation Petal-array support for use with microplates
US6723236B2 (en) 2002-03-19 2004-04-20 Waters Investments Limited Device for solid phase extraction and method for purifying samples prior to analysis
AU2003235970A1 (en) 2002-04-30 2003-11-17 Arkray, Inc. Analysis instrument, sample analysis method and analysis device using the instrument, and method of forming opening in the instrument
US20050277195A1 (en) 2002-04-30 2005-12-15 Gyros Ab Integrated microfluidic device (ea)
US6833536B2 (en) 2002-05-22 2004-12-21 Applera Corporation Non-contact radiant heating and temperature sensing device for a chemical reaction chamber
US6679279B1 (en) 2002-07-10 2004-01-20 Motorola, Inc. Fluidic valve having a bi-phase valve element
WO2004011149A1 (en) 2002-07-26 2004-02-05 Applera Corporation Valve assembly for microfluidic devices, and method for opening and closing same
US7214348B2 (en) 2002-07-26 2007-05-08 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
JP2006511762A (ja) 2002-07-26 2006-04-06 アプレラ コーポレイション 微小流体デバイスのための一方向性マイクロボールバルブ
EP1534430A4 (en) 2002-07-26 2005-11-23 Applera Corp DEVICES, SYSTEMS AND METHODS FOR EXCLUSION OF MICROFLUIDIC SIZE
EP1525052A1 (en) 2002-07-26 2005-04-27 Applera Corporation Size-exclusion ion-exchange particles
US7198759B2 (en) 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
US7041258B2 (en) 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
WO2004011365A2 (en) 2002-07-26 2004-02-05 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US20040018559A1 (en) 2002-07-26 2004-01-29 Applera Corporation Size-exclusion ion-exchange particles
US6817373B2 (en) 2002-07-26 2004-11-16 Applera Corporation One-directional microball valve for a microfluidic device
EP1552013A1 (en) 2002-07-26 2005-07-13 Applera Corporation Microfluidic device including purification column with excess diluent, and method
US7201881B2 (en) 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
CN100380034C (zh) 2002-12-04 2008-04-09 斯宾克斯公司 流体的可程控微量控制用装置和方法
US7507376B2 (en) 2002-12-19 2009-03-24 3M Innovative Properties Company Integrated sample processing devices
US7049558B2 (en) 2003-01-27 2006-05-23 Arcturas Bioscience, Inc. Apparatus and method for heating microfluidic volumes and moving fluids
US7981600B2 (en) 2003-04-17 2011-07-19 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene
WO2005016532A2 (en) 2003-06-13 2005-02-24 Corning Incorporated Automated reaction chamber system for biological assays
US7238269B2 (en) 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
US8012768B2 (en) 2003-07-18 2011-09-06 Bio-Rad Laboratories, Inc. System and method for multi-analyte detection
US7273591B2 (en) 2003-08-12 2007-09-25 Idexx Laboratories, Inc. Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
US20050136545A1 (en) 2003-09-15 2005-06-23 Tecan Trading Ag Microfluidics devices and methods for performing based assays
US7780639B2 (en) 2003-11-12 2010-08-24 Van Lue Stephen J Magnetic devices and apparatus for medical/surgical procedures and methods for using same
US7322254B2 (en) 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7837947B2 (en) 2003-12-12 2010-11-23 3M Innovative Properties Company Sample mixing on a microfluidic device
US20050142571A1 (en) 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7727710B2 (en) 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
US20050142570A1 (en) 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
EP1715954A1 (en) 2004-02-18 2006-11-02 Applera Corporation Multi-step bioassays on modular microfluidic application platforms
JP2005274241A (ja) 2004-03-23 2005-10-06 Advance Co Ltd 生体情報検出ユニット
JP4527431B2 (ja) 2004-04-08 2010-08-18 東京エレクトロン株式会社 プラズマ処理装置
US20060040273A1 (en) 2004-08-17 2006-02-23 Alison Chaiken Method and apparatus for magnetic sensing and control of reagents
SE0402731D0 (sv) 2004-11-10 2004-11-10 Gyros Ab Liquid detection and confidence determination
JP5021486B2 (ja) * 2004-11-10 2012-09-05 ユィロス・パテント・アクチボラグ 液体検出および信頼度判定
JP4422623B2 (ja) 2005-01-17 2010-02-24 株式会社日立ハイテクノロジーズ 化学分析装置および化学分析カートリッジ
TWD113217S1 (zh) 2005-03-30 2006-10-01 東京威力科創股份有限公司 遮護環
USD559993S1 (en) 2005-03-30 2008-01-15 Tokyo Electron Limited Cover ring
TWD121115S1 (zh) 2005-03-30 2008-01-21 東京威力科創股份有限公司 遮護環
US7709249B2 (en) 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7628954B2 (en) 2005-05-04 2009-12-08 Abbott Laboratories, Inc. Reagent and sample handling device for automatic testing system
JP2008542743A (ja) 2005-06-03 2008-11-27 スピンエックス インコーポレイテッド 流体のプログラム可能な微小スケール操作のための計量計
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US20070009382A1 (en) 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
USD564667S1 (en) 2005-07-05 2008-03-18 3M Innovative Properties Company Rotatable sample processing disk
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7527763B2 (en) 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
USD557425S1 (en) 2005-08-25 2007-12-11 Hitachi High-Technologies Corporation Cover ring for a plasma processing apparatus
DE202005019472U1 (de) 2005-12-13 2006-02-23 Eppendorf Ag Laborgerät mit einer Bedienvorrichtung
KR100818274B1 (ko) 2006-09-05 2008-04-01 삼성전자주식회사 미세유동 시스템 제어장치 및 그 방법, 및 미세유동 시스템
KR101343034B1 (ko) 2006-09-05 2013-12-18 삼성전자 주식회사 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템
US7857141B2 (en) 2006-12-11 2010-12-28 Samsung Electronics Co., Ltd. Apparatus and method for separating components
CN101568384B (zh) 2006-12-22 2013-05-01 3M创新有限公司 改进的样品处理装置、系统和方法
ES2753136T3 (es) 2006-12-22 2020-04-07 Diasorin S P A Métodos de transferencia térmica para sistemas microfluídicos
JP5004577B2 (ja) * 2006-12-27 2012-08-22 ローム株式会社 液体試薬内蔵型マイクロチップにおける液体試薬の液量および／または品質が正常であるかを判定する方法、および液体試薬内蔵型マイクロチップ
US8343428B2 (en) * 2007-10-29 2013-01-01 Rohm Co., Ltd. Microchip and method of using the same
JP2008261733A (ja) * 2007-04-12 2008-10-30 Matsushita Electric Ind Co Ltd 血液分析装置
US20100129878A1 (en) 2007-04-25 2010-05-27 Parthasarathy Ranjani V Methods for nucleic acid amplification
KR101228308B1 (ko) 2007-05-23 2013-01-31 삼성전자주식회사 미세유동 칩을 이용한 디스크형 미세유동장치 및 생체물질마이크로어레이 칩을 이용한 디스크형 미세유동장치
WO2008157689A2 (en) 2007-06-19 2008-12-24 University Of Utah Research Foundation Methods of nucleic acid amplification analysis
US20090181366A1 (en) 2007-07-30 2009-07-16 Quest Diagnostics Investments Incorporated Internal positive control for nucleic acid assays
JP5183255B2 (ja) 2008-03-07 2013-04-17 パナソニック株式会社 分析用デバイス駆動装置とこれを備えた分析装置
WO2009085884A1 (en) 2007-12-28 2009-07-09 3M Innovative Properties Company Sample processing device with optical elements
USD600722S1 (en) 2008-05-07 2009-09-22 Komatsu Ltd. Fan shroud for construction machinery
USD605206S1 (en) 2008-05-07 2009-12-01 Komatsu Ltd. Fan shroud for construction machinery
JP5224961B2 (ja) * 2008-07-31 2013-07-03 パナソニック株式会社 分析用デバイスと分析方法
KR101390717B1 (ko) 2008-09-02 2014-04-30 삼성전자주식회사 미세유동장치 및 미세유동장치에의 시료주입방법
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
US20110117607A1 (en) 2009-11-13 2011-05-19 3M Innovative Properties Company Annular compression systems and methods for sample processing devices
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
KR101422573B1 (ko) 2009-11-26 2014-07-25 삼성전자 주식회사 원심력기반의 미세유동장치 및 이를 이용한 면역혈청검사방법
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1346058A (zh) * 2000-09-22 2002-04-24 迪亚西斯公司 用于自动处理液体样本的装置
WO2006085071A2 (en) * 2005-02-08 2006-08-17 Lab901 Limited Analysis instrument for processing a microfluidic device

Also Published As

Publication number Publication date
US9725762B2 (en) 2017-08-08
KR101992503B1 (ko) 2019-06-24
BR112013029181A2 (pt) 2017-01-31
BR112013029181B1 (pt) 2020-11-03
MX2013013149A (es) 2014-05-27
AU2012255151A1 (en) 2013-12-05
CN103648649A (zh) 2014-03-19
ES2870874T3 (es) 2021-10-27
WO2012158997A9 (en) 2013-12-05
US20160040213A1 (en) 2016-02-11
US20120293796A1 (en) 2012-11-22
EP2709762B1 (en) 2021-03-31
HK1212286A1 (en) 2016-06-10
WO2012158997A1 (en) 2012-11-22
US9168523B2 (en) 2015-10-27
JP2014517293A (ja) 2014-07-17
AU2012255151B2 (en) 2015-09-03
EP2709762A1 (en) 2014-03-26
MX337943B (es) 2016-03-29
JP6235462B2 (ja) 2017-11-22
KR20140056186A (ko) 2014-05-09
CN105170203A (zh) 2015-12-23

Similar Documents

Publication Publication Date Title
CN105170203B (zh) 检测选定体积的材料在样本处理装置中存在的系统和方法
KR101441594B1 (ko) 온도 민감 폴리머 합성체를 이용한 핵산 증폭 디스크 장치 및 이를 이용한 분석 방법
JP7167102B2 (ja) 流体検査用カセット
TWI797120B (zh) 流體測試卡匣
JP5282088B2 (ja) 処理実行に使用する機器および容器
US20220186325A1 (en) Systems for sample analysis
US7358078B2 (en) Auto microfluidic hybridization chip platform
CN106795473A (zh) 用于核酸分析的具有集成的测定对照的微流体盒及设备
US20090011417A1 (en) Testing Device
US20070009383A1 (en) Valve control system for a rotating multiplex fluorescence detection device
CN108449996A (zh) 微流体装置及其使用方法
CN105925696A (zh) 使用结合元件用于分析的装置和方法
ES2744237T3 (es) Sistemas y métodos de distribución en un dispositivo de procesamiento de muestra
AU2022270084B2 (en) Systems, methods, and apparatus for automated self-contained biological analysis
CN109490259A (zh) 多色荧光激发及检测装置及其核酸分析设备应用
KR20250162601A (ko) 시험관 내 진단 시스템
HK1212286B (en) Systems and methods for detecting the presence of a selected volume of material in a sample processing device
CN119096130A (zh) 样品测试装置和方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1212286

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20170928

Address after: Vercelli

Patentee after: DIASORIN S.P.A.

Address before: American Minnesota

Co-patentee before: Focus Diagnostics, Inc.

Patentee before: 3M INNOVATIVE PROPERTIES Co.

REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1212286

Country of ref document: HK

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20221101

Address after: Vercelli

Patentee after: soring italian AG

Address before: Vercelli

Patentee before: DIASORIN S.P.A.