CN1051311C - N－杂芳基－n'－苯脲衍生物及其生产和应用 - Google Patents

N－杂芳基－n'－苯脲衍生物及其生产和应用 Download PDF

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Publication number
CN1051311C
CN1051311C CN94101930A CN94101930A CN1051311C CN 1051311 C CN1051311 C CN 1051311C CN 94101930 A CN94101930 A CN 94101930A CN 94101930 A CN94101930 A CN 94101930A CN 1051311 C CN1051311 C CN 1051311C
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China
Prior art keywords
group
phenyl
compound
chloro
productive rate
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Expired - Fee Related
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CN94101930A
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English (en)
Chinese (zh)
Other versions
CN1100417A (zh
Inventor
永峰政志
山本健二
松井良光
堀内谦治
吉田正德
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Nihon Nohyaku Co Ltd
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Nihon Nohyaku Co Ltd
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Publication of CN1100417A publication Critical patent/CN1100417A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
CN94101930A 1993-02-27 1994-02-26 N－杂芳基－n'－苯脲衍生物及其生产和应用 Expired - Fee Related CN1051311C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6346093 1993-02-27
JP063460/93 1993-02-27

Publications (2)

Publication Number Publication Date
CN1100417A CN1100417A (zh) 1995-03-22
CN1051311C true CN1051311C (zh) 2000-04-12

Family

ID=13229879

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94101930A Expired - Fee Related CN1051311C (zh) 1993-02-27 1994-02-26 N－杂芳基－n'－苯脲衍生物及其生产和应用

Country Status (14)

Country Link
US (2) US5464863A (enExample)
EP (1) EP0613894B1 (enExample)
JP (1) JP3143766B2 (enExample)
KR (1) KR940019701A (enExample)
CN (1) CN1051311C (enExample)
AT (1) ATE179706T1 (enExample)
AU (1) AU679021B2 (enExample)
CA (1) CA2116286A1 (enExample)
DE (1) DE69418243T2 (enExample)
DK (1) DK0613894T3 (enExample)
ES (1) ES2133430T3 (enExample)
GR (1) GR3030165T3 (enExample)
NZ (1) NZ250916A (enExample)
TW (1) TW279858B (enExample)

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TW234123B (enExample) * 1992-12-16 1994-11-11 Takeda Pharm Industry Co Ltd
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
FR2734816B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5773459A (en) * 1995-06-07 1998-06-30 Sugen, Inc. Urea- and thiourea-type compounds
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
US5567828A (en) * 1995-06-07 1996-10-22 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side
AU679887B2 (en) * 1995-09-11 1997-07-10 Nihon Nohyaku Co., Ltd. Azole derivatives, their use, production and usage
JP2000515495A (ja) * 1996-06-27 2000-11-21 スミスクライン・ビーチャム・コーポレイション Ｉｌ―８レセプターアンタゴニスト
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
CA2345459A1 (en) * 1998-11-12 2000-05-18 Regine Bohacek Bicyclic signal transduction inhibitors, compositions containing them & uses thereof
WO2002006264A1 (en) * 2000-07-13 2002-01-24 Takeda Chemical Industries, Ltd. Lipid-rich plaque inhibitors
JP2004529855A (ja) 2000-10-10 2004-09-30 スミスクライン ビーチャム コーポレーション 置換インドール類、そのような置換インドール類を含む医薬組成物及びＰＰＡＲ−γ結合剤としてのそれらの使用
AU2002221116A1 (en) * 2000-12-11 2002-06-24 Takeda Chemical Industries Ltd. Medicinal compositions having improved water-solubility
US20040019096A1 (en) * 2001-10-23 2004-01-29 Vlassios Andronis Novel formulations of carvedilol
MXPA04011465A (es) 2002-05-24 2005-02-14 Millennium Pharm Inc Inhibidores de ccr9 y metodos de uso de los mismos.
MY143477A (en) * 2002-10-29 2011-05-31 Smithkline Beecham Corp Il-8 receptor antagonists
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
EP1798223B2 (en) 2002-11-18 2014-07-30 ChemoCentryx, Inc. Aryl sulfonamides
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
EP1742635B1 (en) * 2004-04-20 2018-03-07 Acea Biosciences, Inc. Substituted organosulfur compounds and methods of using thereof
WO2007100066A1 (ja) * 2006-03-02 2007-09-07 Astellas Pharma Inc. １７βＨＳＤｔｙｐｅ５阻害剤
RU2008145871A (ru) * 2006-04-21 2010-05-27 Смитклайн Бичам Корпорейшн (US) Антагонисты рецептора il-8
CL2007001142A1 (es) * 2006-04-21 2008-01-25 Smithkline Beecham Corp Compuestos derivados de sulfona, antagonistas del receptor il-8; procedimiento de preparacion;compuestos intermediarios;composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de asma, enfermedad pulmonar obstructiva cronica, dermatitis, psoriasis, alzheimer, aterosclerosis, osteoporosis.
AR061571A1 (es) * 2006-06-23 2008-09-03 Smithkline Beecham Corp Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un
US7785218B2 (en) 2007-03-26 2010-08-31 Acushnet Company Custom milled iron set
US8609663B2 (en) * 2009-11-18 2013-12-17 University Of Massachusetts Compounds for modulating TLR2
CN104529830B (zh) * 2015-01-15 2016-08-24 成都丽凯手性技术有限公司 一种制备脲类化合物的新方法
GB201521059D0 (en) * 2015-11-30 2016-01-13 Isis Innovation Inhibitors of metallo-beta-lactamases
JP7704982B2 (ja) 2021-12-01 2025-07-08 ファイザー・インク 糖尿病、腎疾患、ｎａｓｈおよび心不全を処置するための分枝鎖アルファケト酸デヒドロゲナーゼキナーゼ阻害剤としての３－フェニル－１－ベンゾチオフェン－２－カルボン酸誘導体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113731A (en) * 1975-08-27 1978-09-12 Gruppo Lepetit S.P.A. Fused isoquinoline derivatives
CN1039416A (zh) * 1988-07-12 1990-02-07 武田药品工业株式会社 喹啉衍生物及其制备和用途
CN1047859A (zh) * 1989-05-25 1990-12-19 武田药品工业株式会社 苯并环烷烃衍生物及其制备方法
CN1067886A (zh) * 1991-05-10 1993-01-13 藤泽药品工业株式会社 新的脲衍生物，它们的制备方法及其药物组合物
CN1080919A (zh) * 1992-05-28 1994-01-19 美国辉瑞有限公司 作为酰基辅酶a-胆固醇酰基转移酶抑制剂的、新的n-芳基和n-杂芳基脲类衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2375228A1 (fr) * 1976-12-23 1978-07-21 Parcor Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants
JPH0753714B2 (ja) * 1988-07-12 1995-06-07 武田薬品工業株式会社 Ａｃａｔ阻害剤、キノリン誘導体及びその製造法
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
TW234123B (enExample) * 1992-12-16 1994-11-11 Takeda Pharm Industry Co Ltd

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113731A (en) * 1975-08-27 1978-09-12 Gruppo Lepetit S.P.A. Fused isoquinoline derivatives
CN1039416A (zh) * 1988-07-12 1990-02-07 武田药品工业株式会社 喹啉衍生物及其制备和用途
CN1047859A (zh) * 1989-05-25 1990-12-19 武田药品工业株式会社 苯并环烷烃衍生物及其制备方法
CN1067886A (zh) * 1991-05-10 1993-01-13 藤泽药品工业株式会社 新的脲衍生物，它们的制备方法及其药物组合物
CN1080919A (zh) * 1992-05-28 1994-01-19 美国辉瑞有限公司 作为酰基辅酶a-胆固醇酰基转移酶抑制剂的、新的n-芳基和n-杂芳基脲类衍生物

Also Published As

Publication number Publication date
DE69418243T2 (de) 1999-09-30
NZ250916A (en) 1995-08-28
CA2116286A1 (en) 1994-08-28
EP0613894A1 (en) 1994-09-07
ATE179706T1 (de) 1999-05-15
CN1100417A (zh) 1995-03-22
DE69418243D1 (de) 1999-06-10
JP3143766B2 (ja) 2001-03-07
ES2133430T3 (es) 1999-09-16
GR3030165T3 (en) 1999-08-31
EP0613894B1 (en) 1999-05-06
USRE36832E (en) 2000-08-22
DK0613894T3 (da) 1999-11-01
US5464863A (en) 1995-11-07
AU5636494A (en) 1994-09-01
TW279858B (enExample) 1996-07-01
AU679021B2 (en) 1997-06-19
JPH06340647A (ja) 1994-12-13
KR940019701A (ko) 1994-09-14

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