CN105125772A - Medicine preparation for treating osteoporosis - Google Patents
Medicine preparation for treating osteoporosis Download PDFInfo
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- CN105125772A CN105125772A CN201510628351.1A CN201510628351A CN105125772A CN 105125772 A CN105125772 A CN 105125772A CN 201510628351 A CN201510628351 A CN 201510628351A CN 105125772 A CN105125772 A CN 105125772A
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Abstract
The invention belongs to the field of a traditional Chinese medicine preparation, and concretely provides a medicine preparation for treating osteoporosis. The medicine preparation is prepared from the following ingredients: 25 parts of acalypha australis, 20 parts of iris japonica thunb, 18 parts of lycopodiumfargesii, 25 parts of libanotis buethorimensis, 20 parts of pericarpium citri reticulatae, 28 parts of codonopsis pilosula, 15 parts of achyranthes bidentata, 15 parts of rehmannia, 20 parts of astragalus, 25 parts of salvia miltiorrhiza, 20 parts of cortex moutan, 25 parts of frankincense, 20 parts of tuckahoe, 15 parts of caulis spatholobi, 15 parts of myrrh, 15 parts of eucommia ulmoides, 25 parts of glossy privet fruits, 15 parts of rhizoma drynariae and 5 parts of liquorice. The medicine preparation can be used for treating the osteoporosis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of osteoporotic pharmaceutical preparation and its preparation method and application.
Background technology
Osteoporosis is one group of osteopathia that many reasons causes, and osseous tissue has normal calcification, and calcium salt and substrate are normal rates, and the metabolic osteopathy being reduced to feature with unit volume inner bone tissues amount becomes.In most osteoporosis, caused by the minimizing of osseous tissue increases mainly due to bone absorption.With skeleton pain, be easy to fracture for feature.The diagnosis of post menopausal and senile osteoporosis, first need to get rid of the secondary osteoporosis caused by other a variety of causes, as hyperparathyroidism and multiple myeloma, osteomalacia, renal osteodystrophy, the osteogenesis imperfecta of child, metastatic tumor, leukemia and lymphoma etc.WHO suggestion in 1994 carries out grading diagnosis according to BMD or BMC (bone mineral content) value to osteoporosis: normal for BMD or BMC is within 1 standard deviation (SD) of adult normal's bone density meansigma methods; Osteopenia is that BMD or BMC compared with normal adult bone density average reduces by 1 ~ 2.5 standard deviation; Osteoporosis is that BMD or BMC compared with normal adult bone density average reduces more than 2.5 standard deviations; Serious osteoporosis is that BMD or BMC compared with normal adult bone density average reduces more than 2.5 standard deviations and with the fragility fractures of more than 1 or 1.In this diagnostic criteria, BMD or BMC can measure at axial bone or periphery skeleton.For this reason, be bursting to develop and manyly treat the needs that osteoporotic medicine meets clinical treatment safely and effectively.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of bone loss disorders.In order to reach this object, adopt following technical scheme:
Technical scheme: one is used for the treatment of osteoporotic pharmaceutical preparation, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Acalyphae 25 parts, Rhizoma Iridis Japonicae 20 parts, Lycopodium fargesii 18 parts, Radix Libanotidis buchotomensis 25 parts, Pericarpium Citri Reticulatae 20 parts, Radix Codonopsis 28 parts, Radix Achyranthis Bidentatae 15 parts, Radix Rehmanniae 15 parts, the Radix Astragali 20 parts, Radix Salviae Miltiorrhizae 25 parts, Cortex Moutan 20 parts, Olibanum 25 parts, 20 parts, Poria, Caulis Spatholobi 15 parts, Myrrha 15 parts, the Cortex Eucommiae 15 parts, Fructus Ligustri Lucidi 25 parts, Rhizoma Drynariae 15 parts, 5 parts, Radix Glycyrrhizae.
Describedly be used for the treatment of osteoporotic pharmaceutical preparation, dosage form is pharmaceutically acceptable granule, tablet, capsule.
Describedly be used for the treatment of osteoporotic pharmaceutical preparation, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
Described be used for the treatment of osteoporotic pharmaceutical preparation preparation treatment medicine for treating osteoporosis in application.
Herba Acalyphae is Euphorbiaceae Acalypha plant iron Amaranthus mangostanus L. AcalyphaaustralisL., with all herbal medicine.Xia Qiu gathers herb, removes earth, dries.Heat-clearing and toxic substances removing, removing food stagnancy, dysentery relieving, hemostasis.For enteritis, bacillary dysentery, amebic dysentery, infantile malnutrition, hepatitis, malaria, spits blood, epistaxis, and hematuria, has blood in stool, metrorrhagia; Carbuncle furuncle infections is controlled in external, traumatic hemorrhage, eczema, dermatitis, venom.
Rhizoma Iridis Japonicae is Iridaceae iris Herba Iridis japonicae IrisjaponicaThunb., is used as medicine with herb and root stock.The four seasons all can excavate, and clean, dry.Herb: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For hepatitis, hepatomegaly, pain in the hepatic region, stomachache, food stagnation distension, laryngopharynx swelling and pain, traumatic injury.Root stock: relieving constipation by purgation.For constipation.The present invention is with all herbal medicine.
Lycopodium fargesii is fern Lycopodiaceae Lycopodium plant Lycopodium fargesii LycopodiumfargesiiHert., with all herbal medicine.The whole year can adopt, and cleans and dries.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For rheumatic arthritis, muscle spasm, traumatic injury, hypertrophic spondylitis, rheumatoid arthritis.
Radix Libanotidis buchotomensis is Umbelliferae Herba Seselis Seseloidis platymiscium Radix Libanotidis buchotomensis SeseligiraldiiDiels, is used as medicine with root.Xia Qiu excavates, and cleans, dries for subsequent use.Deliver cold expelling, dispelling, collateral-activating.For flu, cough, headache, toothache, Fengshi Guanjie pain, traumatic injury.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, osteoporotic is due to eating and drinking without temperance, impairing the spleen and stomach, time one, then spleen and stomach function was weak for a long time, affect food digestion, thus nutrition can not fill passages through which vital energy circulates, thus generation osteoporosis, Herba Acalyphae of the present invention, Rhizoma Iridis Japonicae, Lycopodium fargesii, Radix Libanotidis buchotomensis, Pericarpium Citri Reticulatae, Radix Codonopsis, Radix Achyranthis Bidentatae, Radix Rehmanniae, Radix Astragali heat-clearing and toxic substances removing, the liver and the kidney tonifying is monarch drug, Radix Salviae Miltiorrhizae, Cortex Moutan, Olibanum, Poria, Caulis Spatholobi, Myrrha, the Cortex Eucommiae, Fructus Ligustri Lucidi, Rhizoma Drynariae blood circulation promoting and blood stasis dispelling is ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment osteoporosis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Acalyphae 25g, Rhizoma Iridis Japonicae 20g, Lycopodium fargesii 18g, Radix Libanotidis buchotomensis 25g, Pericarpium Citri Reticulatae 20g, Radix Codonopsis 28g, Radix Achyranthis Bidentatae 15g, Radix Rehmanniae 15g, Radix Astragali 20g, Radix Salviae Miltiorrhizae 25g, Cortex Moutan 20g, Olibanum 25g, Poria 20g, Caulis Spatholobi 15g, Myrrha 15g, Cortex Eucommiae 15g, Fructus Ligustri Lucidi 25g, Rhizoma Drynariae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Acalyphae 25g, Rhizoma Iridis Japonicae 20g, Lycopodium fargesii 18g, Radix Libanotidis buchotomensis 25g, Pericarpium Citri Reticulatae 20g, Radix Codonopsis 28g, Radix Achyranthis Bidentatae 15g, Radix Rehmanniae 15g, Radix Astragali 20g, Radix Salviae Miltiorrhizae 25g, Cortex Moutan 20g, Olibanum 25g, Poria 20g, Caulis Spatholobi 15g, Myrrha 15g, Cortex Eucommiae 15g, Fructus Ligustri Lucidi 25g, Rhizoma Drynariae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba Acalyphae 25g, Rhizoma Iridis Japonicae 20g, Lycopodium fargesii 18g, Radix Libanotidis buchotomensis 25g, Pericarpium Citri Reticulatae 20g, Radix Codonopsis 28g, Radix Achyranthis Bidentatae 15g, Radix Rehmanniae 15g, Radix Astragali 20g, Radix Salviae Miltiorrhizae 25g, Cortex Moutan 20g, Olibanum 25g, Poria 20g, Caulis Spatholobi 15g, Myrrha 15g, Cortex Eucommiae 15g, Fructus Ligustri Lucidi 25g, Rhizoma Drynariae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment osteoporosis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation osteoporosis case 80 example, 45 ~ 67 years old age.The shortest person of the course of disease 4 months, most elder reaches 5 years.
4.2 diagnostic criterias: 1. pain, mainly back extremities aching pain, or whole body skeletal pain; 2. fracture, mainly vertebra wedge sample changes or compression fracture, or extremity fracture; 3. x-ray changes, thinning with cortical bone, and bone trabecula change is loosened into feature, and 4. bone densitometry, bone mineral content density (BMD) is less than peak bone mass 1-2.5 standard deviation.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: back limbs pain transference cure, bone density inspection display bone density increases; Effective: back limbs pain symptom is obviously alleviated, and bone density is without increase; Invalid: to compare without improvement with before treatment.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
Treatment group | 40 | 15 | 22 | 3 | 92.5 |
Blank group | 40 | 2 | 5 | 33 | 17.5 |
Visible, the medicine that the present invention obtains can safe and effective treatment osteoporosis, and has no side effect.
Claims (4)
1. one kind is used for the treatment of osteoporotic pharmaceutical preparation, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Acalyphae 25 parts, Rhizoma Iridis Japonicae 20 parts, Lycopodium fargesii 18 parts, Radix Libanotidis buchotomensis 25 parts, Pericarpium Citri Reticulatae 20 parts, Radix Codonopsis 28 parts, Radix Achyranthis Bidentatae 15 parts, Radix Rehmanniae 15 parts, the Radix Astragali 20 parts, Radix Salviae Miltiorrhizae 25 parts, Cortex Moutan 20 parts, Olibanum 25 parts, 20 parts, Poria, Caulis Spatholobi 15 parts, Myrrha 15 parts, the Cortex Eucommiae 15 parts, Fructus Ligustri Lucidi 25 parts, Rhizoma Drynariae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of osteoporotic pharmaceutical preparation as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of osteoporotic pharmaceutical preparation as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of osteoporotic pharmaceutical preparation in treatment medicine for treating osteoporosis according to claim 1.
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CN201510628351.1A CN105125772A (en) | 2015-09-28 | 2015-09-28 | Medicine preparation for treating osteoporosis |
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CN201510628351.1A CN105125772A (en) | 2015-09-28 | 2015-09-28 | Medicine preparation for treating osteoporosis |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105456524A (en) * | 2015-12-14 | 2016-04-06 | 苏州枫灵医药科技有限公司 | Medicinal preparation for treating osteoporosis |
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2015
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Non-Patent Citations (1)
Title |
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南京中医药大学编著: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105456524A (en) * | 2015-12-14 | 2016-04-06 | 苏州枫灵医药科技有限公司 | Medicinal preparation for treating osteoporosis |
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